Paralyzed Mice Walk! [Dr. Samuel Strupp, Bioactive scaffolds]
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- Опубликовано: 30 ноя 2021
- In an incredible scientific publication, Dr. Samuel Stupp and his colleagues at Northwestern University demonstrated recovery from traumatic spinal cord injury in mice using Bioactive scaffolds with enhanced supramolecular motion.
The article I am discussing was privately requested directly from the author
Citation: Bioactive scaffolds with enhanced supramolecular motion promote recovery
from spinal cord injury
Z. Alvarez1,6, A.N. Kolberg-Edelbrock1,2, I.R. Sasselli1,4,†, J.A. Ortega1,3, R. Qiu1,4, Z.
Syrgiannis1,4, P.A. Mirau7, F. Chen1, S.M. Chin1,4, S. Weigand8, E. Kiskinis1,3, S.I. Stupp
Selected sources:
IKVAV: onlinelibrary.wiley.com/doi/a...
How the extracellular matrix shapes neural development: royalsocietypublishing.org/do...
Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains: www.liebertpub.com/doi/10.108...
Basso Mouse Score: www.researchgate.net/figure/T...
Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration: www.ncbi.nlm.nih.gov/pmc/arti...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. 
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My son was a victim of an armed robbery and shot 3 times. He is presently paralyzed T10. He has sensation and a long road. I told him that I didn't know how but I know for a fact he will walk again in his lifetime. This research gives solid hope that progress is being made. So many are suffering and this medical advancement would be a blessing for the patients and their entire circle of caregivers. Thank you.
I'll post an update on my channel if there are any results from human trials.
@@DrBrandonBeaber Thank you. I have noticed their is zero information available on where they are on FDA approval or the start of human trials. We are really on the brink of new solutions.
Who can we contact if we are willing to participate in those trials.
You lied to your son. It will never happen this technology will never come.
@@vincentwiese8414 How are you so sure? Sounds like you have lost faith for medical advances and natural healing
As a spinal injury patient for the last 6 years this is a ray of hope.coming date in india🙏🙏
:)
Reply me Sri please
Kab aayegi india mein sekhar ye dawai
I would love to walk again it's been 4 years now and I wouldn't wish this on anyone
This isn't the first time that I've seen a Company inject paralyzed mice then amazingly they can walk again. All this does is crush the HOPE of my fellow MSERS. BIG PHARMA will stop the FDA to approve it anyway. Still trying to wrap my head around the fact that the US and Canada doesn't allow the procedure HSCT. ( Because of Big PHARMA ) My wife had it done in Mexico on 3/1/19 and her bladder and bowel system is working fantastic now. Blessed.
Glad to hear your wife is doing well.
Excuse me what...? I've had bowel, bladder issues & sexual dysfunction since 2016 due to an SCI. Please tell me this is true.... where can I get it done in Mexico?! You're talking about stem cells right? Please let me know which institute and who to contact. Thank you!!!
This could be the solution for all the symptoms that I’ve been dealing with since so many years ago!! Please let us know the name of the institution and where’s located please!! Thanks!
Does your wife have MS or did she have a spinal cord injury?
Hsct in mexico only for ms..NVG 291
Is designed both for SCI and MS
Please make some successful treatment available for spinal cord complete injury please we wanna walk again please
Please look into treatment with trehalose that helps cells autophagy. Mice trials showed success as well. And I have came across people saying they are on trial with trehalose and doing much better.
Where are those trials taking place?
Thank you Dr. Beaber. Through participating in the elezanumab trial I have been thinking of Spinal Cord Lesions and the lack of ways to slow them down during an active relapse. I thought that a separate opportunity to see if the drug could work for MS, if administered during a relapse to see if some repair is possible for spinal cord lesions.
Elezanumab is not going forward with MS, but was excited to see this video to see more research toward spinal cord injury. It may be a long while until it gets to MS, but all research starts out with mice. It’s a start.
My spinal cord lesions are all old, but I have kids and there’s more people loosing capabilities due to spinal cord lesions with active MS. So I’m concerned about the future of MS treatment. It’s exciting yo see this research. Thank you.
(I was in the placebo group)
I saw him last month and he's very optimistic it will work in humans!
You saw who last month?
@@vincentwiese8414 Dr. Strupp!
@@justrollwithjesus and where is he now? With Research? Are they doing human clinical trials?
@@justrollwithjesus how did you contact him?
Found out this story is nothing but BS.
Doctor, this is phenominal news! Thank you so much for sharing this local news since there was an additional article over msnewstoday from Australia 🧡🧡🧡
I was paralyzed from T6-T7 at 21 from a snowmobile accident and I’m now 25. I’ve always seen advancements in areas such exoskeletons and such, but those don’t interest me nearly as much as being able to FEEL again. If I could never walk again but feel, I’d choose that. Obviously I’d love be fully cured but this is exactly the type of treatment/cure I’ve been hoping for. I only hope they’re able to find a way to help those who have been paralyzed for prolonged periods rather then needing an immediate treatment. Even when I had my accident it took almost 48 gruelling hours before I was brought in for surgery.
Hopefully this research will lead to life-changing treatments for people like you and many others.
Yes I read about this… I’m glad you touched upon it. #Sharingiscaring
That is incredible! We have come so far... still a long way to go... but this is promising!
Thanks for sharing this. Fascinating to me
Glad you enjoyed it Donna.
Certainly, I have been hearing about these breakthroughs for 20 years, the only breakthrough is to the scientists income by the funding they receive at the injured expense
I saw a similar result in mice by using Lucid-MS.
How does that one work?
Thanks Doc.
😌🙂
Hi Dr. Brandon, thanks for putting this video together. Has there been any update to human trials in the last year?
Not that I am aware of. I will make a new video if I see a published trial with this technology.
Very interesting publication .. Quick Question: Is FGF-2 in use in a drug (on or off label) or under investigation in a MS study to your knowledge ....
I am waiting for this 😭😭😭
Which year this injection come to in hospitals and pharma.
How can I will get this injection and how can I will attempt trial.
Exciting news!
Indeed. I was enthused to see this article. I'm surprised it didn't get more press.
I'm ready
Dr. Beaber, I am a first-year undergrad student reading this article. I love your video because it helps me understand it much better!!! However, it seems to me that for the question you raised at 8:50, the researchers provided a reason for the difference in bioactivity between FGF2-PA1 and FGF2-PA2 on page 7?
Also, just a clarification for 0:03, it is Dr. Stupp.
Great stuff. Still SC nerve regeneration in people with MS seems to be a big challenge, only Terry Wahls can pull that one of. Is it stupid idea to cut off some scarred nerve edges in people with MS before injecting the scaffolds. Or is neurosurgery far from doing something like that. Many thanks for the vid!
It's hard to say this research is directly applicable to MS, but in theory, MS should be more treatable than traumatic injury in the sense that axons are often preserved. Remyelination should be more straight forward than any process involving axon sprouting or cell proliferation.
@@DrBrandonBeaber why do you refer to
Him as Strupp..everything looks like Stupp ..?
Also other labs uphave done scaffold therapy..
But NVG 291 is doing FDA trials for ALZ..SCI..MS
They have done SCI..ON..EAE rejuvenation
Based on 3 breakthroughs..with a peptide.
Seems too good to be true..check it out.
@@barbaradascalos4411 Thanks. I think I messed up the name because I confused him with a different scientist named Samuel Strupp: www.semanticscholar.org/author/Samuel-Strupp/8273631
I am spinal cord injury 6 years 2 months ago. I hope coming date. 🙏 I am North East India. Manipur
I hope this research gives you some hope for future advances
@@DrBrandonBeaber Thinks Dr. Please help spinal cord injurys.
Hi sir my name is niranjan alapati, i am from India
5 years back i had a accident d7,d8 spinal cord compress from then I am totally on bed and no treatment from then because my family can not afford my treatment so I want to be a part in clinical trials for this medicine so please can you help me?
So do they think that this will work after 3yrs? I had lumbar surgery and woke with paralysis in both legs. One leg came back within a few days, other leg still has partial paralysis. I also have MS. There was no indication of any relapse. Rather my MS is now progressive. With mind over matter by tying that leg/foot to pedal of recumbent bike, I started to get get muscles working in that leg. But I am petrified that one little sickness that keeps me in bed longer than a night, I will be back to square one. As I continuously take 1 step back every single night when sleeping by not using it
Hello guys, we are at the end of 2022. Will these injections be used? If anyone knows when they will be used, please tell me because I have been suffering from paralysis for a long time.
They are still doing trials. I think around 2025/2026 unfortunately
Interesting...giving my neuro nurse a call
Any update on human trails yet
Not to my knowledge unfortunately.
My spinal cord injury t3
6 year
Wow!
Has FDA approved yet?
This has not yet been studied in humans
Any updates?
Not to my knowledge
@DrBrandonBeaber
I wonder if this combined with NVG-291 could be an even more effective spinal cord repair therapy.
Well thanks for your response and for all the great MS info, doctor.
बहूत खूब मै भि स्पानल कॉरड इंजूरी हू
Wow! :o
Do you think it will work in ms or is it just empty information?
I doubt it would work in MS in its current form, but this type of research could lead to future CNS repair technologies which could be more broadly applicable.
@@DrBrandonBeaber everything is negative for ms it's not a savior it encourages suicide ms
I am sorry that you think suicide is an option. Please seek help to minimize suicidal thoughts and to focus instead on what you are able to do for yourself or for others who need help. I care about you and your life. You are unique and special so focus on the good you can do, no matter how small. 💕
@@suzanneknepp849 I don't want to be disabled, let them find it, then how long will such a ridiculous order continue?
@@suzanneknepp849 nothing is more important than human health. Even the money to be earned thanks to ms is nothing compared to human health.
nervgen
Please reply my comment I want to come our own risk for trial
Do you have a spinal cord injury?
@@Danny-he4hi yes D3D4 complete injury 13 month
@@bhagvanpatidar6399 do you have an email? I can send you the links to the institute that is doing this research and also a stem cell clinic in the States that can help.
When start to the human body
Do you know when they're going to release dancing molecules to the public?
There is not yet a successful trial in humans, so we will have to wait on this.
@@DrBrandonBeaber I pray to God it works on humans. I was diagnosed with an autoimmune disease 2 years ago which paralyzed my legs.
His name is Samuel Stupp. There is no r.
👍🏻👍🏻👍🏻
Yeni tedavimi çıkdi kesın çözümü🇹🇷🇹🇷🇹🇷
News about people???
👍👍👍👍👍👍
Have you sworn not to find a cure for MS?
Biall
I have seen this kind of different Che..t sance 30 years ago no-one is real work just lies and lies sorry someone get to sais the truth
Honestly sick of hearing about these apparent breakthroughs! I have been hearing this for the last 20 years without further progress in Humans.
Only Dr's and scientists receiving funding to mess around at the expense of the injured.
Get this done in humans ASAP or shut up
I can certainly understand your frustration. Unfortunately there is no guarantee that any individual treatment will pan out in real life.