Recent undergraduate degree in Molecular Genetics chiming in. I began my degree around 2013 when CRISPR was starting to make a buzz, and by the time I hit my 4th year we were already working with it in laboratory courses. It's an incredible tool, and certainly not one to be viewed as some "Scientific Boogeyman" that causes cell death and cancer willy nilly, but as the video states it does come with its fair share of problems (may of which contribute to this behavior.) Even more so than are mentioned. For example it is exponentially more time intensive to work with than the previous standard for gene editing (restriction enzymes, same idea but they only cut at one specific sequence as opposed to being "programmable" and able to cut "anywhere".) That's because CRISPR/Cas9 requires you to make something called a small guide RNA, which is the template the enzyme uses to check the DNA sequence for the correct place to cut. In the lab, in a perfect setting, it took us 6-8 weeks of 4-8 hour days just to generate these RNAs. And that's if nothing went wrong in any of the various steps. In Molecular Genetics due to the incredibly small volumes, concentrations, and unknowable microscopic sources of error, you will have experiments fail, and frequently. So those set backs add even more time. And, once all that work is completed, the sgRNA you generated might not even WORK. And if you didn't choose a spot to cut carefully enough, or it wasn't specific enough, you could be left with something that cuts everywhere, or not at all. So in addition to off target effects and STAR activity (the enzyme cutting non-specifically due to design or experimental conditions) and the large deletions the video mentions, (likely caused by erroneous repair of off-target cuts from the enzyme), there is the aspect of inefficiency. If you are looking to do something highly specific that traditional enzymes just can't, CRISPR/Cas9 is awesome, but it's still a new technology and a pain in the ass at that. Personally I think the delays in human testing are justified, if for no other reason (i.e. morality and the whole designer babies debacle) than the fact that at the moment it would be like giving a surgeon a chef's knife instead of a scalpel to perform an operation. Sure it's sharp and it cuts potatoes and chicken like butter, and the surgeon might even be able to pull of the surgery with it, but is not the best solution and requires more refinement before it can be put to the test with a person's life and well being on the line.
I should mention it was 4-6 weeks of meeting once a week, so if you were working on it 40 hours a week you'd be looking at 1-2 weeks if you did everything back to back. A lot of the time is waiting, so it's easy enough to slot other experiments into that time, but it is nowhere near as "plug and play" as traditional restriction enzymes.
@@gavinstarks2761 This is a common musconception you're body doesn't often become allergic to non-bioreactive elements which is why we use them as implants. The only reason why some metal implants become toxic is due to the way they were handled or treated before implanting them. For example a corroded metal implant will react with your biology in a negative way but if the implant doesn't corrode because it was polished better or otherwise treated so that an oxidized layer isn't allowed to form inside of your body then the chances that you'll become allergic is so low that you actually just might be the first person with any kind of negative reaction at all! On top of all that augmented limbs don't need to be implanted at all they can exist as a totally independent part and may be allowed to interface with your brain activity in a slightly more passive manner through transdermal neuro stimuli detected by next generation of electrodes placed on the artificial limb. When the limb is touching your skin if can still act as if it was connected directly to your brain even though it's not actually physically attached to your body at all.
@@VariantAEC I'm talking about how organ transplants can go wrong and it's not about becoming allergic to it, its whether or not the body accepts the foreign (nonbiological) material in. A lot of people can get the controllable prosthetic arms because of 1. Injury 2. Some bodies straight up reject the object and due to it not being a biological material, it is worse. Yes some people are allergic to certain metals and its possible a metal can be handled wrong but in the end it's up to whether or not the body is ok with the transplant. I have a friend who unfortunately doesn't have much longer left due to a rejected liver.
Which is why we are already working on more modified versions of CRISPR that are much more accurate. You got to remember where CRISPR is coming from. Its a function of a virus(edit: its a bacteria. My bad) we have hijacked, but its still has largely the same functionality, and bacteria are a bit less caring about the damage they can cause than us, as it doesn't cut into their evolutionary fitness to a large degree. Simply put, there's been no strong(there still is) evolutionary pressure to make it better than it is. Which is why we need to step in and guide the process. All in due time folks. Be patient.
I'm having trouble understanding your post. Are you saying we should make this virus more potent to get what we want (because this sounds like a disaster in the making), or are we talking about guiding the virus into making more precise deletion?
Wait, I thought the CRISPR method was derived from a type of immune response in bacteria that survive an attack from a virus. They take the injected DNA and implement it into their own in order to be able to identify it later and prevent it from taking over.
@@Revan2662 Oh darn, did I mix it up? Yea that sounds correct, I'll edit my post. A slip up on my part. The cells ability to do that though is from a virus.
I am for progress in scientific knowledge and methods, so long as it's tempered with wisdom and prudence. Afterall , the goal is to better life, not harm it. RIGHT?
2:24 "The human trials have been delayed ... " I guess delays affect the gene editing world even more than the gaming community ... (shots fired at Persona 5)
If the human trials have been delayed how has there been “several new studies?” It’s funny too, because I bet in 5 years it’ll be leaked that rich people have been using it while everyone else has been waiting for the human trials to start.
*I'd love to hear what people think about the future use of genetic engineering technologies like CRISPR - does it worry you? Fascinate you? Would you want it to be used for something in particular? And what about genetic engineering on humans in general? Whatever really - what do you think?* 🤔
Uneducated people will hate it because of all the bad rep it's gotten in the media (films) like thry don't even know that we have been genetically engineering our food for thousands of years and yet there's all this stigma
it will happen sooner or later. human edited dna gonna ubiquitous in the future. morale not gonna help with the research. it's the same thing back when people started doing operation and sewing your skin. back then they are considered withcraft and evil. if china dare enough to do crispr on human they gonna lead the technology. but probably usa gonna try to steal it after there are some result, by saying china is doing immoral and horrendous thing. it's what happened with nazi and their human research. lot's of them are used nowadays and being patented by usa. slick huh?
Like in-vitro fertilization and cloning before it, CRISPR won’t be without its ethical concerns and technical hurdles. But if we can move past that, Crispr has the potential to be a major game-changer for the health of the environment and we humans that occupy it.
I agree we need to move cautiously in manipulating dna in people. While we certainly know a lot about dna now there is still far more we don't know, the fact that they did not even see the collateral damage initially should scare the heck out of them. It is always hard to decide when it is ok to test on humans but in this case I agree that we need more time to ensure we really understand what is happening. As a programmer (of machines) I can tell you that minor edits on large programs can have all kinds of nasty impacts even in the hands of highly skilled programmers. My guess is dna is the same.
What do you mean could be used for editing crops? I think they already have been. Fact is they have been using many forms of gene editing on crops for quite awhile now. Yes we do need to take a step back and , proceed more carefully.
It will be interesting combining these tools with exponentially more powerful computer systems and more delicate sensors. You could accelerate evolution in a more regulated; controlled environment.
On the contrary, *CHINA* has been publicly *publishing* many of its *_breakthrough_* CRISPR studies in international peer-reviewed journals (e.g. *Nature* ); albeit caveat are included in the context of ethics and varying laws across different countries. Also, *Cas-9* is just the first paired version of *CRISPR.* Aside from the aforementioned in the video *MIT* & *Harvard's Broad Institute* also have *Cpft1,* which allows for greater specificity of edits. The issue of *p53* gene has long been *retracted* by its _investigators._ The said study originally appeared in the journal *Nature* and had since been rectified by the former considering that their were a lot of *faulty premises* and *wrong assumptions* to begin with. Nonetheless, *CRISPR* brings in both *promises* and *perils.* It will surely _transform_ our *society* and _redefine_ our *humanity.* An oversight and regulatory measures must be in-placed not just from the *government* but from *all pertinent sectors* in the society whose *well-being* and *general welfare* would stand to *benefit* (if all goes well) or *suffer injury* (if something goes berserk). Nonet
That's the sweet spot develope anti aging that targets RNA so once you stop getting the treatment your cells presume aging...that's where I see that going.
Both parents: White Wife gives birth to black baby Doctor: Ummm ..... Your child is umm healthy Dad see's baby: Dad: NANI!!!! Mum: it was CRISPR Dad: My god our sons a artificial athlete, he'll yeah Mum: Yeah "our" son
genetic edited could and already is beneficial in some ways to sustaining us. faster growing higher yield crops. modifying all the animals we farm. just think of all the implications this could have. they are already trying to modify some plants to get us a truly sustainable and cheap biofuel. which is the issue right now, like ethanol and algae they are insanely expensive to process, this could all go bad too, like everything else on the planet there is a good side and a bad side,
I have been searching on various sites regarding the test result of lung cancer patient in china. But right now i know its not published anywhere. But if anyone finds what happened plz let me know.
Thanks for the update tell those dang scientists sort it out I got work to do they can keep there blue eyes I need gills and other cool stuff for exploration
I'm interested in what will happen once these test subjects procreate and pass on their edited genes through a few generations. Perhaps serious abnormalities (or benefits) will only be seen generations later.
In Deus Ex, electromechanical augmentations make you dependent on Neuropozyne, in REAL LIFE biochemical augmentations make you dependent on codeine So much for being ‘pure organic’ 😄 But seriously though, I am extremely itchy for the augmentation revolution to begin. Sacrifices must be made. No pain no gain 🤘
you can edit crisper-cas9. Increasing its accuracy is very plausible since crisper-cas9 was not designed to be very accurate (in a complicated way) since it was evolved to destroy viral DNA in bacteria and viral DNA evolves.
My BIGGEST worry, is that this current version will still be used in the form it is today in carelessly creating more GMO crops. Seed stock producers have never had much interest in what GMO gimmicks do to the nutritional value of crops. They only rush to market mods for higher yield, longer shelf life, insecticide properties, appearance. By the time your kids' arms, legs and head start falling off due to the lack of essential vitamins and proteins (instead of useless isomers) "bayer-monsanto-ites" will have sold their controlling interests to a valueless shill holding companies to protect their assets from lawsuits.
That's your best reply? Holy hell, I nailed it with my first guess of your personality. Do you post pictures of your new tattoos and keep a Tumblr blog of anti-GMO and anti-vax drivel?
Why would I ever want to change the color of my child, whatever color eye, hair, skin, (anything that isn't a mutation that can kill my child) I love him/her just the way they are
5 лет назад
I really like the way this channel explain science... And I love her glasses 👓🙂
The potential for greatness is unlimited. The potential for a children of men scenario is also massive. You cannot predict that which is inherently unpredictable. The Asgard (sg1) reaped the benefit and then the destruction of their civilization through DNA manipulation. We cannot rush blindly into this future, we need to see with both eyes what is before us.
Sounds like genetically engineering plants are the best way in attaining accuracy. If people scream about GMOs now listen to the noise they will make when humans are engineered. They will probably think GMHs should be segregated.
Tahnee Thompson you can cure Cancer if you cut all sugar and eat an alkaline diet eg veggies. Cancer survives on fermentation with sugar and co2 if you cut that then it cant grow.
"Safe", ha. "Palusibly deniable" more like. First they have to keep up with the Chinese etc, second they have to follow the profits, third, maybe, safety
0:57 This map of China is incorrect, please remove Taiwan from it as it is a country in itself and is so much different than China. Thanks and keep up the great work!
@Kay Kay That argument is bullshit, for taiwanese people it's a sore topic to be called part of the chinese mainland. To exagurate what i mean: it's as if you would label north and south korea as one "korea". Technically you would be right, but people of the two countries like to differentiate themselves.
because your offspring will inherit traits from the mother and father like normal and if you're both superhumans, the child is likely to be one as well
I really hope CRISPR backfires and never works, having the ability to edit the human genome is too much. You're playing with gods power here, and there's a reason we don't have that.
I agree. At the same time, the FDA hasn't really been looking out for the people lately and more for Big Pharma so if lets say CRISPR did what it was suppose to do, would Big Pharma want it to be available asap?
Yeah I can 50/50 vouch for this. When I delivered appliances at Lowes, I delivered a refrigerator to a genetics lab. From the areas I saw 60% of the workers were women. Some of those women were sexy.
This just in! Cutting out barely-understood parts of your body *might not be safe!* I realize I’m a layman, that geneticists have a comprehension of their subject I could scarcely follow. But c’mon. This was progressing way too fast for major consequences to be anything but inevitable.
The general technological advancement of our species, certainly. But that acceleration should not apply to *specific* technologies. Reckless, hasty science-especially the medical variety-is unethical, and its consequences extremely well documented.
What about affecting someone to the point that they can't reproduce when they grow up, like I have no idea how this works but I'm sure it only does to those that aren't born yet.. and predisposing them to other diseases and cancers and disabilities that we don't know are there before they are born and taking away there right to reproduce in fear of it mutating and doing more harm to overall humanity.. isn't that hitting a pretty large humanitarian right.. If that person were to break away and attempt procreating if they can, like will they be stopped by whoever owns them as the experiment, or will their life be payed for till they die as a an experiment. Haha I am all for it but this was the first thing that came to my mind..
@@pieflavr human trials have to go ahead before they know for sure.. hopefully Chinas human testing will be the research we need. But my concerns still stand as no other trials would be able to predict y concerns without actually testing it on a human first. So do those experiments if they make it to a certain age gets choice over their own life or are they just need experiment aga
Crispr and other techniques like Abe and so on work on any organism of any age. Its a genetic therapy that is not a germline modification. That means your genome would be affected but it will not be passed on to offspring. So any mods to the genome are not hereditary. It does this by basically infecting the host with a bacteria carrying the modified instruction set. Many people don't realise this but every bacterial and viral infection you ever went through altered your genome slightly. You really are different to when you were conceived and born. So these methods just infect you with a designer infection. Its obviously more complicated than my explanation there but as you pointed out you don't know a lot about genomics, so I apologise if it sounds like I'm talking down there. .
I wonder how much the company behind those new editing techniques paid for a half-baked explanation of about half of what's done during a CRISPr treatment.
I'm now even more concerned about crispr being used by governments and corporations to create a caste-like society where the majority of citizens are dumb, broken into separate castes specializing in specific tasks and only the ones with power and influence are intelligent and genetically superior to everyone else. I fear that this technology will be abused by governments and corporations in the future. And I fear the damage will be so severe that it will lead to the extinction of our species.
If you genetically edit the lettuce genome, you can make it CRISPR
Okay. That was actually pretty good XD
These are hard to pull off, we are all getting better but this joke is a good start
Im stupid help me.
CRISPR
what does it sound like
😂😂😂
It would become SOFTR and CHEWR
when will i laugh to that joke?
Simon Obiña LAUGHTR
@@Finnstreams LAFTR
SLAUGHTR
all of you...get out.
I can confirm this. I've put my kids in the crisper and now they're spoiled.
Humor done the right way.
See people this is how you leave a comment
lower the humidity a bit
@@cjenner865 not if you don't know what a crisper is, which I don't.
think fridge
When CRISPR fails, you get Devil's Breath...
Poor Harry.
@@bakaexmachina rip
DLC time!
@@patrickbateman4541 when is it coming out
@@Red-rj7sr no idea but it is.
The why probably has something to do with giving big pharma time to prepare. Gene editing is like what Tesla is to big oil.
No, I'm pretty sure this is actually dangerous.
Hope you know there are is a difference between the complexity of batteries & electric cars and life🤦♂️
'What happens when Crispr backfires'?
Supervillains are born, that's what happens
Wrong universe unfortunately
Real furries. /jk
Then you gotta call Spider-Man to stop the devil’s breath
Omega or evil super soldiers
Think The Fly the 90s one . Warning don't crap your pants !!!!!!!! ruclips.net/video/NH-8L1iZq20/видео.html This make cancer look good
Recent undergraduate degree in Molecular Genetics chiming in. I began my degree around 2013 when CRISPR was starting to make a buzz, and by the time I hit my 4th year we were already working with it in laboratory courses. It's an incredible tool, and certainly not one to be viewed as some "Scientific Boogeyman" that causes cell death and cancer willy nilly, but as the video states it does come with its fair share of problems (may of which contribute to this behavior.) Even more so than are mentioned. For example it is exponentially more time intensive to work with than the previous standard for gene editing (restriction enzymes, same idea but they only cut at one specific sequence as opposed to being "programmable" and able to cut "anywhere".) That's because CRISPR/Cas9 requires you to make something called a small guide RNA, which is the template the enzyme uses to check the DNA sequence for the correct place to cut. In the lab, in a perfect setting, it took us 6-8 weeks of 4-8 hour days just to generate these RNAs. And that's if nothing went wrong in any of the various steps. In Molecular Genetics due to the incredibly small volumes, concentrations, and unknowable microscopic sources of error, you will have experiments fail, and frequently. So those set backs add even more time. And, once all that work is completed, the sgRNA you generated might not even WORK. And if you didn't choose a spot to cut carefully enough, or it wasn't specific enough, you could be left with something that cuts everywhere, or not at all. So in addition to off target effects and STAR activity (the enzyme cutting non-specifically due to design or experimental conditions) and the large deletions the video mentions, (likely caused by erroneous repair of off-target cuts from the enzyme), there is the aspect of inefficiency. If you are looking to do something highly specific that traditional enzymes just can't, CRISPR/Cas9 is awesome, but it's still a new technology and a pain in the ass at that. Personally I think the delays in human testing are justified, if for no other reason (i.e. morality and the whole designer babies debacle) than the fact that at the moment it would be like giving a surgeon a chef's knife instead of a scalpel to perform an operation. Sure it's sharp and it cuts potatoes and chicken like butter, and the surgeon might even be able to pull of the surgery with it, but is not the best solution and requires more refinement before it can be put to the test with a person's life and well being on the line.
I should mention it was 4-6 weeks of meeting once a week, so if you were working on it 40 hours a week you'd be looking at 1-2 weeks if you did everything back to back. A lot of the time is waiting, so it's easy enough to slot other experiments into that time, but it is nowhere near as "plug and play" as traditional restriction enzymes.
this is why i prefer Cybernetic Augmentation
Until your body rejects foreign objects. Ya no. I'm good.
@@gavinstarks2761
This is a common musconception you're body doesn't often become allergic to non-bioreactive elements which is why we use them as implants. The only reason why some metal implants become toxic is due to the way they were handled or treated before implanting them. For example a corroded metal implant will react with your biology in a negative way but if the implant doesn't corrode because it was polished better or otherwise treated so that an oxidized layer isn't allowed to form inside of your body then the chances that you'll become allergic is so low that you actually just might be the first person with any kind of negative reaction at all!
On top of all that augmented limbs don't need to be implanted at all they can exist as a totally independent part and may be allowed to interface with your brain activity in a slightly more passive manner through transdermal neuro stimuli detected by next generation of electrodes placed on the artificial limb. When the limb is touching your skin if can still act as if it was connected directly to your brain even though it's not actually physically attached to your body at all.
Resistance is futile
@@VariantAEC
I'm talking about how organ transplants can go wrong and it's not about becoming allergic to it, its whether or not the body accepts the foreign (nonbiological) material in. A lot of people can get the controllable prosthetic arms because of 1. Injury 2. Some bodies straight up reject the object and due to it not being a biological material, it is worse.
Yes some people are allergic to certain metals and its possible a metal can be handled wrong but in the end it's up to whether or not the body is ok with the transplant. I have a friend who unfortunately doesn't have much longer left due to a rejected liver.
@@VariantAEC forgot allergies bud
"Genetic power is the most awesome force that this planet's ever witnessed, yet you wield it like a kid that's found his dad's gun."
Then my dream of Eagle vision will get out of hand and I'll see the germs on everything and become a sanitary hermit
At the end of the video, I thought she said: “I’m married. Thanks for watching seeker.” 😂😂
filthy is she though? That's the real question
Jake Mitch 🤔
I know 🤣
*CRISPRs are pretty good, I like BBQ flavour*
psh... salt and vinegar..... Ok both c:
I like my BBQ CRISPR...Y than most people
smh....just stop.
all dressed
Which is why we are already working on more modified versions of CRISPR that are much more accurate.
You got to remember where CRISPR is coming from. Its a function of a virus(edit: its a bacteria. My bad) we have hijacked, but its still has largely the same functionality, and bacteria are a bit less caring about the damage they can cause than us, as it doesn't cut into their evolutionary fitness to a large degree. Simply put, there's been no strong(there still is) evolutionary pressure to make it better than it is. Which is why we need to step in and guide the process. All in due time folks. Be patient.
I'm having trouble understanding your post. Are you saying we should make this virus more potent to get what we want (because this sounds like a disaster in the making), or are we talking about guiding the virus into making more precise deletion?
Wait, I thought the CRISPR method was derived from a type of immune response in bacteria that survive an attack from a virus. They take the injected DNA and implement it into their own in order to be able to identify it later and prevent it from taking over.
@@Revan2662 Oh darn, did I mix it up?
Yea that sounds correct, I'll edit my post. A slip up on my part.
The cells ability to do that though is from a virus.
@@Manganization No more accurate. And it has no other function and dies out with time.
+Simone, thanks for clarifying.
Genes create forces-a-nature
I agree. It is even more dangerous than nuclear technology. If one fancies zombies, this is the closest tech to get there
I am for progress in scientific knowledge and methods, so long as it's tempered with wisdom and prudence. Afterall , the goal is to better life, not harm it. RIGHT?
Every time, I hear "I'm married, and thanks for watching Seeker."
Not married
Aren't almost all the cells in the body supposed to have the same DNA,won't the body reject these targeted changes.
I really like how these videos are produced.. especially the sound engineer made the high end sound CRISPR af
Goes far beyond cancer risk!
2:24 "The human trials have been delayed ... "
I guess delays affect the gene editing world even more than the gaming community ... (shots fired at Persona 5)
I have one game for this comment.
Bannerlord
KH3 takes the cake
FFXV basically got delayed for 10 years
If the human trials have been delayed how has there been “several new studies?” It’s funny too, because I bet in 5 years it’ll be leaked that rich people have been using it while everyone else has been waiting for the human trials to start.
Noah Sharp and military. They are half a century (at least) ahead of the general population
The girls shirt makes it look like she drooled all over herself
*I'd love to hear what people think about the future use of genetic engineering technologies like CRISPR - does it worry you? Fascinate you? Would you want it to be used for something in particular? And what about genetic engineering on humans in general? Whatever really - what do you think?* 🤔
Uneducated people will hate it because of all the bad rep it's gotten in the media (films) like thry don't even know that we have been genetically engineering our food for thousands of years and yet there's all this stigma
it will happen sooner or later. human edited dna gonna ubiquitous in the future. morale not gonna help with the research. it's the same thing back when people started doing operation and sewing your skin. back then they are considered withcraft and evil.
if china dare enough to do crispr on human they gonna lead the technology. but probably usa gonna try to steal it after there are some result, by saying china is doing immoral and horrendous thing.
it's what happened with nazi and their human research. lot's of them are used nowadays and being patented by usa. slick huh?
*Shut up with that bold text*
Like in-vitro fertilization and cloning before it, CRISPR won’t be without its ethical concerns and technical hurdles. But if we can move past that, Crispr has the potential to be a major game-changer for the health of the environment and we humans that occupy it.
I love how this thread is starting out. I couldn't agree more!
I was hoping this would be a Maren episode. You look great as always, Maren. Love the shirt!
Glad you liked the video, Craig. Thanks!
I agree we need to move cautiously in manipulating dna in people. While we certainly know a lot about dna now there is still far more we don't know, the fact that they did not even see the collateral damage initially should scare the heck out of them. It is always hard to decide when it is ok to test on humans but in this case I agree that we need more time to ensure we really understand what is happening. As a programmer (of machines) I can tell you that minor edits on large programs can have all kinds of nasty impacts even in the hands of highly skilled programmers. My guess is dna is the same.
What do you mean could be used for editing crops? I think they already have been. Fact is they have been using many forms of gene editing on crops for quite awhile now. Yes we do need to take a step back and , proceed more carefully.
I love this channel and their videos. Great production quality and love the hosts
So basically it's equivalent to "git --reset hard " but without backup. Great.
It will be interesting combining these tools with exponentially more powerful computer systems and more delicate sensors. You could accelerate evolution in a more regulated; controlled environment.
On the contrary, *CHINA* has been publicly *publishing* many of its *_breakthrough_* CRISPR studies in international peer-reviewed journals (e.g. *Nature* ); albeit caveat are included in the context of ethics and varying laws across different countries.
Also, *Cas-9* is just the first paired version of *CRISPR.* Aside from the aforementioned in the video *MIT* & *Harvard's Broad Institute* also have *Cpft1,* which allows for greater specificity of edits.
The issue of *p53* gene has long been *retracted* by its _investigators._ The said study originally appeared in the journal *Nature* and had since been rectified by the former considering that their were a lot of *faulty premises* and *wrong assumptions* to begin with.
Nonetheless, *CRISPR* brings in both *promises* and *perils.* It will surely _transform_ our *society* and _redefine_ our *humanity.* An oversight and regulatory measures must be in-placed not just from the *government* but from *all pertinent sectors* in the society whose *well-being* and *general welfare* would stand to *benefit* (if all goes well) or *suffer injury* (if something goes berserk).
Nonet
I read *CHINA* in Trump's voice.
Other gene editing protocols using zinc finger proteins (ZFPs) have multiple ongoing trials (Sangamo), so not all gene editing trials are being halted
That's the sweet spot develope anti aging that targets RNA so once you stop getting the treatment your cells presume aging...that's where I see that going.
Both parents: White
Wife gives birth to black baby
Doctor: Ummm ..... Your child is umm healthy
Dad see's baby: Dad: NANI!!!!
Mum: it was CRISPR
Dad: My god our sons a artificial athlete, he'll yeah
Mum: Yeah "our" son
alright then
What good is any of this, if we destroy the environment that sustains us?
genetic edited could and already is beneficial in some ways to sustaining us. faster growing higher yield crops. modifying all the animals we farm. just think of all the implications this could have. they are already trying to modify some plants to get us a truly sustainable and cheap biofuel. which is the issue right now, like ethanol and algae they are insanely expensive to process, this could all go bad too, like everything else on the planet there is a good side and a bad side,
I love the smell of DNA in the morning
@Zero Cool dumb joke. also dna isnt just in semen
@Zero Cool i know, HOMIE. but cum still isnt the only thing that has dna
@Zero Cool P.S. humour IS subjective but if the majority of people find your joke bad than its objectively bad
@Zero Cool dude cmon, look at the joke and tell me its not bad
@Zero Cool its 2 pm and you're right, i should.
How exactly do they cut the DNA, I don't think they make scissors that small.
0r3os92 they do out of carbon nano tubes and graphene, you just snip snip snip.. baby got eagle wings and shit
Magnets.
they use a protein from the enzyme group, whose job it is in normal circumstances to make the atoms in a specific spot of DNA to seperate
It’s an enzyme
_Every _*_beacon_*_ should be _*_CRISPR!_*
Crispr needs a way to create backups before acting.
When it backfires, or IF it backfires?
CAN WE PLEASE GET A LINK FOR THAT BACKGROUND
I have been searching on various sites regarding the test result of lung cancer patient in china. But right now i know its not published anywhere. But if anyone finds what happened plz let me know.
I just realised I was moving my head around trying to see through the glare in her glasses.
At the end of the video, "I'm married thanks for watching seeker.".
Me: I'm single, could you fucking stop stabbing my wound!
Where can I see a video of the actual process? I mean in real life, not a cartoon or an explanation. The work itself.
This technology is still leading edge, and leading edge in a way that has the potential to change humanity, history and our future as a species.
Nice shirt!
What shirt? I don't see a shirt.
@Jam it's a rocket..
It looks like she sweats in really weird ways
Matty Man lmao idk why this made me laugh so much
Can you turn off that beeping in your background music? It's really distracting.
Thanks for the update tell those dang scientists sort it out I got work to do they can keep there blue eyes I need gills and other cool stuff for exploration
I'm interested in what will happen once these test subjects procreate and pass on their edited genes through a few generations. Perhaps serious abnormalities (or benefits) will only be seen generations later.
depends on whether the first gen gained benefits or abnormalities from the changes in their DNA
In Deus Ex, electromechanical augmentations make you dependent on Neuropozyne, in REAL LIFE biochemical augmentations make you dependent on codeine
So much for being ‘pure organic’ 😄
But seriously though, I am extremely itchy for the augmentation revolution to begin. Sacrifices must be made. No pain no gain 🤘
Or Warfarin, a blood thinner to stop clotting upon the mechanical parts.
you can edit crisper-cas9. Increasing its accuracy is very plausible since crisper-cas9 was not designed to be very accurate (in a complicated way) since it was evolved to destroy viral DNA in bacteria and viral DNA evolves.
My BIGGEST worry, is that this current version will still be used in the form it is today in carelessly creating more GMO crops. Seed stock producers have never had much interest in what GMO gimmicks do to the nutritional value of crops. They only rush to market mods for higher yield, longer shelf life, insecticide properties, appearance. By the time your kids' arms, legs and head start falling off due to the lack of essential vitamins and proteins (instead of useless isomers) "bayer-monsanto-ites" will have sold their controlling interests to a valueless shill holding companies to protect their assets from lawsuits.
Take off that tin foil hat and stop selling those damn "essential oils" on Facebook please.
Hey aaaaron troll, first learn to control your bowel movements before you try controlling other people, at least you'll smell better. lol !
That's your best reply? Holy hell, I nailed it with my first guess of your personality. Do you post pictures of your new tattoos and keep a Tumblr blog of anti-GMO and anti-vax drivel?
I need update information about research that oxford done for hiv cure. In the past it said that the result comes this year
Why would I ever want to change the color of my child, whatever color eye, hair, skin, (anything that isn't a mutation that can kill my child) I love him/her just the way they are
I really like the way this channel explain science... And I love her glasses 👓🙂
The Egyptians messed with DNA and look what happened. Read genesis 6
The potential for greatness is unlimited. The potential for a children of men scenario is also massive. You cannot predict that which is inherently unpredictable. The Asgard (sg1) reaped the benefit and then the destruction of their civilization through DNA manipulation. We cannot rush blindly into this future, we need to see with both eyes what is before us.
Sounds like genetically engineering plants are the best way in attaining accuracy. If people scream about GMOs now listen to the noise they will make when humans are engineered. They will probably think GMHs should be segregated.
It can't apologize for being a new technology, like anything else, it will get better as we learn more.
Notice that they said _when_ not _if_ ...
I hope it never works out. Theres already a cure for cancer and it's in the food you eat and a proper diet.
Except those aren't cures
Tahnee Thompson you can cure Cancer if you cut all sugar and eat an alkaline diet eg veggies. Cancer survives on fermentation with sugar and co2 if you cut that then it cant grow.
"Safe", ha. "Palusibly deniable" more like. First they have to keep up with the Chinese etc, second they have to follow the profits, third, maybe, safety
Notification scientists
Nature is our (Human) Father
So human can never became Father of Nature... It wud definitely lead to chaos
Did she just say at the end of this video that she is married? Where did that come from?
She said, "I'm Maren." because that's her name. Maren.
Failure is always there, we Just need to try and Research more!
PUSH ON LIKE A MAD SCIENTIST!
ITS SO COOL SUNOVABICH
Is anyone else admiring her glasses or am I the only one?
0:57
This map of China is incorrect, please remove Taiwan from it as it is a country in itself and is so much different than China. Thanks and keep up the great work!
@Vault HunterTaiwan has been independent for almost 70 years now trying to pretend it isn't because it would make China feel bad is asinine.
@Kay Kay That argument is bullshit, for taiwanese people it's a sore topic to be called part of the chinese mainland. To exagurate what i mean: it's as if you would label north and south korea as one "korea". Technically you would be right, but people of the two countries like to differentiate themselves.
@@ponylynx no the US thinks it is.
Well isn't there like the One China thing where both countries claim both countries like Taiwan claim mainland China and China claim Taiwan
It backfires and gives the children randomized powers
It either turns into X-Men or My Hero Academia
Assuming it doesn't kill us or turn us into blobs of jelly, how do you know this change won't adversely affect the offspring?!!
because your offspring will inherit traits from the mother and father like normal and if you're both superhumans, the child is likely to be one as well
needs to be done.
Oh lord, the rebirth of Eugenics. This technology will definitely fall into the wrong hands, there is no question about it.
So how long before i can be like deadpool?
Safe, how come anyone thought it is safe to meddle with genes
at 1:00 you listed taiwan as part of china :(
I really hope CRISPR backfires and never works, having the ability to edit the human genome is too much. You're playing with gods power here, and there's a reason we don't have that.
No undelete?
There is zero chance that scientists won't figure it out soon once again frustrating the Luddites and their paralysing and failurist philosophy.
Monsanto should handle human trials.
They'll make sure any mutations don't pass on to a next generation, unless they pay extra.
The thing is, in case CRISPR is successful with humans. You will never know about it. No businessman will give you a permanent solution.
Editing DNA is the best way to augment humans
I agree. At the same time, the FDA hasn't really been looking out for the people lately and more for Big Pharma so if lets say CRISPR did what it was suppose to do, would Big Pharma want it to be available asap?
How about we stop screwing around altogether!?!?
0:41 I bet this is from stock video. People working in lab aren't usually this hot.
Yeah I can 50/50 vouch for this. When I delivered appliances at Lowes, I delivered a refrigerator to a genetics lab. From the areas I saw 60% of the workers were women. Some of those women were sexy.
Many are, in my experience in S FL labs anyway
@@BothHands1 new friend?! :D
Interesting development.🔬 What's the latest with stem cells?
This just in! Cutting out barely-understood parts of your body *might not be safe!*
I realize I’m a layman, that geneticists have a comprehension of their subject I could scarcely follow. But c’mon. This was progressing way too fast for major consequences to be anything but inevitable.
Technological progression is only going to get faster, and exponentially so at that
The general technological advancement of our species, certainly. But that acceleration should not apply to *specific* technologies. Reckless, hasty science-especially the medical variety-is unethical, and its consequences extremely well documented.
Is this Gundam SEED reference?
I thought she said: "I'm MARRIED. Thanks for watching Seeker." :P
Andcthe W.H.0 want to mandate certain injections?
The vocal fry is strong with this one
😬😬 this is way worse than I expected...
Sounds like we shouldn't mess with DNA.
WE DEMAND Athena Brensberger COMES BACK!
What about affecting someone to the point that they can't reproduce when they grow up, like I have no idea how this works but I'm sure it only does to those that aren't born yet.. and predisposing them to other diseases and cancers and disabilities that we don't know are there before they are born and taking away there right to reproduce in fear of it mutating and doing more harm to overall humanity.. isn't that hitting a pretty large humanitarian right..
If that person were to break away and attempt procreating if they can, like will they be stopped by whoever owns them as the experiment, or will their life be payed for till they die as a an experiment.
Haha I am all for it but this was the first thing that came to my mind..
InconsistentlyConsistent Cauk this is why research is being done.
@@pieflavr human trials have to go ahead before they know for sure.. hopefully Chinas human testing will be the research we need. But my concerns still stand as no other trials would be able to predict y concerns without actually testing it on a human first. So do those experiments if they make it to a certain age gets choice over their own life or are they just need experiment aga
Crispr and other techniques like Abe and so on work on any organism of any age. Its a genetic therapy that is not a germline modification.
That means your genome would be affected but it will not be passed on to offspring. So any mods to the genome are not hereditary.
It does this by basically infecting the host with a bacteria carrying the modified instruction set.
Many people don't realise this but every bacterial and viral infection you ever went through altered your genome slightly. You really are different to when you were conceived and born. So these methods just infect you with a designer infection.
Its obviously more complicated than my explanation there but as you pointed out you don't know a lot about genomics, so I apologise if it sounds like I'm talking down there. .
@@mickelodiansurname9578 no that does actually make some sense to me, thanks :)
I wonder how much the company behind those new editing techniques paid for a half-baked explanation of about half of what's done during a CRISPr treatment.
I'm now even more concerned about crispr being used by governments and corporations to create a caste-like society where the majority of citizens are dumb, broken into separate castes specializing in specific tasks and only the ones with power and influence are intelligent and genetically superior to everyone else.
I fear that this technology will be abused by governments and corporations in the future. And I fear the damage will be so severe that it will lead to the extinction of our species.
Someone read Huxley recently... Good
it get extra CRISPY
Anyone can get a crisper kit sent to their house!!! This is how monsters are made.
How are you doing Maren?
The thumbnail is completely inaccurate