Reactivated Latent Viruses in Long Covid and ME/CFS | With Dr Bhupesh Prusty
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- Опубликовано: 1 июн 2024
- In first of a series of three videos, Dr Asad Khan and I talk to virologist Dr Bhupesh Prusty about the latest research that shows how reactivated latent viruses can cause havoc at cellular level in both ME/CFS and Long Covid.
The content does get quite technical at times - if it starts to melt your brain, there is a digested summary at the end.
Supporting resources:
Latest pre-print:
www.medrxiv.org/content/10.11...
Herpesviruses, Messed Up Mitochondria and a Biomarker for ME/CFS and Long COVID:
www.healthrising.org/blog/202...
Tissue specific signature of HHV-6 in ME/CFS
www.researchgate.net/publicat...
Chronic viral infections in ME/CFS:
translational-medicine.biomed...
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The Long Covid Handbook (Feb 2023) by Gez Medinger & Professor Danny Altmann (and published by Penguin Books) is now available in paperback, ebook and audiobook. A singular resource that brings together everything patients, clinicians and academics have learnt about the condition to date, as well as lessons from sufferers and researchers of ME/CFS and other chronic conditions. It offers world leading expert advice on understanding, managing and treating Long Covid. It is available from the following links.
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This is huge!! Big step forward made in uncovering the mystery. 11 years of ME/CFS and I feel like there's light at the end of the tunnel. So many doctors told me I had psychological issues because they couldn't detect anything in my blood and this is why...
There is no mystery.
Only stupid medical dogmas...
We're almost there......
@@thegangov14 sorry we are no where near there. After 30 years of hell sorry to say not over. Maybe for next generation but not for us. I have heard this for 30 years now and nothing happens. Stole best years of my life and no one has really cared.
@@thegangov14 👍🏿 every minute there is something or someone that inches closer ~ hold onto your own feelings & beliefs, you know holistic type treatments work slowly and the body regardless of what it is fighting, it is always trying to heal 24/7 - I have stiff person syndrome 32 years, I thank my body, I smile in the mirror, chant in my head, "energy gets energy", and now, I am doing pt for my anxiety and all other stuff that SPS causes(plus I've always had anxiety) and also seeing a holistic person for mindfulness ~ I love them both, I mean for goodness sakes "yeah 32 yrs of having this is hard to ignore, though I'm trying to change my thinking, the brain is wonderful, so both of these people are working on that, now it's challenging because I over analyze, taking energy away from staying in the moment. ~ take care ~ you know our brains that run everything is like the sun, no matter the storm or duration of dark clouds, it's there shining, always take those moments to feel the healing warmth, oh you did with your comment!! ❤😊
@@jewelleryaddictsame. It’s a modern tragedy
My girfriend suffers from ME/Fibromyalgia, and I suffer from CFS. From our POV the more research that is done, which could lead to effective treatment, the better. Thank you for your research, and I hope this starts to be accepted by the medical fraternity worldwide.
Sadly, although I've had CFS for the last 36 years, there has been bog all research done, and frankly very few people seem to give a damn, *especially* within the medical community, who are VERY keen to blame the patients themselves by claiming that CFS is 'psychosomatic' and 'all in the mind.'
It is EXTREMELY hurtful and hard to be told that I'm not ill when I know my own body a damn sight better than these clowns who in their hubris and arrogance believe that they know everything and that I know nothing.
If such people were to be structural engineers who couldn't find out why a bridge collapsed, they'd be made redundant - and rightly so.
Yes, I know the human body is complex - but this is the point. Medical science still knows bog all about CFS/ME/Fibromyalgia - because unitl now there has been almost NO scientific research into this area.
Sufferers such as my lady love and myself are 'inconvenient' and the medical profession, who would sooner just pretend that we're depressed or have some mental illness than to ADMIT the following:
1) That we really ARE very unwell, and
2) That they have NO CLUE as to what causes CFS/ME.
3) That they ONLY care about recognised diseases such as heart disease, cancer, etc. - and that they couldn't care LESS about us.
Haven't you noticed how humans do the simple things first? How having mastered those move on to attempting complex ideas. The same is true with science, understanding diseases with interwoven effects across multiple systems was beyond scientists understand until now. It took Long Covid effecting the massive numbers to make governments willing to redirect massive amounts of money and more importantly the time of the small number of scientists with expertise to address the problem. In the last three years, influx of world wide research fast tracked completion of research creating a foundation of simple building blocks for the faze where treatments and cures will be discovered.
Science in a sense is being changed. In the past trying to address the direct cause and effect of a disease was the gold standard in research. Within Academia and the scientific community writ large was a resistance to considering the wider, multiple functions of every part of the body in relationship to illness. Fourth year ago, I remember the lack luster response at conferences were some were advocating against singular focus, saying that wouldn't in the long run produce an accurate understanding issue, because it disregarded too many interactions. Reminding researchers the systems in the body are nonexistent, a fiction made up to simplify the overwhelming complexity bodily functions. Today looking at cellular level interactions we see the cascading effects throughout the body. For instance scientists have identified enzymes doing multiple jobs not just one. In understanding the cause of an illness the over production of a specific enzyme is problematic and a drug to interfere with production is given there may be unforseen consequences in other areas.
What I trying to say is human understanding of how the body functions is still rudimentary and there is much we are nowhere nearly to fully grasping. Chronic illness is a trial. Living with limits and pain suck, we can live our best lives if we do what we can, give ourselves and others grace. 😉👍💙🕊
yes... the Dr's I have seen and there are quite a few... suggest psychotherapy and anti-depressant drugs because it's "obviously" all in my head......
Yeah it's a schtick and the jig is up so many of us are subjected to the medical industrial complex who wants to demonize us for daring to expect some progress instead of just walking through their doors and sitting around for 5 minutes so they can make their worthless wage while they pretend to scroll through our online chart notes when we all know at this point that their real jollies come from when you're gone, f****** you over behind the scenes in medical records which are legal documents(!), and I'd like to see this blown out of the water and people sued if not jailed for how not only cavalier they are in there high-and-mighty false sense of superiority, but in a profession that demands they do no harm WHEN THEY DO premeditatedly! Literally sick of it. And their retaliation.
Yes after 30 plus years sounds like you contracted about time I did. About the time of large outbreak in the Incline Village Outbreak in Nevada if you have never heard of. The woman a doctor during this time who was at forefront of research was jailed and her research was stolen on computer and paperwork while jailed with NO charges. Her book tells all because no one wants the truth. They still call it lies. The Plague of Corruption. I agree no one’s help has helped, lot of worthless studies keeping places in research dollars. I finished college part time and did my own study in college non medical to try and find a common thread. Got published but no cure just good info I found. Hoped would help doctors. Hop you both having a decent day.
What the hell pill do we take for this!!!
Brilliant work. It fits my experience of ME/CFS. I think they've cracked it! For me the initial viruses implicated were HHV6, CMV, EBV back in the late 80s. It explains the very specific fatigue, often described as if someone "pulled the plug out". Nothing compares to it. If you haven't experienced it you wouldn't understand it. I've long thought the powerhouses of the cells were affected. What incredible research. We early sufferers experienced so much abuse.
Most of the 80s epidemic outbreak patients i.e. incline village, are positive for cocksakievirus as well which fits Here's hypothesis as the probable cause of M.E.
Same here, but my diseases are late stage lyme, reactivated Epstein Barr, long covid, and ME/CFS.
*I WAS FINE AFTER COVID* untill I went back to the gym - then long covid hit me...
Thinking I was being soft and pathetic I "trained through it" - the worst mistake of my life.
You’re very much not alone
@@RUNDMC1 I was full of the usual gym bro mentality of the harder it hits yo the harder you fight back. Big mistake...
@@piccalillipit9211Exactly what happened to me. Your story is the same as mine.
if you don't exercise you'll be super unhealthy, it's a catch 22
Same mistake here
Now it really make sense! For me, the trigger is stress (any kind of it, including junk food or sleep deprivation). That’s why I am trying to retire for now… I can’t tank you enough, Gez, for sustaining our need for research! God bless you and your familly!❤
Same, physical exercise as well
Thank you Anamaria!
I’ve noticed emotional stress, definitely triggers, and if I over exercise. If I “push” thru fatigue, I get set back.
@@2000disneyland Yes, there is no pushing through. Just trying and then getting set back.
Stress is a culprit for me to
Makes sense. After a mild infection I just went on doing intense traveling through Latin America, was running, living life in the fast lane. 6 months later a walk to the shop was a big day out lol. Seeing improvements though, my world is slowly getting bigger.
Great to hear that Dan!
This makes a lot of sense to me. My mitochondrial tests show Mitochondrial Respiratory Chain Complex numbers that are below normal and significantly below normal (MitoSwab Test).
My neurologist said she sees similar Mitochondrial test results with her patients with CFS/ME.
I’m looking forward to your next films. Thank you for all you do for the long covid community.
Thanks Melanie!
"My mitochondrial tests show Mitochondrial Respiratory Chain Complex numbers that are below normal and significantly below normal (MitoSwab Test)."
Try prolonged fasting (1-2 weeks at least).
Fasting (and ketogenic diets - and any physiological state of ketosis [not ketoacidosis]) boost a) mitophagy (and thus mitochondrial regeneration), b) mitochondiral genesis, c) mitochondrial fission.
Also, fasting boosts autophagy and macroautophagy which helps getting rid of the viral RNA.
I'm copying this for the test name -- thank you for posting.
this is the most credible information on long covid yet. Thanks for reinforcing what I know but has been denied for so long by MD's.
I think there must be a list of viruses in addition to SARS-CoV2, that can cause similar illness. For instance ME/CFS. Long before COVID, there were outbreaks from time to time where a noticeable percentage of people basically developed ME/CFS after illness.
Its mostly Herpesviruses, which are also carcinogenic viruses. Pharma doesn't care.
This makes a lot of sense explaining why standard blood testing show no anomalies. Thx Gez,
Thank you for the research and for sharing this with the community ❤
Thank you Gez for all the work you do! You have brought more insight into what I'm struggling with and helped me figure out what options to try. You have shared medical information and given hope to some of us who would have never had it otherwise.
Thank you!
So, this explains why someone like me ,almost three years latter, starts feeling better, but once I start exercising again and engage in work, the fatigue comes back?
Quite possibly!
Thank you for the readers digest version Gez 👏👏👏👏👏I'm not having a great week so went straight to your summary 🙏
That’s what it was there for 😊
About time we discussed the gain of function research and spike protein contained in the injection and the non novel coronavirus. Prof Judy Mickovits mentions CovidAids. Please interview her.
Thank you Gez. The more we know, the better! I appreciate you!
Thank you Kelly!
@@RUNDMC1 YOU are sooo welcome!!!
Thank you Gez and Asad. It’s an eye opener! So much appreciated what you both do!
Thank you Tanja!
Good video. I've said from beginning I've had multiple relapses like with surgery. Keep these coming!
YEP ive said the same - usually I lose my sense of smell, thats a dead giveaway
Will do!
Thanks for this AND for making it easier to watch too👍✌️💜😊
I've been trying to fathom M.E, FMS since 1998 and now ALCS since April 2020. It's hard😕 I've worked on EBV several times, reactivation came six months into ALCS, my partner had a very nasty bout of shingles too. These viruses and illnesses are devastating, life destroying. Oh and the government's Psy Op against us coupled with broken Britain hasn't helped one bit either💔🙄🤬 I'm not aware in the UK of lots of money being spent on M.E, CFS or ALCS et al either - as far as I can tell those illnesses have all but been abandoned in the UK🤔 Interestingly this isn't a new illness in some ways, I'd refer back to Florence Nightingale who had FMS symptoms from viral infections in the Crimean War and the stress and trauma that she experienced🤔 Conversely Samuel Hahnemann did good work using homeopathy on the front line for sick soldiers (don't look to Wikipedia they call homeopathy "pseudoscience" - I can only assume that big pharma must sponsor Wikipedia 🤔🙄💔). If I recall correctly, using homeopathic Rhus Tox and Bryonia Hahnemann chased out the virus by stimulating the immune response appropriately, coupled with bed rest and that rare thing these days, convalescence 🤔✌️👍💜💜 Unlike his contemporary allopathic colleagues he never lost one soldier (patient) to the virus.
That’s because there isn’t :(
@@RUNDMC1 Thanks - Are you referring to research into these illnesses in the UK🤔
Please see my edited comment (above)😊😉😇
I hope other scientists ( not just ME/CFS or LC researchers ) will see this, take notice and offer support for the investigation of this avenue of inquiry.
Love this work. You are the best and are doing a tremendous job by saving critical lives (speaking both for myself and for the masses).
This research is a giant step forward to understanding what is at the root of Long Covid and similar conditions. I'm doing a little happy dance inside, because answering the the question what is happening leads to what can we do about it or at least what can we do about symptoms. 😉👍💙🕊
Excellent presentation. So glad youve got this out there , read his paper. This man and his team are doing incredible work ...and so are you , Gez , making it digestible for the masses so people can then present it to their primary care providers, in the hope of some eficacious treatment and empathy .😊👍
I think we’re some way off primary care providers using this research to help patients, unfortunately!
@@RUNDMC1 l mean using it as a way to enlighten practitioners , to show patients are actively involved in searching for answers...and perhaps get practitioners to watch your channel and self -educate, as it seems most haven't a clue ! 👍😁
@@carolenmarch7445 haha, indeed!!
Makes so much sense. Looking forward to the followup films. Thanks so much for your ongoing research.
It’s a pleasure Nancy!
There's an important preprint out about herpesviruses: "Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases" - "corresponding to a 19.9% relative reduction in the occurrence of dementia" (over a 7-year period). That may also help with long covid as well. Preprint is up on medrxiv and is based on data from Wales, where everyone born before a certain date could not get the shingles vaccine, but people born after that date could.
Interestingly, when I was so ill I was bedbound, I convinced a doctor to check me for all the known herpes virii. This was in 2015... I had very high IgG titers of EBV...and CMV...also high IgG for HSV1...all suggestive of potential reactivation....unfortunately...I have not recovered much over the years despite grand efforts of trying to do so. Interestingly...I also ultimately had an elispot test done for Borrelia burgdorferi....and was positive for activity against antigen at T Lymphocyte level...also was pos for Mycoplasma and Chlamydia pneumoniae then per IgG again...and pos and untreated via Labcorp IFA for Rocky Mountain Spotted Fever...I fought as hard as I could to survive each day while doctors constantly dismissed and gaslighted me... I am wondering about this research in the context of tickborne illness...also am wondering if brain morphology was affected and volumetric analysis... I developed a lack of IgM but it was probably preexisting due to a mutation IEI that affects TACI and causes B cell issues. Have B cell class switching phenotypes been analyzed in a study like this one?
Excellent. Thank you for summing it up at the end. I was struggling to follow it a bit (ME/CFS brainfog). I'm so grateful for your videos.
THANK YOU SO MUCH!!
Explains why one doctor told me if my Epstein-Barr IGG was over 100 he'd say ME/CFS... but he only tested Early Antigen and it was 59 so was diagnosed with reactivated Epstein-Barr. But I've been having PEM for at least 3 years and my current doctor has finally diagnosed ME.
Which tests did you have done please. I'd like to replicate and get my doc to run them.
@MaryinOmshanti
Epstein-Barr IGM , IGG, Early Antigen and Nuclear antigen . IGM and Early Antigen are current and reactivation. Others will show you've had it in the past and be present for life.
This fits in so well with my self observation pattern over the Covid period. The symptoms were always mild but often persistent, especially skin irritations which took much longer than normal to heal, making me think that auto immunity was developing. Also connective tissue inflammation causing much discomfort in muscles and joints. These complaints would flare up after suspected re-exposures to the Covid variants. On one occasion there was a period of very uncharacteristic bouts of extreme tiredness. I remember showing a persistent rash on my foot to the health professional who gave me my second Covid shot. She was not in the least interested in my suggestion it had anything to do with Covid. It would be so great if there was an on line research site where such self observation can be reported to collect raw data for this kind of research.
Check out your pathogen and parasitic load ~ I use Rife to eliminate. You also appear to have gut dysbiosis ~ get this right and those skin irritations will be alleviated.
And of course, so many of us have been gaslit and given pharma meds to hide the problem. Not okay 😢
I have this exact same problem. There’s been some irritation on the tops of my feet for months. And most of my pain is from walking. My lymph nodes in my armpit also swell whenever I try to lift weights, or do any strenuous activities.
Today marks month 6 for me with this insanity, and well this was a little depressing because I guess once past this mark recovery is harder per this research eh?
Still lots of people recovering before a year 👍
thank you Gez and everyone.
Im a long hauler and have adverse reactions to many drugs, supplements and some foods. I wish there was a way to treat this. If a medical emergency happened to me my body would not tolerate the drugs given to me at the ER. I almost died from a penicillin antibiotic, 3 beers will destroy me for 4 days, sleep medicine makes me feel like I’m going to have a heart attack
Watch my films talking about MCAS
I also have intolerance to medication. Pure poison.
Alcohol pure poison in me/cfs
Really good stuff, Gez!
Thank you for sharing these brilliant discoveries. Some days I feel like Covid is creeping back (after 2 years), especially with emotional stress. I get that covid sound to my voice, and get achy and fatigued, which can last for days. My singing voice still hasn’t returned.
I wish someone would do some research about why cognitive problems get better after reinfection - it's not just me, apparently lots of others experienced that too!
My brain fog and inflammation goes away anytime I catch a cold or flu, it's the strangest thing. it's like my immune system can't fight me and the new invader simultaneously.
Thank you, Gez! ❤
Thanks Barbara!
Another great video thank you Gez. Great to have you back 👍🏼😁
I've been lucky to be in a medical practice with younger GPs who seem to be more open minded and less threatened by my googling medical research about MECFS and Long Covid. If your GP is unsupportive then move to another. We all hate admitting we don't know and doctors are trained to treat A with 41b, B with 22n and C with 74k. With MECFS they have no treatment or answers and "I don't know" isn't in their vocabulary. A doctor recently told me they now know that cancer is caused by stress, but since they don't have a cure for stress they'll carry on with radio- and chemotherapy so at least they can feel they are doing something.
I think Long COVID has been a watershed for medicine. Doctors now see the cracks in the system and the model. Hopefully the years ahead will bring a lot more mutual healthcare. People have to learn to take care of their own precious body with reduced stress, better food, moderate exercise (few people actually have a physiology that can tolerate long distance running) and good circadian health. I have MECFS and LC and started Andrew Huberman's morning protocol and feel much better with it, including natural evening tiredness which I haven't had for decades. There is so much good info out there and thanks to people like Gez it's being widely distributed.
Amazing
Yes. It's more common than most people realize post-covid and post vaccine-injury. Dr. Mobeen Syed has been talking about this for a very long time, and has been interviewing intelligent specialists like this bright man.
You are one of the best communicators I've ever come across Gez.
That’s very kind of you!
Thanks for the excellent update.
A pleasure Randolph!
Really helpful as ever. Much appreciated 😊
Thanks Caro!
Specialists in u.s. measure ebv early antigen to assess latent infection activity level.
Is there any treatment for that?
Brilliant thanks Gez.. makes sense this does. Perhaps this would explain why over time some people get better due to cells dying and reproducing? I’ve read of people with me/CFS and long covid now, get better after 3yrs or more 🤔
I'm so glad you summarised at the end because it all sounds like technical mumbo jumbo to me. Localised virus seems very likely and the reactivation also when comparing to my symptoms
Thank you!
You're welcome!
Gez, i so look forward to your greatly enlightening interviews, and this one is so compelling. Wanted to reach out to you for a research topic that was briefly covered in your book. What is the best way to reach you, please?
DM me on twitter!
I don't tweet,..
Thanks Gez. So are there standard antibody signature tests? Or ………. Great hearing from you again! Missed ya,!
Hi Louis - not so sure these are standard tests! Specific research lab ones…
So I just had something come up in my YT feed about NACE2i and was wondering if anyone in Gez's community had heard of this. I have been following Gez closely since mid 2020 (when my respirologist said "Yeah, I have half a dozen OTHER patients with LONG COVID" at the same time as other doctors were saying LC was anxiety or even "mass hysteria".
Has ANYONE else seen anything useful / have an opinion on this? Based on my previous medical history, what I know about my genetics (indirectly) and the way my symptoms work I subscribe strongly to the theory that LC is a viral reactivation of latent virii in cells with ACE2 receptors, so this drug would seem to have utility if that were true.
Like so many of us in that first cohort, I kinda figure that when Gez declares himself cured (and how) I'll have some hope of getting my life back.
Working on it :)
GREAT!
Any info on late effects of the polio virus? "Long polio", post-polio syndrome...
Covid three times, each worse, then long Covid... OMG... Going to bathroom i need a nap. Im working two days a week and exhausted. And i have symptoms of chicken pox (persistent itchy rash in torso) and now persistent herpes also. So depressed
NAC and vit B1 helps.
BCAA pouder jelps
To lower the Spike proteine S1 after activation reaction to start to hang on cling/ hang on your artery walls and generate a inflamatoir response.
Do you mean BCAA for jym?
Thanks 🙏🙏🙏
at 4:37, can you look into the mucosal in the interstitial fluid ? possibly by aspirating a syringe intramuscular looking into the fluid drawn into the needle until blood is found
So would a round of Paxlovid possibly help with latent virus localized to specific cells? Would the medication not be able to reach the virus effectively since the virus is no longer in the bloodstream?
Only possible way to overcome long covid is to recover immune system by any way possible, it requires effort but everything else is like applying band aid on water tank
What kind of effort though??!! 🤦
@@lalitupadhyay9271 dry fasting
The immune system doesn't have a linear regulation mechanism. There's no such thing as a generally weak or strong immune system with regards to viral response.
@@lalitupadhyay9271it's hit and try, only you can decide what work for you, diet, fasting, hydration, supplement, cold shower, wim hoff method, deep breathing, yoga, meditation, lofi music, Polyvagal theory exercise, Vitamin d, pacing and radical rest are some of the option
@@max-cs9ko those are all placebos, do nothing to virus
From a DIY point of view Nattokinase is impressive for reducing fibro & asthma severity post viral.
So interesting. Before covid I was trying to find out why I was always fatigued. Mild cronic fatigue- so many blood tests! And got EBV test- which is sort of unhelpful as it can’t tell you when it was active. Medical Medium (I read widely and don’t buy in to everything!) states a lot of unwellness comes back to the body holding EBV. Looks like they were onto something…
Also interesting in my case, I reacted to the vax in Sept 21… very weird (and scary) leg pains, but I ‘got better’. This year one month ago I pushed my energy levels (pushed past my threshold)and I had gentle leg manipulation and boom leg pains back with a vengeance. It’s like I’ve released the spot the spike proteins have been hiding out. (I never got the leg pains with actual covid illness) And inflammation is high again.
can you do a microscopy video of a wound healing in time lapse?
this is where im at also, we need to devise the best testing available here in the uk and what order and see what co pathogens we may have, then treat accordingly, if anyone can point me in the right direction id be very appreciative thanks.
Doctors prefer to keep treating random symptoms rather than looking at causation. Looks like we're going to wait a long time before the necessary tests are invented and implemented.
Very nice to see Prusty explaining and emphasising the nuance of his group's results. 👍
I don't suppose he'll be going into more detail about why there is mitochondrial hyper*fusion* seen there? When their earlier paper demonstrated mitochondrial *fission*. Been puzzling me.
Maybe both are happening?
@@RUNDMC1 For sure. But what causes the opposite phenotypes. What contexts. And do they compete, etc. 🙂
Please, please, please can we have a cure?
This second video makes me wonder one more thing. If he says that auto recovery is not so possible after a period of time… why do some people fully recover doing brain retraining after a long time? By the way I agree this is a great step forward. Thank you for sharing with us Gez!
These people have likely just got a residual dysautonomia after the rest of the pathology has resolved
Thank another brilliant video 🙏 And there is the other group with viral reactivation in those with c##id vacc##e injuries. This is happening for us as well
It’s slightly disconcerting after all this time to hear an interviewee talking at hyperfocused excited pace instead of I’m still recovering from long covid myself pace. My brain apparently still does not hear this fast yet 😅
I’m with you!
I'm a post vaccine longhauler, its called Post Vac Syndrome in Germany. There is one Uniklinik in the city of Marburg that treats Post Vac Patients and they have the exact same symptoms as Covid longhaulers. The Spike Protein in the virus and the vaccine can cause the exact same problems and it would be so important to include Post Vac Patients into this research to make vaccines safer in the future. Its just really frustrating that this problem is still being ignored and downplayed. As long as one doesnt work to identify if the symptoms are being caused by virus or vaccine spikes, its absolutely unscientific to call post vaccine longhaulers very rare. Its only safe to say that longhaulers before vaccines were available are of course suffering from Long Covid. Everyone with these symptoms who have been vaccinated and infected should be tested before concluding what caused the symptoms.
I just hope there is research into what can treat this altered immune system and reactivated viruses.
your b est bet at this point is plenty of rest/sleep and eating well
@@juststeve7665 what a dumb thing to say. You don't have LC, do you? All I do is rest. It doesn't help. I've been suffering for 2 years. Tried a sh*t load of treatments and supplements. Nothing has helped. I only datiorated.
So if the serum tests positive for IgG and IgM, is that a silver lining, meaning symptoms can be explained through serum (not beyond detection because it is deep in the tissues), and if you can make the virus latent again then you can recover?
I've been trying to find some help for my adult daughter who suffers from CFS. She has to be very careful with her diet and she can't over work or over exert herself or it can bring back her disabling symptoms. It makes her life very difficult at times for a young woman at 43 years old and this has been going on for at least 10 years.
I’m so sorry to hear this about your daughter Johanna :(
So does the chart he showed of aB response against herpes viruses mean that there is a greater reactivation of HSV-1 and that it might be a more likely strain causing problems? It has the highest immunoglobulin detected of the heroes tested.
consider the amount of wbc's in mucosal, lymphatics and interstitial fluid and space and plasma there could be more wbc's than rbc's in the body
Today I realised that my long list of symptoms also perfectly map the symptoms of mould toxicity. This might also have made me susceptible for Long Covid since 2020. Will have to look into testing for mould.
GEZ my tryptase levels are high and I seem to be having allergy like symptoms. Can this be just mast cell activation from Covid or is it more mastocytosis? I am waiting to have a virtual with Mt Sinai. I’d love one with you. They also want to test for preload insufficiency. Getting very nervous. Thoughts???? 🙏
Mastocytosis pretty rare in LC. My money would be on MCAS. Hope Mt Sinai can help you!
Thanks so much for this video, yet again. I’m not sure if I have LC, mainly because I have Cfs prior to COVID infections, but this video makes me feel like we’re finally getting somewhere with mecfs. I’ve been using the ANS rewire program from CFS unravelled, and I have been improving. Slowly, but improvements nonetheless.
I had shingles several years ago in my mid-forties. Shingles is dormant from chichen pox which I believe is part of the herpes virus. It came out during a time of stress. I recently had a long covid re-lapse after about a year of not having one. The re-lapse was triggered by stress and not physical work. I also had elevated EBV levels in my blood when I had bloodwork done early on in my infection. Most people have had EBV (mono), whether you knew it or not. So I think covid behaves the same where its dormant and then re-activates during a time of stress or other triggers. At least for me its why I think it comes and goes the way it does.
I got shingles during my long covid
SARS-CoV-2 can also reactivate existing latent viruses, as it shares some of their reactivation mechanisms.
covid is what causes the stress which lets epstein barr run wild
Really interesting have had covid 5x in the past 3 years, last time May 2023 some days i am better than other days, i loose my sense of taste again, stress make me worse with nausea dizziness anxiety
In December 2019 i had a mysterious virus that only gave severe hot snd cold fever.. after 2 weeks recovered, but i noticed every few weeks i would feel very cold shiver for a day or two then return to normal. Then in march 2020 i got infected by covid and recovered after 2 weeks and was then left with long covid .
The first mysterious virus was more severe in terms of pain and fever, but covid caused while infected more mental anxiety dir fear and isolation and severe gut issues unable to eat and losing weight and everything smelling food related smelling disgusting 🤢
I alwaye suspected the virus was lingering and hiding somewhere. Could the December 2019 mystery virus been covid too? However it iy affected not my lungs at all , no cough , np sore throat, runny nose etc yet my urine loocked darker despite drinking lots . I saw in the news about covid in December 2019 and China... So that thought crossed my mind ..but i didn't believe it.
May God help us all
Yes, it was COVID. My Mom and I got it from Chinese tourists that were being hauled around on unmarked United Nations buses (yes, it was intentional...an attack on us by the UN and their Agenda 21/30 population reduction program, so do not blame the Chinese. They were very nice Chinese families that visited all be the hotels in and around Costa Mesa and Newport Beach, CA. My Mom loved talking to them when they wanted to practice their English, because Mom and Dad had spent some time in China. Mom got the sniffles, because she was taking an ACE inhibitor, but I got a nearly collapsed lung from it. These tourists were taken by force it seemed, (as they just wanted to rest) to visit Disneyland, Knott's Berry Farm, and other tourist attractions. When I got sick in the remaining months of 2019, I had been having a dispute about what I called abusive lack of care by my Mom's PCP. I ended up going with her to a non-corporste private urgent care facility. We were told by our Chinese and Anglo doctor we could never go to an ER or hospital again, because we would be murdered. I knew something about plans to cull elders, but was surprised that it was finally going to be acted upon. Turns out he was right. I got early treatment using one of the protocols that was later published online. I got better pretty fast, and spread the word about this group. People that I had sent, said that the Anglo doctor had mysteriously died, and the group was dissolved. I never found out what happened, but you can be sure it wasn't COVID, more probable it was a hit on him, as he did not take his nondisclosure oath seriously. I had seen the run-up to this before I retired from academic medicine after 34 yrs. After COVID, I regularly. visited 15 hospitals I dealt with. They all had the obligatory tents, but we're closed, and empty...all of them!
Later my brother and I were dosed with contaminated PCR swabs at the VA, having been in isolation separately, preparing for my brother's major surgery. We both got some horrible weaponized version, which gave me long COVID and right at the two month mark, my hair started falling out in handfuls, and I could no longer taste or smell. I still can tell I have some mitochondrial dysfunction, as I was a fitness expert and bodybuilder, and specialized in mitochondrial optimization, and was very successful too. At age 59 I was being recruited for the USA Women's Cross-country Mountain Biking Team, and being tested to find out why I looked, and performed as a 30 yr old at age 59. Even Joe Weider told me he was going to make me a star. But since that long COVID bout, I feel like crap. After my initial COVID collapsed lung, I was back in the gym very quickly with nearly zero sequelae. Now, going to the gym actually scares me. I had grown to know every signal my body gave. Now I feel like I am living in a foreign entity.
And I forgot to add that my first bout in 2029 started with being ice cold, even with a suboptimal temperature. I never ran a temp the 2nd time either. I am sure this was engineered into this manmade virus to prevent the body from burning it out with a fever. I know lots of people who had no fever. A person just had to wrap up, turn on an electric blanket and let'er burn.
@@gretchensaaduddin5123 The evidence has come out now with lab leak people saying they engineered to be extra contagious! And infect humans easier. New variants are around in the US , so if you have long COVID it's essential to avoid reinfection because it will delay recovery and just cause more damage
so does this mean antiviral agents against EBV will cure ME/CFS? I thought this had been tried.
13:43 is where the summary starts
I do have ME/CFS, LC, diagnosed with Lupus, VWF, APS, HSV 1 and HSV 2, thrombosis, low cortisol, petechia and other severe skin condition. But no real help in Germany.
Viral or postviral illnesses dont get any help in general.
Interesting. I used to suffer from warts on my fingers; mainly around my finger nails, when i was a child. I was about 11/12 years old. They cleared up during the first stages of puberty and I have not had any warts since then. Not until long covid kicked in; after contracting the covid virus in March 2020. With too many to mention, numerous and weird symptoms during this 3 year journey of long covid, this has reminded me that warts started to appear in the first year. I had been curious to know why, maybe this is the reason why?
wow i as a kid also used to get warts on my fingers especially my knuckles but I used to bite the crap out of them and then about 15 years old they just disappeared. now 45 and I suddenly find I got one growing under my skin on my finger tip. had lc since dec 2020 , fikken sucks man!
There was shingles resurgence too!
I think this is herpes simplex. I collapsed and fell into a doorway (long Covid) and injured my ankle, hand and head. The injury to my head converted into a wart which I had removed. This, in my view, is latent virus/es in our bodies being reactivated with gain of function research and spike protein contained in the injection and the non novel coronavirus.
The damage from to the mitochondria by the virus RNA is NOT the most important factor.
It is far more important that the "standard american diet" with too much sugar, too much plants and too little meat and animal food causes a damage to the mitochondria by itself. Especially sugar (sucrose/fructose) is a very serious factor as eating sugar leads to hyperinsulinaemia which in turn switches off mitophagy (which would enable the mitochondria to regenerate). Also, high insulin causes mitochondria to be less uncoupled, smaller und more fragmented (less fission). Of course, this makes mitochondria much more susceptible to further damage.
There are on the other hand some interventions which should be considered when treating long-covid / ME/CFS, which are known to increase the mitophagy, mitochondrial genesis and fission. Those interventions are: prolonged or even short term / periodic fasting, ketogenic / carnivore diets, physical activity.
Have you tried ArtemiC Rescue
Its not just EBV, its also CMV.
And many more!
Hhv6, Cmv, Ebv...
Did we know at what tissue temperature did SARS COV2 better replicate ?
Why ?
Because at TWiV 659 at min29 virologist Christian Drosten suggest that SARS COV2 better replicate at very low tissue temperature.
I'm convinced I have long covid induced Parkinson's which is severely debilitating, there is no test for parkinsons, they calculate what you tell them, I have a medical degree and could have a PhD in neurology from the amount of hours I've researched this, I'm disabled..it makes me extremely mad knowing it's from a lab created bioweapon, I'll happily declare war on the actors that did it.
Could you do a video on the origin of COVID?
Very interesting perspectives on that but it’s not really my field :)
Makes me think coronaviruses have a stronger potential for dormancy than we understood.
See for example this very old study: Allen, T. R., et al. “An Outbreak of Common Colds at an Antarctic Base after Seventeen Weeks of Complete Isolation.” The Journal of Hygiene, vol. 71, no. 4, 1973, pp. 657-67, DOI:10.1017/S0022172400022920
So apart from the potential for SARS-Cov-2 to trigger other known dormant viruses, maybe it can be dormant itself to trigger COVID repeatedly as well? This could explain some of the mystery of people getting COVID long after potential exposure to the virus.
Is this why some people were getting sores in their mouth with lc.?
That might also be microbiome related
Have got two brothers both had cold sores appear after having Covid. They had never had them previously
I wonder, are we having so many different symptoms, because there are so many different viruses that can activate?
It’s not that simple - more that there are many different systems affected by different parts of the subsequent pathology. Also - autoimmunity, if it is targeted at our own DNA (like Lupus) can have an impact on just about any kind of cell.
Fungi has lots of healing properties
I have long covid but EBV is controlled with supplements but herpes virus comes out in my muscles n skin and I know I’m going to get sick! Systemically.. I can only use valtex to control this for 5 days and I’m ok! But this mixture and balance is all time consuming! My fatigue is constant! Tramadol once per day helps! Yes I’d say it affects me locally.. no Drs have ever understood.. had this since childhood! But now long covid.. I wish there was some help so many of us can live again as you know!
What supplements you use to treat EBV? I have confirmed EBV reactivated and suffer 2.5 years after covid infection.
I took Ivermectin (controversial I know) but it sorted the post covid symptoms. It was worth any risk. I couldn't face a return to the bad old days of ME/CFS.
I also find IVM very helpful for my me/Cfs crashes.@sallygreavesbrown1396. It’s such a cheap readily available drug, yet no one is looking into it
I think its going to come down to needing to clean and reboot the immune system. IgG immunoabdsoption but even things like cancer drug Cyclophosphamide to reboot immune system down to the stem cells.
Is the pathomechanism localized in the immune system though? Or is it located in endothelial cells, red blood cells, nerve cells, some other organ?
Perhaps, we just have an overall too large reservoir of latent viruses? That's my hypothesis, though difficult to verify.
Yeah I've thought about that too. But it would seem that an autoimmune response is being triggered that is going to far possibly.
I have to take up to 3 all day antihistamines a day to level the mast cell explosion.
Going abroad to source the meds. Antivirals. Hep C..
Longcovid
Latin for
Jabbosideeffect.
I hear this a bit- but how does that work for those who got LC prior to any vx?
Would antiviral treatment help?
Ivermectin helps me markedly with me/Cfs crashes
Can viruses be reactivated because of pregnancy? All I know is that I became ill during that time (over 20 years ago).
Good question! I wouldn’t be surprised if they did - the immune system changes during pregnancy.
@@RUNDMC1 Yes, immune system changes would be my explanation too.
I suspect some latent viruses were triggered in me during/after pregnancy in 2017, which perfectly prepared my body to be susceptible to Long Covid in 2020.
Any stressor or change can reactivate them.
In my experience, hormones were major triggers. Pregnancy, Menopause, stress and insomnia.
Shingles recurring for me
I got Covid again at the beginning of the year and, in the hospital they gave me antibiotics via IV as i didn't want to mess my gut up with antibiotics.
I Came out of hospital feeling good and determined NOT to screw it up this time so I stayed away from exercise. But it was the Mental stress thatput me back to square 1 again.
The thing that has always bothered me was I felt like back to myself almost immediately after that IV of antibiotics, it certainly did something to pull me right but somehow it became less effective or I overdid it somehow???
Makes one wonder about this ivermectin ,paxload etc. as one of their methods is also antireplication and some people it seems to work for. (it didn't work for me unfortunately)