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Cushing's Syndrome and Disease | Clinical Medicine
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- Опубликовано: 15 авг 2024
- Premium Member Resources: www.ninjanerd....
Ninja Nerds!
In this lecture, Professor Zach Murphy will present on Cushing's Syndrome and Cushing's Disease. We will discuss the pathophysiology, differentiating between Cushing's Syndrome, which refers to the clinical manifestations of glucocorticoid excess from any cause, and Cushing's Disease, a specific form caused by a pituitary adenoma leading to excessive ACTH production. The lecture will include a discussion on the clinical manifestations, such as obesity centered on the face, neck, and trunk, skin changes, and hypertension. The digital presentation will begin with the diagnostic approach, highlighting the importance of cortisol measurements, dexamethasone suppression tests, and imaging studies to locate tumors. Finally, we will review management strategies for both conditions, emphasizing surgical removal of the causative tumor, radiation therapy for pituitary adenomas, and medications to control cortisol levels. Enjoy the lecture and support us below!
Table of Contents:
0:00 Lab
0:07 Cushing’s Syndrome & Disease Introduction
0:54 Cushing’s Syndrome
3:47 Hyperfunctioning Adrenal Gland
4:41 Exogenous Steroid Use
6:51 Cushing’s Disease and Ectopic ACTH Production
9:00 Hyperpituitarism
10:44 Paraneoplastic Syndrome
11:38 Classic Findings of Cushing’s Syndrome and Disease
18:12 Complications of Cushing’s Syndrome and Disease
28:38 Diagnostic Approach to Cushing’s Syndrome and Disease
32:29 Treatment of Cushing’s Syndrome and Disease
34:54 Comment, Like, SUBSCRIBE!
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Man, anyone else just going on a binge of their clinical medicine videos?
I watch at 3x speed when reviewing, using script editor in chrome:
• Ctrl+shift+j
• $('video').playbackRate=3
• Enter
(It can go in decimals, even up to 16x)
I thank God everyday for this channel
not only is Zach an amazing teacher, he has faster reflexes than all of us combined
Man these are the best medicine contents I've ever seen thank you a lot!!
The amount of creativity and information is beyond words✨
Your videos are the best! Your videos deserve a ton of love from everyone viewing them...I always get a ton of value from your Vids! Thank you, thank you!
19:00 - He's seriously nerding-out on the vasoconstrictive mechanisms. Love it!
Thank you mr the best explication ever despite I study in French but your explanation is more detailed so I prefer always to see it
As per usual, amazing video! Thank you Thank you Thank you!
Question: If the suspected cause of Cushing Disease is a pituitary adenoma, wouldn't the high dose dexamethasone test suppress only the cortisol and the levels of ACTH would remain high? Cramming for my PANCE right now. Take it in 3 weeks. These videos are saving my life!!!
Thank you so much!! Super helpful for my finals
Great video, thanks Ninja Nerd!
I like the new videos more showing the manifestation of the clinical signs in real life it s really cool and the approch to diagnosis and i hope that u make some videos about gyneco clinical medicine
this is a beautiful explanation of the disorder
Studying for my FNP certification exam, thank you!!!
Thank you sir for making it easy for me
Quite lucid
Thank you Prof
You are indeed impacting on humanity🎉🎉🎉❤
Thank you so much ❤!
Was struggling with this topic. Thank you!
Great video. Thank you, Ninja Nerd!
I have several of these symptoms including fatty hump between shoulders, significant trunk fat, uncontrolled hypertension despite 2 hypertensive meds, round face, adult acne in my 60's and osteoporosis with history of severe T9 compression fracture and other minor compression fractures, but I have not yet had any cortisol tests or the dexamethasone test. I have had two PET scans due to having smoldering multiple myeloma which did not reveal either pituitary or adrenal gland tumors. However, I do have a parotid adenoma and a suspected adenoma on the right dome of the hemidiaphragm. I am wondering if either of these could cause Cushing's Syndrome? If not, then I suspect I may have Cushing's Syndrome from years of inhaled corticosteroids for my asthma as well as 8 months of prednisone for polymyalgia rheumatica and occasional prednisone for chronic bronchitis and a few bouts of pneumonia. I would really like to be able to ask my PCP intelligent questions about getting more testing, so I'd appreciate any insights.
Very good video, I have cushing disease cause by a pit adenoma, my red flag was not getting my menstrual cycle/having issues getting pregnant, also have a cushing body, had surgery on 2018 that fail, now not cadidate to have surgery, just did radiation and taking levoketoconazole to lower my cortisol levels
Thank you very much Prof Murphy. You are Awesome.
i love ninja nerd so much
thankyou prof, im from indonesia n always watch ur video, and help me, thankyou prof !!!
thanks so much proff murphy
Love your vidoes! They have helped me so much!
I love you so so so much.. thanks a lot Dr.. what a great job!
Wow! It’s amazing. Any of us are alive. What type of doctor do you recommend to diagnose Cushings syndrome/disease? hi I’m an anal cancer survivor and I just had my annual CT scan. It came back with minimal uptake in the anal canal, but I have a hump on my back and I have suffered from chronic stress. Heart palpitations/sweating.. I prefer to find a natropath.
wow, thank you
thank you
Interesting lecture, thanks! I guess similar symptoms could also develop from glucocorticoid abuse in sports
The goat 🙌🏾
Could years of chronic, terrorizing stress (a constant state of fight or flight) cause Cushing's? I'm talking domestic violence...I am 99.9% sure I have Cushing's (all symptoms). Getting tested next week.
Love you, ninja nerd!!!
Love these videos!
Thank you so much ☺️
Loved the video! I was diagnosed with PCOS & insulin resistance from my obgyn but my rheumatologist agreed it would also be a good idea to see an endocrinologist to check for Cushings when I asked if I could have both. My Corozal level is high but I don't have a huge hump on my back and I have thick wrists and ankles, overweight, diabetes... face is round/wide but I am not sure if it's as "moon face" as your example. I had Tinea incognito for over 10 years (fungal infection that was made worse by steroids being prescribed to treat the rash and they kept giving me steroids for years on and off until i finally found a good dermatologist that figured it out)... I also suffered from MRSA outbreaks for years (but only when my immune system was compromised due to the Tinea incognito), very weak immune system (flu would land me in the hospita every year turning into Pneumonia or other long term respiratory issue), chronic inflammation and muscle weakness/ pain. I am also unable to get pregnant and my doctor said that even if we did successfully conceive, it would probably be too high-risk to carry the baby to full term. I just keep wondering... could it be Cushings even if I don't have the big physical "identifiers" for it? At this point- I honestly hope it is Cushings just to get some answers. I have a new patient appointment with an endocrinologist and I can only hope they are as well informed as you! 🤞🤞🤞🤞🤞🤞. ♡
Any update ??
im gonna get hihg grade after watching this high yield video
Thank you so much ❤❤❤❤
All of these high quality videos and I still failed 🔥🔥🔥
Very helpful 💓
Your videos are super helpfull !!!!!
Great work
Thanks
What a legend
You are amazing!!
THANKYOU THANKYOU!!!
Thanks prof
I have pituitary and adrenal adenomas. I cannot get the VA to do anything related to cushings. They just keep telling me they are watching the tumors. My quality of life is going down fast. They won’t take the tumors out, and blood work comes back with 4 items high (ADH, cortisol, TSH, B12) and 3 items low (Imm gran#, eosin#, baso#) What can I ask them to do so that the Endo will accept its cushings? She just says I’m weird and won’t consider cushings. But I can tell something is wrong with my body. And it’s been 8 years….
Prayers for you - 8 years is TOO long! Can you get a different endo.?
Even endos expect very overt symptoms, as listed in this vid. And Cushie's suffer greatly especially when they have mild or cyclic Cushing's. I wish mild and cyclic was mentioned here. And mention that it takes a really good doc to role their sleeves up, to get an accurate diagnosis.
sigh***
@@janesjourney9564thanks for your prayers. I did not know about cyclic cushings. Thank you!
@@garrettbenson7743 Generally, people feel better when the cycle is "on". (higher cortisol gives energy and relieves pain) Dr Theodore Friedman has a YT channel with very good info. All the best to you!
PS Cushing's is nuanced. I did not have fat on my neck or stretch marks. I kept my weight gain to only 40 lbs. -trying to take care of myself. I was very beat down by the time I had an adrenalectomy - and was actually under weight/emaciated. Mild, cyclic is no joke.
Do yourself a favor. Look at The Adrenal Center in Tampa FL. If you click on the interest button, you will fill out a lengthy online form. It asks questions about medical history and labs. They are very quick to respond to your interest form. They will talk to you about how to send them your labs and scans. All of your info will be evaluated by Dr T Carling. He is the #1 ranked adrenal surgeon in the US. The center attracts people worldwide to have surgery with Dr Carling. You will be set up to have a phone call with Dr Carling to discuss your condition. I know the center accepts a lot of insurance. Do not know about your VA benefits, they will discuss it with you. Read everything you can from their website, a wealth of knowledge. Hope this helps.
Amazing
Gracias
You’re the best ❤
Nice ❤❤
First of all thanks prof Zach ❤
Second, regarding the High dose dexamethasone supersession test, if it's done to a Cushing's disease with a pituitary adenoma it's making it stop releasing ACTH ? Isn't adenoma secretion of hormones independent of any other exogenous hormones or am I getting it wrong or it's a different type?
Love youuuu ninja nerd :)
Thanks 🙏🙏🙏🙏
good
11 th like sir, I'm pratheesh from india( tamilnadu).big fan of you sir.say one hii sir.
Legend 🫡
Always love
Superhelpfull for my finals .. best wishes , from iraq , any body from iraq ?
Savior❤
18:57 HTN
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beast
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this very bad... thank you for your service rip ninja nerd where are original videos
Bro wtf.. who bombs our feed this like? My god
who tf complains for having that ton of education for FREEEEEE !!! how ungrateful for real !!
If you didn't like it , just scroll man you don't have to spread hate , remember he's doing us a favor !
I would choose you as my best man in my wedding you saved my life. 💀🤍
this is a beautiful explanation of the disorder
Thank you mr the best explication ever despite I study in French but your explanation is more detailed so I prefer always to see it
Thanks
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