Always enjoy hearing different perspectives especially from those who spend their time studying the science of aging. Hopefully AI (especially AGI) will become our partners in solving this healthy longevity question.
The questions of ethics and prolonging life… my stance is, we haven’t made as many advancements as a race as we could because our lives (until recently) are short. Basically we’re just here to reproduce and die We don’t need more inventions imo, we need more wisdom to be passed down. When I was young I didn’t see anything wrong with capitalism but now I see how it’s destroying the planet, for example. My 21 yo son sees it, kind of, but he’s not as anti-capitalism/pro socialism as I am. He eats Doritos and pizza and thinks it’s ok for health. I know how processed his diet is, how it’s ruining his health and the planet through manufacturing… so yes, I’m pro-longer life if for no other reason than to try and change our self-imposed system of governments which colors everything else in our lives and on the planet 🤷♀️
Personally, I love online interactions a lot more than physical interactions with humans. Even with the best people I know. With other animals (pleasant ones) it's the other way around. I'm probably a bit unusual about this. Internet is fantastic for me, like well chosen content like this channel 👌💜.
@@SkyRiver1 I've always been drawn to talkative people more so than quiet ones, or maybe they have been drawn to me. I'm silent, so with two silent people it can be difficult to communicate.
awesome as always. however, not a word on fontana's human and monkey studies, and too little about igf1. i'm still waiting for luigi to come on the show.
Interesting interview though “I don’t really know” seems to be an all-too-frequent answer. Kinda frustrating but, then again, this whole field seems to very new. So, I appreciate the professor’s honesty regarding caution.
Well that's a real scientific answer, unlike what most guests say, pretending that all the questions are closed. It is sobering to have someone to remind the audience that it's not so simple as a lot of popular pundits claim.
It is not just sleep that is important but dreaming. I have often awoken after a nights sleep and felt groggy and still tired, BUT if I fall back asleep and have a final dream, even if it only lasts a few minutes, when I then awaken I feel completely refreshed. So there is that. . . .
He says I didn't do a deep dive into the literature bec I already see that you can find what you want without reading a lot of evidence. Well maybe if you do a deep dive you will find that's not the case when you clearly understand the totality of evidence. In addition he says I agree I'm biased I like meat and basically admits that he doesn't want to look into it.
Excellent information, so much common sense. Dog (Atlas), fed twice a day, he loves his food, alas he is CHUNKY, my daughter a vet feeds her dogs one meal a day, they are lean. I would only feed once if a new puppy.
Puppies actually should eat more frequently but be kept thin. You measure their food. I have always fed my dogs twice a day and they are lean but, again, measuring not free feed and I adjust based on condition. [They were working dogs, but now retired, they don't need as much]
So refreshing to hear "I don't know" for some of these questions instead of speculative pontification. As a >65 person also looking to my remaining time and with kids and grandkids to "impart my wisdom" (whether they want it or not)....I will say that moving on the side of bumping up protein and doing a lot more resistance training makes sense to me even though there are pros and cons. Just lost a friend a short time after he broke his hip. I agree. What I don't want is to be old and in a wheelchair or immobile. I would rather die sooner in my kayak or out in the woods than years in a wheelchair or hobbling around with a cane. I will say that my friend who did pass away introduced me to vegetarian eating over 40 years ago and has been a vegan of recent years, always an avid outdoorsman, but I don't believe he did the resistance training and was lean and wiry.
Great interview - hugely informative. Thank you. This guy is really balanced and solid. I trust what he says 100 per cent. I’ve always thought that David Sinclair was a fraud and Valter Longo was all about the money. This only confirms it!
I have a question: Matt says that higher metabolic rate is probably linked to faster aging and shorter lifespan. Could this mean that having more muscle mass (which increases metabolic rate) will make us age faster? I get it for older folks to do a lot of resistance training to prevent muscle loss but what about younger people between 20-40? Isn't higher muscle mass potentially bad for the speed of aging?
Amazing how long people can talk without saying anything other than calorie restriction seems to make mice live longer - hey, we’re not mice! Funny how many times he said “ I don’t know”
Love Dr Kaeberlain answer on plant vs animal protein and how Simon makes a claim of lower life span from meat eaters, This comes from studies that do not say like fried chicken or chicken breast like come on Simon lol
Hey Simon. I am super super interested in getting into longevity research. How would you recommend I get my start in the field? I absolutely love everything you do and look up to you like no one else!!
So once again a very practical doctor who confirms that a balanced healthy omnivore diet that includes protein (both plant AND animal) carbohydrates and fats (from plants and animals) is best for humans. Very good interview.
When he says he doesn’t think you need to limit protein in middle age because the absolute mortality is low in that age group… Personally I wouldn’t draw that conclusion. Wouldn’t that increase risk of cancer in your 60’s and 70’s ? Since tumours can take decades to grow until they become a threat. Since I probably don’t need more than the RDA of protein to be healthy and have enough muscle mass I don’t think it’s worth it to exceed the RDA or include animal protein just for a couple of extra pounds of muscle. And if a lower protein intake also delays biological aging(which seems probable) , that would also make it easier to avoid age related muscle loss.
RDA = minimal nutrient requirements to prevent disease or deficiencies but not for Optimal Health. in any case, outdated and invalid guidelines. even Valter Longo, the anti-protein alarmist, recommends for the elderly to increase their protein intake.
@@reason3581 please provide evidence that the RDA is enough for optimal health. everyone knows that the RDA guidelines were established to prevent malnutrition. but i'll play along... Protein "requirements" beyond the RDA: implications for optimizing health -- Stuart Philips, 2016. "Substantial evidence supports the increased consumption of high-quality protein to achieve optimal health outcomes. A growing body of research indicates that protein intakes well above the current Recommended Dietary Allowance help to promote healthy aging, appetite regulation, weight management, and goals aligned with athletic performance." like many have said, "anyone can find any study to support any viewpoint." if you want to exist by surviving on minimal nutrients, then go for it.
@reason many Drs have talked about how the RDA is a very minimal allowance to prevent wasting and decline. DRs Fung, Peter Atia, Westman, Hayman, Sinclair, Lustig and many others have lectured on this. Look up this information and inform yourself.
Amazing guest! Kaeberlein rocks! Hopefully one day not very far away I could find a doctor that could prescribe me Rapamycin here in Perth, Australia. So far, what I have seen are just a bunch of robots playing only "by the book" even if they are indeed allowed to prescribe it off-label.
Good luck. There are other routes other than docs, but I would be very cautious about them. Most docs I have interacted with, with one or two notable exceptions are most concerned about legal consequences as opposed to your possible life extension.
I would love it if you could add a 5-10 minute discussion of your thoughts after each one of these interviews. I'm often left with a lot of questions and looking for what your opinion is and a good summary for how we can use this information in daily life. This guest questions if fruit is healthy?! All the major dietary guidelines recommend several servings of both fruit and vegetables a day. Have you seen any large studies that show harm from fruit consumption?
are you referring to Dave Asprey, the King of Bio-Hacks? he takes 80 supplements a day and says that 5 minutes of exercise per day is better than 1 hour. sounds legit. or David Sinclair and his daily dose of 1 gram of Resveratrol?
Super Interesting and Informative. Many thanks to you and your host Simon. For me the ethical dilemma is that if pharmaceutical drugs are helping prolong life span, then what is the trade off? If the trade off is band aiding a diseased process at the expense of a poorer quality of life in the sense of mulriple side effects from a single or combination of pharmaceuticals necessary to keep a person alive longer? What if in cases where the risks of treatment outweigh the risks of taking your chances with a disease. I know those are individual decisions. And on the fllip side if discoveries and use of pharmaceuticals have great benefit in enhancing or improving quality of life, then I personally am all for that. In both cases, I guess you can argue that the greatest benefit is to society and the individual if pharmaceutical interventions keep people from repeated emergency room visits and more costly medical interventions that a person may not be able to afford especially in countries where any medical costs small or large have to be paid out of pocket which may not be affordable or those with fixed incomes even with insurance coverage
In my opinion, the aging research community doesn’t put nearly enough focus or weight on the social & psychological contributors to aging. I believe they are massive.
This has been a real question for me. I personally am in my seventies, but am in obvious better shape than many people in their fifties or even forties. While it has not always been the case, for many years, I have had minimal social interactions with anyone. Mostly because I find most people uninteresting. So I should be suffering because of this, but I am in pretty perfect health, workout regularly, am plant based, and perhaps most telling of all can still have sex all night long. My relatives my age, and even my old friends all look like they could be my parents. So their obviously are some outliers to the social benefit assumption. And strangely enough my hair was perfectly white three years ago and is now kind of a dark grey and getting slowly darker.
@@SkyRiver1 can have sex all night long? Who are you having sex with? One doesn’t need many friends to thrive. One needs to maintain a sense of purpose, a reason to wake up and be active every day, and the level of social connection that feels good to them and supports their wellbeing. Sounds like you have those things. Congrats.
@@Seanonyoutube Yeh, maybe. Purpose is not a problem, so maybe. Finding people that interest me enough for me to care about being earnest with them is. But, like I said, in my case at least, it doesn't seem to matter that much. When I do come across someone like that, it is always unexpected and sometimes delightful.
@@Seanonyoutube One really doesn't need a sense of purpose if they have a real purpose (to their life). As for my "personal" (really isn't personal) purpose: I do not mean to be evasive or mysterious, but I am incapable of describing my purpose to someone else in a manner that would not lead to a gross misunderstanding. But I will say that since early teens, I have been actively striving to consciously evolve physically, emotionally, and mentally. Which brings up the question, "What does one mean by conscious evolution?" To which I can only truthfully respond: Since we are using words and concepts and I neither know your experience nor your relationship to the whole prospect of the possibility of the evolution of consciousness: actually, you can't get there from here. Any explanation would be less accurate than no explanation, if for no other reason than it perpetuates the delusion that this "purpose" can be conceptualized and that such a conceptualization can be somewhat functional in any way at all. So there you go. You asked, and I gave you the truth.
Simon Hill, your channel is new to me, but I'm pleased I found it. Excellent interview with one of my favorite gerontologists, Dr. Matt Kaeberlein. You asked him all the questions I would have asked, and his answers helped clarify some issues I was muddling through. Yep.
The thing Kaeberlein says about about the polyphenols is the same Dr Colin Campbell says about nutrition as a whole (“it’s complex, you will not be able to understand its actions using reductionism”). You should have him on your show.
What does he eat in a day? That's what I was really hoping for. Folks in the longevity space are all over the place with that quesiton.
It doesnt matter as his unique make up wont neccarily benefit you, if he was 150yr old man then you could be eager to follow his lead but he isnt
Always enjoy hearing different perspectives especially from those who spend their time studying the science of aging. Hopefully AI (especially AGI) will become our partners in solving this healthy longevity question.
The questions of ethics and prolonging life… my stance is, we haven’t made as many advancements as a race as we could because our lives (until recently) are short. Basically we’re just here to reproduce and die
We don’t need more inventions imo, we need more wisdom to be passed down. When I was young I didn’t see anything wrong with capitalism but now I see how it’s destroying the planet, for example. My 21 yo son sees it, kind of, but he’s not as anti-capitalism/pro socialism as I am. He eats Doritos and pizza and thinks it’s ok for health. I know how processed his diet is, how it’s ruining his health and the planet through manufacturing… so yes, I’m pro-longer life if for no other reason than to try and change our self-imposed system of governments which colors everything else in our lives and on the planet
🤷♀️
Personally, I love online interactions a lot more than physical interactions with humans. Even with the best people I know. With other animals (pleasant ones) it's the other way around. I'm probably a bit unusual about this. Internet is fantastic for me, like well chosen content like this channel 👌💜.
Introverts love the internet. Real people are too draining.
@@CurieBohr True. I do enjoy short visits in real time, but it tires me out fast.
@@carinaekstrom1 2-3 minutes is my limit.
If you meet someone who is silent inside that will change.
@@SkyRiver1 I've always been drawn to talkative people more so than quiet ones, or maybe they have been drawn to me. I'm silent, so with two silent people it can be difficult to communicate.
This leaves Longo on an island. Kaeberlein, Phillips. Lyons and Layman all advocating for higher levels of protein in healthy populations.
I thought it was interesting to hear what kind of study his recommendation is based on.
Longo, Sinclair, Steve Horvath, Luigi Fontana and others. Hardly on an island
awesome as always. however, not a word on fontana's human and monkey studies, and too little about igf1. i'm still waiting for luigi to come on the show.
Interesting interview though “I don’t really know” seems to be an all-too-frequent answer. Kinda frustrating but, then again, this whole field seems to very new. So, I appreciate the professor’s honesty regarding caution.
Well that's a real scientific answer, unlike what most guests say, pretending that all the questions are closed. It is sobering to have someone to remind the audience that it's not so simple as a lot of popular pundits claim.
I found this to be very interesting. Simon your a great interviewer..ask great questions.
Exercise: Per Axeel Montagne, exercise is very important for small blood vessel preservation in brain and holding off dementia
It is not just sleep that is important but dreaming. I have often awoken after a nights sleep and felt groggy and still tired, BUT if I fall back asleep and have a final dream, even if it only lasts a few minutes, when I then awaken I feel completely refreshed. So there is that. . . .
Most physicians are stuck into giving medications and receiving kickbacks from the pharmaceutical industry!
He says I didn't do a deep dive into the literature bec I already see that you can find what you want without reading a lot of evidence. Well maybe if you do a deep dive you will find that's not the case when you clearly understand the totality of evidence. In addition he says I agree I'm biased I like meat and basically admits that he doesn't want to look into it.
Excellent information, so much common sense. Dog (Atlas), fed twice a day, he loves his food, alas he is CHUNKY, my daughter a vet feeds her dogs one meal a day, they are lean. I would only feed once if a new puppy.
Puppies actually should eat more frequently but be kept thin. You measure their food. I have always fed my dogs twice a day and they are lean but, again, measuring not free feed and I adjust based on condition. [They were working dogs, but now retired, they don't need as much]
So refreshing to hear "I don't know" for some of these questions instead of speculative pontification.
As a >65 person also looking to my remaining time and with kids and grandkids to "impart my wisdom" (whether they want it or not)....I will say that moving on the side of bumping up protein and doing a lot more resistance training makes sense to me even though there are pros and cons. Just lost a friend a short time after he broke his hip. I agree. What I don't want is to be old and in a wheelchair or immobile. I would rather die sooner in my kayak or out in the woods than years in a wheelchair or hobbling around with a cane.
I will say that my friend who did pass away introduced me to vegetarian eating over 40 years ago and has been a vegan of recent years, always an avid outdoorsman, but I don't believe he did the resistance training and was lean and wiry.
yes, let's slow down the SCIENCE of aging. Definitely making ridiculous claims.
Great interview - hugely informative. Thank you. This guy is really balanced and solid. I trust what he says 100 per cent. I’ve always thought that David Sinclair was a fraud and Valter Longo was all about the money. This only confirms it!
I have a question: Matt says that higher metabolic rate is probably linked to faster aging and shorter lifespan. Could this mean that having more muscle mass (which increases metabolic rate) will make us age faster? I get it for older folks to do a lot of resistance training to prevent muscle loss but what about younger people between 20-40? Isn't higher muscle mass potentially bad for the speed of aging?
Amazing how long people can talk without saying anything other than calorie restriction seems to make mice live longer - hey, we’re not mice! Funny how many times he said “ I don’t know”
Love Dr Kaeberlain answer on plant vs animal protein and how Simon makes a claim of lower life span from meat eaters, This comes from studies that do not say like fried chicken or chicken breast like come on Simon lol
Would it be 'extreme' to eat only meat during the ice age? You know that's where we originated.
I don't believe humans are living longer. Your guest lives in a Disney movie
Hey Simon. I am super super interested in getting into longevity research. How would you recommend I get my start in the field? I absolutely love everything you do and look up to you like no one else!!
Simon would you say you have an extreme view on diet ?
Alcohol: Same here, alcohol messes my sleep up as well. Body temp higher, less REM, less restful.
So once again a very practical doctor who confirms that a balanced healthy omnivore diet that includes protein (both plant AND animal) carbohydrates and fats (from plants and animals) is best for humans. Very good interview.
When he says he doesn’t think you need to limit protein in middle age because the absolute mortality is low in that age group… Personally I wouldn’t draw that conclusion. Wouldn’t that increase risk of cancer in your 60’s and 70’s ? Since tumours can take decades to grow until they become a threat. Since I probably don’t need more than the RDA of protein to be healthy and have enough muscle mass I don’t think it’s worth it to exceed the RDA or include animal protein just for a couple of extra pounds of muscle. And if a lower protein intake also delays biological aging(which seems probable) , that would also make it easier to avoid age related muscle loss.
RDA = minimal nutrient requirements to prevent disease or deficiencies but not for Optimal Health. in any case, outdated and invalid guidelines. even Valter Longo, the anti-protein alarmist, recommends for the elderly to increase their protein intake.
@@chuckleezodiac24 Please provide evidence for your claim that the RDA is not enough for optimal health.
@@reason3581 please provide evidence that the RDA is enough for optimal health. everyone knows that the RDA guidelines were established to prevent malnutrition. but i'll play along...
Protein "requirements" beyond the RDA: implications for optimizing health -- Stuart Philips, 2016.
"Substantial evidence supports the increased consumption of high-quality protein to achieve optimal health outcomes. A growing body of research indicates that protein intakes well above the current Recommended Dietary Allowance help to promote healthy aging, appetite regulation, weight management, and goals aligned with athletic performance."
like many have said, "anyone can find any study to support any viewpoint."
if you want to exist by surviving on minimal nutrients, then go for it.
@reason many Drs have talked about how the RDA is a very minimal allowance to prevent wasting and decline. DRs Fung, Peter Atia, Westman, Hayman, Sinclair, Lustig and many others have lectured on this. Look up this information and inform yourself.
@@beardumaw24 ”to prevent wasting and decline” Sounds perfect to me. I don’t want big muscles, I just want to stay biologically young.
Amazing guest! Kaeberlein rocks!
Hopefully one day not very far away I could find a doctor that could prescribe me Rapamycin here in Perth, Australia. So far, what I have seen are just a bunch of robots playing only "by the book" even if they are indeed allowed to prescribe it off-label.
Good luck. There are other routes other than docs, but I would be very cautious about them. Most docs I have interacted with, with one or two notable exceptions are most concerned about legal consequences as opposed to your possible life extension.
I would love it if you could add a 5-10 minute discussion of your thoughts after each one of these interviews. I'm often left with a lot of questions and looking for what your opinion is and a good summary for how we can use this information in daily life. This guest questions if fruit is healthy?! All the major dietary guidelines recommend several servings of both fruit and vegetables a day. Have you seen any large studies that show harm from fruit consumption?
Great job. This is a realistic view of the longevity field. It’s easy to tell people that if they fast or take something they will live till 200.
are you referring to Dave Asprey, the King of Bio-Hacks? he takes 80 supplements a day and says that 5 minutes of exercise per day is better than 1 hour. sounds legit. or David Sinclair and his daily dose of 1 gram of Resveratrol?
@@chuckleezodiac24 ha ha. I wrote that months ago so I can’t remember but I guess both! Have a good night.
Super Interesting and Informative. Many thanks to you and your host Simon. For me the ethical dilemma is that if pharmaceutical drugs are helping prolong life span, then what is the trade off? If the trade off is band aiding a diseased process at the expense of a poorer quality of life in the sense of mulriple side effects from a single or combination of pharmaceuticals necessary to keep a person alive longer? What if in cases where the risks of treatment outweigh the risks of taking your chances with a disease. I know those are individual decisions. And on the fllip side if discoveries and use of pharmaceuticals have great benefit in enhancing or improving quality of life, then I personally am all for that. In both cases, I guess you can argue that the greatest benefit is to society and the individual if pharmaceutical interventions keep people from repeated emergency room visits and more costly medical interventions that a person may not be able to afford especially in countries where any medical costs small or large have to be paid out of pocket which may not be affordable or those with fixed incomes even with insurance coverage
In my opinion, the aging research community doesn’t put nearly enough focus or weight on the social & psychological contributors to aging. I believe they are massive.
This has been a real question for me. I personally am in my seventies, but am in obvious better shape than many people in their fifties or even forties. While it has not always been the case, for many years, I have had minimal social interactions with anyone. Mostly because I find most people uninteresting. So I should be suffering because of this, but I am in pretty perfect health, workout regularly, am plant based, and perhaps most telling of all can still have sex all night long. My relatives my age, and even my old friends all look like they could be my parents. So their obviously are some outliers to the social benefit assumption.
And strangely enough my hair was perfectly white three years ago and is now kind of a dark grey and getting slowly darker.
@@SkyRiver1 can have sex all night long? Who are you having sex with?
One doesn’t need many friends to thrive. One needs to maintain a sense of purpose, a reason to wake up and be active every day, and the level of social connection that feels good to them and supports their wellbeing. Sounds like you have those things. Congrats.
@@Seanonyoutube Yeh, maybe. Purpose is not a problem, so maybe. Finding people that interest me enough for me to care about being earnest with them is. But, like I said, in my case at least, it doesn't seem to matter that much. When I do come across someone like that, it is always unexpected and sometimes delightful.
@@SkyRiver1 do you still work or did you retire? What gives you a sense of purpose? How do you spend your days?
@@Seanonyoutube One really doesn't need a sense of purpose if they have a real purpose (to their life). As for my "personal" (really isn't personal) purpose: I do not mean to be evasive or mysterious, but I am incapable of describing my purpose to someone else in a manner that would not lead to a gross misunderstanding. But I will say that since early teens, I have been actively striving to consciously evolve physically, emotionally, and mentally. Which brings up the question, "What does one mean by conscious evolution?" To which I can only truthfully respond: Since we are using words and concepts and I neither know your experience nor your relationship to the whole prospect of the possibility of the evolution of consciousness: actually, you can't get there from here. Any explanation would be less accurate than no explanation, if for no other reason than it perpetuates the delusion that this "purpose" can be conceptualized and that such a conceptualization can be somewhat functional in any way at all. So there you go. You asked, and I gave you the truth.
Simon Hill, your channel is new to me, but I'm pleased I found it. Excellent interview with one of my favorite gerontologists, Dr. Matt Kaeberlein. You asked him all the questions I would have asked, and his answers helped clarify some issues I was muddling through. Yep.
One of your beat interviews ever. Excellent episode!
So picas disease has a great rational evolutionary basis)
No the science is your consciousness!
❤
leaving bball 😢
Great Video!!
could you provide a summary? i'll give u a like if you do.
ele faz "shorts"... dê o "like"
@@Rafas216 I live in Karachi
Lithium?
The thing Kaeberlein says about about the polyphenols is the same Dr Colin Campbell says about nutrition as a whole (“it’s complex, you will not be able to understand its actions using reductionism”). You should have him on your show.
I think you meant reductionism and not minimalism. And yes, I think Campbell would be a great guest on this podcast
@@reason3581 yes! Thanks! (Corrected)
Resveritrol w/ lucine is the bomb!!!for me...
He reminds me of Eric Clapton
Eric Clapton does not wear a hairpiece.
Check out the new study ”Higher dietary protein intake is associated with sarcopenia in older British twins”