Introduction to Antihistamines
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- Опубликовано: 14 окт 2024
- Everybody knows what allergies are, but what causes them? What drugs do we have available to address them? As we learned in the immunology series, allergies are symptoms of an immune response to a perceived threat. Histamine is a molecule in the body that orchestrates many aspects of this response, and antihistamines are a class of drugs whose purpose it is to neutralize the effects of histamine in the body. Many of these are over-the-counter drugs which should be familiar to us, like Benadryl, Claritin, Zyrtec, and Allegra. How do these drugs work on the molecular level? Let's find out!
Script by Chris Hofmann
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I'm a pharmacist and teach pharmacology and psychopharmacology. I'm impressed with your content here. I honestly can't find any errors in your content. Great job. 👍
True, also a Pharmacist as well from Kenya and i approve this content.
As a Pharmacy student I've been using this channel for additional notes
Same, pharmacist here. Solid videos with great explanations.
Yeah I don't believe that you're a pharmacist all are women nowadays
@@mokamolimokoena201Yeah right really
I'm an epileptic and I noticed a pattern that most of my seizures occurred during the spring and I eventually learned that antihistamines can lower the threshold for seizures, so I stopped taking them. I haven't had a seizure since.
It was interesting to learn about the lipophobic antihistamines so I now know that they have a tougher time crossing the blood brain barrier they are a safer alternative for me.
Benadryl can be nasty, even have habit forming properties that I've seen happen to close people. Didn't know it can lower the threshold for seizures too.
I love that you studied yourself and solved the issues 😉
@@bigbeans202repent!
@@selamyemane1640repent!
I saw this video on recommended, I thought he weren't really posting anymore, but it's nice to see he still posts his amazing content.
he posts almost daily wym?
Dave puts out a new video about 3 times a week, on a variety of academic topics. He's amazing.🙂
I post three times a week, as I've been doing for about five years.
You 'thought'? What else are in your thoughts?
the youtube front page is so weird smh, it never gives you videos from people you actually have subscribed to
Hey professor dave, just wanted to check in and say that your content is so broad and thorough yet well explained- it's really amazing. Thank you for what you do and please keep on doing it. You've definitely inspired and informed a new generation of scientists
Get this man to 10M. I hate how 10M RUclipsrs are moustly clowns who say shit or get his subs scamed and the cry on a video for appology. But you. You deserve it.
Alas, you're talking about an average cross section of society being interested in science and knowledge.. not going to happen.
I feel like the internet has been taken over by morons. Back in the 90s when it was difficult to use a computer and the internet was far more niche - you were called a nerd or geek for being into computers,. Now that we all use them they've been dumbed down to allow it for everyone. Not sure if that's a good thing or not.
There's still good stuff out there, like this channel and many others - I have no idea why the top youtubers have any following at all. It baffles me that people want to watch swag, reaction, crying people, teen girls doing makeup, influencers - the general popular junk. And everyone has lost their attention span so badly that they now need it delivered in a few second chunks on Tik Tok. Never used it - never will.
@@MOSMASTERING facts
I am pharmacy student from Turkey and i will start learning pharmacology this semester. Please keep them coming. Like idk how are you have this so much knowledge but i loveee your videos.
It's interesting how the same brand names are used for different drugs around the world. Here in the UK, Benadryl is mainly acrivastine, while diphenhydramine is often found in brands of chesty cough mixtures like Benylin
Excellent video Dave very informative, I didn't realise antihistamines were negative agonists of H1 receptors
Very interesting that Allegra is second gen considering it's age compared to the others. I did a college pharmacokinetics project on fexofenadine 20 years ago.
The first Gen's date back as far as 50 years ago!
Don’t know what I’d do without you professor , thank you so much for these
Hey man I really value your opinion. I work in the sports supplement industry rn part time and I have been researching a lot about some stuff. Seems like there are some things that have very clear benefit like protein Creatine and citrulline and then some snake oily type things like test boosters and fat burning stuff.
With your history in biochemistry and your love for debunking things I would love to see some of your ideas on the difference between these and I think it would make for a great video
Professor Dave has already done a number of videos on these things, including some good debunks (just do a search on his channel for them). Also, consider reading his book, "Is This Wi-FI Organic?" which covers these topics in a brief, informative way.
I plan to do an extensive nutrition series one day so I will cover everything in that realm! For now I do not have knowledge unfortunately.
@@glennpearson9348 I have literally watched every single video on his debunk playlist and it didn’t cover this… which is why I wrote him about it. He also confirmed he had not made a video on this topic in his reply. But thank you for your response.
@@ProfessorDaveExplains I tend to jump into topics you talk about in my own time and I’ve always looked at more practical applications and not the actual chemistry of it. Like for example I read a couple pieces about benefits of electrolytes and a lot of these products I sell have alkaline ph balance and your water videos enlightened me and led me to my own research and it’s like, unequivocally fake. So that’s why I would love your take on some of these supplements. Thanks for responding.
@@cairoingram1329 Well, there you go. He has done a debunk on "magic water" and has covered various chemophobia topics, which seem similar to the topics you're describing. I agree, though, it would make for some interesting content.
I didnt know he had a pharmacology playlist too! Thank you chemistry jesus
I helped write materials for a course on medication management for seniors. If I could only take one thing away from that work, it would be that people over 65 should generally stay away from first generation antihistamines because of those anticholinergic effects.
As someone who has chronically used Zyrtec for more than 20 years, this drug should never be use prophylactically for extended periods of time.
The side effects / withdrawal symptoms of getting off this drug for some people are worse than anything you can imagine. I would envision it rivals the withdrawals from opioids. It can create a histamine cascade response that causes itching all over your body on a level that is psychologically traumatizing. However bad you are imagining, it is worse than that. Yeah, seriously, that bad. It can persist for weeks or even months.
I have never been able to stop using this drug because of this, and I wish someone had informed me this was possible before I started. I would not wish the withdrawal symptoms of this drug on my worst enemy.
I posted another comment about this here, but for some reason it was scrubbed. I am hoping I can save someone else from these serious side effects. Antihistamines are a great technology, but they should absolutely never be suggested for prophylactic use on a regular basis.
Damn dude.. I used Zyrtec for colds as a child a lot and it’s taste was pretty addicting.. but I never knew extended use fucks you up that bad…
I have been taking Zyrtec in pill form for 10 years every single day and didn’t even know there was withdrawals.
@@petermcgill5365 have you tried coming off it yet?
Love your scientific approach
"I'm going to take benadryl"
To stop your allergic reactions right?
...
To stop your allergic reactions.... right?
It's my lucky day, new pharmacology video!
I'm very much looking forward to this series!
Thank you so much, for the detail and clear explanation....it's easier to understand about allergy and that medication. Sometimes I allergy and take cetirizine..
Do you know the mechanism behind diphenhydramine that can cause excitation in certain people? I think it was common in people who had a very high level of CYP2D6 activity. Would that mean one of its metabolites cause stimulation?
Thanks for this lecture. One comment, my pharmacology professor has Fexofenadine as a 3rd generation antihistamine rather than a 2nd gen as indicated here.
Thanks!
Profesor Dave how do know so much?
Love your content 👍🏽
Interesting insights. Thank you for sharing. Video welldone🙂👍
Please continue the history of drugs
Next one is coming next week!
I use diphenhydramine as a sleep aid when needed. Works very well.
I stopped taking montelukast recently and started taking cetirizine
Why did you stop taking Montelukast?
My life is heavily effected by Histamine I have several conditions that effect my life with it, 1 Asthma 2, Dermatographism aka as its simple name Skinwriting and 3 Mastocytosis a Mast cell activation syndrome, My day can be really bad with itching and pain to hives swellings and random Anaphylaxis blood pressure drops and a whole range of other symptoms mentally and physically
Hi Professor Dave, could you make a video explaining toxicity of compounds and how they affect the body?
Question, what is the best antihistamine or drug to take for histamine intolerance/chronic urticaria
How can you upload in this frequency, I genuinely don’t know
Please make a series on inorganic chemistry...
It begins tomorrow!
@@ProfessorDaveExplains thank you Sir
awesome video as always
Hello professor Dave , do you have a video about antibiotics and their side effects ?
Professor Dave I am your regular viewer ... Love From India🇮🇳 Continue your Drug mechanism series.. want more
Thank you so much for this video!! 🙂
Cetirizine makes me drowsy & sleepy everytime I take it while Diphenhydramine HCl does not. Weird!
I'm an allergy sufferer, and I work in a place where there is lots of dust in the air. Wearing a mask is impractical due to the physical nature of the work. I find that OTC antihistamines don't work for me anymore and I don't want to take drugs every day in case I *might* have an attack on any given day. I don't have attacks every day. I wonder what else there is out there for people like me.
Doc, you please provide a short list of 1st gen antihist. Which may be good for Covid brain fog as "refers only". Tks
I took Seldane as a kid. I can totally remember when it got pulled and how freaked out we were.
thank you Dave
I tried antihistamine for 4 weeks to treat hives,didn't work i am now on steroids
Thank you
great video
Can’t wait for the video about adrenaline lol
Your videos are great for informing me about a wide range of topics that I am actually interested in while out of school, and that I thank you for doing this on a multiple-time per week basis
Would you (Dave) comment on the australian drugs? We use promethazine hydrochloride and Chlorpheniramine maleate and i am ignorant as to where they sit in this hierarchy?
Unfortunately our medicine industry focused on inhibiting the symptoms rather than treating the cause, my opinion it’s increasing the immunity by taking quercetin will stop immediately the whole allergy story.
You have no clue what you’re talking about.
How do you feel about DAO?@@ProfessorDaveExplains
what about the benadryl shadow hat man, you can’t forget about the benadryl shadow hat man.
1. Presence of suffering bad 2. presence of pleasure good!!!!!!!!!!!!!!!!!
Great stuff here but maybe try to make the information a little more digestible. It seems your purposefully using lesser used words, which makes me rewind as I’m listening to this whole doing other tasks. Example: efficacious, just say effective lol.
Efficacy is a specific word with a specific meaning in pharmacology.
Pharmacology series wen
Can you make video about tramadol or opioids?
Yep I'll hit all the major classes.
I'm allergic to all metals & only certirizine works for me, I take it every day. It's not the worst allergy to have but it's impossible to avoid metal...I've tried! 🤷♀️🤦♀️
what is it like to be allergic to a whole genre of music?
@@DanyalArcadio It is the most brutal pain imaginable...when you love the metal music but cannot be in contact with it, my struggle is real 😔💔
I m using certirizine ND I have wrong effect ND hv lots of puffiness on my face what can I do😥
So basically my body sets itself up for a crisp high five from histamines but antihistamines high fives my body first?
I’m one of those rare uninary retention havers whenever I take antihistamines
Deslorstadin, Bilastine are also 2nd generation antihistamine...?
Hello, Can I ask what type of intermolecular forces is CdTe( Cadmium Telluride) ?
that's an alloy, metallic bonding
I'm lactose intolerant. Does that count as an allergy?
My understanding is that people who are lactose intolerant do not have the enzyme lactase, so they are not able to digest lactose. So being lactose intolerant does not involve the immune system at all and therefore is definitely not an allergy. However, being allergic to milk is also a condition that exists. So there are at least two different possible reasons why a person might not be able to drink milk (I guess there is a third type which is galactosemia but that's kind of rare).
Lactose intolerance is when you do not have the enzyme lactase. This condition does not involve the immune system, therefore it is not an allergy. However, being allergic to the protein in milk is also a condition that does exist. So there are multiple possible medical reasons for not being able to drink milk. Another type is galactosemia which is much more rare and serious.
I genuinely didn't know the details. Thanks!
Antihistamines won't work for lactose intolerance. That's due to the lactose not being broken down and thus gut bacteria using it as a good source. It creates gas and causes osmotic diarrhea. Basically it happens in the gut where histamine isn't a player. Use lactose free products or take lactase (enzyme) tablets before eating any dairy that causes you problems.
is there any particular reason why taking a single one of these makes me immensely drowsy
I'm feeling wheezy just hearing about it.
dear dave can u make dc server? it will be fun place to discussion
Grate!
Great aise likhte hai
I still get drowsy when I take cetirizine.
i love hallucinating on dyphenhydramine
Hydroxizine is still Best for me
How do you make learning more entreteining than playing videogames?
Help! Globebusters talked about lunar eclipses. I don’t understand lunar eclipses help please.
Thanks Prof
👏👏
So basically what your saying is If I took a Whole small Bottle of Alegra or sum Shi I would Feel high as a kite?
Question: I'm 6'6" (198cm, 78 inches) and weigh 13 stone (80 kgs, 182lbs), should I be taking a greater dose than a 12 year old child?
💕Sometimes you let go of people without even noticing . You stop thinking of them every day . You stop waiting for them to reply to you . You stop allowing them to take up so much space in your life🎈 . You move on , you go about your day without worrying about them . You stop expecting them to come back with an apology . You accept that they are no longer a part of your life . You just let them go , simple as that .🦋✨
Cheering for You💕
Love From a Small RUclipsr💛🖤.
dave
Before watching this video: I know a bit how the body works 🙂.
After watching the video: I have learned something but I still know nothing about the body 😦.
How the hell can anyone even learn anything about the body if that's the level of precision shown on RUclips 😦? (I'm assuming you're skipping tons of details that would make the videos last hours instead of 10 minutes.)
This pharmacology series presumes prerequisite knowledge in chemistry, biochemistry, biology, and anatomy & physiology. If you need to brush up on those areas, visit my playlists on those topics.
@@ProfessorDaveExplains I've started to watch some of them and plan on finishing them but following "Dunning-Kruger logic", I have a feeling that even though your videos are extremely helpful and concise, it'll take a long time before anyone watching only your channel as a source of knowledge will have a sufficient level of expertise to say "I know how the body works" 🤷♂️.
Maybe it's wrong to think this way, but I'd rather think that I know nothing (very little) about a subject instead of thinking I know a lot about it.
This is bizarre logic. Your solution to not knowing enough is to avoid learning things? The more knowledge you have the better. That you won't become a leading expert in a field by watching my tutorials doesn't negate the value of the information. Just know as you go that your knowledge is not complete, as all humans should do at all times.
@@ProfessorDaveExplains I guess I didn't explain myself properly. I'm just saying that no matter how much I learn about a subject, I still consider that there's infinitely more to know about it, which is where the "knowing nothing" compared to the whole subject comes from.
Well, not "infinitely". Let's just say a lot. Nevertheless it's fun to learn, no?
i love you ❤️
5:45 *cough*LSD*cough*
Cetirizine FOREVER))
Kaunsi lipi bol rhe ho bhai
Please use Hindi language
I don't speak Hindi.
👍🏻😀❤️❤️❤️❤️❤️❤️
🤓
Feminists wondering why it can't be antiherstamines
Hey Dave.
We need a massive era changing video about God vs Science.
People unfortunately use science to lie to humanity and proves that god exist and other silly stuffs.
So please next video:
Science VS God 🙏
Elon Musk by the way said many times he doesn't believe in god. But only science
And so what if he doesn't believe in god and only science. That is his right as a human being. He doesn't have to believe in god if he doesn't want too. Science is backed up by facts, God isn't. Religions indoctrinate people into believing what they want you to believe in without facts. They tell you to believe in god with no questions asked. That's called willful ignorance. Dave is an atheist btw, so he won't side with you on this one lol
@@nappssnapps2891 I'm an atheist as well. 😂
And i like how dave explain things. I'm sure he will do a good job. Disproving a lot of pseudo science
God exists, believe him or not🤷♂️.And go to hell
@@mahdi_naeem Proof? Otherwise it's merely faith that he exists, also which God are you referring to?
Praise Thanatos!
Yes, this is where the name Thanos came from Marvel fans...
@@mahdi_naeem the god idea made you wish the hell to other humans.
No thank you. I'm not a believer
Thanks really helped me out!
id rather learn this from an actual allergist than a general space scientist
Why did you watch the video then ?
Ok. Go on then.
Thank you.