Thanks for watching super nerds! *I should have been more clear* on one thing: because I interpreted the journals to mean that experiments were done on Mewtwo AFTER it was born, meaning that my approach also involves a kind of gene therapy (taking cells from an already born animal and putting modified cells back) in addition to cloning/transgenics. Thanks! -- kH
As Pokémon have the ability to evolve and you suggested fully evolved Pokémon couldn't the gene's/powers have showed immediately rather than having to go back and forth? Also edit Kyle you are great and thank you for doing these videos :)
Gene therapy would not be an effective way to make a mewtwo. At most you would graft power-specific organs and use gene therapy to reduce rejection. Making a new creature would require alterations to the genome of the creature(CRISPR before implantation), not just local alterations(gene therapy). Gene therapy could help make a chimera, but it wouldn't help you build a dragon.
Because Science Given that Ditto was only found in the lab on Cinnabar, and that it is the only Pokémon other than Mew that can transform in this way, most fans agree that Ditto is the result of the failed attempts. The plasmids they used for the gene therapy likely came from Mew, the only Pokémon able to use every move in the game and therefore likely to be a natural source.
tbh i always kinda assumed it was less "no one's ever seen pokemon reproduce", more "i'm not gonna explain sex to a 10 year old" sort of thing. it's easier to go "oh look, an egg!" than to explain exactly why and how say, a wailmer fucks a skitty. also weird that most of the pokemon are born from eggs, even mammalian ish pokemon.
Hey Kyle, pretty good theory overall, but I think there are some things you overlooked about mew's biology and lore. 1st, Mew's genome; According to multiple Pokedex entries Mew's genome contains the genome of EVERY Pokemon, most of which is probably stored in non-coding sections of the DNA. This means that you would't need to introduce new genetic material to Mewtwo's genome at all, you would just need to alter the expression of those genes. Researchers in real life have already done similar experiments with chicken embryos, turning on deactivated genes to give the chicken more dinosaurian traits like teeth and scales. 2nd, The move Transform; You mentioned getting plazmids from Ditto, because It can use the move Transform. That is unnecessary in this case because Mew is the only other Pokemon capable of using Transform. It could be that Mew is activating the other Pokemon's DNA in the non-coding section of it's DNA when transforming. In fact there is a pretty well-substantiated theory that Ditto are failed clones of Mew since they share many characteristics and Ditto are usually found in places related to Mew, like the Pokemon Mansion and Cerulean Cave. 3rd, Mew birthing Mewtwo; We've seen in the first Pokemon Movie and in Let's Go Pikachu/Eevee that Mewtwo was grown in a tank likely filled some sort of amniotic fluid substitute. It could be that Mewtwo was put in here as a zygote or very early in development and that is when the researchers altered it's gene expression like they did IRL with chicken embryos. The "Mew giving birth" part may be metaphorical in this case, or could be referring to a Cesarean Section preformed on Mew when Mewtwo got too big for Mew's reproductive system. 4th, Mewtwo's anger management issues; There is another theory surrounding Mewtwos creation which states that Human DNA was also used which gave it increased intelligence, and possibly it's more humanoid appearance and size. Also adding a human level of consciousness and human emotions are likely the cause of Mewtwo's anger issues when it realized what it was and why it was created. This could also be what the game was referring to when it talked about the "Horrific gene splicing."
Raxius Bloom At least I wan't the only one thinking about these very same issues when watching this video!!! BTW the manga covers the part about Mewtwo getting its human genes from Blaine.
In the Pokemon Manga, Mewtwo's Genetic Makeup contains Human DNA, specifically the Gym Leader Blaine of Cinnibar Island That could explain why Mewtwo is so much larger and more of a "Tube Kangaroo" as you put it
@@johnbloodythumbs4015 it's Blaine, he created Mewtwo and added his DNA as a way to stabilize it, giving the two a sorta twin ESP due to then sharing genetics
But Kyle Uppercut is not super effectiv against Zubat. Zubat is a Poison/Flying type which means Fighting type moves will only do 1/4 the damage they normaly would. P.S. Love the show
He could have been using his powerful mind to enhance the uppercut, making it a physical psychic type attack, which would be super effective against a poison type
You've mentioned that gene splicing is extremely unlikely to work and only has a small chance to actually produce a stable "creature" which would function properly. This goes hand in hand with the theory that Ditto is most likely a failed clone of Mew. The evidence is undeniable. First of, they're both pink and share the same color pallet. Secondly, Mew is the only Pokemon able to learn every move in the game due to being the genetic ancestor of all Pokemon. Ditto, can only learn a single move, which is Transform, but by using that move, it can in theory use any move in the game aswell, just like Mew but with an extra step. Furthermore, Mew has perfectly balanced base stats in the game, 100 HP, 100 Attack, 100 Defense, etc. It is the only Pokemon in the game where all stats are the same... The only one except for Ditto, which has 48 across the board, evenly balanced and conveniently just below half of Mew. Coincidence? And lastly, probably the biggest piece of evidence. Guess where the only locations are you could encounter Ditto in Pokemon Yellow? That's right, the Pokemon Mansion where Mewtwo was cloned and the Cave where Mewtwo resides. There has clearly been thoughts put into the connection between Ditto and Mew/Mewtwo when the game was created. (Also Ditto looks like your cliché failed clone attempt, it's just a blob of goo.) It makes perfect sense for there to be a lot of Dittos around to encounter in the Pokemon Mansion, it's because they had to go through A LOT of trial and error when cloning Mew and Dittos were the result of those attempts.
1. There are other pink pokemon. With 151 in the first generation alone, colors are bound to be repeated. Perhaps the next theory should be about how Ditto is actually a Clefairy that had a bad reaction to a Moon Stone. 2. So being exact opposites makes them the same by a loophole? That sounds more like an argument against Ditto being Mew. 3. "just below half of Mew. Coincidence?" Yes, absolutely, and not even a good one. An interesting coincidence would be if it were exactly half (and even then would still likely just be coincidence). 4. This is cherry-picking evidence, because in the two earlier games, Red and Blue, Ditto could be found in several different routes and not at all in the Pokemon Mansion.
Would like to point out that they also share the same weight and the same Shiny color palettes. There may be several pink Pokémon, but to have the exact same Shiny palette is something to keep in mind. The stat base was more of an emphasis on the fact that both their stats are BALANCED. As in, all their base stat values are identical. They’re also the only two Pokémon that can learn Transform.
7:11 Using "Sky uppercut" (a fighting move) on a Zubat (Poison/Flying) is as far off from super effective as you could reasonably get. But you're a strong man from all that climbing so I'll give you STAB atleast.
There is problem though. _Mew already can Transform_ and you don't need Ditto for plasmids at all. Actually, this makes things much simpler, because we can then assume that Mew (and therefore Mewtwo) itself has plasmids in its own cells (much like many bacteria and possibly even Ditto). Then, you wouldn't need an external vector at all because you can straight up use plasmids from Mewtwo's own cells. This also eliminates the potential issue of Mewtwo not properly accepting the new genes inserted into it. Basically, if that were true, you can save a lot of resources coz you don't need Ditto anymore. I won't say I love the show because that's technically implied at this point. Keep it up!
Pokémon evolutions aren't really evolutions, they're lifestages of individuals, so a Staryu genome IS a Starmie genome anyway. If you want butterfly genes, it doesn't matter if you get the samples from an adult butterfly, or the coccoon, or the caterpillar life stage.
Today's science fiction is tomorrow's science. Also art, inspires life as art imitates life. We have a lot of Star Trek tech now because real scientists were inspired by it.
Wait... *What if a scientist fucked Mew and, BANG, Mewtwo...* What I have said is indeed disturbing... He didn't point out that Mewtwo is indeed a human mixed with a cat... Adds up, easier, not wasting any money..
Wouldn't it be easier to apply genetic splicing to the "zygote" before triggering it's mitosis instead of applying it to the full grown pokemon or is it not possible to do that?
Well if something went wrong during the splicing it would kill the embryo , whereas if you do the splicing in the full grown organism. .. Well There are chances that this could cause mutations leading to cancer but if it's only a gene getting in a region of so called "junk DNA" it wouldn't hurt that much . The only drawback of this method is that you have to do the splicing over and over again because the cells that have the desirable genetic material won't live forever .
By "cells with the desirable genetic material" I mean the cells that have been spliced in the way that we wanted and now have and express the genes that we want them to
Not sure but maybe that would interfere with Mew's capability to give birth to MewTwo? Given how tough it is to even get a clone I'd assume that messing with the zygote and ultimately altering the embryo to another species could mean that Mew can't deliver the MewTwo
Mew is no kitteh, it's a gerbil, a desert mouse =D And if I remember correctly Mew was the forerunner of every other Pokemon in Arceus's creation, that's why it can learn every move there is. So no need to splice in other genes. You just have to switch around those you already have. But I get why you explained it like this and found it a nice way to show how to splice. Keep it up!
there are actually plenty moves mew can not learn. obvious ones being signature moves of other legendary pokemon. mew can only learn all TM's but not much else as it's own natural moveset is actually fairly small. however seeing that mew can learn all TM's and HM's as well as most tutor moves, i believe that it's offspring can also learn other moves as egg moves when the corresponding genetic material is injected during the cloning process.
Pretty darn good episode. I quite enjoyed that. The only major thing I would add is that Mew actually knows the move transform (as it should considering it is the ancestor of a Pokemon). Since Mew already contains the blueprints for all Pokemon, it is far more likely that Mewtwo is the result of the scientists trying to breed a cloned version of Mew that more actively exhibits certain traits Mew already had the capability of expressing.
Hey Kyle, could you analyze the defeat of Kars, from JoJo's Bizarre Adventure? If the volcano and rocks could have sent him to space, if he could have survived lava and if there was a way he could have got back to earth. It's a pretty interesting case.
You randomly encountered the Mewtwo after several zubats but Mewtwo is a static encounter so you can't stumble upon it. Also, the game mentions Guyana which is interesting because, pokefact, the Kanto region where Cerulean Cave is its based on a real life region in Japan called Kanto. Great video, BS team!
The lore around Mr. Fuji was pretty cool. In emerald, if you cheated and made it to faraway island where mew is found, there's a sign that was posted by Fuji. Then there's all his journals and the pokedex's descriptions of how mewtwo was made and how horrible it was. And earlier in red and blue, you visit an old Mr. Fuji in his home, where he takes in and cares for abused Pokemon. A real 180 with that guy.
Hi Kyle! Love the show, and I really loved your approach to creating Mewtwo using specific Pokémon to express the moves that it uses. I feel like the scientists may have used a few more Pokémon in this experiment as well, such as Gengar for Shadow Ball and Electrode for Explosion, both are things we see Mewtwo do in the first movie. Perhaps the scientists tried all 149 other Pokémon (maybe excluding the legendary birds) to see which experiments would survive, thus leading to the higher attempt count similar to the horse cloning experiment
As far as I know to clone an animal you need a somatic cell and a germinal cell from different animals or the nucleus would be rejected, so you would need 2 mew to clone one.
BTW, Mewtwo is definitely the most charismatic human created pokemon in gen 1 but I would be WAY more curious how we managed to create Porygon, a digital construct that can exist beyond digital space.
It’s already established that Pokémon can be converted into data to be stored in the PC or traded across the globe. Porygon could’ve been an attempt to reverse the process; create an organism digitally, and then run the digitizer in reverse (they started off simple, of course), with the caveat that its data would be far easier to edit anywhere down the line (hence Porygon 2 just being a software update, and Porygon Z being an illegal fan mod).
@@narutardkyuubi well maybe, but if thats the case how can Porygon breed? Theoretically if they are just digitally created constructs they shouldn't be able to, but they can interbreed with other pokemon species as well as their own.
As a Brazillian Pokémon trainer since 1999 and that played every single game since then.... Mewtwo is not a Villain... He just thinks that humain being are cruel (and they are) for everything they done to him and other Pokémon, all he wants is to go in to a lonely place and live there with other clones, wich he manage to get for a while until... Guess what.... Humans ruined that too... In the end he "sets" free the clone Pokémon to go over the world once he realize that what they wanted and that others Pokémon would not discriminate them... In the end it's not a Villain but a fruit the Human arrogance... Not born, but created... And all he wanted was to leave in peace... Alone... But humans wanted to use him as weapon... I Love Mewtwo! PS: Pokémon is in my family roots... My daughter and nephew also LOVES Pokémon, not only "like it"... Pokémon, Star Wars, Harry Potter and Resident Evil are the pillar to a healty family rofl #JK MEGA EDIT: What about a DITTO video?!?!?!?!?!??!?! Heyyyy it's a good ideia =]
In the mangas, the scientists actually ran out of cells to fully form Mewtwo with, so one of them extracted their own cells and put it into Mewtwo. This is actually a very fascinating idea, as not only does it explain Mewtwo's humanoid appearance, but it also makes sense with it's psychology being an animal mentality with human emotions and intellegence.
@@Animemus Well, Entei did get Blaine rid of Mewtwo's cells but Mewtwo still has Blaine's cells, they are part of his biology. The Mewtwo cells in Blaine however were acting more like some sort of parasite who was slowly killing him.
I object your objection... you are assuming he used uppercut, if he is using strenght (or another normal type move) and has the ability refrigerate it would be a super effective (ice type) move
I didn't realize that you said random names at the end of videos until I watched some of the live videos. Even though it was random, it still took me by surprise and made me smile :)
According to the in-game lore, Mew is supposed to have the genetic material of all pokemon, and I think that would change the way you would approach tinkering with it's genetic code, since it isn't so much adding to it, but rather activating or inactivating which genes it expresses out of its natural gene pool, be it through removing genes from it or through epigenetic changes. I know that the games say gene splicing, but it seems more likely to me that the scientists of the project would focus on gene expression and epigenetics because you don't have to change the DNA of every cell on an organism's body, just the expression, and thus is much more feaseable. Especially on a subject which already hosts all the necesary genes you would ever want. In the real world techniques exist that let you turn on or off certain genes in lab animals, and I recently learned on a simposium that scientists are working treatments for humans that have a kill switch, so that you give the patient the treatment and if it works as intended then you leave it alone, but if it starts acting out somewhere it shouldn't or the effect isn't the desired one then you can give the patient a drug that destroys it and as long as they take it everything goes back to the way it was. Lastly it is interesting to think about pokemon reproduction and the in-game mechanic of egg moves. In the games pokemon can reproduce with pokemon outside their own species, as long as the parents share at least one egg group. Sometimes if the male knows the right move the offspring will be born knowing said move, even if they can't learn it naturally through leveling up. If we think back to how mew has all the genes of all the pokemon it could mean that the different species we now have have been the result of different mew populatioms evolving (the darwinian way, not the pokemon way) into different species of pokemon, and that while over time most of the genetic material has been selectively taken out of the gene pool enough remains so that two different pokemon can breed and produce viable, fertile offspring that has the genes for those dormant moves activated and thus can use them in battle. Wait... Is that what TMs, HMs and Move Tutors do!? Gene modification therapy to induce the expression of genes in the already existing genetic code of the pokemon!? It seems there is still a lot more we could speculate about pokemon genetics that just the cloning of Mewtwo.
I'm guessing it would. Think about our own ﹰDﹰNﹰA - its the result of random mutations over millions of years and as we evolve, some traits become more dominant over time. The weaker traits aren't necessarily lost completely but they get buried in amongst the other information. Mew might well have the traits for every Pokemon in its DNA but the traits for tail, pink skin, psychic power and adorable eyes have become dominant enough to give it its current form. If all its traits had equal dominance, then it would probably be a Ditto. So returning to your question, although Mew might have Staryu and Kadabra traits in its DNA, they are recessive normally, so by splicing in more dominant versions from actual Staryus and Kadabras, they will reshape Mew accordingly.
Crossed xD even as a kid I thought that ditto looked like someone put a Mew in the microwave. And I did always find it suspicious that you could also use transform.
Hi Kyle, fun episode! I was thinking about something that would help stabilize your theory a little. In Pokemon lore, Mew was essentially the first Pokemon and was created by Arceus to become/birth every Pokemon in the world. That, and the fact that it can learn Transform, would probably make clones from it a lot more stable or even easier to genetically modify, since all of its offspring are supposed to be unique Pokemon. You could think of MewTwo as the result of some sort of feedback loop, too; forcing the Pokemon that can only give birth to new Pokemon to give birth to itself would probably result in some screwy science.
Hummm this all makes sense for you to do Kyle, since your obviously a clone of thor with gene splicing of Bill Nye and Adam Savage. And now we all know your origin story.
Oh this was a fantastic episode! I'm really happy with the way everything was explained, especially the GMO piece as too few people are aware of their necessity. Kyle, do you think you could do something on the "science" of the Warhammer 40k property in some respect? Like the creation of Space Marines or how the Orks have no physical growth limit? Or whatever you want to do, I just like the show. Keep rocking!
Different gene expression. There was a mutation in fly, that made her grow eyes out of her knees. Just during the stage of development, the body mistook its own body parts and made one gene to be expressed somewhere else than it shouldve...
Great show as always! In Pokemon Silver the pokedex states that "Its DNA is said to contain the genetic codes of all Pokémon, so it can use all kinds of techniques." Would this have any impact on the ability to splice the genes into it? I would think that a pokemon that already naturally has all the genes in it would be more receptive to splicing those same genes to be more prominent.
I wounder if we'd be able to use grafting techniques to Frankenstein different elements from Grass types (should be classified as Plant type fight me) together to create new super Grafted Modified Pokemon (Hence forth known as G.M.P.'s) We'd probably also be able to just combine a large number of Grass types together, just think of how powerful a solar beam we could generate from a large fields of growing Glooms in parallel connections. And we shall use these G.M.P's to combat all forms of pollution and the destruction of nature!
Grimer and Muk ARE the solution to pollution. Also, Type-Null is basically a Frankenstein already, grafted together to use the RKS system to take on Ultra Beasts as a Sylvally. Besides, why specifically a grass type Frankenstein? I could imagine a lot of other more useful amalgamations, and something tells me that Solar Beam's power is more dependant on the efficiency of the solar conversion, not the specific parts of Pokemon using the move.
Fun thing I learned about SCNT: I did a paper last semester on de-extinction, or the process of restoring extinct species. Somatic cell nuclear transfer is one of the most popular theoretical methods for de-extinction. The catch is that it is only doable for cells that are fresh or relatively so and in great shape. This wouldn't allow us to play Dr. Wu, but we could maybe try to grow something older than a few thousand years if we got an extremely good specimen. So, not Jurassic Park, but Pliocene Park at the best.
I cant stop focusing on the two lights reflected in each of Kyle's eyes. Now that Ive noticed it I cant unsee it and it looks like he has freaky spider eyes.
IDK what Pokemon games you played, Kyle, but the sequence of events is ABSOLUTELY clear. Its explicitly stated that they found a *fossilized* eyelash of a Mew, and extracted DNA from that. This DNA was then used as a base for creating Mewtwo. At no point is there ever anything indicating in any way that the team of scientists encountered, much less captured, a live Mew. Also, when they say "Mew gave birth" its very clear from the context in which it is presented that this isnt meant literally. (Again, they *never* encountered a live Mew) Rather, they simply meant that they managed to get a viable specimen to survive for and begin developing and growing in a test tube. Mewtwo was "birthed" out of a large glass tank.
Kyle, what's your level? You just OHKOd a Zubat with Sky Uppercut, a fighting-type move, that's not super effective. Actually you only did 1/4 of the damage, Zubat is Poison/Flying. And I thinking that you only knew Rock Climb.
12:22 thanx Kyle that would have bugged me all day. Great Pokémon episode. Now that the Mortal Kombat series is done what do you have planned next? Super powers you wouldn’t want 👀
I think something that also has to be taken into account is how flexible some Pokémon’s genes are. For example, eevee is one of the most amazing Pokémon when it comes to genes. Pokédex entry in ultra moon states “Its genes are easily influenced by its surroundings. Even its face starts to look like that of its Trainer.” All the scientists would have to do is splice some of eevees genes into mewtwo and subject mewtwo to some harsh environments and we would get what we see in the games. This could also be why mewtwo is so tall, as it could copy the scientists height. Eitherway, this was a really good episode!
This has me thinking about genetic modification on grass Pokémon. I studied botany and plant taxonomy with a sprinkling of microbiology when getting my master's degree, so I did some research on plant gene modification. Lateral gene transfer is VERY easy to accomplish in plants, and even if the addition of the new genes would cause the plant to become sterile there's a process in plants called allopolyploidy, which basically means they can spontaneously double their genome and render themselves fertile again. This is part of why it's so easy to breed new cultivars of plants and cross breed crop species. So I bet that genetic modification in plant/grass type Pokémon would be significantly easier than in Pokémon that are animal like. Especially since cloning of plants is similarly more simple, sometimes requiring only a rooting hormone for it to work. Anyway, excellent episode! I love the show, thank you for doing what you do!
But Kyle, Dittos are failed attempts at cloning Mew/creating Mewtwo. So how could you use a Ditto as a "vector" for creating a perfect Mewtwo? 🤔 Also, you might want to use a MAX-REPEL to keep the Zubats away 😊👍🏻
Hi Kyle, a very good start to cloning and G.M.O.'s. A couple of things I personally would have talked about though include things like retro-viral gene-therapy, and CRISPR, two different ways of introducing new genes into the cells. Not necessary, but would have been nice to touch on (Also, love the gene-gun touch, so much fun...) One tiny correction I'd like to point out is that I think you have your order of operations a little bit wrong though. In order to get an organism as different as MewTwo is from Mew, it would have been nigh impossible to do so after birth, and so a much more likely scenario would have been they created the fertilized embros, grew them in a lab for a while, then performed the gene-splicing while they were still embryos, done testing on the resulting DNA of the cells to see if their genes were spliced correctly, and then re-cloned the resulting DNA. Then proceeded to do all of this process many many times, and only once they had what they believed to be the "perfect" specimen implant that one fertilized embryo into Mew to have it birth its clone. This is essentially the same process that He Jiankui (Chinese scientist) claims to have used to create the worlds first genetically modified humans. Freaky, but cool. That said, you mentioned there are ways to create our own "pocket monsters" which is entirely correct, and I've actually put some thought into it, and how one might go about doing things like creating hyper-intelligent sea-creatures. Most recently I had come up with a creature that combines traits of Cuttlefish (and other cephalapods), Bottlenose Dolphins, Walrus, and the Immortal Jellyfish, to create a creature that would be as intelligent or MORE intelligent than humans, has amazing tool-use capabilities, effectively immortal unless eaten or killed, can breathe air if needed, can talk and mimic sounds, can move-around in air for prolonged periods of time without drying out, can use ultra-sonic pulses to disorient prey, and even work cooperatively. Even though they would be almost entirely aquatic, this kind of a creature could really give us a run for our money! Or even dragons... Combining a hexapod body, with lots of mammalian traits like intelligence, prehensile tails, wings like bats, with reptilian traits like spitting venom, insect traits like the bombardier beetle for spitting highly-corrosive self-igniting chemicals (aka, fire), etc... I think it's entirely plausible that people could create these kinds of creatures eventually. Honestly the possibilities are almost endless, and I think that it's really just a matter of time before someone makes them a reality. Well... Either that, or we wipe ourselves off the planet first, because science!
So..... did you pick Ditto as a Vector because it was a failed Mew Clone and would be the Pokemon equivalent of the "other 840 attempts"? Also, with "horrific gene splicing experiments" you can pretty much use that itself to explain the physical differences.... for example, they could've even used human cells for the experiments to see what would happen.... it's also possible that some of its body is artificial material created to hold the creature together when experimentation when horrifyingly wrong.... I'm saying that because (outside of the live action film) its tail and rest of its body are two different colors and look like they were put together rather than.... grown at the same time.... so why couldn't some or all of the body be an artificial shell that was created to hold the decaying body of Mewtwo inside with the head of Mewtwo being held together (explaining the ear differences), the back tube essentially providing nutrients from an artificial stomach setup, and the tail perhaps being a portion of the original body that survived (it might even be everything except the arms and legs which were attached to the much larger artificial shell so it could walk without much alteration) I'm just theory-crafting some explanations as to why it looks like a bigger and more badass version of Mew, and it could very easily have a lot to do with that it was a near perfect clone that, through gene splicing and tampering could've become incapable of surviving any longer.... but that's my personal thoughts after seeing this video.
Couldn't post on last video but, Hey, if we some how be able to build instruments made of quantumly entangled particle such that obervations at one end instantaneously re created or observed at other entangled end then we in theory could observe WHAT'S INSIDE SINGULARITY, CENTER OF BLACK HOLE. or at least get some information out something that won't even let light out of its grasp
Kyle: etc etc fancy science jargon Me: ... Mew has eyelashes ? Also kinda bummed out that I only found this channel now and the last upload was 2 years ago :/
Loved this episode, as a molecular biology background I can say you explained it very well. The only thing I'm thinking is the pokémon involved, because the traits of mewtwo are not really found anywhere in gen 1. If you extend it however : The hands and feet could be from seismitoad, the legs from breloom. This could mean that the creators of mewtwo knew about all other zones of pokémon but decided to keep it secret from us :o was gallar region leaked in gen 1?
Just to clarify: somatic cell nuclear transfer is the cloning method you've mentioned in the past that could be used to bring back the woolly mammoth using a modern elephant, correct? Also: >Kadabra, not Alakazam >Staryu, not Starmie
Nah, if you want into footnotes you need to a) make a comment or correction relevant to the video and b) getting a lot of likes and comments seems to help to but doesn’t necessarily mean you will get in. And sometimes KH will just jot a quick response if it’s a short enough answer.
I was hoping that this was going be a video of how we could make an actual Mewtwo (or at least a creature that looks like mewtwo) in real life, but I love this too.
Someone is gonna point out that it's not /poe-key-mon/, but the é is supposed to sound like the 'e' in 'pocket', because they are pocket-monsters. But as long as you know this, I don't really care how you pronounce it, as long as you're consistent.
The way you explained how to theoretically create Mewtwo just sounds like breeding the perfect Pokémon for battling. You want the best IV’s, EV’s, and personality depending on the Pokémon.
Nice little dig at anti-GMO marketing. Perhaps you could expand on the topic a bit more in a footnotes episode to help people understand just how misleading and harmful it is.
Hey Kyle, another cool episode, so thanks for that. Now I was wondering, is the process you decried, adding genes to something to make whatever animal, I guess you could say custom, would you go about that using the crisper technique that we have heard you talk about. I ask because I’m not sure and it kind sounds like how you have explained crisper to us in the past. Thanks again and keep on keeping on with the awesome content.
Hi, love the show and I wanted to say that in school we are learning about genetics, specifically designer babies. We learned that it can be hard and sometimes bad. One thing that can occur is one part of a gene is replaced with a “good gene” but can implant a bad personality trait as many scientists don’t know how to change that.
I believe mewtwo's moveset is the end results of the experiments that were done on him and what was needed for him to survive. Psychic so that his mind could stay intact and focused, barrier for protection as previous iterations would have been fragile or weak, recover for the eminent damage of said experiments, etc.
Thanks for watching super nerds! *I should have been more clear* on one thing: because I interpreted the journals to mean that experiments were done on Mewtwo AFTER it was born, meaning that my approach also involves a kind of gene therapy (taking cells from an already born animal and putting modified cells back) in addition to cloning/transgenics. Thanks! -- kH
Maybe its part primape that would explain its aggression and focus blast
I thought it was clear
As Pokémon have the ability to evolve and you suggested fully evolved Pokémon couldn't the gene's/powers have showed immediately rather than having to go back and forth? Also edit Kyle you are great and thank you for doing these videos :)
Gene therapy would not be an effective way to make a mewtwo. At most you would graft power-specific organs and use gene therapy to reduce rejection. Making a new creature would require alterations to the genome of the creature(CRISPR before implantation), not just local alterations(gene therapy).
Gene therapy could help make a chimera, but it wouldn't help you build a dragon.
Because Science Given that Ditto was only found in the lab on Cinnabar, and that it is the only Pokémon other than Mew that can transform in this way, most fans agree that Ditto is the result of the failed attempts. The plasmids they used for the gene therapy likely came from Mew, the only Pokémon able to use every move in the game and therefore likely to be a natural source.
*Gen 1* "Mew gave birth".
*Gen 2-7* "No one has ever seen a pokemon reproduce, but we found this egg".
tbh i always kinda assumed it was less "no one's ever seen pokemon reproduce", more "i'm not gonna explain sex to a 10 year old" sort of thing.
it's easier to go "oh look, an egg!" than to explain exactly why and how say, a wailmer fucks a skitty. also weird that most of the pokemon are born from eggs, even mammalian ish pokemon.
@@leeman27534 a wailord fan breed with a skitty too. Even a diglet yikes XD
Hey Kyle, pretty good theory overall, but I think there are some things you overlooked about mew's biology and lore.
1st, Mew's genome;
According to multiple Pokedex entries Mew's genome contains the genome of EVERY Pokemon, most of which is probably stored in non-coding sections of the DNA. This means that you would't need to introduce new genetic material to Mewtwo's genome at all, you would just need to alter the expression of those genes. Researchers in real life have already done similar experiments with chicken embryos, turning on deactivated genes to give the chicken more dinosaurian traits like teeth and scales.
2nd, The move Transform;
You mentioned getting plazmids from Ditto, because It can use the move Transform. That is unnecessary in this case because Mew is the only other Pokemon capable of using Transform. It could be that Mew is activating the other Pokemon's DNA in the non-coding section of it's DNA when transforming. In fact there is a pretty well-substantiated theory that Ditto are failed clones of Mew since they share many characteristics and Ditto are usually found in places related to Mew, like the Pokemon Mansion and Cerulean Cave.
3rd, Mew birthing Mewtwo;
We've seen in the first Pokemon Movie and in Let's Go Pikachu/Eevee that Mewtwo was grown in a tank likely filled some sort of amniotic fluid substitute. It could be that Mewtwo was put in here as a zygote or very early in development and that is when the researchers altered it's gene expression like they did IRL with chicken embryos. The "Mew giving birth" part may be metaphorical in this case, or could be referring to a Cesarean Section preformed on Mew when Mewtwo got too big for Mew's reproductive system.
4th, Mewtwo's anger management issues;
There is another theory surrounding Mewtwos creation which states that Human DNA was also used which gave it increased intelligence, and possibly it's more humanoid appearance and size. Also adding a human level of consciousness and human emotions are likely the cause of Mewtwo's anger issues when it realized what it was and why it was created. This could also be what the game was referring to when it talked about the "Horrific gene splicing."
Raxius Bloom weren’t ditto created from failed attempts to clone mew?
NEEEEEEEEEEERD!!!!!!!!
mewtwo having human dna is not a theory lol xd its blaine ;) its a lore fact
Raxius Bloom At least I wan't the only one thinking about these very same issues when watching this video!!! BTW the manga covers the part about Mewtwo getting its human genes from Blaine.
NERDDDDDD!!
In the Pokemon Manga, Mewtwo's Genetic Makeup contains Human DNA, specifically the Gym Leader Blaine of Cinnibar Island
That could explain why Mewtwo is so much larger and more of a "Tube Kangaroo" as you put it
Thought it was giovoni?
@@johnbloodythumbs4015 it's Blaine, he created Mewtwo and added his DNA as a way to stabilize it, giving the two a sorta twin ESP due to then sharing genetics
@@Quote_Cannon in an alternate version of the manga, they curbed mewtwo's agression by giving him clefairy DNA XD
Wait how did he get his DNA into Mewtwo......... OMG! More like Mewewwwwww
@@Painfully_Punny He got a needle and took a blood sample, took genes out that and inserted that into Mewtwo when it was a pile of Cellular mush
“If I were experimented on I’d want to hide in a cave too” he says with his perfect flowing hair from inside his endless void.
LEAVE ME BE -- kH
But Kyle Uppercut is not super effectiv against Zubat.
Zubat is a Poison/Flying type which means Fighting type moves will only do 1/4 the damage they normaly would.
P.S. Love the show
Kyle does what he wants.
Obviously he was using either Ice Punch or Thunder Punch
He was using the Science Punch. 4x damage against anything to do with movies or video games.
He could have been using his powerful mind to enhance the uppercut, making it a physical psychic type attack, which would be super effective against a poison type
@@90kalos1 Zen Uppercut, the hybrid of Zen Headbutt and Mega Punch.
When I was a kid I watched Bill Nye. Now I'm 30 and watch Because Science. #Nerdforlife
Dashiell Millner back when Bill Nye was still scientific. I used to want to meet Bill, but now though... I’m not so sure
Bill is kind of a nut now.
Bill Nye and Beakman's World
Beakman > Bill Nye
All hail nerds! if it weren't for us, there would not be computers! or quite a few other things for that matter.
RUclips...is evolving into...ACTUALLY WORKING!
I got a subscription notification for once!
Cody Sketch
Same!
You forgot the WHAT at the beginning
Cody used NOTIFICATION BELL
It's super effective!
Sure it's not some kinda super potion?? Sure it'll wear off an RUclips will revert to its usual marginally functional self
a glitch in the matrix
For the love of Arceus go buy some Repels, man!
biohazard724 they don't even cost that many pokédollars
At the most buy some Max Repels and Escape Ropes
But they don't last as long in my personal opinion but those items are subjective to change based on personal opinions and preferences
But for me as another trainer has stated Dugtrio is a much more viable option for escaping caves
You guys do realize Rattatas and Pidgeys are more common than Zubats, right?
You've mentioned that gene splicing is extremely unlikely to work and only has a small chance to actually produce a stable "creature" which would function properly.
This goes hand in hand with the theory that Ditto is most likely a failed clone of Mew. The evidence is undeniable.
First of, they're both pink and share the same color pallet.
Secondly, Mew is the only Pokemon able to learn every move in the game due to being the genetic ancestor of all Pokemon. Ditto, can only learn a single move, which is Transform, but by using that move, it can in theory use any move in the game aswell, just like Mew but with an extra step.
Furthermore, Mew has perfectly balanced base stats in the game, 100 HP, 100 Attack, 100 Defense, etc. It is the only Pokemon in the game where all stats are the same... The only one except for Ditto, which has 48 across the board, evenly balanced and conveniently just below half of Mew. Coincidence?
And lastly, probably the biggest piece of evidence. Guess where the only locations are you could encounter Ditto in Pokemon Yellow? That's right, the Pokemon Mansion where Mewtwo was cloned and the Cave where Mewtwo resides. There has clearly been thoughts put into the connection between Ditto and Mew/Mewtwo when the game was created.
(Also Ditto looks like your cliché failed clone attempt, it's just a blob of goo.)
It makes perfect sense for there to be a lot of Dittos around to encounter in the Pokemon Mansion, it's because they had to go through A LOT of trial and error when cloning Mew and Dittos were the result of those attempts.
1. There are other pink pokemon. With 151 in the first generation alone, colors are bound to be repeated. Perhaps the next theory should be about how Ditto is actually a Clefairy that had a bad reaction to a Moon Stone.
2. So being exact opposites makes them the same by a loophole? That sounds more like an argument against Ditto being Mew.
3. "just below half of Mew. Coincidence?" Yes, absolutely, and not even a good one. An interesting coincidence would be if it were exactly half (and even then would still likely just be coincidence).
4. This is cherry-picking evidence, because in the two earlier games, Red and Blue, Ditto could be found in several different routes and not at all in the Pokemon Mansion.
Would like to point out that they also share the same weight and the same Shiny color palettes. There may be several pink Pokémon, but to have the exact same Shiny palette is something to keep in mind. The stat base was more of an emphasis on the fact that both their stats are BALANCED. As in, all their base stat values are identical. They’re also the only two Pokémon that can learn Transform.
7:11 Using "Sky uppercut" (a fighting move) on a Zubat (Poison/Flying) is as far off from super effective as you could reasonably get. But you're a strong man from all that climbing so I'll give you STAB atleast.
It was a joke, he literally said super effective!
You shouldn't take this too seriously either then ;P
@@simblast ?
I'm not taking it seriously?
Wrong, Earthquake is as far as you can get.
Given the fact that Sky uppercut is used, ofcourse.
If you really want to be nitpicky any ground move is just as ineffective.
There is problem though. _Mew already can Transform_ and you don't need Ditto for plasmids at all. Actually, this makes things much simpler, because we can then assume that Mew (and therefore Mewtwo) itself has plasmids in its own cells (much like many bacteria and possibly even Ditto). Then, you wouldn't need an external vector at all because you can straight up use plasmids from Mewtwo's own cells. This also eliminates the potential issue of Mewtwo not properly accepting the new genes inserted into it. Basically, if that were true, you can save a lot of resources coz you don't need Ditto anymore. I won't say I love the show because that's technically implied at this point. Keep it up!
Correct, according to pokemon lore Ditto are actually failed Mew clones.
@@Axel-VIII I thought that was simply a fan theory and not proven canon.
@@DakodaOK yeah, but... it's really cool
>Kadabra instead of Alakazam
>Staryu instead of Starmie
Kyle plz. I thought we were trying to make the world's most powerful pokémon here.
Would you even need Kadabra/Alakazam? Mew is a psychic type and can use Psychic.
@@GundamFranxx but it doesn't have the 5000 IQ of alakazam! ;D
Well, if you want to create the most powerful Pokémon in the universe there is only one Pokémons genes that are suitable for that task. Magicarps.
Pokémon evolutions aren't really evolutions, they're lifestages of individuals, so a Staryu genome IS a Starmie genome anyway.
If you want butterfly genes, it doesn't matter if you get the samples from an adult butterfly, or the coccoon, or the caterpillar life stage.
Their genes would be the same as they're the same creatures in different parts of their life cycles.
It's super cool how science has (kinda) caught up sci-fi technobabble.
Today's science fiction is tomorrow's science.
Also art, inspires life as art imitates life.
We have a lot of Star Trek tech now because real scientists were inspired by it.
@@gamingelementalist6725 And life also imitates art
Scientists: If Mew is so good, why there's no Mewtwo?
"Genius!"
_creates Mewtwo_
Wait...
*What if a scientist fucked Mew and, BANG, Mewtwo...*
What I have said is indeed disturbing...
He didn't point out that Mewtwo is indeed a human mixed with a cat...
Adds up, easier, not wasting any money..
@@d_y_n_a_m_o
Are you saying, Mewtwo is a Neko?
@@d_y_n_a_m_o ..thanks for ruining pokemon for me
"with a lot of luck and a little bit of literally" Hahahaha!!! I love the writing on this channel.
Wouldn't it be easier to apply genetic splicing to the "zygote" before triggering it's mitosis instead of applying it to the full grown pokemon or is it not possible to do that?
Well if something went wrong during the splicing it would kill the embryo , whereas if you do the splicing in the full grown organism. .. Well There are chances that this could cause mutations leading to cancer but if it's only a gene getting in a region of so called "junk DNA" it wouldn't hurt that much . The only drawback of this method is that you have to do the splicing over and over again because the cells that have the desirable genetic material won't live forever .
By "cells with the desirable genetic material" I mean the cells that have been spliced in the way that we wanted and now have and express the genes that we want them to
You could only do that once with each generation. It sounds like Mewtwo has had it's genetics played about with multiple times within the same animal
I'm guessing since the cloning process could fail, they wanted to make sure the embryon is able to sustain itself before experimenting on it.
Not sure but maybe that would interfere with Mew's capability to give birth to MewTwo? Given how tough it is to even get a clone I'd assume that messing with the zygote and ultimately altering the embryo to another species could mean that Mew can't deliver the MewTwo
"Son of a Glitch"? Hmmmm... This sounds... familiar...
_cough cough_ A+Start _cough_
As soon as that came up on the screen I was hoping it was a surprise collaboration.
I thought A+start would be there
Mew is no kitteh, it's a gerbil, a desert mouse =D
And if I remember correctly Mew was the forerunner of every other Pokemon in Arceus's creation, that's why it can learn every move there is. So no need to splice in other genes. You just have to switch around those you already have.
But I get why you explained it like this and found it a nice way to show how to splice. Keep it up!
Jerboa, more like
there are actually plenty moves mew can not learn.
obvious ones being signature moves of other legendary pokemon. mew can only learn all TM's but not much else as it's own natural moveset is actually fairly small.
however seeing that mew can learn all TM's and HM's as well as most tutor moves, i believe that it's offspring can also learn other moves as egg moves when the corresponding genetic material is injected during the cloning process.
Pretty darn good episode. I quite enjoyed that. The only major thing I would add is that Mew actually knows the move transform (as it should considering it is the ancestor of a Pokemon). Since Mew already contains the blueprints for all Pokemon, it is far more likely that Mewtwo is the result of the scientists trying to breed a cloned version of Mew that more actively exhibits certain traits Mew already had the capability of expressing.
So thor decided to become a pokescientist after endgame
probably uses Electabuzz
He had done enough yelling at kids playing Fortnite, obviously.
And lost weight
A drunkass speedster named barry well he has to lose the weight somehow ...
He gave life to Vision with lightning like Frankenstein, so mad scientist was kind of an obvious career path...
One of your best episodes: perfectly plausible, smoothly narrated and totally canon in both the universes.
Amazing work!
Well, you can only have one Mewtwo, after him you would get a Mewthree, Mewfour, etc
Wellllllll, No, there's at least 3 different surviving Mewtwo. And Mewthree is just a Clefairy's transformation
IT'S OVER MEWNINETHOUSAND!!!
Hey Kyle, could you analyze the defeat of Kars, from JoJo's Bizarre Adventure? If the volcano and rocks could have sent him to space, if he could have survived lava and if there was a way he could have got back to earth. It's a pretty interesting case.
You randomly encountered the Mewtwo after several zubats but Mewtwo is a static encounter so you can't stumble upon it.
Also, the game mentions Guyana which is interesting because, pokefact, the Kanto region where Cerulean Cave is its based on a real life region in Japan called Kanto.
Great video, BS team!
kyle hill: ur pokemon cant get atronger with rare candies
wolfeyvgc: laughs in competitive pokemon
But ditto is a failed mew clone so u couldn't have grabbed that gene
Perhaps Ditto were failed clones but the scientists realized it has uses and used Ditto as a stepping stone to create Mewtwo.
Mew already knows transform, I think he got that part reversed, its because of Mew that Ditto knows transform
While a popular theory, it is technically unconfirmed
It’s a theory not confirmed
It's just a Theory....
A Game Theory!
EPISODE SUGGESTION!!!!
Attempt to determine Sonic's speed in the new trailer during the scene where he dodges missiles.
Man, I almost spit Snapple everywhere when you said, "poor tube kangaroo".
The lore around Mr. Fuji was pretty cool. In emerald, if you cheated and made it to faraway island where mew is found, there's a sign that was posted by Fuji. Then there's all his journals and the pokedex's descriptions of how mewtwo was made and how horrible it was. And earlier in red and blue, you visit an old Mr. Fuji in his home, where he takes in and cares for abused Pokemon. A real 180 with that guy.
"poor tube kangaroo...."
Favorite line so far....
Hi Kyle! Love the show, and I really loved your approach to creating Mewtwo using specific Pokémon to express the moves that it uses. I feel like the scientists may have used a few more Pokémon in this experiment as well, such as Gengar for Shadow Ball and Electrode for Explosion, both are things we see Mewtwo do in the first movie.
Perhaps the scientists tried all 149 other Pokémon (maybe excluding the legendary birds) to see which experiments would survive, thus leading to the higher attempt count similar to the horse cloning experiment
I actually understood everything here. I guess my biology classes this semester paid off 😂
I understood most of it myself. Though a couple times it got a bit fast.
As far as I know to clone an animal you need a somatic cell and a germinal cell from different animals or the nucleus would be rejected, so you would need 2 mew to clone one.
BTW, Mewtwo is definitely the most charismatic human created pokemon in gen 1 but I would be WAY more curious how we managed to create Porygon, a digital construct that can exist beyond digital space.
Yes how is this possible? All I can come up with is anime logic.
It’s already established that Pokémon can be converted into data to be stored in the PC or traded across the globe. Porygon could’ve been an attempt to reverse the process; create an organism digitally, and then run the digitizer in reverse (they started off simple, of course), with the caveat that its data would be far easier to edit anywhere down the line (hence Porygon 2 just being a software update, and Porygon Z being an illegal fan mod).
@@narutardkyuubi well maybe, but if thats the case how can Porygon breed? Theoretically if they are just digitally created constructs they shouldn't be able to, but they can interbreed with other pokemon species as well as their own.
As a biotechnologist, a molecular biologist and an avid Pokemon player,
i heartily approve the science in this video! Good job! :D
VALIDATION thank you Aristotelis! -- kH
As a Brazillian Pokémon trainer since 1999 and that played every single game since then.... Mewtwo is not a Villain...
He just thinks that humain being are cruel (and they are) for everything they done to him and other Pokémon, all he wants is to go in to a lonely place and live there with other clones, wich he manage to get for a while until... Guess what.... Humans ruined that too... In the end he "sets" free the clone Pokémon to go over the world once he realize that what they wanted and that others Pokémon would not discriminate them...
In the end it's not a Villain but a fruit the Human arrogance... Not born, but created... And all he wanted was to leave in peace... Alone... But humans wanted to use him as weapon...
I Love Mewtwo!
PS: Pokémon is in my family roots... My daughter and nephew also LOVES Pokémon, not only "like it"...
Pokémon, Star Wars, Harry Potter and Resident Evil are the pillar to a healty family rofl #JK
MEGA EDIT: What about a DITTO video?!?!?!?!?!??!?!
Heyyyy it's a good ideia =]
This sounds a lot like what happened to Jeff Goldblum in David Cronenberg's 1986 masterpiece The Fly. Let's cover that next.
Yes!
A real scientist would know that rare candies are bad.
I R O N Y
In the mangas, the scientists actually ran out of cells to fully form Mewtwo with, so one of them extracted their own cells and put it into Mewtwo. This is actually a very fascinating idea, as not only does it explain Mewtwo's humanoid appearance, but it also makes sense with it's psychology being an animal mentality with human emotions and intellegence.
What would you say to the idea of Mewtwo being part human?
In the manga, he is. They didn't have enough cells so they had to use human cells to stabilize it (or something like that)
Well until Johto after Entei burned Mewtwo’s DNA away from Blaine and getting rid of Blaine’s DNA from Mewtwo.
Yeah thats what I was thinking, I was just wondering how badly it would turn out in reality haha
@@Animemus Well, Entei did get Blaine rid of Mewtwo's cells but Mewtwo still has Blaine's cells, they are part of his biology. The Mewtwo cells in Blaine however were acting more like some sort of parasite who was slowly killing him.
This is your best video in a long time. Love this.
OBJECTION!! uppercut would not have been a super effective move on zubat with it being a fighting type move and zubat being a poison/flying pokemon.
That's footnotes worthy pal. 🤔
Should of been a thunder punch.
@@blazedgamingkr you are indeed...a super nerd!
I object your objection... you are assuming he used uppercut, if he is using strenght (or another normal type move) and has the ability refrigerate it would be a super effective (ice type) move
He made it super effective! He is Thor after all.
Pretty sure Mewtwo was a test tube baby in almost every canon
Mewtwo is too good that there's a Mewtwo part two
Mewtwo part 2: electric boogalo?... i can see the door, i'll let myself out
I didn't realize that you said random names at the end of videos until I watched some of the live videos. Even though it was random, it still took me by surprise and made me smile :)
But my question is, can I use this to make a Meloetta?
Yes officer, this comment right here.
I JUST WANT MY DAUGHTER PLEASE
No not possible I don't think anyways.
This is a pretty technical and complex procedure which you broke down and explained extremely well. Well done! Really enjoyed this video :)
"C'mon if its another zubat I'm gonna loose my sh--"
- Literally everyone of us playin pokémon back in the day
Me on the matter of Tentacools in surfed WATER •_•
According to the in-game lore, Mew is supposed to have the genetic material of all pokemon, and I think that would change the way you would approach tinkering with it's genetic code, since it isn't so much adding to it, but rather activating or inactivating which genes it expresses out of its natural gene pool, be it through removing genes from it or through epigenetic changes.
I know that the games say gene splicing, but it seems more likely to me that the scientists of the project would focus on gene expression and epigenetics because you don't have to change the DNA of every cell on an organism's body, just the expression, and thus is much more feaseable. Especially on a subject which already hosts all the necesary genes you would ever want.
In the real world techniques exist that let you turn on or off certain genes in lab animals, and I recently learned on a simposium that scientists are working treatments for humans that have a kill switch, so that you give the patient the treatment and if it works as intended then you leave it alone, but if it starts acting out somewhere it shouldn't or the effect isn't the desired one then you can give the patient a drug that destroys it and as long as they take it everything goes back to the way it was.
Lastly it is interesting to think about pokemon reproduction and the in-game mechanic of egg moves. In the games pokemon can reproduce with pokemon outside their own species, as long as the parents share at least one egg group. Sometimes if the male knows the right move the offspring will be born knowing said move, even if they can't learn it naturally through leveling up. If we think back to how mew has all the genes of all the pokemon it could mean that the different species we now have have been the result of different mew populatioms evolving (the darwinian way, not the pokemon way) into different species of pokemon, and that while over time most of the genetic material has been selectively taken out of the gene pool enough remains so that two different pokemon can breed and produce viable, fertile offspring that has the genes for those dormant moves activated and thus can use them in battle.
Wait... Is that what TMs, HMs and Move Tutors do!? Gene modification therapy to induce the expression of genes in the already existing genetic code of the pokemon!? It seems there is still a lot more we could speculate about pokemon genetics that just the cloning of Mewtwo.
Explain Missingno with Science! XD
Philip Dyer Think lovecraftian space brain
A bunch of bees?
But if Mew already has the DNA of all other Pokemon, would adding the genetics of other Pokemon even do anything?
I'm guessing it would. Think about our own ﹰDﹰNﹰA - its the result of random mutations over millions of years and as we evolve, some traits become more dominant over time. The weaker traits aren't necessarily lost completely but they get buried in amongst the other information. Mew might well have the traits for every Pokemon in its DNA but the traits for tail, pink skin, psychic power and adorable eyes have become dominant enough to give it its current form. If all its traits had equal dominance, then it would probably be a Ditto.
So returning to your question, although Mew might have Staryu and Kadabra traits in its DNA, they are recessive normally, so by splicing in more dominant versions from actual Staryus and Kadabras, they will reshape Mew accordingly.
At least MewTwo is not that scary than the Sonic movie
I'm mortified
at the lack of command of the English language?
Shots fired -- kH
@@becausescience Huh
@@joshuaivery3041 *r/woosh*
“tube kangaroo” honestly i love this man
Ditto mentioned, but not the fact he's probably a failed Mew clone?
Crossed xD even as a kid I thought that ditto looked like someone put a Mew in the microwave. And I did always find it suspicious that you could also use transform.
Hi Kyle, fun episode!
I was thinking about something that would help stabilize your theory a little. In Pokemon lore, Mew was essentially the first Pokemon and was created by Arceus to become/birth every Pokemon in the world. That, and the fact that it can learn Transform, would probably make clones from it a lot more stable or even easier to genetically modify, since all of its offspring are supposed to be unique Pokemon. You could think of MewTwo as the result of some sort of feedback loop, too; forcing the Pokemon that can only give birth to new Pokemon to give birth to itself would probably result in some screwy science.
Hummm this all makes sense for you to do Kyle, since your obviously a clone of thor with gene splicing of Bill Nye and Adam Savage. And now we all know your origin story.
Oh this was a fantastic episode! I'm really happy with the way everything was explained, especially the GMO piece as too few people are aware of their necessity.
Kyle, do you think you could do something on the "science" of the Warhammer 40k property in some respect? Like the creation of Space Marines or how the Orks have no physical growth limit? Or whatever you want to do, I just like the show. Keep rocking!
Any theories on why MewTwo n Mew look so different?
I was wondering the same thing. Maybe the scientists triggered an evolution of sorts with all the gene editing.
Different gene expression. There was a mutation in fly, that made her grow eyes out of her knees. Just during the stage of development, the body mistook its own body parts and made one gene to be expressed somewhere else than it shouldve...
Read the manga, he is mixed with human lol
In the game he was spliced so splicing made him look really different.
Great show as always! In Pokemon Silver the pokedex states that "Its DNA is said to contain the genetic codes of all Pokémon, so it can use all kinds of techniques." Would this have any impact on the ability to splice the genes into it? I would think that a pokemon that already naturally has all the genes in it would be more receptive to splicing those same genes to be more prominent.
I wounder if we'd be able to use grafting techniques to Frankenstein different elements from Grass types (should be classified as Plant type fight me) together to create new super Grafted Modified Pokemon (Hence forth known as G.M.P.'s) We'd probably also be able to just combine a large number of Grass types together, just think of how powerful a solar beam we could generate from a large fields of growing Glooms in parallel connections.
And we shall use these G.M.P's to combat all forms of pollution and the destruction of nature!
Grimer and Muk ARE the solution to pollution. Also, Type-Null is basically a Frankenstein already, grafted together to use the RKS system to take on Ultra Beasts as a Sylvally. Besides, why specifically a grass type Frankenstein? I could imagine a lot of other more useful amalgamations, and something tells me that Solar Beam's power is more dependant on the efficiency of the solar conversion, not the specific parts of Pokemon using the move.
Fun thing I learned about SCNT:
I did a paper last semester on de-extinction, or the process of restoring extinct species. Somatic cell nuclear transfer is one of the most popular theoretical methods for de-extinction. The catch is that it is only doable for cells that are fresh or relatively so and in great shape. This wouldn't allow us to play Dr. Wu, but we could maybe try to grow something older than a few thousand years if we got an extremely good specimen. So, not Jurassic Park, but Pliocene Park at the best.
I feel like Kyle is a bad Pokemon trainer...
Raichu, Staryu, Kadabra, and Vaporeon. On top of that actually uses escape ropes over having a Dugtrio?
He was basing the choices off Mewtwos appearance and abilites.
Don't call Mewtwo a armored tubed kangaroo :(
Hey Kyle, a punch (fighting type move) on a Zubat (a flying type pokemon) would not be super effective, in fact quite the opposite.
But, if Kyle has either the Refrigerate or Galvanize abilities and used Mega Punch or any other normal type punch, it would be super effective.
I cant stop focusing on the two lights reflected in each of Kyle's eyes. Now that Ive noticed it I cant unsee it and it looks like he has freaky spider eyes.
We have the army of Pokemons at your side...
*Me:* [run towards the strongest Pokemon in history and punches it]
IDK what Pokemon games you played, Kyle, but the sequence of events is ABSOLUTELY clear. Its explicitly stated that they found a *fossilized* eyelash of a Mew, and extracted DNA from that. This DNA was then used as a base for creating Mewtwo. At no point is there ever anything indicating in any way that the team of scientists encountered, much less captured, a live Mew.
Also, when they say "Mew gave birth" its very clear from the context in which it is presented that this isnt meant literally. (Again, they *never* encountered a live Mew) Rather, they simply meant that they managed to get a viable specimen to survive for and begin developing and growing in a test tube. Mewtwo was "birthed" out of a large glass tank.
YES!
Kyle, what's your level? You just OHKOd a Zubat with Sky Uppercut, a fighting-type move, that's not super effective. Actually you only did 1/4 of the damage, Zubat is Poison/Flying.
And I thinking that you only knew Rock Climb.
His level is B3CAU53 5C13NC3
12:22 thanx Kyle that would have bugged me all day. Great Pokémon episode. Now that the Mortal Kombat series is done what do you have planned next? Super powers you wouldn’t want 👀
Dittos are failed Mew/Mewtwo clones: change my mind...
Mewtwo isnt a clon.
@@endikaaspeurrutia1013 yes he is
@@Kiki-gs6ml in the first game it is clearly said that mew has given birth and has been named Mewtwo
@@endikaaspeurrutia1013 "Given birth to" could also mean "spawned from"...
@@Kyzoren no,
I think something that also has to be taken into account is how flexible some Pokémon’s genes are. For example, eevee is one of the most amazing Pokémon when it comes to genes. Pokédex entry in ultra moon states “Its genes are easily influenced by its surroundings. Even its face starts to look like that of its Trainer.” All the scientists would have to do is splice some of eevees genes into mewtwo and subject mewtwo to some harsh environments and we would get what we see in the games. This could also be why mewtwo is so tall, as it could copy the scientists height. Eitherway, this was a really good episode!
DON'T BE A ZUBAT
Edit: Oh good, it wasn't.
This has me thinking about genetic modification on grass Pokémon. I studied botany and plant taxonomy with a sprinkling of microbiology when getting my master's degree, so I did some research on plant gene modification. Lateral gene transfer is VERY easy to accomplish in plants, and even if the addition of the new genes would cause the plant to become sterile there's a process in plants called allopolyploidy, which basically means they can spontaneously double their genome and render themselves fertile again. This is part of why it's so easy to breed new cultivars of plants and cross breed crop species.
So I bet that genetic modification in plant/grass type Pokémon would be significantly easier than in Pokémon that are animal like. Especially since cloning of plants is similarly more simple, sometimes requiring only a rooting hormone for it to work.
Anyway, excellent episode! I love the show, thank you for doing what you do!
But Kyle, Dittos are failed attempts at cloning Mew/creating Mewtwo. So how could you use a Ditto as a "vector" for creating a perfect Mewtwo? 🤔
Also, you might want to use a MAX-REPEL to keep the Zubats away 😊👍🏻
I thought the whole Ditto being a clone of Mew was just a theory.
Hi Kyle, a very good start to cloning and G.M.O.'s. A couple of things I personally would have talked about though include things like retro-viral gene-therapy, and CRISPR, two different ways of introducing new genes into the cells. Not necessary, but would have been nice to touch on (Also, love the gene-gun touch, so much fun...)
One tiny correction I'd like to point out is that I think you have your order of operations a little bit wrong though. In order to get an organism as different as MewTwo is from Mew, it would have been nigh impossible to do so after birth, and so a much more likely scenario would have been they created the fertilized embros, grew them in a lab for a while, then performed the gene-splicing while they were still embryos, done testing on the resulting DNA of the cells to see if their genes were spliced correctly, and then re-cloned the resulting DNA. Then proceeded to do all of this process many many times, and only once they had what they believed to be the "perfect" specimen implant that one fertilized embryo into Mew to have it birth its clone.
This is essentially the same process that He Jiankui (Chinese scientist) claims to have used to create the worlds first genetically modified humans. Freaky, but cool.
That said, you mentioned there are ways to create our own "pocket monsters" which is entirely correct, and I've actually put some thought into it, and how one might go about doing things like creating hyper-intelligent sea-creatures. Most recently I had come up with a creature that combines traits of Cuttlefish (and other cephalapods), Bottlenose Dolphins, Walrus, and the Immortal Jellyfish, to create a creature that would be as intelligent or MORE intelligent than humans, has amazing tool-use capabilities, effectively immortal unless eaten or killed, can breathe air if needed, can talk and mimic sounds, can move-around in air for prolonged periods of time without drying out, can use ultra-sonic pulses to disorient prey, and even work cooperatively. Even though they would be almost entirely aquatic, this kind of a creature could really give us a run for our money!
Or even dragons... Combining a hexapod body, with lots of mammalian traits like intelligence, prehensile tails, wings like bats, with reptilian traits like spitting venom, insect traits like the bombardier beetle for spitting highly-corrosive self-igniting chemicals (aka, fire), etc... I think it's entirely plausible that people could create these kinds of creatures eventually.
Honestly the possibilities are almost endless, and I think that it's really just a matter of time before someone makes them a reality. Well... Either that, or we wipe ourselves off the planet first, because science!
You forgot to add a machoke dna so we could get a mega Mewtwo X.
And Mewtwo Y
@@abdulmuhaimin5274 mega mewtwo y is only psychic type
"You were so caught up with whether you could you never stopped to think if you should!"
Seems like school did its job. Or at least the biology prof. because i was like yep knew that.
"Oh, *Son Of A **_GLITCH!"_*
I subscribed 20 minutes ago and got a notification.
THE CONTENT TRAIN KEEPS A ROLLIN -- kH
7:10 not sure if that was an ice punch or thunderpunch.
So..... did you pick Ditto as a Vector because it was a failed Mew Clone and would be the Pokemon equivalent of the "other 840 attempts"? Also, with "horrific gene splicing experiments" you can pretty much use that itself to explain the physical differences.... for example, they could've even used human cells for the experiments to see what would happen.... it's also possible that some of its body is artificial material created to hold the creature together when experimentation when horrifyingly wrong.... I'm saying that because (outside of the live action film) its tail and rest of its body are two different colors and look like they were put together rather than.... grown at the same time.... so why couldn't some or all of the body be an artificial shell that was created to hold the decaying body of Mewtwo inside with the head of Mewtwo being held together (explaining the ear differences), the back tube essentially providing nutrients from an artificial stomach setup, and the tail perhaps being a portion of the original body that survived (it might even be everything except the arms and legs which were attached to the much larger artificial shell so it could walk without much alteration) I'm just theory-crafting some explanations as to why it looks like a bigger and more badass version of Mew, and it could very easily have a lot to do with that it was a near perfect clone that, through gene splicing and tampering could've become incapable of surviving any longer.... but that's my personal thoughts after seeing this video.
Couldn't post on last video but,
Hey, if we some how be able to build instruments made of quantumly entangled particle such that obervations at one end instantaneously re created or observed at other entangled end then we in theory could observe WHAT'S INSIDE SINGULARITY, CENTER OF BLACK HOLE. or at least get some information out something that won't even let light out of its grasp
But can science fix Sonic?
If you take nuclear physics and weapons engineering to create a nuke powerful enough to wipe out the entire earth.....yes.
Or just a big enough E.M.P generator and reboot the whole internet...
Only reshoots could do that -- kH
Kyle: etc etc fancy science jargon
Me: ... Mew has eyelashes ?
Also kinda bummed out that I only found this channel now and the last upload was 2 years ago :/
go to kyle hill channel he makes videos there now. This channel's owned by nerdiest.
Your moveset is
Rock climb
Power up punch
Future sight
Ice punch
Thunder punch would be more thematic.
Take the last two moves and replace them with Sky Uppercut, and Submission and you have a realistic move set for Kyle Hill
Loved this episode, as a molecular biology background I can say you explained it very well.
The only thing I'm thinking is the pokémon involved, because the traits of mewtwo are not really found anywhere in gen 1. If you extend it however : The hands and feet could be from seismitoad, the legs from breloom. This could mean that the creators of mewtwo knew about all other zones of pokémon but decided to keep it secret from us :o was gallar region leaked in gen 1?
Just to clarify: somatic cell nuclear transfer is the cloning method you've mentioned in the past that could be used to bring back the woolly mammoth using a modern elephant, correct? Also:
>Kadabra, not Alakazam
>Staryu, not Starmie
“I took *ONE STEP* -Oh it’s a zubat not even worth it...”
0 comments! If I type fast enough, I might get into footnotes! D:
Nah, if you want into footnotes you need to a) make a comment or correction relevant to the video and b) getting a lot of likes and comments seems to help to but doesn’t necessarily mean you will get in.
And sometimes KH will just jot a quick response if it’s a short enough answer.
@@NinjaBearFilms NOOOO! I had one shot. I failed. NOOO!
@@guyclykos You could alway just, you know, edit your comment.
@@durandol Genius!
@@NinjaBearFilms You figured me out -- kH
Loved all the Pokémon references. It is always a Zubat (except when it’s a Geodude) and any Grimers is too many.
Wouldn't be better to modify the genes before the insemination process?
Rodolfo Antonici And higher the Risk of abortion? heck nah
There was one Mew and its neutral now so... yeaaaaaaaaah...
I was hoping that this was going be a video of how we could make an actual Mewtwo (or at least a creature that looks like mewtwo) in real life, but I love this too.
Someone is gonna point out that it's not /poe-key-mon/, but the é is supposed to sound like the 'e' in 'pocket', because they are pocket-monsters. But as long as you know this, I don't really care how you pronounce it, as long as you're consistent.
The way you explained how to theoretically create Mewtwo just sounds like breeding the perfect Pokémon for battling. You want the best IV’s, EV’s, and personality depending on the Pokémon.
Nice little dig at anti-GMO marketing. Perhaps you could expand on the topic a bit more in a footnotes episode to help people understand just how misleading and harmful it is.
Hey Kyle, another cool episode, so thanks for that. Now I was wondering, is the process you decried, adding genes to something to make whatever animal, I guess you could say custom, would you go about that using the crisper technique that we have heard you talk about. I ask because I’m not sure and it kind sounds like how you have explained crisper to us in the past. Thanks again and keep on keeping on with the awesome content.
Hi, love the show and I wanted to say that in school we are learning about genetics, specifically designer babies. We learned that it can be hard and sometimes bad. One thing that can occur is one part of a gene is replaced with a “good gene” but can implant a bad personality trait as many scientists don’t know how to change that.
I believe mewtwo's moveset is the end results of the experiments that were done on him and what was needed for him to survive. Psychic so that his mind could stay intact and focused, barrier for protection as previous iterations would have been fragile or weak, recover for the eminent damage of said experiments, etc.