First Clinical Trial of Ketogenic Diet for Bipolar & Schizophrenia - Shebani Sethi, MD
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- Опубликовано: 5 май 2024
- Early data from the first clinical pilot trial of the ketogenic metabolic intervention for serious mental illness shows promising results that could transform how the field of psychiatry understands and treats serious mental illness.
“In this pilot study, we taught 22 patients with severe bipolar disorder or schizophrenia how to maintain a ketogenic diet. It was all real-world, meaning we didn’t control food intake in a temporary inpatient setting and we didn’t deliver meals, but instead taught patients how to buy and prepare their own food. Despite the severity of their mental illness, our patients were able to successfully adopt the ketogenic diet as a lifestyle change. However, there is a selection bias, as those who entered the study may have been a more motivated population.
After four months, our preliminary results were very encouraging: They included a 30% reduction in central abdominal fat, an 11% drop in BMI and a 17% drop in cardiac inflammation, as measured by a marker called high-sensitivity C-reactive protein. Perhaps most importantly, we saw a 30% improvement in our patients’ clinical global impression inventory, which is the gold-standard psychiatric assessment we use to evaluate symptoms of mental illness. Additionally, we saw improvements in sleep.”
Dr. Shebani Sethi - Stanford Metabolic Psychiatry Clinic
Dr. Shebani Sethi is a board-certified physician in psychiatry and obesity medicine, a clinical assistant professor of psychiatry at Stanford University, and the founding director of Stanford's metabolic psychiatry clinic. In this talk, she describes the preliminary findings from her pioneering study on ketogenic diets and mental illness.
Bio: profiles.stanford.edu/shebani...
Twitter: @ShebaniMD
This video was recorded at the first ever Metabolic Psychiatry roadmap retreat, hosted by Baszucki Group and the Milken Institute for Strategic Philanthropy in May, 2022 in Santa Barbara. The conference brought together physicians, neuroscientists, dieticians, entrepreneurs, venture capitalists and philanthropists to build community in the emerging field of Metabolic Psychiatry.
Learn more about metabolic psychiatry and meet the visionary Metabolic Mind Award Winners at tinyurl.com/Baszucki-Group
About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission over time will be to provide resources and build community in metabolic psychiatry.
JOIN OUR MAILING LIST AT metabolicmind.org/
Other resources for Metabolic Psychiatry, metabolic neuroscience and ketogenic metabolic therapy for mental disorders:
Diagnosis Diet - www.diagnosisdiet.com/
New Study: Serious Mental Illness Improves on Ketogenic Diet -
www.psychologytoday.com/us/bl...
The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review
www.ncbi.nlm.nih.gov/pmc/arti...
Chris Palmer MD - www.chrispalmermd.com/
Stanford Metabolic Psychiatry- metabolicpsychiatry.com/
What Is Metabolic Psychiatry? 5 Questions Answered by Dr. Shebani Sethi
med.stanford.edu/news/all-new...
Baszucki Group - baszuckigroup.com/our-work/me...
BipolarCast: Keto + Bipolar youtube channel, Hosted by Matt Baszucki and Iain Campbell, PhD
/ @bipolarcast1133
/ iaincampbellphd
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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I have bipolar 1 and paranoid psychosis. The root of my problem appears to be TTG6 antibodies which I produce when I eat gluten, and these have been detected using blood tests and spectroscopy MRI. However, a gluten free diet doesn’t seem to reverse the symptoms. Instead, I follow a therapeutic keto diet, it’s actually a diet called the autoimmune protocol and promotes very low levels of ketones, while giving me a very good nutritional intake. I’m pleased to say that so long as I adhere to this diet, and completely avoid gluten I remain well, and have remained well and med free for most 7 years at time of writing. This is remarkable when you consider I had 5 psychiatric hospital admissions before I started the diet, and had tried over 20 psychiatric drugs. Diet is key, and needs to be the first line of treatment for severe mental illness.
Thank you for your testimonial. I have a loved one who is currently dealing with psychosis, they are being monitored and trying to calm them down. This would be the 5th relapse, so similar to you, and its comforting to hear that you are doing better. Gives me hope for her future. Currently they put her back on medication to stabilize her, she was medication free for about a year, but unfortunately stress may have been the reason for the relapse. Im learning that keto diet may help and also certain supplements like naicin, b3, vitamin d, could help.
What else has helped you ? Any test that can be done or should be checked regularly ??
Try iodine/iodide, lugols iodine, read iodine protocol. Then take 12mg per day with selenium supplement. Then change your water to distilled water + only consuming celtic sea salt as your electrolytes. Dr Brownstein is a good teacher for all of this + Dr Ken berry. Good luck
@@o221e3I have four children, two have these reactions to Gluten, unfortunately one does not believe it is gluten and refuses to avoid it, is now back in hospital with all you have described, the other has also got celiac but was diagnosed late , however is going well on gluten free diet, I have witnessed 3 generations with this horrible illness, the toll on human health can never be measured, it should be mandatory to have all babies tested at birth to protect them from this .
Wow! Blessings to you and thank you for sharing ❤❤❤
Where would one find the guidelines for this DIET! Please Share. TIA
Keto and fasting has changed my bipolar life. Depression gone, anxiety gone. I love my life now.
Hi. I am bipolar. Your comment made me hopeful as I want to give up bipolar meds too. Can u guide please.
In Indonesia, we have a combination of ketogenic and fasting community that we call ketofastosis
What type of fasting ?
@@pahtashow you can use intermitting fasting, water fasting or dry fasting
I guided myself with Christopher Palmer's book Brain Energy. I do a daily 8/16 eating/fasting, with a monthly longer fast, from 24 to 80 hours. I watch my diet closely. I'm up to 100 grams carbs (because I'm a weight lifter/runner) and I eat home-made sauerkraut with Greek Yogurt before every meal. I strive to eat starch resistant carbs.
My body has changed from a dad bod to ripped. I dropped from a 36 inch waist to 32 inches. From 215 lbs to a ripped 200 lbs. I try getting dawn sun before I start my day. Andrew Hueberman has also been important in having information on how the body works. At 66 I can do 100 sit ups, push ups, lift weights for an hour and walk 4 to 5 miles in an hour and I do that all in one session. I do breathing exercises while I walk the track. My first meal of the day is after work out and I never eat after dark.
This past year has been one of my best and most productive. I wrote a screenplay that won awards with others in stages of rewrites. After reviewing my year's journal, I've had few depressions, few suicidal ideation sessions. And when they arrive, they don't stay long.
We live in a society that values ill health. Sickness is a business. Our foods don't have the best nutrition. Fasting resets your body. Eating right and exercises sharpens it. I'm saddened my my friends that have let themselves get old. Anything you don't exercise in your body will degenerate.
I eat less than before. I make my own bone broth for collagen and do take supplemental collagen as well. No processed food of any kind. No wheat or grain products. I go through a lb of butter a week, 4 pounds of bacon, eggs and meats. I eat organ meats once a week, tendons, cartilage and fats. Pumpkin and almond seeds galore; Lots of cabbage, feta and sharp cheeses. Knowledge is constantly changing so I listen to podcasts for any new useful information .
Study your body. Take a picture of it when you start. You will be amazed how fast it changes. The hard part of fasting is getting past the first time you are hungry. I felt like a drug addict going through withdrawals. But that feeling goes away, and it hurts less every time until it becomes fun. The key to health is understanding your own body. What works for me may not work for you, but you do have to try different things.
I love my life, and I'm not manic! @@marinakarim2187
My 31 y.o. daughter has schizoaffective & has lost her young adulthood to this disease. It's been nearly 4 years since she has lived on her own, currently she is again in a secure mental healthcare clinic. I've been keto/ketovore with great success for 3 years now. The will not allow her to have a ketogenic diet although they would let her eat a vegetarian diet & that's just sad.
I'm so sorry to hear that. I can see how frustrating that must be for you. Maybe sharing some of these videos will help open their eyes.
The keto diet is treated like witchcraft by mainstream medicine and it's ridiculous because it was used over a hundred years ago to treat epilepsy. I believe they are well aware that it could put them out of business. A psychiatrist told me 2 weeks ago that my son could not have vitamins in hospital, just psych drugs that have not helped him in 22 years.
@stevec3872 stand up for your daughter. Get a court order for diet change, show the proof from here. Take her home and help her if you have to. Don't let them continue to destroy and rob your daughter of her life. This is a terrible tragedy😢. 😢. 😢😢
Hang tough and keep at it.
What a lovely caring woman and bless her for her efforts and wisdom--in treating these disorders!
I have bipolar and started body-building, 11 months later my cholesterol improved
After before
Total chol. 4 6.2
Hdl 1.1 0.9
Ldl 2.2 3.8
Non hdl chol 2.9 5.3
Triglyceride 1.5 8.2
Ldl/hdl ratio 2 4.2
Chol/hdl ratio 3.6 6.9
My waist went from 47 inches to 38. Strength went up 50%. I gained some muscle. No Blood pressure or insulin issues before or after, slightly better after.
I think the lifting weights has done more for my mental health than diet improvements. I have cut ultra processed foods, decreased starch, increased fat (especially flax seed oil) and eating more red meat and eggs.
“ Most things that get worse with time, get better with exercise.” I learned at lot of rubbish when I trained at the YMCA to become a fitness insructor, but this chestnut is a keeper! 🌰
And were you also using vitamins or vitamin enriched protein powders etc ? My son experienced some of the best times of his life when bodybuilding and I put it down to the higher protein and vitamins and amino acids contained in protein powder. It's interesting.
@@helenlawson3203 I have one whey protein shake a day, which is pretty much whey. Co enzyme q10 every second day. Creatine, tribulus and ginseng before working out. Magnesium and ashwaganda at night time
Thanks for this presentation, this and the work of other highly respected health professionals is finally bringing this ground breaking information to the general public. Unfortunately nutrition related interventions have been widely undervalued in the mental health field for far too long.
It's not groundbreaking. It's a repeat of past treatment. The keto diet has been around since the 1920s. It is just being rebranded as something new. A money grab.
It's interesting that some psych meds work for some people and not others. The keto diet seems to work for everyone. Says it all.
The psychiatric diseases are a group of different diseases that got lumped together by bad scientific practice.
Grateful for brilliant minds that are helping those who are struggling🙏🙌
Would be nice to mention obesity rates before schizophrenia and after is diagnosed. Since antipsychotic meds cause massive weight gain, it only follows that without good stats, you wouldn’t know if obesity correlated with schizophrenia or the meds.
It's hard to track because nobody is testing for insulin resistance before medications are prescribed. We're trying to change that.
If you listen to Harvards Chris Palmer who treats schizophrenia with ketosis, he says it's both. Schizophrenia is caused by mitochondrial dysfunction of a certain area of the brain, and while the medication do help some people, they also cause metabolic damage to the body on the long run, aka. make the situation worse. And obesity is linked with insulin resistance and metabolic syndrome, which both cause mitochondrial damage. They are all intertwined.
For example: early symptoms of Alzheimers diseases, which too is caused by mitochondrial dysfunction, can include schizophrenic hallucinations. Why? Because according to the latest science it's the same exact thing.
I was a normal, healthy weight before I started Seroquel for bipolar disorder. Many years later, I am more than 100 lbs overweight and I hate it.
@@shenandoah1322 My son gained 25 pounds in 6 weeks on Zyprexa. He is down from a high of 25mg to a 2.5mg with no metabolic side effects. Have you tried nutritional ketosis as an intervention?
@@jan_ellison_baszucki A few years ago I managed to lose 38 lbs with keto and intermittent fasting. But I find it really hard to stick with it because it is so restrictive and I have past history with various forms of disordered eating. When I feel deprived, I end up bingeing.
Thank You for sharing this research via RUclips. I have over thirty years of various experiences of trying to assist my wife with her illnesses, but as of yesterday after seeing Dr. Chris Palmer's interview discussing Ketogenesis as a treatment for Bi-Polar /schizophrenia illness and now your research I'm feeling much more hopeful. Since we relocated I haven't found a psychiatrist that has been willing to take my wife as a new patient, but now I know in more detail the type of Psychiatrist I will be looking for. You have given me hope...I will try to get her to watch this video presentation. Thank you
Thank you for your comment. You can look for a trained psychiatrist here www.diagnosisdiet.com/directory Hopefully that will help you find someone to work with.
@@metabolicmindare the people on this directory vetted? How did they get onto this directory in the first place? Thank you for all you guys do!
Most of them took Dr. Ede's training course
I also had issues with visual snow and lasik complications. That's where all the more severe problems I've suffered in life started. My heart goes out to you Blaze. You've come farther than I have with your mental health. I envy you. I'm also an LICSW/Therapist in the Ohio Valley. I struggle a lot with my dissociative traumatic anxiety. I have crazy thoughts that terrify and weigh me down. Idk why I opened up about this, but after seeing that I felt it on my heart. I hope I can recover.
Wow, how true. T1D patient 44 years, overcame PTSD injury. Publishing Forensic Aspects of Hypoglycaemia as Legal Case Studies after near fatal Hypoglycaemia with Neuroglycopenia and link to mental Health Hypoglycaemia in Addison's Disease.
This is awesome and I’m a witness on how keto has help my son a lot. His dx is schizoaffective disorder
Does it also help stop all meds? Docs give a cocktail for schizoaffective.
There is a big difference between help and fully healing.
Yes there is and no medication achieves a cure.@@samh.6272
I intend to try my son on it, his diagnosis has been schizophrenia in the early days and schizoaffective disorder now. He is treatment resistant and has been for the entire 22 years he has been ill, he's about to turn 44. It's a terrible illness but the treatment is worse, and pointless.
@@helenlawson3203 There is no such thing as treatment resistant. People are treated with drugs that don't work. Antipsychotics dull symptoms only. They are heavy tranquilizers. Since there is no other treatment that exists outside of drugs, it doesn't make one treatment resistant. It makes the drug treatment unworkable. People make drug free recoveries all the time, but you won't hear about those cases in modern psychiatry. The keto diet can have the same result as the placebo effect, which makes the keto diet appear to be working. It's just hype. Though, diet improves mood. Diet doesn't heal trauma. And schizophrenia is linked to severe trauma. That's a fact. The symptoms of schizophrenia overlap trauma which leads to the sufferer having no insight.
As a schizophrenic I just want to say that patient with Schizophrenia isn't the type of change in the talk around schizophrenia that I'm looking for... We don't need censorship around words, we'd like for our portrayals to change to better reflect our struggle and not just to show outliars that sensationalize positive symptoms. We don't need people to avoid using the word schizophrenic, especially in a clinical setting...
Really glad to see a trial by Stanford.
A huge thank you to the folks who shared their stories. You are helping a lot of people. ❤
Fantastic presentation. Looking forward to seeing the complete results published later this year.
Jan good to see you here watching all of this. Keep up with your awesome work.
Another incredible presentation! The new Metabolic Mind collaborative and all the research, information and personal experience are absolute gold! Thank you for fighting for not only your son but for so many of us who have been trapped in a prison of our own mind.
Four months ago I “happened”upon Bipolarcast, Dr. Chris Palmer’s book and the resources shared on Matt’s podcast. My life is forever changed bc you all decided to share what you had been through and the treatment that changed everything. God bless you and your family Jan. Thank you for also assembling the Dream Team of metabolic specialists to bring awareness, research and personal testimony! It has certainly changed my life but also the way I counsel and advise others. Forever grateful to you and your family. Especially to Matt for being transparent and vulnerable with regard to the most difficult times of his life. It is such an incredible story that gives hope and is also a reminder of the power of a mother’s love. Thank you for fighting for him and now all of us!
@@heathersmith6177 Oh gosh, this note brought a tear or two. You made my day and you made it all feel worthwhile.
Thank you!
Thank you ❤
It would be VERY interesting if this diet was included in the treatment of hospitalized psychiatric patients - what better place to find out if it works? But no, hospital food is atrocious and helps no-one. I wonder if orthomolecular medicine is ever considered as well. The niacin treatment can also vastly improve psychiatric symptoms but medicine ignores both solutions in favour of pills that don't work and compromise the physical health of recipients as well. I believe combining these treatments - keto and niacin - would be a step in the right direction.
One day that will be called medical mispractise ....
If you mean malpractice, that's exactly what's happening now. @@debbiehooper4081
This brings so much hope.
I work in a nursing home and I believe of a lot the residents would benefit from this diet. I know it has helped me mentally and physically.
How humans have been conditioned to place people into categories - or even categories within categories. Excellent video 👍
Very interesting. Many thanks.
Words have power...I like that
A heartfelt thank you for doing such important research. Along with the vital work being done in the field of Psychedelics this could mark a (desperately needed) paradigm shift in the way mental illness is treated.
How encouraging. This is wonderful!
this is absolutely awesome
hurrah, well done. it's about time keto is getting the truly positive attention it deserves
What a brilliant doctor.
I wish you can educate psychiatrists here in the Philippines.
Amazing! Are there any materials on the neurobiological basis of these changes?
The second of the Patient Testimonials here, the young man, mentioned Visual Snow (about 18:50). This is so rarely mentioned and yet it's not uncommon! He didn't say how it went on keto but I am going to assume things improved. I will relay this to a Visual Snow patient I know.
yes bipolar is reversible
Could I please get the biographical details of the presenter/the clinic she is affiliated with, an I wonder if it was possible for me as an 🇦🇹 (Austria/EU) citizen to check into the clinic at Stanford (at an affordable price, if self-pay?); besides, any recommendations for clinics/researchers ... in Europe who follow this (Chris Palmer?) approach to battling chronic, med-resistant bipolar disorder (have a painful history of 40 years, and regional psychiatrists offer nothing else but pills - Thanks a lot for the insightful presentation - regards, Johanna Franziska Schwarz
Thank you for your comment. You can search www.DiagnosisDiet.com/Directory to see if you can find a practitioner to work with. You can see they have the following info for Dr. Sethi info@siliconvalleypsychiatry.com We hope that helps!
Metabolic Mind, I wanted you to know that I came to your channel because Bret Sher is with you now.
We love him too!
:)
The Gaps diet is very healing.
Some doubts on the data- Small dense LDL is more than LDL? Fat mass + skeletal muscle mass not adding upto total weight, considering that bone mass may be very small not more than 6 or 7 lbs.
I would wager that the lower the BMI the less helpful the effect of the diet would be.
How would one address the issue of social conformity when going out in public. Everyone would want to eat, even if it's once a week or something. I guess sugar less coffee and tea is fine. But still. Please do take a look at risk of relapse after re introduction of a healthy diet. And also any changes with gluten / milk free diet.
Where can we find the DIET used in this programme. Is there a Special method? The Keto Diet can be quite general
Any dietary intervention that provides adequate nutrition and raises endogenous ketone levels above 0.5 mmol/L is likely a sufficient starting point. It shouldn't matter if it's vegan, vegetarian. carnivore, omnivore, Mediterranean, etc. That can look different for different people. Some may eat 20g carbs, some 50, It depends on baseline metabolic health, physical activity, etc
What's the exact diet?
Typically anything under 20g of carbs per day at the beginning. This can be variable from person to person however. I’d recommend looking up Keto diet and checking on how other people do it.
Where is the post study data?
The data was recently presented at the ISBD 2023 conference and is being submitted for publication. Stay tuned!
@@metabolicmind Hi, any update?
Please help me understand what a mine trial is... data mining perhaps?🤔
Very compelling presentation. My own suicidal ideation has vanished with low carb carnivore.
There's no way I could do Keto for the rest of my life. I don't want to even start it because I know, for me, it won't be sustainable. But what effect on metabolism and blood sugar does intermittent Keto have on the body? Would it improve both or make both worse when I go back to a regular diet? I remember reading that people who went on "The Biggest Loser" TV show and did an extreme diet and exercise routine really wrecked their metabolisms long-term. Does anyone know the answer to this question?
That's a great question, There isn't much research around this. But some clinical experience suggests that some people can improve metabolic health by being in ketosis for a number of months and maintain those benefits by transitioning to a low carb diet (around 100g of whole food, complex carbs). This doesnt work for everyone, and we don't have enough experience to know about the mental and psychiatric benefits, but I am sure we will learn more as more people try it.
Did they really burn less calories because of metabolic failure, or because they don't have to carry the extra 10 stones around 24 hours a day. Plus fitter people have very efficient circulation and lungs so burn fewer calories.
8😊@@metabolicmind
Is it a cure or is it just a fix
Same thing.
Has anyone managed to stop weight gain from taking anti psychotics by doing keto?
Yes! Here's an interview we did with Dr. Matthew Bernstein sharing his experience with that. ruclips.net/video/UF9bWXoenbg/видео.html
Makes sense, as the organ with the highest amount of cholesterol and saturated fat is the brain - so dont starve it from what its made of.
Branch off of Abram Hoffer studies
I disagree with people with developmental issues being excluded from the study - I assume this also includes autistic people. Autistic people have an increased likelihood of mental health issues and have as much right as non autistic people to benefit from medical research.
They always start with a narrow criteria so as not to cloud the outcome. Most times they exclude women too because their hormones keep changing and affecting the outcome. Keep reminding them about autism as I feel it could be a great benefit to at least some autistic people. A grain free diet helps a lot of people if you felt it could be safe to try.
Carnivore is even better ;)
Meat heals
@@KaayJaay definitely, I see huge results with mental health issue
All the best*
Healthy keto, salmon, olive oil, etc. is more balanced and better for long term health than carnivore.
I really hope they do studies with Carnivore and the benefits with autoimmune as well.
@@TheeJaneDoe they are doing already, but of course we Will not see them much ;)