Pretty sure my daughter suffered from this during her bout of neuroleptic malignant syndrome from Reglan. Her lips turned blue but the pulse oximeter measured normal. She was on high doses of fluoxetine and protonix, the latter inhibits paraoxonase 1. She was in hospital due intractable vomiting which turned out to be caused by Celiac and oral allergy syndrome. Her grandfather had multiple system atrophy and I suspect problems with dopaminergic function; we are also carriers for MCAD deficiency (I'm symptomatic despite being just a carrier). Celiac can cause carnitine deficiency but they said her acylcarnitine profile was normal. Would like a video on dopamine antagonists and methemglobinemia, but that's probably out of the scope of this channel.
@@chrismcnab478 hey Chris thanks for your reply. My percentage is 27.5. physically I am not facing any problems or symptoms. Just my nails , lips and tongue is blueish colour. My I know your blood oxygen level (the one we check with oxymeter). Also are you facing any difficulties? Do you smoke?
@@mariaelizabethgeorge5873 nothing, all the doc told my mother when I was born was that I might need a vitamin C or D (can’t remember) from time to time. All it affects is my Sp02 levels on a hospital monitor where mine sits about 85% when typically they should be 96%-100% but doesn’t affect me in the slightest.
I have a confusion. If met Hb can't binds with Oxygen..... Then why will it have high affinity to Oxygen?.....we know Oxyhemoglobin dissociation curve shifts to left mean high affinity of Oxygen.... I am trying to understand this things from yesterday but still i am confused 😑😢
Hello sir, thank you for the nice discussion! But there's one thing I do not understand well huhu I hope you can help. How does MetHgb increase its oxygen binding affinity when it cannot bind oxygen itself? as stated at 11:26 Thank you so much sir!
As you can see at 10:00 , now the O2sat is 50%, this 50% that represents the normal hgb has high affinity now to O2 not as usual, this is due to the other 47% that represents the Met hgb that can’t bind to O2 This was explained very well at 11:37.
The ferric hemes of methemoglobin do not bind oxygen, but they increase the oxygen affinity of the normal ferrous heme in the hemoglobin tetramer, shifting the curve left.
@@MedicosisPerfectionalis haemoglobin Haem gene arranged in chromosome number 11 and 16 I want to know about genes arrangement on chromosomes and which type of gene arrangement disorder occur that cause thalassemia
to be honest your old videos where you were talking slowly were way better than this and you had your own unique style now you are talking way too fast i can barely keep up , please consider returning to your old way 🙏, your videos are great keep up the hard work!🌹🌹
The ferric hemes of methemoglobin do not bind oxygen, but they increase the oxygen affinity of the normal ferrous heme in the hemoglobin tetramer, shifting the curve left.
Can you speak slowly next time so we get what you saying we know you’re smart or nerd or showoff but not everyone like you so pls make it better next keep going good job
When I speak slower, people ask me to speak faster. While watching the video, Kindly click on the gear ⚙️ icon and choose a slower speed (e.g. 0.75x). Thanks 🙏
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at 6:30 minute, the diagram is wrong regarding NADPH
AND why can't acidosis correct the oxygen-dissociation curve so that it can neutralize the effect of methemoglobinemia on the curve?
One of the best physiology teacher in world👍👍👏👏
Thank you 😊
This video was awesome, thank you for breaking this disease down so well!
My pleasure 😇
Thank you for watching!
Thank you, as a non medical person with a cat that keeps trying to die from this your video has helped me understand what’s going on
"phosphate fixes stuff" -love it
Thanks 🙏
Love your lecture! It's so much fun listening to tour explanations
Thank you so much 😊
The explanation was easily understandable. Much appreciated
Iron which doesn't bind to O2 is only in 0.5% of RBCs when you have methemoglobin disease. I didn't know that. Neat.
I'm really bad at English, but your videos are very easy to understand... Thank you so much.
Your English is good!
You are awesome 😍 ... I love your way in presentation 👏👏👏..
God bless you 🙏⚘
You too!
Thanks 🙏
Amazing as usual,
لما بتتكلم بسرعه بتضحكني 😅
Thanks 😂😂
Pretty sure my daughter suffered from this during her bout of neuroleptic malignant syndrome from Reglan. Her lips turned blue but the pulse oximeter measured normal. She was on high doses of fluoxetine and protonix, the latter inhibits paraoxonase 1. She was in hospital due intractable vomiting which turned out to be caused by Celiac and oral allergy syndrome. Her grandfather had multiple system atrophy and I suspect problems with dopaminergic function; we are also carriers for MCAD deficiency (I'm symptomatic despite being just a carrier). Celiac can cause carnitine deficiency but they said her acylcarnitine profile was normal.
Would like a video on dopamine antagonists and methemglobinemia, but that's probably out of the scope of this channel.
So freaking amazing
Thank you so much, Eva!
I really appreciate it!
Can you please help me by sharing?
before we could watch it for free, i really need to watch it again, plzz make it available
This is very interesting as I actually suffer from this, I was born with it and didn’t develop it.
may i know your methemoglobin percentage?
Rohit Gupta I’m not sure but I remember when I was last in hospital (December 2019) it was about 25%
@@chrismcnab478 hey Chris thanks for your reply. My percentage is 27.5. physically I am not facing any problems or symptoms. Just my nails , lips and tongue is blueish colour. My I know your blood oxygen level (the one we check with oxymeter). Also are you facing any difficulties? Do you smoke?
@@chrismcnab478 May i know the treatment u took for it? My niece is 2 days old and is having the same problem.
@@mariaelizabethgeorge5873 nothing, all the doc told my mother when I was born was that I might need a vitamin C or D (can’t remember) from time to time. All it affects is my Sp02 levels on a hospital monitor where mine sits about 85% when typically they should be 96%-100% but doesn’t affect me in the slightest.
I knew you're Arabian from the accent and the road views lol... love from Palestine!
Thank you 🙏
Hey Deena! I'm from Pakistan and we're praying for you all! May Allah give you strength, I really hope you're doing well in this tough time.
thaank youu so much but please try to talk slowly , i became anxious trying to follow n understand what u r saying , cause it's aall important
Thanks dear for your nice words and honest feedback, you can play the video at 0.75x speed. Thanks again!
@@MedicosisPerfectionalis yes tht's what i did ! keep up
Great! I sure will 👍
Thank you great lecture!
My pleasure 😇
Thank you so much ❤️!
great 👍
I will use sodium nitrite to treat it.
Hummas her in Jordan 🇯🇴
and favism in Egypt and in middlestrean area
I love 💕 your videos
Thank you 🙏
I have a confusion. If met Hb can't binds with Oxygen..... Then why will it have high affinity to Oxygen?.....we know Oxyhemoglobin dissociation curve shifts to left mean high affinity of Oxygen.... I am trying to understand this things from yesterday but still i am confused 😑😢
No, it means that the normal Hb will now have more affinity for O2...it will increase the hypoxia since the Hb will find it hard to let go of the O2
It is great lecture honey🤣😂
Thanks 😊
Superb
Thank you 🙏
Are you from Egypt?
Falafel 😂.... I miss eating them😭😭.... Falafel arfa❤️❤️
Really gud video tho 👌👌
Thanks 🙏
Hello sir, thank you for the nice discussion! But there's one thing I do not understand well huhu I hope you can help. How does MetHgb increase its oxygen binding affinity when it cannot bind oxygen itself? as stated at 11:26 Thank you so much sir!
As you can see at 10:00 , now the O2sat is 50%, this 50% that represents the normal hgb has high affinity now to O2 not as usual, this is due to the other 47% that represents the Met hgb that can’t bind to O2
This was explained very well at 11:37.
The ferric hemes of methemoglobin do not bind oxygen, but they increase the oxygen affinity of the normal ferrous heme in the hemoglobin tetramer, shifting the curve left.
Egyptiona falafel are amazing yes. 😂😂😂
Indeed!
In thalassemia you are not discussed on the behalf of genetics fully
I need guidance
I don’t quite understand. Can you explain more?
@@MedicosisPerfectionalis Genetics disorder of haemoglobin which cause thalassemia
So, what do you wanna know?
@@MedicosisPerfectionalis haemoglobin
Haem gene arranged in chromosome number 11 and 16 I want to know about genes arrangement on chromosomes and which type of gene arrangement disorder occur that cause thalassemia
That’s a great question...But unfortunately, I don’t know!
2:35 i dont think ortho was that position
to be honest your old videos where you were talking slowly were way better than this and you had your own unique style now you are talking way too fast i can barely keep up , please consider returning to your old way 🙏, your videos are great keep up the hard work!🌹🌹
Thanks for your feedback!
You can click on the gear ⚙️ icon and lower the playback speed.
I can't understand how methemoglubinemia is leading to shifting the curve to left 😴
The ferric hemes of methemoglobin do not bind oxygen, but they increase the oxygen affinity of the normal ferrous heme in the hemoglobin tetramer, shifting the curve left.
Great job but Speak more slowly .
Hey, can you give more subtitle language?😂
In other words...Thanos disease!
Who’s Thanos?
Can you speak slowly next time so we get what you saying we know you’re smart or nerd or showoff but not everyone like you so pls make it better next keep going good job
When I speak slower, people ask me to speak faster. While watching the video, Kindly click on the gear ⚙️ icon and choose a slower speed (e.g. 0.75x). Thanks 🙏