I just wanted to thank you for all the amazing lectures you provide. Everything is clearly explained and repeated enough times that things actually stay in my memory. It's great! Thanks!!!
Q: During gluconeogenesis, does it happen exclusively to one molecule? Ex. does gluconeogenesis only happen with amino acid alone, or is it a combination of amino acids, glycerols, and lactates?
I would like to ask you something, u said that;'' Once Glucose 6 phosphate is formed , is usually NOT transformed into glucose in the majority of our cells'', and explain why , also u gave an example which is skeletal muscle cells.. My question is , Only the kidney and liver cells can undergo glyconeogenesis(as u said) , Than, how come the Glucose 6 phosphate formed in skeletal muscle cells? (Also u said, glucose 6 phosphate cannot escape out of the cell) ... By the way, thank you so much for videos... These are really good, i ll keep watching. I hope u answer it soon.
Necmettin durmuş I believe that G6P is already present in skeletal muscles because in order for glucose to enter the cells, it has to be phosphorylated into G6P. Furthermore, the G6P in the skeletal muscle will be turned into glycogen because skeletal muscles do not have the enzyme that requires it to become glucose.
G6Pase does not exist in brain or muscle. These tissues are not gluconeogenic; they cannot lose any glucose from the cell via this pathway (even though they have the rest of the pathway).
What he was saying was that when g6p is formed in the first step during GLYCOLYSIS ,the reaction is irreversible and hence cannot be brought back to glucose
I think you wanna know that why does glucose 6phoshate formed in muscle ? Answer is : Gluconeogenesis occurs during starvation or when you don't take daily sugar requirement ..In those conditions our blood glucose level drops ...Now suppose there's sandwich on a table ..you require muscle n brain to be active to do dialy biological activity ..So in order for muscle to contract or relax it needs glucose , if glucose was made after glucose 6 phosphate in muscle cell it would have escaped which we don't want cause ultimately that's the aim of gluconeogenesis ..And In liver cell it doesn't stop at glucose 6 phosphate , it become glucose so it can leave the cell and reach to muscle or brain during starvation ..
Thank you AK- does all of this complexity and beauty in biology/nature lead you to the conclusion that there must have been a Creator? I've been watching a lot of your lectures and they have benefitted me immensely so thank you and please don't think of the question as being intrusive as after watching this, I cant help but think what conclusion somebody like you would come to
I can't undertand why you are talking about what happens to glucose 6 phosphate in muscle cells, didn't gluconeogenesis only take place in the liver and kidneys?
What he is trying to get at is that the enzyme glucose6phosphatase is not present in the muscle cells, which is why muscle cells cannot do gluconeogenesis. The glucose-6-phosphate in the muscle is diverted into other pathways, such as the pentose phosphate pathway or glycogen synthesis.
What he was saying was that when g6p is formed in the first step during GLYCOLYSIS ,the reaction is irreversible and hence cannot be brought back to glucose
if gluconeogenesis is taking place only in liver and kidney then how can u say that the last reaction that is g6p>>>glucose doesnt take place in muscle cells
He meant that during glycolysis in other cells When the g6p is formed in the first step, the reaction is irreversible and hence cannot be brought back to glucose
better than my college classes which is worth $200 each, should donate that here
I just wanted to thank you for all the amazing lectures you provide. Everything is clearly explained and repeated enough times that things actually stay in my memory. It's great! Thanks!!!
at step 7, it should be glyceralaldehyde phosphate, DHAP rather then glyceralaldehyde and DHAP, right? which forms the 1,6 fructose bisphosphate
Thank you for sharing your knowledge
Thank u for all your magic moment you give to us you are great and god bless u
the best lecturer ever!!!
Sir very well explained !
You've been a great help!
Keep up the good work !
God bless :)
Thanku sir ☺☺☺☺
Why are you not seen with new videos?
Q: During gluconeogenesis, does it happen exclusively to one molecule? Ex. does gluconeogenesis only happen with amino acid alone, or is it a combination of amino acids, glycerols, and lactates?
Thank you so much this is much better than my online college classes.
işe yaradı mı
I would like to ask you something, u said that;'' Once Glucose 6 phosphate is formed , is usually NOT transformed into glucose in the majority of our cells'', and explain why , also u gave an example which is skeletal muscle cells.. My question is , Only the kidney and liver cells can undergo glyconeogenesis(as u said) , Than, how come the Glucose 6 phosphate formed in skeletal muscle cells? (Also u said, glucose 6 phosphate cannot escape out of the cell) ... By the way, thank you so much for videos... These are really good, i ll keep watching. I hope u answer it soon.
Necmettin durmuş I believe that G6P is already present in skeletal muscles because in order for glucose to enter the cells, it has to be phosphorylated into G6P.
Furthermore, the G6P in the skeletal muscle will be turned into glycogen because skeletal muscles do not have the enzyme that requires it to become glucose.
G6Pase does not exist in brain or muscle. These tissues are not gluconeogenic; they cannot lose any glucose from the cell via this pathway (even though they have the rest of the pathway).
What he was saying was that when g6p is formed in the first step during GLYCOLYSIS ,the reaction is irreversible and hence cannot be brought back to glucose
I think you wanna know that why does glucose 6phoshate formed in muscle ?
Answer is : Gluconeogenesis occurs during starvation or when you don't take daily sugar requirement ..In those conditions our blood glucose level drops ...Now suppose there's sandwich on a table ..you require muscle n brain to be active to do dialy biological activity ..So in order for muscle to contract or relax it needs glucose , if glucose was made after glucose 6 phosphate in muscle cell it would have escaped which we don't want cause ultimately that's the aim of gluconeogenesis ..And In liver cell it doesn't stop at glucose 6 phosphate , it become glucose so it can leave the cell and reach to muscle or brain during starvation ..
Thank you AK- does all of this complexity and beauty in biology/nature lead you to the conclusion that there must have been a Creator? I've been watching a lot of your lectures and they have benefitted me immensely so thank you and please don't think of the question as being intrusive as after watching this, I cant help but think what conclusion somebody like you would come to
yes, the creator is LUCA
*and you said phosphoglyceral kinase instead of mutase
I can't undertand why you are talking about what happens to glucose 6 phosphate in muscle cells, didn't gluconeogenesis only take place in the liver and kidneys?
It applies in glycogen metabolism , but here in gluconeogenesis you're right he shouldn't have talked about it .
What he is trying to get at is that the enzyme glucose6phosphatase is not present in the muscle cells, which is why muscle cells cannot do gluconeogenesis. The glucose-6-phosphate in the muscle is diverted into other pathways, such as the pentose phosphate pathway or glycogen synthesis.
What he was saying was that when g6p is formed in the first step during GLYCOLYSIS ,the reaction is irreversible and hence cannot be brought back to glucose
if gluconeogenesis is taking place only in liver and kidney then how can u say that the last reaction that is g6p>>>glucose doesnt take place in muscle cells
He meant that during glycolysis in other cells
When the g6p is formed in the first step, the reaction is irreversible and hence cannot be brought back to glucose
Great lecture.T2 transports glucose and T3 transports Phosphate however