Clostridium and Clostridioides (Part 1) - Veterinary Bacteriology and Mycology

In this lecture, we discuss the wonderful world of Clostridium and Clostridioides, including the agents of tetanus, botulism and C. diff. I provide an overview of the extensive collection of toxins that bacteria within these genera may produce, and describe the most common diseases of animals associated with each. As always, I cover the basic microbiological characteristics, taxonomy, sample collection and diagnostic strategies, zoonotic potential and treatment options.
Credits
Music: Schumann, R. Aufschwung, Op. 12 No. 2 by Robert Schumann. (August 12, 2023). [Recorded by M.C. Gaunt] Used with permission of the performer.

[@samwesley8958]

Hi doctor you have mentioned lecithinase activity is not there for clostridium perfringes then how it could produces Neagler reaction in egg yolk agar?

[@therubinlab]

Hi Sam - I have to admit that you've stumped me! I'm going to have to refer back to a textbook as I don't have the answer immediately at hand...

[@samwesley8958]

@@therubinlab thank you Dr Rubin ❤️

[@samwesley8958]

@@therubinlab Nagler's reaction is a biochemical test used to identify organisms that liberate phospholipases (lecithinases) e.g. Clostridium perfringens. The alpha (α) toxin of C. perfringens has phospholipase activity and hence, helps in the differentiation of C. (This is what I read in my book)