Monobactam [Aztreonam] | Mechanisms | Administration | Adverse Effects

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The antibacterial activity of the clinically established monobactam ATM is mediated mainly by inhibition of penicillin binding protein 3 (PBP3), interfering with peptidoglycan synthesis and cell division (septation).
Monobactams, with aztreonam as the only commercially available agent, are effective against aerobic gram-negative organisms and have no activity against gram-positive organisms or anaerobes.