Facilitating Drug Discovery: Automated High-Content Inflammation Assay: Zebrafish l Protocol Preview

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Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish - a 2 minute Preview of the Experimental Protocol
Christine Wittmann, Markus Reischl, Asmi H. Shah, Ralf Mikut, Urban Liebel, Clemens Grabher
Karlsruhe Institute of Technology, Karlsruhe, Germany, Institute for Toxicology and Genetics; Karlsruhe Institute of Technology, Karlsruhe, Germany, Institute for Applied Informatics;
Here we describe a novel high-content chemically induced inflammation assay aiming at the identification of immune-modulatory bioactives. We have successfully combined automated microscopy with custom developed software scripts enabling automated quantification of the inflammatory response as well as further data processing, analysis, mining, and storage.
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