Exceptional lecture. You explain / break down subject matter better than 99 % of MDs. I appreciate that you cover subjects that actually matter instead of covering trendy topics.
Hi, great video! I actually had very high homocysteine at 45. It was then confirmed that I have MTHFR homozygous C677, with low B12 and Folate. I initially went on a supplement that had Methyl B12, Methyl Folate and Methyl B6 - Methyl Guard. In two months I became B6 toxic! Awful neurological symptoms. I stopped the supplement and now take the RDA of B12, RDA of Folinic Acid along with RDA B2 daily. My homocysteine is now at 7 :) :) And the B6 side effects are slowly going away, thankfully. People need to be very careful taking mega doses of supplements, in particular B6. My naturopathic doctor was not even aware of this potential toxicity with B6, but she is now. Thank you for doing this video! You always have excellent content.
Curious, we’re you taking the P-5-P form of B6? Many w MTHFR need this form of B6 (especially those of us w a 2nd toe that is longer than the big toe). I am taking Dr Ben Lynch’s formula, HomocysteX, trying to get my homocysteine down. He has clean products.
@@annettewebster296 Yes I was taking the P-5-P version. The product was Thorne Methyl Guard. The recommended dosage was 3 a day, and I was only taking 2. And Yes, I’ve watched a lot of Dr. Ben Lynch’s videos!!! He’s helped me a lot in coming up with a plan. I now take his Folinic Acid supplement. It’s about 4 times the RDA so I take 1/4 lozenge a day. His combo product that also had the B12 with it was out of stock when I ordered so I take a separate B12 that is dropped dosed to be close to the RDA. He actually talked about not needing to take Folinic acid or MethylFolate every day if you don’t have a lot of stress, and you’re eating your leafy greens. He views the supplement as just that, a supplement, not something that needs taking daily regardless.
Patrick holford speaks a lot about high homosistein levels and Alzheimer's/vascular dementia prevention. supplementing with B12 including other b vitamins, omega-3 and vitamin C .
Thank you so much Dr. Sung. I had no idea that my homocysteine level was dangerous. It is 12.2. I don’t have any symptoms that you mentioned, but I am addressing it with the proper B vitamins as you suggested
I just asked my doctor if it was ok for me to take vitamin B complex because I recently started using and she said yes that they use to recommend patents take it ! Thank you for your wonderful information and how you explain so we all understand!
Thank you for the very clear description! I didn't understand the real root of the issued until your video! Lung Blood Clot led to discovery of Homozygous C677T. Now I use Dr. Lynch's Homocysteine support supplement instead of the pharmaceutical the doctor prescribed and I feel good. On days when I feel exhausted he also offers an L-5 lozenge I add on. Will definitely get some Vitamin C into my supplementation program. Again, Thank you!
nteresting about diet nutrition and Homocysteine blood levels with a reading of 7 being optimal. Include foods with b-12 soil and foods providing B-12. Cruciferous Vegetables are important and a diversified diet. Glutathione production is paramount for good health. B-12 B-6 and B-9 deficiency can be the issues.
Thank you for a great video. I inherited the MTHFR-C677T polymorphism, heterozygous. My homocysteine is 11.7 My PCP informed me that my level is within the normal limits. However most of videos that I watched about homocysteine advise levels of 6 or less. My normal lab value: 5 to 15
I just got my labs back and my homocysteine is 132. They double checked it and an outside doctor looked at it too. They just decided it was a fluke. I’m a little concerned.
You should be concerned. Optimal range of homocysteine is in between 5-7. Homocysteine is used for assessment of cardio vascular health as well about you methylation status. Methylation is THE most important process in your body. Mainstream MD'S are clueless about methylation
Thank you DR. You are a Great Representation on what Every Physician shoul DEFINITELY SHOULD KNOW in ORDER for Us The Maive & Trusting Patients should be able to Put Our Already Weakened Overall Health Conditions due to THOSE CONSTANTLY & UNJUSTIFIED Antibiotics & Anti- Inflammatory & pain killers HAVE INDISCRIMINATELY BEEN Prescribed each and every DOCTORS Visitation we may need to go. Thank you and Best Wishes for You & Your Family.
The elation between Meth, Hcys and cysteine has been described in the wrong way! amazingly. hcys is not the intermediate between meth and cysteine. For the route from HCys to cysteine only B6 is needed. Overall it is wrong to say, HCys must be broken down. Its a crucial component in the metabolic cycle producing the capacity for methylation.
I have a skin problem that is helped by taking folic acid and tmg with my food when I consume animal products. Methyl folate also helps but overall taking folic acid and tmg works best.
I am homozygous MTHFR and it got really bad for me before I was diagnosed. It stills blows my mind that this condition isn't more widely understood by doctors. Two of my four daughters unfortunately also are homozygous and I hear it can be much more of a problem for females, especially during pregnancy. I am an unrepentant knucklehead when it comes to following a good diet so supplementation and physical activity have helped me. Metagenics makes methylated multi and specifically B vitamins supplements, Ceralin Forte being a lifesaver for me. Seeing my homocysteine reading go from red (as high as 20 consistently) to green on my blood tests (it's still at 10, but has stayed ridiculously stable at 10 for over a year now which is about 5 blood tests) and knowing I have answers for my daughters so it doesn't have to get as bad for them as it did for me is a good feeling.
Also look into the B12 sub q! I did the b12 injections, but felt awful and numbers never went up. There's 1 more step down the methylation b12 supplement.
Got my tests back today and my score is 179. The doctor wants the test repeated, saying she has never seen this high of a number. I’m still trying to understand how to lower the homocysteine. I’m already taking so many supplements for my other genetic mutations. 😢
I did the test this week and my score is 130. Off the charts. I want to take the test again with another lab just in case it could be an error. In the mean time I started B12 injections and a supplement.
My homocysteine came back at 60. I've also been taking creatine with tmg and then switched to phosphatidylcholine and creatine. So who only knows what my homocysteine actually is if i wasn't taking those to reduce it. I have not been taking normal does of any of that because my body has a strong reaction to all of it. Im homozygous for c677t and have had depression, anxiety, insomnia, migraines, chronic fatigue all of my life. I cannot tolerate b vitamins. I cannot tolerate coq10. I now know coq10 is produced via methylation and if you're deficient in mthfr you're body wont produce enough coq10. I cannot tolerate protein. Protein shakes, high protein meats gives me a migraine within 30 minutes after consumption.
In my Optimizing Nutrition group, the micro and macro nutrient intake is charted and analyzed from thousands of users. Eating enough methionine is the number one nutrient that reduces calorie intake by 19%. (after methionine, the data shows potassium at 8%, calcium at5%, sodium at 3.7%, vitamin B2 at 3.3% etc). But isn't methionine associated with cancers??
I had gastric bypass surgery long time ago but found out my body was no longer producing vitamin B-12. My health went downhill. I take monthly shots as well as doses of sublingual as well. I would imagine I need to increase my other B Vitamin intake! ??
How about low homocysteine? Like really, really low - below 1. There is an adequate sources of dietary methionine intake (meat), no genetic MTHFR defect. I believe there would be low/no cysteine in this case which will result in low glutathione. This is equally as bad as high homocysteine as detoxification would struggle and there would be high oxidative stress. Just thinking logically after listening to the lecture…
Hi Doctor Where are you located? I would like to get a consultation. I found out I have MTHFR mutation but all the doctors I’ve been to they have no experience on this health problem
Homocysteine 78. Ive been on high doses of D3, Folate, and B12. Nothing is bringing it down. Still low levels of D3 and folate. I am 36, and have battled this MTHFR stuff for 6 years. Even my Hemophilia dr blows the Homocysteine levels off. 😢😢😢where do I go from here?
@rredding Spot on! Added an MTHF/P5P/R5P^ supplement recommended by Custom Meds in Indianapolis. I feel awful physically starting this combination, but I'm thinking one of those slash marks means B2 supplement. Lol. Increased D3. I will give it 3 months and see how it goes. Thank you for the comment.
@@ashleyshredder let's hope it will be the solution to your health issue!. I don't know how much D3 you take, be sure you get enough magnesium. I personally combine D3 with K2 to avoid hypercalcemia.
@@DrJinSung First off all, thank you very much for your answer. Despite following a ketogenic diet ( refractory celiac disease, insulin resistance) I have high cholesterol ( 269 ), low hdl (38), low vitamin d ( 7,85), really low folate and vitamin b 2. I also have the mthfr C667t mutation on . Do you think that there is a connection? It seems a Metabolic syndrome. I am not seeking for any medical advice.
Yes so they say that's what I'm trying to fix myself. I've been experimenting with all sorts of things for 4 years now with no luck. I've recently started taking 1000mg of lysine at night on a empty stomach and I feel less anxious now 🥳. Also been taking Sam e in the morning and some methylated b vitamins with my breakfast it might be this to that is helping
Vitamin B6-ruclips.net/video/8xCc1Xd1mxU/видео.html
B12 and autoimmunity-ruclips.net/video/sFpPwShk5QA/видео.html
B12-Cobalamin-ruclips.net/video/WJdZKimTZKA/видео.html
B1 Thiamin-ruclips.net/video/HuJRIIDeBPU/видео.html
Exceptional lecture. You explain / break down subject matter better than 99 % of MDs. I appreciate that you cover subjects that actually matter instead of covering trendy topics.
Thanks for your video
Hi, great video! I actually had very high homocysteine at 45. It was then confirmed that I have MTHFR homozygous C677, with low B12 and Folate. I initially went on a supplement that had Methyl B12, Methyl Folate and Methyl B6 - Methyl Guard. In two months I became B6 toxic! Awful neurological symptoms. I stopped the supplement and now take the RDA of B12, RDA of Folinic Acid along with RDA B2 daily. My homocysteine is now at 7 :) :) And the B6 side effects are slowly going away, thankfully. People need to be very careful taking mega doses of supplements, in particular B6. My naturopathic doctor was not even aware of this potential toxicity with B6, but she is now. Thank you for doing this video! You always have excellent content.
Could you please share what was the symptoms of b6 toxicity?!
And what brand of B complex do you recommend?! Appreciate your help 🙏
@@moniryousefian8782 Waiting for reply
Curious, we’re you taking the P-5-P form of B6? Many w MTHFR need this form of B6 (especially those of us w a 2nd toe that is longer than the big toe). I am taking Dr Ben Lynch’s formula, HomocysteX, trying to get my homocysteine down. He has clean products.
@@annettewebster296 Yes I was taking the P-5-P version. The product was Thorne Methyl Guard. The recommended dosage was 3 a day, and I was only taking 2. And Yes, I’ve watched a lot of Dr. Ben Lynch’s videos!!! He’s helped me a lot in coming up with a plan. I now take his Folinic Acid supplement. It’s about 4 times the RDA so I take 1/4 lozenge a day. His combo product that also had the B12 with it was out of stock when I ordered so I take a separate B12 that is dropped dosed to be close to the RDA. He actually talked about not needing to take Folinic acid or MethylFolate every day if you don’t have a lot of stress, and you’re eating your leafy greens. He views the supplement as just that, a supplement, not something that needs taking daily regardless.
@@jhakkuagadhi842 My reply disappeared………..
Patrick holford speaks a lot about high homosistein levels and Alzheimer's/vascular dementia prevention. supplementing with B12 including other b vitamins, omega-3 and vitamin C .
Thank you so much Dr. Sung.
I had no idea that my homocysteine level was dangerous. It is 12.2.
I don’t have any symptoms that you mentioned, but I am addressing it with the proper B vitamins as you suggested
12.2 is normal
Im a student nurse and this helped me alot in understanding how hyper homocysteinemia can risk arteriosclerosis
I just asked my doctor if it was ok for me to take vitamin B complex because I recently started using and she said yes that they use to recommend patents take it ! Thank you for your wonderful information and how you explain so we all understand!
Best video EVER! Soooo to the point and full of information... lovecit!❤👏🏾
Thank you for the very clear description! I didn't understand the real root of the issued until your video! Lung Blood Clot led to discovery of Homozygous C677T. Now I use Dr. Lynch's Homocysteine support supplement instead of the pharmaceutical the doctor prescribed and I feel good. On days when I feel exhausted he also offers an L-5 lozenge I add on. Will definitely get some Vitamin C into my supplementation program. Again, Thank you!
nteresting about diet nutrition and Homocysteine blood levels with a reading of 7 being optimal. Include foods with b-12 soil and foods providing B-12. Cruciferous Vegetables are important and a diversified diet. Glutathione production is paramount for good health.
B-12 B-6 and B-9 deficiency can be the issues.
Very good information
Great information! Thanks 😊👍🏻
Thank you for a great video.
I inherited the MTHFR-C677T polymorphism, heterozygous. My homocysteine is 11.7
My PCP informed me that my level is within the normal limits. However most of videos that I watched about homocysteine advise levels of 6 or less.
My normal lab value: 5 to 15
Dr Sung, would you please do a presentation on COMT snp.
Thank you Dr. Jin. Love to watch
And learn about healthy ways to help our body to heal. 💘
Wish dosage would have been included.
I just got my labs back and my homocysteine is 132. They double checked it and an outside doctor looked at it too. They just decided it was a fluke. I’m a little concerned.
You should be concerned. Optimal range of homocysteine is in between 5-7. Homocysteine is used for assessment of cardio vascular health as well about you methylation status. Methylation is THE most important process in your body. Mainstream MD'S are clueless about methylation
Amazing great information
Thank you DR. You are a Great Representation on what Every Physician shoul DEFINITELY SHOULD KNOW in ORDER for Us The Maive & Trusting Patients should be able to Put Our Already Weakened Overall Health Conditions due to THOSE CONSTANTLY & UNJUSTIFIED Antibiotics & Anti- Inflammatory & pain killers HAVE INDISCRIMINATELY BEEN Prescribed each and every DOCTORS Visitation we may need to go.
Thank you and Best Wishes for You & Your Family.
Awesome video!
Awesome video, thank you! Merry Christmas 🎄
The elation between Meth, Hcys and cysteine has been described in the wrong way! amazingly. hcys is not the intermediate between meth and cysteine. For the route from HCys to cysteine only B6 is needed.
Overall it is wrong to say, HCys must be broken down. Its a crucial component in the metabolic cycle producing the capacity for methylation.
I have a skin problem that is helped by taking folic acid and tmg with my food when I consume animal products. Methyl folate also helps but overall taking folic acid and tmg works best.
May I ask what skin problem do you have?
I felt they deliberately not suggest homocysteine test
Yes of course more pills
You mentioned magnesium but there are different forms which one would you suggest? Thank you for sharing.
Magnesium Glycinate.
And Magnesium Threonate for the brain.
HCY is a relatively expensive marker in HK. it was first introduced to HK 20 years before. even now, not many ppl know this marker.
Interesting how you dont mention meat, eggs, liver.. much better sources than those supplements.
Take your MEDS: Meat, Eggs, Dairy and Seafood!
Sir my son age 3.11 months having normal B12 and Folic acid levels and having homocysteine at 17.8(Normal less than 15) please suggest sir
I am confused. Dr. Walsh says to avoid folate even B9 if you are under methylated and have low serotonin. Can you clarify?
Great info thank you.
I am homozygous MTHFR and it got really bad for me before I was diagnosed. It stills blows my mind that this condition isn't more widely understood by doctors.
Two of my four daughters unfortunately also are homozygous and I hear it can be much more of a problem for females, especially during pregnancy.
I am an unrepentant knucklehead when it comes to following a good diet so supplementation and physical activity have helped me. Metagenics makes methylated multi and specifically B vitamins supplements, Ceralin Forte being a lifesaver for me.
Seeing my homocysteine reading go from red (as high as 20 consistently) to green on my blood tests (it's still at 10, but has stayed ridiculously stable at 10 for over a year now which is about 5 blood tests) and knowing I have answers for my daughters so it doesn't have to get as bad for them as it did for me is a good feeling.
My daughter is homozygous c677T and I’m wondering what supplements did you give to your daughters?
@WesselsReaper methylated multi-vitamins. We use Metagenics brand.
@@Degarth I’m browsing their website, which one do you use?
@@WesselsReaper Phyto Multi
@@WesselsReaper Phyto Multi without Iron
brilliant explanation!💛
Also look into the B12 sub q! I did the b12 injections, but felt awful and numbers never went up. There's 1 more step down the methylation b12 supplement.
Should multivitin be taken for life long?
I spoke to head of vascular medicine and he did not really care about homocysteïne.
I can’t get this test thru any of the ‘doctors’ I’m seeing 🙄
Got my tests back today and my score is 179. The doctor wants the test repeated, saying she has never seen this high of a number. I’m still trying to understand how to lower the homocysteine. I’m already taking so many supplements for my other genetic mutations. 😢
I did the test this week and my score is 130. Off the charts. I want to take the test again with another lab just in case it could be an error. In the mean time I started B12 injections and a supplement.
@johnnym6700 I think you would be dead with that kind of number. Yes retest.
Mine is 13.5. How do I bring it down?
BONJOUR, est-ce que je peux prendre du TMG si insuffisance rénale stade 4 ?
My homocysteine came back at 60. I've also been taking creatine with tmg and then switched to phosphatidylcholine and creatine. So who only knows what my homocysteine actually is if i wasn't taking those to reduce it. I have not been taking normal does of any of that because my body has a strong reaction to all of it. Im homozygous for c677t and have had depression, anxiety, insomnia, migraines, chronic fatigue all of my life. I cannot tolerate b vitamins. I cannot tolerate coq10. I now know coq10 is produced via methylation and if you're deficient in mthfr you're body wont produce enough coq10. I cannot tolerate protein. Protein shakes, high protein meats gives me a migraine within 30 minutes after consumption.
In my Optimizing Nutrition group, the micro and macro nutrient intake is charted and analyzed from thousands of users. Eating enough methionine is the number one nutrient that reduces calorie intake by 19%. (after methionine, the data shows potassium at 8%, calcium at5%, sodium at 3.7%, vitamin B2 at 3.3% etc). But isn't methionine associated with cancers??
Are people who are only eating meat (carnivore) having low homocysteine levels or increased or elevated homocysteine levels?
How much per day do you recommend in supplements?
What if the levels are too low ? Seems impossible to find info on how to resolve low numbers and cause , appreciate help thank you
So to clarify, B vitamins help bring sulfur levels to proper, normal levels in the body?
Supplementing with Betaine would be a good idea?
yes.
Beating HCL? Stomach acid supp? Thank you! I’m having many issues and doctors are stump as I am…
Yes.
What is The role of MSM is here
Dose it help to Detoxify?
I know that helps rebuild the gut, can go against parasites, help detoxification, and may help with arthritis, but increase very slowly if taking it.
I had gastric bypass surgery long time ago but found out my body was no longer producing vitamin B-12. My health went downhill. I take monthly shots as well as doses of sublingual as well. I would imagine I need to increase my other B Vitamin intake! ??
Yes
Hello , which form of b6 do you recommended . Thank you
My Homocysteine is 31.17 umol/L. Should I be alarmed?
Vitamin B9 (Folic Acid) 3.79 ng/ml
Vitamin B12 341.0 pg/ml
Yes. I have similar results. B12 twice as yours but don’t know if it is in active form.
How about low homocysteine? Like really, really low - below 1. There is an adequate sources of dietary methionine intake (meat), no genetic MTHFR defect. I believe there would be low/no cysteine in this case which will result in low glutathione. This is equally as bad as high homocysteine as detoxification would struggle and there would be high oxidative stress. Just thinking logically after listening to the lecture…
How should one raise homocysteine? Levels are too low, should I stop taking b vitamins daily?
Please verify this but I believe NAC raises homocysteine level.
Hi Doctor
Where are you located?
I would like to get a consultation.
I found out I have MTHFR mutation but all the doctors I’ve been to they have no experience on this health problem
Massachusetts. We also do tele-health.
I’m going to get a homocysteine test tomorrow
I will contact you once I get the results back
Thank you for your response
Can anyone tell me my c reactive protein is ok has this no bearing on homocysteine?
Yes it has no bearing on CRP. MY CRP is great but my Homocystein is 13
Sir my homocysteine level is above 77 what should i do??
I never tried homocissdein
Your pathway from methionine to homocysteine seems reversed. Should be homocysteine to methionine and even more steps to get to cysteine.
What's cracking
I’m trying to learn about low homocysteine, any suggestions on that, 4.1L
That's fine. Mine is at 16, I'll trade you 😂
Homocysteine 78. Ive been on high doses of D3, Folate, and B12. Nothing is bringing it down. Still low levels of D3 and folate. I am 36, and have battled this MTHFR stuff for 6 years. Even my Hemophilia dr blows the Homocysteine levels off. 😢😢😢where do I go from here?
Check B 2 vitamin
@rredding Spot on! Added an MTHF/P5P/R5P^ supplement recommended by Custom Meds in Indianapolis. I feel awful physically starting this combination, but I'm thinking one of those slash marks means B2 supplement. Lol. Increased D3. I will give it 3 months and see how it goes. Thank you for the comment.
@@ashleyshredder let's hope it will be the solution to your health issue!. I don't know how much D3 you take, be sure you get enough magnesium. I personally combine D3 with K2 to avoid hypercalcemia.
Inflamation is in your stomach is quite possible and perhaps you need to look into it
Any updates?
Should this lab marker homocysteine be checked if pt is taking blood thinners???
Yes. Everyone should have it checked.
But i do Not know about menthion i think IT makes sick
Is it 29 then dangerous ?
Homocysteine of 29 is way too high.
@@DrJinSung First off all, thank you very much for your answer.
Despite following a ketogenic diet ( refractory celiac disease, insulin resistance) I have high cholesterol ( 269 ), low hdl (38), low vitamin d ( 7,85), really low folate and vitamin b 2.
I also have the mthfr C667t mutation on .
Do you think that there is a connection?
It seems a Metabolic syndrome.
I am not seeking for any medical advice.
@@angelfreedom911 hey do you experience any elevated blood pressure,i have 28 and blood pressure is 140/95
Is homocysteine linked to anxiety?
Yes so they say
that's what I'm trying to fix myself.
I've been experimenting with all sorts of things for 4 years now with no luck. I've recently started taking 1000mg of lysine at night on a empty stomach and I feel less anxious now 🥳. Also been taking Sam e in the morning and some methylated b vitamins with my breakfast it might be this to that is helping
Mine is 17 😢😢
You forgot Alzheimer’s
Very good information