Leah, your presentation is excellent. Thanks for the clear (and entertainingly whimsical) information. I look forward to watching your other videos. I do have a question: like many people explaining viruses, you describe the virus using language that suggests the virus has agency. (For example, "attacks", "looking", "push and push", "creating a new membrane around itself", "creates a hole", "simple viruses will self-assemble", "trying to exit", "trying to escape", "finds", "cuts", "if it feels", "forget how to be a virus".) I know it's human nature to do this in explaining things, but should we be thinking of viruses this way? Or is it all "just chemistry" happening in there? How much do we know of what's happening at the chemical level?
Thanks for the compliments Joshua. Are you asking why I describe the virus as if acting with malicious intent? Perhaps if the virus had a brain it would think 'I am only trying to survive' but since it doesn't I supposed I don't feel guilty making such accusations against it. (you make an interesting point though, good food for thought)
I came here because I wanted to understand lytic and lysogenic phases, but you exlpained so good and i wanted to know more about coronavirus. I did not find in your website, I hope you will do a video explaining how it works coronavir, because you explain so good. Sorry for my english, I need to practice more.
That is an interesting and complicated question that is beyond the scope of this video. Some viruses are capable of reproducing through both cycles, while some prefer one over the other. The preference depends on a variety of factors. As far as “danger”, both of these are means of viral reproduction. The end result is the same, but the means are different. I don’t think we would consider one more “dangerous”.
i dont understand something + strand rna have rna in the 5'--3' so they dont have to carry the RNA dependent RNA polymerase so it can go straight into proteins right? but what about - strand rna??? in my princeton book it says they must carry the RNA dependent RNA polymerase because its in the 3---5' direction but i thought replication always occur in the 5---3' direction?
- sense RNA viruses have to carry their RNA polymerase in the capsid in order to facilitate replication. First the RNA pol will use the negative strand as a template to make positive strands (using the 3'-5' template to make a 5'-3' copy), that will then be used as mRNA. Then the polymerase will use those positive strands to make more negative strands. Yes, replication does happen in a 5'-3' direction, but the -ssRNA viruses only package the equivalent of the DNA coding sequence.
Everything you have said here is correct. In the replication of the negative-strand RNA virus, RNA polymerase is required to produce a new strand that is oriented in the 5’ -- 3’ direction, but it must “read” (or copy) the RNA in the 3’ -- 5’ direction. Positive-strand RNA viruses, being initially oriented in the 5’ -- 3’ direction, are similar to mRNA in that they can be immediately translated to proteins. This video does not cover RNA virus replication in such detail, but you are absolutely on the right track.
If you mean does the DNA synthesis happen the same way as standard DNA synthesis then the answer is yes. The reasoning for this is that the the structure of individual nucleotides requires the polymerase to find an OH group (on the 3' end) where it can grab and attach. Remember, the energy 'cost' for growing the DNA strand is paid for by a phosphate group on the 5' end of the incoming nucleophile
Thanks for watching and asking. The answer to your question is complicated, and a full explanation would be beyond the scope of what I cover in this video. Once the bacteriophage attaches to the membrane and inserts its DNA into the bacteria, it ‘takes over the cell machinery’ by using the cell’s own helper proteins and other resources to replicate the viral DNA as well as to construct proteins that will help build the capsids for newly assembled phages. At a certain point, enough of the new phages exist to trigger lysis of the cell’s membrane.
Glad you enjoy it! I understand what you're saying, but at this time that's not an option, sorry. However, you can turn on closed captioning and read along with me, slowing down the speed if that helps.
@@Leah4sciMCAT thanks a lot for your guidelines. ☺ I am a student of class twelve. This topic is in our botany book.In which class is this topic taught in your country?? I want to know whether the education in our country is world class.
Being bilingual is such a blessing, i could make use of this video❤
Glad you've found it useful!
Wow I've already covered this on my Microbiology Classes. Thank you So much for making me understand it more
You're very welcome
Thank you so much,this helped me get better marks in my biology exam
Glad it helped!
Leah, your presentation is excellent. Thanks for the clear (and entertainingly whimsical) information. I look forward to watching your other videos. I do have a question: like many people explaining viruses, you describe the virus using language that suggests the virus has agency. (For example, "attacks", "looking", "push and push", "creating a new membrane around itself", "creates a hole", "simple viruses will self-assemble", "trying to exit", "trying to escape", "finds", "cuts", "if it feels", "forget how to be a virus".) I know it's human nature to do this in explaining things, but should we be thinking of viruses this way? Or is it all "just chemistry" happening in there? How much do we know of what's happening at the chemical level?
Thanks for the compliments Joshua. Are you asking why I describe the virus as if acting with malicious intent? Perhaps if the virus had a brain it would think 'I am only trying to survive' but since it doesn't I supposed I don't feel guilty making such accusations against it.
(you make an interesting point though, good food for thought)
QUEEN! So easy to understand THANK YOU!👑👑👑💕
You're so welcome! Glad it helped you understand!
lol this was such a good video, I love the delivery bc it helps me stay engaged
Thanks so much! Glad you liked it!!
Yay! I am so lucky to be able to find this information on your channel! I love it! Thanks
You are so welcome, happy to help!
You explained it in a really easy way
Glad to help you understand!
I came here because I wanted to understand lytic and lysogenic phases, but you exlpained so good and i wanted to know more about coronavirus. I did not find in your website, I hope you will do a video explaining how it works coronavir, because you explain so good. Sorry for my english, I need to practice more.
You're very welcome, I'm glad you enjoyed the video!
You have got a new follower. You are the best👍
Thanks so much!
This was such a good explanation, thank you!!
You're welcome!
Wow Leah - what a phenomenal video.
So glad you like it!
thank you so much, this is so helpful
Glad it was helpful!
Really wonderful explanation
Thanx
You are most welcome!
Very perfect explanation
I must subscribe
Thank you so much! I appreciate you watching. :)
Just surfacing from COVID - thanks for a very clear explanation!
Hope you're feeling fully well soon, and you're so welcome
Thank you very much
You are welcome!
Can u please make for me a simple video on termination
Termination of?
How transcription is terminated or genes
Nice lecture 💯💯👍
Glad you enjoyed it!
This was extremely helpful. Thank you!
So glad!
Thank you very much Leah
You are so welcome!
Thank you so much, you are soooo good at explaining, so expressive👌👌👌👌
You're welcome 😊
What does make virus prefer to replicate through lytic or lysogenic cycle? And which cycle is more dangerous?
That is an interesting and complicated question that is beyond the scope of this video. Some viruses are capable of reproducing through both cycles, while some prefer one over the other. The preference depends on a variety of factors. As far as “danger”, both of these are means of viral reproduction. The end result is the same, but the means are different. I don’t think we would consider one more “dangerous”.
Ma'am how can I get your other videos
If you are talking about the Study Hall videos, you can find that on my website
Full details here: leah4sci.com/selfstudy
Really appreciate it
Good video that helped me study.
So happy to hear it!
i dont understand something
+ strand rna have rna in the 5'--3' so they dont have to carry the RNA dependent RNA polymerase so it can go straight into proteins right? but what about - strand rna??? in my princeton book it says they must carry the RNA dependent RNA polymerase because its in the 3---5' direction but i thought replication always occur in the 5---3' direction?
- sense RNA viruses have to carry their RNA polymerase in the capsid in order to facilitate replication. First the RNA pol will use the negative strand as a template to make positive strands (using the 3'-5' template to make a 5'-3' copy), that will then be used as mRNA. Then the polymerase will use those positive strands to make more negative strands. Yes, replication does happen in a 5'-3' direction, but the -ssRNA viruses only package the equivalent of the DNA coding sequence.
Everything you have said here is correct. In the replication of the negative-strand RNA virus, RNA polymerase is required to produce a new strand that is oriented in the 5’ -- 3’ direction, but it must “read” (or copy) the RNA in the 3’ -- 5’ direction. Positive-strand RNA viruses, being initially oriented in the 5’ -- 3’ direction, are similar to mRNA in that they can be immediately translated to proteins. This video does not cover RNA virus replication in such detail, but you are absolutely on the right track.
Well understood thanks
You're so welcome
Really very useful thanks 🌷
I have exam after 5 hours from now 💛😅 hope me a good luck
You're welcome and hope your exam turned out well!
I love Leah 😍
thanks?
@@Leah4sciMCAT you got me through organic chemistry. And for this, I am quite prepared to marry you.
I hope you understand but I don't see that as a compliment, I'm already very happily married thank you
Wait, for Corona virus, light symptoms accure befor the 14 days right?
Since this is a new virus, our understanding is constantly changing as we learn more. Check the CDC for the latest informatin.
Does the retrovirus still follow the transcribe from 5' --> 3' rule?
If you mean does the DNA synthesis happen the same way as standard DNA synthesis then the answer is yes. The reasoning for this is that the the structure of individual nucleotides requires the polymerase to find an OH group (on the 3' end) where it can grab and attach. Remember, the energy 'cost' for growing the DNA strand is paid for by a phosphate group on the 5' end of the incoming nucleophile
Thank you
You're very welcome!
thank you so much for this video
You're so welcome!
I don't understand something, how the dna of bacteriophage takes over the cell machinary, I mean why the degradation of bacterial dna happens?
Thanks for watching and asking. The answer to your question is complicated, and a full explanation would be beyond the scope of what I cover in this video. Once the bacteriophage attaches to the membrane and inserts its DNA into the bacteria, it ‘takes over the cell machinery’ by using the cell’s own helper proteins and other resources to replicate the viral DNA as well as to construct proteins that will help build the capsids for newly assembled phages. At a certain point, enough of the new phages exist to trigger lysis of the cell’s membrane.
Good explanation
Thanks so much!
Thank u so much 🥺
You're welcome!
1, temperature change
2.stress
3. Healthy diet
4.mask
5.social distance
6.onion, garlic, ginger soup
Great tips!
26.5/100 how to divide it or any this kind of number quickly mcat point out view
See my MCAT Math videos leah4sci.com/mcatmath
Thankuu ❤️
You're very welcome!
excellent
Thanks! Glad you like it!
There’s herd immunity in a kiss
lol
Your class is very interesting.But I am a Bangladeshi.So I have less listening power.It would be more useful if what you are saying was written below
Glad you enjoy it! I understand what you're saying, but at this time that's not an option, sorry. However, you can turn on closed captioning and read along with me, slowing down the speed if that helps.
@@Leah4sciMCAT thanks a lot for your guidelines. ☺ I am a student of class twelve. This topic is in our botany book.In which class is this topic taught in your country?? I want to know whether the education in our country is world class.
yasss thank you so much
You're very welcome!
Thanks mam
You're welcome
THANK UUUUUUU
You are very welcome!
thank u i have an exam tomorrow
You're so welcome! How did it turn out?
@@Leah4sciMCAT it was easy!! yayy
this is epic lol thanks
you're very welcome!
She sounds the chick from american pie band camp
I'll take that as a compliment.
@@Leah4sciMCAT could you help me understand immunology?
Bruh
Is that a good bruh or a bad bruh?
Present
#waseem
awesome