Slow Aging with a Pill? | Nir Barzilai, MD | The Proof Podcast Bonus EP
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- Опубликовано: 19 окт 2024
- In this RUclips-exclusive episode, I’m joined by Professor Nir Barzilai to examine the possibility of a drug that could slow aging.
👇 Visit The Proof website for supporting studies and the full show notes 👇 theproof.com/p...
Dr Barzilai joins me in this conversation for an exploration of a potential drug intervention for aging: the diabetes medication metformin. Is it possible to comprehensively target the biomarkers of aging? How much benefit can a medical intervention have over lifestyle factors? Where is the science now, and where is it heading? We discuss these questions and many more in this conversation.
Dr Nir Barzilai is a geroscientist, chaired Professor of Medicine and Genetics, and principal investigator of the Einstein Nathan Shock Center and the Glenn Center in the Biology of Aging Research. His paradigm-changing studies focus on families of centenarians, providing genetic and biological insights on the protection against aging. Dr Barzilai has authored over 300 peer-reviewed papers and received a number of prestigious awards, and is now leading the TAME (Targeting Aging with Metformin) study, among other research.
You will learn about the potential functions of metformin as a treatment for aging from a pioneer in the field. We discuss how we can slow aging and increase health span, including the effect metformin could have on a population level. We also cover longevity genes, the significance of growth hormones, and much more.
Specifically, we discuss:
01:54 - Can we slow down or even reverse aging?
05:36 - The secret of centenarians
12:18 - Can genes be the key to unlocking longevity?
15:53 - What safe interventions look like
26:07 - Treating aging vs treating diseases
30:24 - TAME - Targeting Aging with Metformin
52:04 - Effective indicators of health and disease risk
54:44 - Can Metformin protect against cognitive decline?
1:06:40 - Metformin and exercise
1:13:46 - How promising is Metformin?
1:22:50 - Expectations for TAME trial
1:25:24 - Tips for achieving good health and targeting hallmarks of aging
1:31:52 - Protein and aging
1:35:03 - Can supplements combat aging?
1:38:10 - Outro
On The Proof, we often cover lifestyle changes people can implement to improve their health - and this was a very interesting opportunity to examine where the drug-based science is headed for aging. Aging is an intriguing field of study, and I’m glad to have had Dr Barzilai on the show today to offer his insight into the TAME Trial and more information about metformin.
To connect with Dr Nir Barzilai, you can find him on Twitter: / nirbarzilaimd . Read his book, Age Later: Health Span, Life Span, and the New Science of Longevity www.amazon.com..., to learn more.
Connect with Dr Nir Barzilai:
Twitter: / nirbarzilaimd
Book, Age Later: www.amazon.com...
TAME Trial: www.afar.org/t...](www.afar.org/t...
If you have any additional questions you would like answered in the future, let me know in the comments.
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Enjoy, friends.
Simon
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I am currently reading Age Slower, and recommend it.
This is my THIRD Simon Hill episode I’ve listen to today (relistened to both Rick Johnson episodes)…it’s been a STELLAR and STUDIOUS day 😎 🙏
Very informative and interesting for all of us concerned with living healthily! Your questions to Dr. Barzilai are spot on, thank you Simon.
I remain hopeful that you will have a conversation with Dr Joel Fuhrman one day. He seems to have the most common sense ideas around health and longevity.
Wouldn‘t it be interesting to find out the difference in health and lifespan of people with disease who are on Metformin vs. people without disease who are also on Metformin?
I’m in my mid-50s and just started taking 500mg of Metformin two weeks ago. I am generally very fit and healthy. My doctor asked me if it interested me and, after research it, started taking a low dose. I have had none of the side effects.
Monitor your B12 while on Metformin. Read pack insert. B12 deficiency risk lower on low dose. But best to know baseline and monitor, potentially take B12 prophylaxis. Discuss with your doc.
@@DrTomMD I'm beginning low dose Metformin this week due to "pre-diabetes" A1C of 6.0, also I have high IGF-1 (361) after having pituitary macroadenoma removed last summer. I am hoping the IGF-1 will reduce too, my endocrinologist will re-check me in 3 months. But she didn't seem to know of any association between metformin and IGF1! Do you have any experience with this?
How much do u take?
Great episode! Thank you
That was so interesting, thank you a lot!
On using the proteome for aging biomarkers, I recall that Irina Conboy also favored the proteome and used some of the proteome as makers to assess effects of plasma exchange. A simple check on aging biomarkers is PhenoAge (spreadsheet calc is free) developed by Morgan Levine. It is based on the basis blood panel (CBC) plus hsCRP. I also like the biomarkers which Dr. Barzilai mentioned but they are a bit more expensive.
Hello Friends,
I'm curious to know which part of the conversation you found the most insightful and engaging. Also, if you have any other questions related to this subject, please post them below this comment. I'll make sure to include them in our next discussion.
I would argue his take on evolutionary selection is not very well thought out. He says evolution only cares if you live long enough to have kids.
This is a shortsighted viewpoint. If children are born but don’t thrive, that’s a problem. If children are born and have grandparents and great grandparents to help support them, there is a higher chance those children will have grand children. So in our case, longevity would seem to be a selection trait that would be passed on from generation to generation.
I am beginning a low dose (500mg) metformin therapy this week. Had a hormone-producing pituitary macroadenoma removed last summer and my GH and IGF-1 were off the charts. GH is normal now but IGF-1 is still a bit high at 361. Going to be re-checked in 3 mos. I'm hoping metformin will have some effect on bringing that down further. My A1C has been chronically around 5.8 but went up to 7.1 pre-tumor removal. Right now it is 5.9. So I'm hoping metformin will do good things for me (age 53 female). I'll try to update here, if I remember!
@@wendyp718been on Metformin the last 2 yrs bc I have Mito dysfunction. Do u have side effects?
Brad Stanfield believes the clinical evidence is, on the whole, against Metformin for healthy folk. The TAME trial will be interesting; but for now I am unconvinced it is a good idea (e.g. reducing VO2 max).
@robertstancliffsr9575
I have been taking metformin for about 25 years for type 2 diabetes. It works great for me both in controlling my A1C and perhaps even longevity. I will be 80 soon and that is about 5 years older that the 2 second longest lived people in my immediate family lived to be. I have no idea if the metformin has anything to do with this, but I plan on continuing to take it.....also, it's free with my insurance.....
Brad is not a scientist!
Gentlemen!
You are wonderful!
Outstanding information!
Thank you both so much!
Random question for you, Simon: Is there an ETA on when the lipid PDF is being sent out? Or did I somehow miss it? That’s always possible. Thanks for all you do!
@@TheProofWithSimonHill Fantastic! Thank you so much for the update! 😀
Let us know when the studies completed, and the results are analyzed and published in a peer reviewed journal
what do you think about Bryan Johnson and his ideas to extend life or reverse aging.
He has built an amazing team and a seemingly unlimited budget. Fascinating!
I would love it if he stopped using the non vegan collagen peptides.
+1 would be really interesting to hear Simon’s thoughts on it
Low opinion of him...more money than brains!
I have been taking metformin for about 25 years for type 2 diabetes. It works great for me both in controlling my A1C and perhaps even longevity. I will be 80 soon and that is about 5 years older that the 2 second longest lived people in my immediate family lived to be. I have no idea if the metformin has anything to do with this, but I plan on continuing to take it.....also, it's free with my insurance.....
Just stop eating carbs (or substantially reduce, as appropriate) and your diabetes will be gone. How people can be so dumb in 2023. Absolutely no need for metformin or other drugs.
If the comparison is normal people taking Metformin to healthy people doing all the good diet and lifestyle habits, I bet there would be no difference or better results for the good diet and lifestyle. And no improvement for doing both the good lifestyle and Metformin, because Metformin only does what diet and lifestyle can do better.
Do both. I’ve been WFPB for years. Obviously (with exercise, not smoking, socializing, etc) diet is over 60%, but the science of longevity is growing rapidly with gene alteration coming. Sirtuins, mTOR, AMPK are ver compelling with some mind blowing reality and a powerful future.
One can start anytime.
Stay tuned and become
8:09 informed.
As a retired MD my profession will be the last to realize what can be accomplished.
@@sallywolfe535 Yes, I'm definitely staying tuned, this has always been a main interest of mine 🙂.
I agree that if it’s one vs the other all or nothing that the exercise and healthy lifestyle far beats Metformin for health and longevity. That said I personally live a healthy lifestyle lifting 5x a week, eating quality whole foods high in micronutrients, doing prolonged fasting occasionally, eating in a 8 hour window, sauna 5x a week, 12k+ steps a day, with yoga and meditation, prioritizing sleep, etc. I think diabetic doses of Metformin is not the best idea on days I lift or do moderate to higher intensities of cardio but on days I rest and recover I think it’s a great tool to use. Especially if I eat a cheat meal like on the holidays for example. It blocks some of the negative effects of that meal if taken with it. I think it’s a great tool for my tool box to get a little extra benefit on top of my healthy lifestyle on days when it makes sense.
@@Biohacker24 What Metformin can do for a very healthy person needs to be studied, but I have not gotten the impression that it can do anything worthwhile. The research seems to be all about what it does for/to unhealthy people.
Been on Metformin the last two years bc i have mitochondrial dysfunction. I am hoping it will reverse it...or at least improve. 🤞
What’s your exercise regime. That’s the best way to restore mitochondrial function
@@TheProofWithSimonHill sadly, bc of my severe fatigue, I am limited to walking and stretching.
Hi simon, how can i follow the study being conducted?
@@TheProofWithSimonHill thank you Simon! 🙏
will there be a shortage of etformin if everyone takes it like ozempic is?
Instead of just fasting that doesn't cost and is 100% safe and effective, you want to buy metformin that copies fasting in some ways and maybe it's not safe?
So when young people shouldnt take it, when does old start? I have asian blood and have a baby face, I am 30 and still look like 20, how long should I wait?
Idk, but I would not take it at 30, unless u got hi blood sugar.
I have always been reluctant about medications and supplements. On a different subject,(FYI), my problem is insulin resistance. William Shang M.D. has a self-published book out and a few RUclips video's. What he presents is the subject of "Insulin-Independent Glucose Uptake". This is a second way to get glucose into muscle cells. With exercise to product an anaerobic condition in muscles cells, these cells are able to take glucose directly into the cell using a different chemical process. Supposedly, increasing insulin sensitivity. I have seen this process mentioned mostly in the Low Carb community. Thanks. 🌻
Memo: Metformin lowers testosteron and growth hormone in men when u take it while being young
I am looking forward to that antiaging cocktail, hoping it wont be too late for me. My skin needs something NOW! I'll be 65 this year, but I would love to do a biological age test to see my real age :-).
Start sooner rather than later. No benefit to waiting. I just started,
Age 73; cancer survivor x 3, sincerely jan🎉❤
The Denmark study is key: Danish non-diabetic population is not as SICK as the us/uk "non-diabetic" population. In the US/UK, 95% of the population is metabolically ill. So better to fix metabolism with right ingredients, amount and timing. Plus good sleep and exercise rather than think on using Metformin.
Simon, please ask all these Longevity guys on experiments where control group is eating + sleeping + exercising right. And with that "good" control then the study should ask: on top of these, is intervention X or Y does anything? (In humans, mice, worms, flies, yeast, etc.). So far all studies I have seen, the controls are eating Ad Libitum, and eating not proper food. Then, all these Caloric Restriction studies are only showing that the fat and sick controls are OVEREATING TRASH ~40ish%
For example, currently what the ITP project is studying is: how to reduce damage on mice that is eating A LOT of TRASH along their whole life. No surprise that anti-diabetes drugs/interventions are giving good results there. It is really NOT a longevity project at all. Control group does not get sick because of age but because of awful diet and excessive amount.
Here is your Denmark lifespan with no meds. The lowest risk of all cause mortality was found at an LDL-C concentration of 3.6 mmol/L (140 mg/dL). BMJ 2020 study title: Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study.
@@Jeffs60 Thanks. But I do not get the point you are making with the phrase "Here is your Denmark study". Could you please explain without sarcasm of any kind? Thanks.
@@espinosalexis You are asking about longevity and the Denmark study said a LDL of 140 mg/dL had the lowest mortality. Also Nir Barzilai has a book and in it the longest living people he studied all had higher than normal HDL cholesterol levels.
@@Jeffs60 ok. Got it. Many thanks.
About the LDL paradox, I agree that LDL is not the right measure for predicting Cardiovascular desease in the absence of metabolic illness. But I know Simon has a very strong different opinion.
@@Phoebus_Apollo Thanks. Good to hear that. Although I have heard similar scary numbers for UK and Australia. And, even if not to as bad as current US status, the trend is moving towards the US direction.
There isn’t slow aging with a pill, there are good results of physical efforts combined with careful choices of food, attention towards avoiding stressful situations and all this aren’t available to anyone with an ordinary life, the vast majority even in ultra modernised countries don’t pass the taste tests, everyone dies eventually…. The life span is not important the health span is the goal derived from common sense and if it is about goals, the goal is a completely independent life until the last breath ❤
Memo: when u r a bodybuilder u dont take metfoemin
2 episodes this week. what a treat!