I found the BEST coronavirus depiction (+ explanation)
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- Опубликовано: 3 мар 2021
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Ever found a fantastic coronavirus illustration that led him to learn about viral attachment and entry.
LEARN MORE
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To learn more about this topic, start your googling with these keywords:
Virus: a submicroscopic infectious agent that replicates only inside the living cells of an organism. The study of viruses is known as virology.
Virion: a complete virus particle, and consists of nucleic acid surrounded by a protective coat of protein called a capsid.
Coronaviruses: a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal and include some cases of the common cold, SARS, MERS, and COVID-19.
SARS-CoV-2: the virus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic.
Class I fusion proteins: resemble influenza virus hemagglutinin in their structure. Post-fusion, the active site has a trimer of α-helical coiled-coils
Proteins featured in this video:
- SARS-CoV-2 Spike (S) Protein
- Heparan Sulfate Proteoglycan (HSPG) (Syndecan-4, especifically)
- Angiotensin-converting enzyme 2 (ACE2)
- Furin
- Transmembrane protease, serine 2 (TMPRSS2)
If you liked this week’s video, you might also like:
Coronaviruses 101: Focus on Molecular Virology by Britt Glaunsinger
• Coronaviruses 101: Foc...
Virology Lectures 2021: Attachment and entry by Vincent Racaniello
• Virology Lectures 2021...
Building a visual consensus model of the SARS-CoV-2 life cycle
animationlab.utah.edu/cova
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CREDITS
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Ever Salazar | Script Writer, Narrator, Director, and Illustrator
Aldo de Vos (Know Art) | Music
MinuteEarth is produced by Neptune Studios LLC
neptunestudios.info
OUR STAFF
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Sarah Berman • Arcadi Garcia Rius
David Goldenberg • Julián Gustavo Gómez
Melissa Hayes • Alex Reich • Henry Reich
Peter Reich • Ever Salazar • Kate Yoshida
OTHER CREDITS
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SARS-CoV-2 Fusion, 2020 - Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-026
pdb101.rcsb.org/sci-art/goodse...
Coronavirus outbreak (covid 19) explained through 3D Medical Animation - Video by scientificanimations.com
• Coronavirus outbreak (...
Coronavirus, Explained: This Pandemic - Video by Netflix
www.netflix.com/title/81273378
How the Coronavirus Hijacks Your Cells - Video by Bloomberg Quicktake
• How the Coronavirus Hi...
Ink Drop/Drip in water - Video by CyberWebFX
/ cyberwebfx
MinuteEarth Tamil: / @minuteearthtamil
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REFERENCES
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Afzelius, B. (1994). Ultrastructure of human nasal epithelium during an episode of coronavirus infection. Virchows Archiv 424:295-300
Bestle, D., Heindl, M., Limburg, H., et all (2020). TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. doi: 10.26508/lsa.202000786
Buijsers B., et al (2020) Increased Plasma Heparanase Activity in COVID-19 Patients. Front. Immunol. 11:575047. doi: 10.3389/fimmu.2020.575047
Casalino, L., et al (2020). Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein
ACS Central Science 2020 6 (10), 1722-1734. doi: 10.1021/acscentsci.0c01056
Clausen, T. M., et al (2020). SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell Volume 183, Issue 4, Pages 1043-1057.e15. doi: 10.1016/j.cell.2020.09.033
Elenius, K & Jalkanen, M. (1994). Function of the syndecans - a family of cell surface proteoglycans. Journal of Cell Science 107, 2975-2982
Shang, J. et al (2020). Cell entry mechanisms of SARS-CoV-2. PNAS May 26, 2020 117 (21) 11727-11734. doi: 10.1073/pnas.2003138117
Thomas, G. (2002). Furin at the cutting edge: From protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002 October; 3(10): 753-766
Zhang, Q., et al (2020). Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro. Cell Discovery (2020) 6:80. doi: 10.1038/s41421-020-00222-5 
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I wanna thank EVER SALAZER for the vid from all of us
I wasn't really interested in this to begin with. But now I have an idea to present to Elon Musk for a Breaching Pod for his SpaceX program. FOR THE GOD EMPEROR!
Why are these comments older than the videos
Pin me
clamoroso
"I like putting faces on everything except stick figures" 😆 love you guys at MinuteEarth!
So smiling cloud?
@@kaykayabuel230 I'd draw that
@@Elisa-vq4dk me:hey cloud how you doing your looking good
Cloud that never got a complimented before: : )
i love you! minute earth!
yes
"Faces on everything except stick figures"
What has been seen cannot be unseen, but then again... I couldn't see them in the first place! haha
Turned out great! Feels good to be part of it :)
And cats
Coronavirus walks into a bar
“Sorry, we don’t serve viruses here!”
“Well, you’re not a very good host!”
Nice username
Was curious about your username so clicked on your channel. Amamzing content man
good one, hahaha
Viruses don't walk.
Ha ha
Is this the first time we've ever seen a walking animation on minute earth?
I'm pretty sure Arcadi did one a while ago. I did this one inspired in that one, but then Arcadi told me he has never done a walking animation.
I guess?
@@UnPuntoCircular This video was put together well
wow, you might be right
definitely not
As a science teacher, this video strikes me as a BIG part of what I try to do with my students. Students create models of a phenomenon- in this case, a virus entering a cell- and then we compare the models looking for strengths and weaknesses of them. You should take your skills to the classroom! Or create a new channel and have people send in models so you can review them! I enjoyed this a lot!
After getting my bachelor in bio-informatics and starting in IT in 2019, I thought I would never need the microbiology I learned in college. Then the pandemic hit... This is one of the most complete but still comprehensable videos I’ve seen on viruses in general. Great vid! It should be used in schools along with a nice big print of the painting!
At first I was like, "So you're telling me these bundles of lifeless DNA just float around until they accidentally bump into the right kind of thing, so they can then replicate and spread around more bundles of lifeless DNA? What a cruel, pointless joke." But then I remembered what I am fundamentally and now I'm staring into the abyss.
Existentialism at its worse
To be fair, its human nature to do other things beside reproduction, and while everything has its source at this instinct it would be inaccurate to compare humans to somethings that is barely alive
@@dafl00 Oh dear, my throwaway reductionist joke has spawned upset comments. Please everyone understand that I know the human organism shouldn't seriously be considered *just* packets of lifeless DNA. We could have a long and interesting conversation about it if we wanted to. Not in the comments section, tho. None of us wants that.
Just beware. Sometimes the abyss stares back.
What if we're just an advanced stage virus infecting the cell that is the earth, on the function that is the solar system, in organ that is the galaxy, in the body of the universe?
They'll draw faces on anything.
Except stick-figures.
I don't know if you noticed, but the music on this episode is different. It was made by the talented Aldo de Vos
Who?!
huehuehue
@@KnowArt you!!
Well done 👍
When he compliments your language:
*சன்தொசம்*
awww 🥰
மன்னிக்கவும், அது சந்தோசம்.
Technically he complimented your writing system, not your language.
@@felipevasconcelos6736 it's still thing to be proud of, don't you think?
@@felipevasconcelos6736 Reading, Writing and Speaking, these three together will decide the beauty of a language.
David Goodsell's illustrations are indeed fantastic, I recommend just putting his name into an image search and looking at all the cool stuff.
"I like putting faces on everything except actual humans"
I'm already fan of David Goodsell when I started my PhD. Purchased his illustration book
I love this explanation because it's so much more in depth and different - visually, especially - as opposed to the billion other explanation videos out there. Thank you so much for taking the time to explain! I enjoyed the little details.
Any illustration/animation is going to be somewhat abstracted, and should be! This is a technical communication strategy choice. Just like you chose to put faces on viruses or not go deep down a rabbit hole on the difference between a virus and virion, we have to simplify and abstract anything we explain depending on the audience. And it almost all the cases here, it's an audience of laypersons.
So while the painting is indeed incredible in its detail and beauty, Stickfigure Henry needs to chill on the simplified Netflix animation that probably does the job for the purpose it serves and the audience it's delivered to. ;) Simple illustrations and animations aren't necessarily "wrong", just necessarily abstracted. I think the video more or less explains this.
I do agree that in all other circumstances illustration should be abstracted because how something looks generally isn't the focus point of a particular lesson, but sometimes it's nice to see the pure complexity of biology. You can't film cells (at the protein and chemical level) after all.
@@Zcon18 Indeed! We're in a beautiful overlap between highly-accurate instructional graphics and pure art with that painting. Brings me back to being a kid and gazing at science article illustrations in National Geographic for hours on end.
It is possible to simplify without depicting something that is purely wrong. Simplification is wished for but biologically wrong info is unnecessary.
I'm curious, why that rabbit hole has a tentacles >__>
0:41 Tamizhan da moment 🔥 Thank you minute earth for recognizing this beautiful language
I was also shocked when saw 😂
The "zh" here is pronounced WAY different to what you may expect.
@@Think_Inc yes it is very unique to the tamizh language
But with practice it will become easy to pronounce
@@amiyavatsa Hard to explain, it's almost like saying an r and an l sound while curling your tongue back. I'm probably explaining it wrong but that's how I say it in words like Kozhikode.
@@redcoat4348 yes exactly, in fact it reminds of the korean r as well
Have not seen a MinuteEarth video this good in a long time. For some reason the music and Ever and illustrations were just perfect together.
P. S. I know I am a little late. And I still do like every other video, but for some reason Ever just does it way better.
Thanks for making an informed video and not just some fear-based videos without understanding the scientific background involved! I think that's the best video I've seen so far on the topic.
Minute earth actually makes videos with real and interesting facts
Fantastic! I loved this. Animations reminded me of cgp grey
Thank you for making David Goodsell's amazing illustrations more famous. His work on Molecule of the Month for the PDB is also really cool
The graphics like those made by David Goodsell are exactly what made me want to be a biologist!
Now that is a paint that is worth 1000 words
If it wasn't causing so many deaths, crises and lockdowns everywhere one could even argue Covid is actually beautiful
Only the appearance, and not what it caused
I think really any biological process is beautiful.
The barrier between life stuff and dead stuff is the beautiful thing here, covid-19 is FAR from beautiful
It can be both
covid is good.
4:38: that sync of content and music is a really nice detail. Not to lessen the content of the video, but IMHO the music really puts this on another level!
Thanks! Really nice to hear that because it's an interesting balance between adding something noticeable but not distracting too much
Me: * sees walking animation *
Me: * Surprised pikachu face! *
right? haha
I saw that too
I thought it was cool
This picture is so beautiful that I'd put it on a wall in my apartment.
Same😯
You can get posters of David Goodsell's work
@@roidroid Immediately after the video I was looking at Goodsell's page to figure out if he was selling the painting or not. Despite his name, he doesn't advertise it, so the only way would be to contact him directly. A poster just wouldn't be the same.
I love the minuteearth team as a whole but Mr. Salazar this video, with its tangents and variedness, is spectacular.
Thank u for the intro 😊
I really wanna know what program/software you used for this video, it looks really cool
This might be the most beautiful episode of MinuteEarth. As beautiful as Goodsell's paintings.
Amazing background music!!!
Thanks!
Who would've known that a painting would be a better example than most film media.
Ever Salazar, nice video ;) I hope you get to make more! This was very well explained, illustrated and paced. Seriously.
Thanks!
this video has a lot of humor considering how educational this is
The art was amazing in this video and I like the new animation
Keep up the good work👍
I love this slightly different style of video
Great format! I'll love to see more like this :)
I want that painting on a poster. It is gorgeous
When minuteearth uploads as you’re getting off lunch break
It’s 1:23 am where I’m from haha
@@J11_boohoo It's currently 12:25 here.
How can content like this be free? Amazing.
Support them on Patreon! I do!
this is so fascinating! models are so important to understanding physical processes, but if you don't understand them, they're useless. great job breaking things down, i really appreciate it.
This is the first time I need to turn on captions for watching minute earth videos.
Pleasing to the eye, yet wonderfully accurate.
That creator is a genius!
I enjoyed this video a lot. Had a different style. Great work!
Great job with the animation its detailed yet easy to understand and its pretty
That painter is really good at selling his work!
Lovely format. Congrats.
I wanna thank EVER SALAZER for the vid from all of us
Thanks MinuteEarth. Rabbit holes are what I'm here for 😁
How did you comment 9 hours ago
Ah, Doofenschmirz wants to learn some Sience! 😃
@@darkbobblackpants9747 Videos get released earlier to Patreon patrons
I love Goodsell's work. I can spend an evening looking at his gallery in PDB.
MinuteEarth: Uploads video.
MinuteEarth fans: Who thou hast summoned me?
You mean hath?
I can read Tamil as I'm from Tamil Nadu! And it's cool you mentioned Tamil!
What did it say?
Seeing a walking animation in minuteearth is scary
I knew viruses connected with host cells via their spike proteins and fused their membranes with the cell, but I didn’t know they harpooned the cell membrane in order to so, that’s amazing! I wish we were taught such details in school.
Please, I need the virion rabbit hole
yay a brand new minute earth video.
I love David Goodsell’s paintings! I read his book last year and am happy he did a Sars-CoV-2 depiction!
One thing lack:
ruclips.net/video/dNVXJhjJXEs/видео.html - camostat mesylate (Dr. Mobeen Syed)
Microscopes that could clearly see cells would open so many doors.
We've been able to do that for a pretty long time, viruses are just a lot smaller still
That's a really good painting :)
I love the brevity of the mini-debate at 4:47 with Henry. The audience understands both positions, so move on. Concise!
A SMOOTH LEG MOVING
What a nice video about biology/ medicine illustration! You could definitely work as a medical book's illustrator.
0:50 it's meaning is
Do you know?
That you can hear these simple and awsome science stories in Tamil.Minute Earth, which has attracted the attention of many around the world , is now in Tamil for you.
Also love the actin scaffolding in the watercolor
I think that the duplicating process should get a whole video of itself, it will be a good one
Holy hell watercolor?????? That is absolutely incredible. I suck at watercolor
Finally an 'Indian guy on RUclips' explaining things to me in a way I can understand!
Beautiful painting! And scientifically accurate, i could see why you like it 💛
I remember in 2013 when the ebola outbreaks were happening and my friends asked me why we couldn't make a vaccine for ebola and I said b/c it's a retrovirus and they said what difference does that make, and I said I'll get back to you.
And then I found out the gulfs of my ignorance on how vaccines work.
We actually have drugs aganist Ebola...very effective ones.
@@WadcaWymiaru Approved 2019 and another in 2020, I didn't know about that.
I was talking about finding out about how antibodies respond to cell antigens and how the genetic memory system of mast cells work and something about head and tail proteins which are totally different from alpha and beta anchor proteins and I was so out of my depth so quickly.
I love minute earth it's so original
This new person is amazingly good
The animation though!
and info.
this was very interesting. you explained about CoronaVirus awesomely.
I love this narrator!! Bring him back!!!
Realmente me encantó la explicación y la voz de ever. Maravilloso trabajo hacen (!
People really need to understand that virus has no agency. It's like an SD card with malware on it floating around. Before it manages to plug itself to a computer's SD slot by random brownian motion it's completely inert. Anyway, this is a great video giving a glimpse of the actual complexity of the biology involved.
I'm from Tamilnadu 💞.
But I really do not know that I can watch your vedios in tamil. Wow......
You can watch them here
ruclips.net/channel/UCIrFGdwp_FzEkF7uHEjSShw
Was shocked for a second when I saw Tamil. Love to you guys from Tamilnadu :)
Dude, you sound like a guy from about ten years ago who used to make pokemon-related videos. It isn't the accent either...I was wracking my brain trying to figure out who you sounded like, since it was driving me crazy. It just clicked. XD I know you aren't the same person, but sometimes I hear videos with voices very, very similar to ones I listened to, years ago.
I love Ever’s accent/voice!
As a software engineer I just realized how unbelievably similar computer viruses and biological viruses are and it blew my mind.
spikey ball make cell go ouchy ouchy
The Forest of all knowledge contains many rabbit holes
Very good explained! ^^
That's awesome!
I love creating science visualizations, especially in 3D
4:50 9/10 it has a little something for everyone
Thank you for the video
Describing some wrong illustrations reveals they were created by artists misunderstanding poor descriptions:
"...the virus injects *inside* the cell membrane..."
Policygenius: sells life insurance in middle of pandemic
customer: buys life insurance and dies of pandemic 3 months later
Policygenius: surprised_pikachu.jpg
That "SARS-CoV-2 Fusion, 2020" by David Goodsell looks amazing. Is there anywhere we can get a high quality print of that made?
Can confirm, I am Covid-19.
How does it push the fused membrane into 2 so it can enter?
"Painting of SARS-CoV-2 infecting a cell goes viral"
I want a print of this painting. It matches my bathroom.
Lol
thank you, this was awesome
This is why I am nothing. Still cannot accept that I once get sick by it. Must hated thing ever
I always thought of viruses trying to rip apart the cell membrane and get in with spiked (heh) maces.
Now it's starting to look more and more like a wandering mine
I have immunology lecture in like half an hour
Lol