Hm. I'm not sure if I agree with you on "it is invasive because it now has blood vessels and can spread through blood" - if it does so it's metastasized. I would say when a carcinoma is able to grow through the basal membrane (thus no longer carcinoma in situ) then it is called "invasive carcinoma".
Great video!!! I just would like to add Information about the invasion of the lymph nodes, and mention the sentinel lymph node which is the first lymph node(s) to which cancer cells are most likely to spread from a primary tumor. A biopsy of the sentinel lymph node can help us determine the extent or stage of the cancer in the body
Amazing video! There's just one little thing, that cancer cells will reach the heart through the vena cava superior, not inferior. But anyway - I love the way you teach! It's really helpful ;) Thanks.
Hi there. My wife Ann and I being married for 48 years this year 14th sept. 2022 . Stage 3 cancer just disclosed last week. Scan due on Sunday coming. Hope all ok. Your video relaxed me and took some of my emotions away not knowing the facts as to what was actually going on on physically. BRILL VIDEO.
Thankyou Gaurav for your reply much appreciated. Ann is going for a CT scan in 2 weeks time to probrably determine the appropiate procedure to continue with the treatment she requires. Will keep you informed. Once again your videos are brilliant and I shall. if any of my friends/relatives have any upsets like we are having, I shall direct them to this video. T@@_gauravdeep_
@@_gauravdeep_ Ann had first chemo last week, she felt a little bit poorly but she had to inject herself with certain drugs etc. Which I think made her worse but never the less it will make her better. At the end of the day I would like to say if it was not for your video on you tube I would not have had a clue to whats happening to my wife.
I really appreciate what you're doing!!! Your videos are very beneficial and helpful, I really wish you a happy successful life because you help many people ❤️❤️
Great information, it helps to understand what is going on and the meaning of the medical terminology used to describe it. I really appreciate you sharing this, we could use this information to get answers, and there are so many!
it is called tumor induced angiogenesis, so basically tumor cells also secretes growth factor to help the cells grow and some of the growth factors are also a growth factor that could induce the making of new blood vessels (angiogenesis) such as VEGF . Because we know that cells need protein (which contains within the blood) thus it causes angiogenesis so that the tumor cells could grow more. i hope this helps🙏🏽
My uncle was diagnosed with Metastasis. I am going to go to Mexico because I want to find out exactly what is going on, are there specific questions that I should be asking?
Great explanation but I have a question as carcinomas are known to spread through lymphatic channels n so is true for breast carcinoma which can invade axillary lymph nodes if on right upper quadrant n lymph nodes around internal mammary artery if on medial side then how can you explain metastasis saying breast cancer spread through hematogenous route?
Is this what makes stage four cancer difficult to treat? After removing a primary and secondary melanoma will the cells still be in the blood or likely to start new masses elsewhere?
Hello...Stage 4 cancer is treatable..BUT it is not curable. Someone who has Stage 4 will be receiving treatment for the rest of their lives. The prognosis (how long someone w/stage 4 will live) depends upon different things, one of which is 'where' the cancer traveled to, ( lung, liver, bone, brain) and/or 'how many tumors' there are, etc. A secondary, metastatic tumor might be able to be removed, but that will not cure the cancer. Once you have it, (stage 4--metastatic cancer) you will never be "cancer-free." Metastatic cancer is terminal....it will eventually cause death. I have metastatic breast cancer, (stage 4) in my bones. So my diagnosis is now called "Bone Metastasis," or "Bone Mets" for short. In July of 2021 my prognosis was 3 & 1/2 years at the most. But keep in mind, that is only the Dr.s educated guess...it's just an "estimated" amount of time.
I have a question. Cancer cells are transported to the heart. Why do the cancer cells metastasize to other organs, except heart? Because I never heard "Heart cancer".
They do but it is very rare - form 0.25 percent of all cancers. Primary cancers in the heart are called angiosarcomas. It's very poorly understood but it's hypothesized that the heart cells, myocytes, have a very tight proliferative cycle thus making it difficult for cancer to survive and thus metastasize. Therefore, most cancers of the heart would be benign anyway and found in autopsies from patient's dying from other diseases.
Also because it depends on the microenvironment of the sites. It is called the Seed and Soil hypothesis, If the primary site has a different microenvironment (Growth factors, nutrients, cytokines etc..) than the secondary site, it is hard for the tumour cell to metastasis there as it won't live. Lungs are perfect for breast-originated cancer cells due to to similar microenvironment, but maybe breast and heart have different microenvironment which makes it hard for a metastasised tumour to survive in?
+Yashika Raghuwanshi well I know the blood vessels that grow toward cancer from angiogenesis are considered 'leaky' - the gap junctions aren't as tight between the endothelial cells forming new veins. The microenvironment of the tumor allows for some cancerous cells to break off from the tumor and enter those veins. I suppose the case may be similar in lymph vessels, but I'm not sure - i guess we can look it up in PubMed or something
Perhaps. There wasn't any mention about the formation of new lymph vessels as well. But your assumption might be true. I looked it up but didn't get a clear answer.
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What have I been doing for these first 3 years of my Pharmacy degree, reading textbooks and crap??
This is the way.
Thank you, so much.
8 years!!! How r u? ur career ?
Same hereeee
first class explanation of how cancer cells spread. Excellent graphics and easy to follow. A real help for me on my BSc
Thanks for getting me through my degree, you legend!
RUclips world seems beautiful and wonderful due to you dear Armando...
You deserve millions of subscribers and likes ✌
Hm. I'm not sure if I agree with you on "it is invasive because it now has blood vessels and can spread through blood" - if it does so it's metastasized. I would say when a carcinoma is able to grow through the basal membrane (thus no longer carcinoma in situ) then it is called "invasive carcinoma".
yeah I would say its about local invasion not metastasis
Agreed
Great video!!! I just would like to add Information about the invasion of the lymph nodes, and mention the sentinel lymph node which is the first lymph node(s) to which cancer cells are most likely to spread from a primary tumor. A biopsy of the sentinel lymph node can help us determine the extent or stage of the cancer in the body
Thanks for the information 😀
I searched for the movie but got this
Amazing video! There's just one little thing, that cancer cells will reach the heart through the vena cava superior, not inferior. But anyway - I love the way you teach! It's really helpful ;) Thanks.
Hi there. My wife Ann and I being married for 48 years this year 14th sept. 2022 . Stage 3 cancer just disclosed last week. Scan due on Sunday coming. Hope all ok. Your video relaxed me and took some of my emotions away not knowing the facts as to what was actually going on on physically. BRILL VIDEO.
More power to you and your wife buddy. I hope everything turns out to be well.
Thankyou Gaurav for your reply much appreciated. Ann is going for a CT scan in 2 weeks time to probrably determine the appropiate procedure to continue with the treatment she requires. Will keep you informed. Once again your videos are brilliant and I shall. if any of my friends/relatives have any upsets like we are having, I shall direct them to this video. T@@_gauravdeep_
@@georgebelfield7802 Hoping for the best. Take care.
@@_gauravdeep_ Ann had first chemo last week, she felt a little bit poorly but she had to inject herself with certain drugs etc. Which I think made her worse but never the less it will make her better. At the end of the day I would like to say if it was not for your video on you tube I would not have had a clue to whats happening to my wife.
Kaha hua
still the best technique for teaching ever !! masha ALLAH
thx alot for your effort .. keep going plz ^^
No
It helped me in cancer pathology studying, thank you very much :)
I really appreciate what you're doing!!! Your videos are very beneficial and helpful, I really wish you a happy successful life because you help many people ❤️❤️
These lessons are teriffic! I want to learn more about cancer and you're helping me in that process. Thank you!
Wow, this was amazing! Nice work.
Great overview of Cancer. Illustrations are simple to understand. Thank you.
Amazing drawing, easy to understand, thanks!
I love your drawings!
a fantastic video as usual 🥰
Great information, it helps to understand what is going on and the meaning of the medical terminology used to describe it. I really appreciate you sharing this, we could use this information to get answers, and there are so many!
fantastic video, well done
Thank you for making this amazing video! I didnt have pharmacy background but this video is so easy to understand! Thanks!
Impressive thank you doctor 🌹
thanks a lot sir love from india🇮🇳 METASTASIS WORD is in 7:11
thank you sir for amazing video
You've got some talent man. I wish I could draw half as good as you and remember all the crap written in my books.
Is there a way to obtain the finished illustrations? Your videos are phenomenal!!
Excellent video to understand the metastasis.....
Congratulations for one million subscriber's..
are there any videos other than the 3 in your channel? They're so useful. got an exam on tuesday. when will you be uploading the next one?
Nice explanation...watch from India
I like your video very much. Please make video about cell injury 🙏
thank u sooooo much^^ all your videos are awesome and greetly summarising every thing in a such simple way
thank u for that effort :) god bless u *.*
Awesome video.. Thank u
Thank you so much!
thank you
Thanks a lot nice explaination
I appreciate and enjoy your teaching videos
Thanks so much!
Awesome video!!
Thank you 🙏🙏🙏
Very good explanation, and nice drawings!
This is great!
What a fantastic revision tool for students. You seem to condense whole chapters and articles to your unique drawings.
Great video thank you!
Thank you so much.. Sir..
Bravo!!! Well Explained! Thoroughly enjoyed! I’d like to learn A little more about how angiogenesis is influenced by the tumor?
it is called tumor induced angiogenesis, so basically tumor cells also secretes growth factor to help the cells grow and some of the growth factors are also a growth factor that could induce the making of new blood vessels (angiogenesis) such as VEGF . Because we know that cells need protein (which contains within the blood) thus it causes angiogenesis so that the tumor cells could grow more. i hope this helps🙏🏽
Very helpful thank you so much
You are incredible, amazing. THANK YOU VERY MUCH.
Thank you so much =)
THANKS MAKING VIDEO
God sent friend for us in need
Makasi kaaa!! your videos help me a lot ;)
Best lecture
Thank u so much
Thank you
My uncle was diagnosed with Metastasis. I am going to go to Mexico because I want to find out exactly what is going on, are there specific questions that I should be asking?
Thnku sir
Thank you.
Great video! You should do subscriber giveaways with your posters
is there any possibility that the heart become secondary site ?
Usually cancer cant spred to muscular organs such as heart bcoz its lined by endothelial cells
Doctor I have one question can benzene exposure causes metastatic testicular cancer.
Great explanation but I have a question as carcinomas are known to spread through lymphatic channels n so is true for breast carcinoma which can invade axillary lymph nodes if on right upper quadrant n lymph nodes around internal mammary artery if on medial side then how can you explain metastasis saying breast cancer spread through hematogenous route?
I got it know. Thanks. EXELENT EXPLANATION.
Fantastic!
I LOVE YOU!!
Great videos and thanks for helping explaining things clear!
Is this what makes stage four cancer difficult to treat? After removing a primary and secondary melanoma will the cells still be in the blood or likely to start new masses elsewhere?
Hello...Stage 4 cancer is treatable..BUT it is not curable. Someone who has Stage 4 will be receiving treatment for the rest of their lives. The prognosis (how long someone w/stage 4 will live) depends upon different things, one of which is 'where' the cancer traveled to, ( lung, liver, bone, brain) and/or 'how many tumors' there are, etc. A secondary, metastatic tumor might be able to be removed, but that will not cure the cancer. Once you have it, (stage 4--metastatic cancer) you will never be "cancer-free." Metastatic cancer is terminal....it will eventually cause death. I have metastatic breast cancer, (stage 4) in my bones. So my diagnosis is now called "Bone Metastasis," or "Bone Mets" for short. In July of 2021 my prognosis was 3 & 1/2 years at the most. But keep in mind, that is only the Dr.s educated guess...it's just an "estimated" amount of time.
anyone knows where is the overall and clear image for this video. thx.
thannnnnnnnnnnnnnnnnk you
ty so mutch =)
thank you from a cancer warrior makes it easy to understand and explain to loved ones. 😊
So could you please tell whats the treatment suggested
Metastasis patient how to control spearding body. My mom position present please reply me
Perfect.
Fantastic
Great vídeo. That vídeo so amazing :D
Plz can u do Vdz about Bone microscopic anatomy ?
How brest cancer spread to the liver?????
cool!
How long it we'll spread if u had a sign of cancer
Wow....really nyc video, it helped me a lot in science project:D:) thanks
Why do people always say that women have breast cancer, when both men and women can have breast cancer.
bro can u explain chemotheraphy all the types please
please make a video on breast cancer
Great videos! Awesome work; you really should have more subscribers. :)
You are alaways help me in your video.thanx aloot
I love your videos but there are errors in this which is such a shame.
Wonderful! Armando!!!
U presentation is impressive
Ur presentation is impressive
Thank you for this video ,it was enjoyable and understandable 👍🏼
We all know that every awesome video starts with ”so here is a breast”
Wow so meta
Thanks to my doctor who cured me of cancer that almost get rid of my life.
traduscanlaaaa
You could play baby blue background
Breaking
i loved it!!!! x
Who are watching this video in 2021 raise ur hands 😂🙌
My grandpa died of metastasis today 😭 f*ck cancer
I have a question. Cancer cells are transported to the heart. Why do the cancer cells metastasize to other organs, except heart? Because I never heard "Heart cancer".
They do but it is very rare - form 0.25 percent of all cancers. Primary cancers in the heart are called angiosarcomas. It's very poorly understood but it's hypothesized that the heart cells, myocytes, have a very tight proliferative cycle thus making it difficult for cancer to survive and thus metastasize. Therefore, most cancers of the heart would be benign anyway and found in autopsies from patient's dying from other diseases.
Thank you for your information
Also because it depends on the microenvironment of the sites. It is called the Seed and Soil hypothesis, If the primary site has a different microenvironment (Growth factors, nutrients, cytokines etc..) than the secondary site, it is hard for the tumour cell to metastasis there as it won't live. Lungs are perfect for breast-originated cancer cells due to to similar microenvironment, but maybe breast and heart have different microenvironment which makes it hard for a metastasised tumour to survive in?
thank u, u r #1 (Y)
How can cancel cells enter lymph vessels? While RBCs cannot?
+Yashika Raghuwanshi well I know the blood vessels that grow toward cancer from angiogenesis are considered 'leaky' - the gap junctions aren't as tight between the endothelial cells forming new veins. The microenvironment of the tumor allows for some cancerous cells to break off from the tumor and enter those veins. I suppose the case may be similar in lymph vessels, but I'm not sure - i guess we can look it up in PubMed or something
Perhaps. There wasn't any mention about the formation of new lymph vessels as well. But your assumption might be true. I looked it up but didn't get a clear answer.