Antigen A and Antigen B from H substance on red cell. Genotype & Phenotype of ABO |

This video explains about the formation of H substance on the red cell membrane with the help of chromosome no 19 where a gene called FUT 1 expresses and produce an enzyme called fucose transferase. This transferase enzyme can transfer a fucose molecule on the oligosaccharide chain on the red cell membrane and form H substance. Later this H substances are converted further and form antigen A in some individual and antigen B in some other individual. The chromosomes are present on the RBC precursors. Chromosome no 9 takes the major role in converting the H substance to antigen A and antigen B. A special locus from chromosome no 9 expresses a gene called Gene A which produce an transferase enzyme called N - acetylgalactosamine transferase which transfer a N - acetylgalactosamine to the H substance an form antigen A. On the other hand same locus of the chromosome no 9 expresses a slightly different gene variant known as Gene B which produces a transferase enzyme known as galactose transferase. This enzyme can transfer a molecule of galactose to the H substance and form antigen B. In the case of AB blood group both this phenomenons are happening. If we talk about the O blood group then it is only limited to H substance. Means H substances will be formed but from the same locus of chromosome no 9 expresses a non functional gene variant which can not produce a functional protein as a result the H substances can not be converted to antigen A and antigen B. the H substances will remain unchanged. The genotype and pjenotype of ABO blood group systems are also explained in this video.
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#Hsubstance #ABObloodgroups #BiochemistryofABObloodgroups

[@judithtembo4060]

I struggled to understand this topic but this explanation is top notch, thank you

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Nice presentation, understood coach!

[@mustafafiruj1363]

Thank you sir.for the information

[@pathogenesis_mb]

You are welcome

[@kanchanborah8215]

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[@pathogenesis_mb]

Thank you.

[@AditiSharma-yh5iq]

This video is actually showing your hardwork.... it is very easy to understand. Thank you sir🙏

[@pathogenesis_mb]

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[@aminudanjumaliadi9643]

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[@pathogenesis_mb]

Thank you so much.

[@deanamber2793]

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[@vabalaji7743]

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[@umaseelhassan8401]

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[@pathogenesis_mb]

Keep watching.

[@mikinishihara638]

great!

[@pathogenesis_mb]

Thank you

[@fathi1688]

Hi, if one parent has genotype AO, and the other parent has genotype OO, will the child get blood group O?

[@pathogenesis_mb]

Not always blood group O. There is a chance of either blood group A or blood group O.

[@leighdeocampo2039]

Is it chromosome #19 or chromosome #9???

[@pathogenesis_mb]

Chromosome #19 is responsible for H substance.
Chromosome no #9 is responsible for antigen A, B and AB.