Friendly Neighborhood Immunologist
Friendly Neighborhood Immunologist
  • Видео 30
  • Просмотров 793 418
Guillain barre | Molecular mimicry
Guillain barre is the main cause of short-term muscle weakness or the short-term inability to move your muscles. It is primarily caused by the bacteria Campylobacter jenjuni which is found in undercooked, infected chicken. One to three weeks after your immune system fights off the infection, the immune cells begin to target the nerves. This is due to molecular mimicry. The bacteria has a protein that looks almost exactly like the coating of your nerves. Therefore, the B cells, T cells, and macrophages begin to destroy the myelin coating around nerves and even destroy nerves themselves. Nerve destruction leads to the inability to move. Removing the antibodies that the B cells make seem to ...
Просмотров: 2 462

Видео

How does Lyme Disease Happen?
Просмотров 847Год назад
Lyme disease is caused by black legged ticks also known as deer ticks. Lyme disease happens because ticks drink bacteria-infected blood from deer and mice in the wild. The deer and mice have Borrelia bacteria in their system which transfers to the ticks. Then when the ticks bite humans, the ticks transfer the bacteria to people. If caught quickly and treated with antibiotics, Lyme Disease can b...
T cells | Immunology Lecture | MHC-I versus MHC-II
Просмотров 3,8 тыс.Год назад
This lecture is about T cells and major-histocompatibility complex I and II (MHC-I and MHC-II). The video will go over how T cells and antigen presenting cells fit together and activate. We will discuss where proteins come from to load into MHC-I (the cytosol) and MHC-II (vesicles). Furthermore, I will discuss the differences between CD4 and CD8 T cells. We will also cover positive and negative...
Immunology Lecture 5 | Pathogens and the immune response
Просмотров 2,7 тыс.Год назад
Immunology lecture 5 is about pathogens and the immune response. Specifically the life cycles of bacteria, the Gram-stain, life cycles of RNA and DNA viruses. Then we will talk about which parts of the viruses and bacteria bind to toll-like receptors. Lastly we will cover other innate immune mechanisms of killing pathogens including reactive oxygen species such as superoxide and hydrogen peroxi...
Immunology Lecture 4 | Cytokines and Chemokines | Toll like receptor signaling NFkB
Просмотров 10 тыс.Год назад
This lecture is about cytokines and chemokines as well as the toll-like receptor pathway. We will focus on Myd88 and NFkB and how toll-like receptor engagement causes most innate immune cell inflammation. The second half of the lecture will be about individual cytokines such as IL-1, IL-6 and TNF-a.
Immunology Lecture 3 | Innate immune cells | Leukocyte rolling adhesion
Просмотров 3,7 тыс.Год назад
This is immunology lecture 3. We will cover innate immune cells including macrophages, neutrophils, basophils, and natural killer cells. Importantly, we will also cover how immune cells leave the blood stream and enter tissue, a process called leukocyte rolling adhesion. Here's a link to my favorite video about real immune cells during leukocyte rolling adhesion. ruclips.net/video/Ys6RlglMTMg/в...
Immunology Lecture 2 | Primary and Secondary Lymphoid Organs and Blood (Hematopoiesis)
Просмотров 7 тыс.Год назад
Immunology lecture 2 will cover both the primary and secondary lymphoid organs and the components of blood. We will briefly cover innate and adaptive immune cells, as well as granular versus agranular cells. Additionally, you will find information about hematopoiesis.
Immunology Lecture 1 | Brief History of Immunology
Просмотров 15 тыс.Год назад
Welcome to my immunology lecture series! There will be 10 lectures about immunology. The first lecture will be a brief history of Immunology, including the discovery of the microscope, the smallpox vaccine, the cholera vaccine, and the polio vaccine. Additionally, we will talk about the discovery of antibodies and passive versus active immunity. The remaining lectures will be about Neuroimmunol...
Prion Disease | How does Prion Disease Happen
Просмотров 115 тыс.2 года назад
Prion Disease is caused by a single protein that makes a mistake and misfolds. If you want to know how Prion Disease happens then this video is for you. I will go over the top 3 most likely ways a person can get Prion Disease, what Prion proteins do in the body, and the role of the immune system in Prion Disease. Here are my sources: www.hopkinsmedicine.org/health/conditions-and-diseases/prion-...
Vitamin D and the Immune system
Просмотров 28 тыс.3 года назад
Vitamin D and the immune system work together. You might be surprised that vitamin D can boost and suppress the immune system. Vitamin D can boost primitive defenses of macrophages (Cathlecidin, LL-37, and Beta Defensins. However it reduces classic inflammatory cytokines like IL-1beta, Il-6, and TNF-a. Vitamin D also suppresses the adaptive immune system, B and T cells. This means that high lev...
ADE | What is Antibody Dependent Enhancement
Просмотров 18 тыс.3 года назад
Many people are wondering what is Antibody Dependent Enhancement or ADE. Antibody Dependent Enhancement (ADE) is a second key for a virus to enter your immune cells. Viruses have spike proteins that allow it to enter one or two types of cells like lung cells or neurons. That is the first key. If antibodies bind to a virus in a non-neutralizing way, the virus can enter immune cells called macrop...
How scientific papers are published
Просмотров 1,8 тыс.3 года назад
You might be wondering how scientific papers are published. I have published 12 scientific papers, and I can tell you the 7 steps need to publish a scientific paper. I have been accepted and rejected from scientific journals, and I will even show you my reviewer comments from two of my accepted papers. The review of research by other researchers is called peer-review. One peer reviewer is kind ...
A little bit about me
Просмотров 4,1 тыс.3 года назад
Hi! This is a video about my background, education, a few personal things. Hope it's interesting and helpful. B.S. Microbiology 2006 Ph.D Microbiology 2007-2012 - Studying T cells, microglia and bacteria Post-doctoral research 2012-2016 - Studying Alzheimer's disease and microglia Visiting Assistant Professor 2016-2021
APOE2 | APOE2 Longevity and Alzheimer's Disease
Просмотров 6 тыс.3 года назад
APOE2 is an important protein in the brain. APOE2 has been found to increase longevity in people as well as animals. APOE2 has been found to reduce the risk of Alzheimer's disease. The video is a requested video about doing a deep dive into APOE2. Overall, APOE2 reduces total cholesterol and increases activity which could be why people with APOE2 live longer on average. Review Paper APOE2: mole...
Natural Killer cells | Top 5 ways Natural Killer cells work
Просмотров 39 тыс.3 года назад
Natural killer cells are unique immune cells that kill virus infected and cancer cells. In this video, I will draw the top 5 ways Natural Killer cells work for you. Natural Killer cells are related to B cells and T cells, and interact with your "name tag," the MHC-I receptor that is on all of your cells except your red blood cells. The Natural Killer cell will spare any cell with your name tag,...
Valneva | How does Valneva work
Просмотров 19 тыс.3 года назад
Valneva | How does Valneva work
Autoimmune Encephalitis | What is Autoimmune Encephalitis
Просмотров 28 тыс.3 года назад
Autoimmune Encephalitis | What is Autoimmune Encephalitis
T cell memory | CD4 and CD8 T cell memory
Просмотров 42 тыс.3 года назад
T cell memory | CD4 and CD8 T cell memory
APOE4 | APOE4 versus APOE3
Просмотров 16 тыс.3 года назад
APOE4 | APOE4 versus APOE3
Novavax | How does Novavax work?
Просмотров 299 тыс.3 года назад
Novavax | How does Novavax work?
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
Просмотров 6 тыс.3 года назад
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
Просмотров 23 тыс.3 года назад
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
How do allergy shots work? | Th2 cells and IgE
Просмотров 20 тыс.3 года назад
How do allergy shots work? | Th2 cells and IgE
Why do allergies happen? | Immune cells and allergy
Просмотров 6 тыс.3 года назад
Why do allergies happen? | Immune cells and allergy
How does the immune system fight Cancer
Просмотров 20 тыс.3 года назад
How does the immune system fight Cancer
Don't want cancer? Be an elephant
Просмотров 3,6 тыс.3 года назад
Don't want cancer? Be an elephant
How does thrombocytopenia happen | Low platelets and the COVID vaccine
Просмотров 27 тыс.3 года назад
How does thrombocytopenia happen | Low platelets and the COVID vaccine
COVID Vaccine side effects are Good! *Mostly
Просмотров 2 тыс.3 года назад
COVID Vaccine side effects are Good! *Mostly
Don't take Tylenol before COVID mRNA vaccine
Просмотров 3,6 тыс.3 года назад
Don't take Tylenol before COVID mRNA vaccine
How does the COVID mRNA Vaccine work?
Просмотров 19 тыс.3 года назад
How does the COVID mRNA Vaccine work?

Комментарии

  • @ronstephenson4899
    @ronstephenson4899 5 дней назад

    Excellent discussion!

  • @angelitorivera6976
    @angelitorivera6976 6 дней назад

    Fantastic video! Thanks!!

  • @vanessaannmiller
    @vanessaannmiller 7 дней назад

    Is there a certain point where removing the lymph nodes and using stem cell therapy to reestablish healthy cells would be too late?

  • @roreetinkerbell6893
    @roreetinkerbell6893 7 дней назад

    Can you do a video on Herpes encephalitis and about the spinal cord, tests and treatments please?

  • @rhyntaler6211
    @rhyntaler6211 10 дней назад

    Isn't pfizer working on vaccine, already in phase III, hopefully ready for 2026?

  • @Menstral
    @Menstral 12 дней назад

    1) this was a fantastic video, cogent & thorough. Subscribed! 2) if there are 3 ways to spread dysfunctional prions, then cannibalism (BSE or Kuru) involving the consumption (of the spinal cord or brain) seems to be the "on steroids -mega-super-effective" way to 'best' facilitate the transmission of ANY bad/rogue/defective prions (to unaffected individuals), no matter which of the 3 ways they were created. 3) when an infected dendritic cell dies, does this always result in the spread of extracellular PrP-sc to other dendritic cells, or is there any way this chain of infection can be stopped? 4) my roommate and I, as non-militant vegetarians, had great hopes that vCJD would take out a few billion, but no such luck. Ebola let us down, along with numerous other disappointments involving the quick and easy dispatch of unproductive homosapiens. As a statistician, the 'unspecified virus of unknown origin' was clearly a non-starter, because right from the first batch of information, the lethality without the presence of the multiple other co-factors was tiny.

  • @Logan2009ful
    @Logan2009ful 12 дней назад

    I learned that with HIV virus packs his bags and moves in a healthy cell and bind and becomes the Exact replication of a healthy cell. Can killer cells even spot those unhealthy cells as well?

    • @Logan2009ful
      @Logan2009ful 12 дней назад

      Nevermind you covered it 😂😂😂❤️ in number 4 killing the dna 🧬 and rna and number 5. ❤thanks this video is awesome 😎

  • @theascott1656
    @theascott1656 13 дней назад

    This was so so helpful - thank you so much!!!!!

  • @devinnewman2397
    @devinnewman2397 15 дней назад

    Looking this up since chronic wasting disease is on the rise in deer, and obviously a lot of people like their yearly deer meat.

  • @felicitydeikos5250
    @felicitydeikos5250 21 день назад

    The Bible does mention that very old viruses will return, more stronger, because lab pros and medical industries don't leave it to God. Which is why all acient deadly diseases will come back.

  • @felicitydeikos5250
    @felicitydeikos5250 21 день назад

    In the bible, Leprosy was the first discovered diease.

  • @viktorialang1922
    @viktorialang1922 23 дня назад

    very good,tjank you

  • @richardburklin4861
    @richardburklin4861 24 дня назад

    T CELLS FOUR OF THEM ! CAN YOU COUNT THEM ? T HELPER , T CYTOTOXIC , NATURAL KILLER , T Suppressers THANKS ❤ BUDDY

  • @Meathed.fitnessmedia
    @Meathed.fitnessmedia 26 дней назад

    Liver king

  • @andromedagalaxy9729
    @andromedagalaxy9729 Месяц назад

    Great❤

  • @Able11_
    @Able11_ Месяц назад

    This was sooo educational but also my fear is unlocked now

  • @bergalicious911
    @bergalicious911 Месяц назад

    Aight. So if I still don’t have this in 20 years, I just take it that I don’t have it 😂 🙏 another 20 years to go

  • @ML-or2ot
    @ML-or2ot Месяц назад

    So will vit d stop me getting inflammation and therefore stop my psoriasis flare ups ?

  • @emmanuelhamilton9503
    @emmanuelhamilton9503 Месяц назад

    you're the most beautiful scientist I've ever seen😍. I never new I was interested in prion disease until this day. I watched the whole video, couldn't look away.

    • @corvidae2741
      @corvidae2741 Месяц назад

      this comment is weirdly horny for being under a video about prion disease. your mind must he a fascinating place.

    • @emmanuelhamilton9503
      @emmanuelhamilton9503 Месяц назад

      @corvidae2741 how is it horny? all I'm saying is I watched the entire video, and it wasn't because I was interested in finding out more about Prion Disease. don't you get compliments? figures😒

    • @corvidae2741
      @corvidae2741 Месяц назад

      @@emmanuelhamilton9503 'god your just so hot i HAD to finish this video about a topic i dont care about. Is this woman discussing an interesting topic in the medical field in a way i could understand? WHO CARES! Shes hot!' and, of course, 'its just a compliment, geez!' you know women are more than their physical appearance, right? or, no, based on your comment and response all you got from the video is 'woman hot'. Dont admit that the only reason you watched a video was due to the presenter being 'beautiful' if you dont want people assuming your shallow and objectify woman. I pity any woman who has to deal with you in a professional setting.

    • @blurayz3
      @blurayz3 20 дней назад

      @@emmanuelhamilton9503 Yeah not really a compliment. Definitely creepy to go 'I don't give a fuck about you educating people on terrible, fatal, degenerative illnesses. I just watched you because I think you're hot.' Stop presuming women want commentary on their appearance 24/7.

    • @gabrielreinalter2269
      @gabrielreinalter2269 14 дней назад

      @@emmanuelhamilton9503 Very simply because you see a woman on the internet and feel the need to tell them how incredibly beautiful they are, instead of talking about the very clear reason why they made it in the first place. You might see that as a "compliment" when most people will find this to be creepy

  • @monisiay
    @monisiay Месяц назад

    Thank you for sharing your knowledge for free. Your teaching style is amazing and the information you’re presenting is so helpful. I’m a biomed phd student trying to not get lost in the overload of new information that I’ve never needed to know before about cell signalling cytokines and cancer. I greatly appreciate people like you sharing knowledge in a very digestible and useful way. I’m amazed by your content so far!

  • @_Trakman
    @_Trakman Месяц назад

    ApoE e3/e3 genotype - just learned from a DNA test - school me on what to do - I already have metabolic disorder, HBP, pre-diabetes, 23kg overweight, Low T and Sleep Apnea

  • @PueMonTen
    @PueMonTen Месяц назад

    ...did she really just say "Thankfully it's incredibly rare but increasing" WHAT DO YOU MEAN THANKFULLY IT IS INCREASING

  • @ansuanil6439
    @ansuanil6439 Месяц назад

    Hi, Thanks for this video. Recently did the nk cells and came low. Planning to do the IVF. Whether I have to correct the NK cells before the procedure. Please reply. Thanks in advance.

  • @BrendanReilly-v1r
    @BrendanReilly-v1r Месяц назад

    What is TGF-b role in the immune system and why would be indicative of if increased in lab work?

  • @porkchop2218
    @porkchop2218 Месяц назад

    So I took Tylenol 8 hours after the vaccine because I had a fever 103.7 did I mess up?

  • @devonholbrook3603
    @devonholbrook3603 Месяц назад

    How much did you get paid by Billy for this ???🙄

  • @francinejones2524
    @francinejones2524 Месяц назад

    What a scary scary illness. I’m sad for anyone that has gone through this with a loved one.

  • @matthewhouston1855
    @matthewhouston1855 Месяц назад

    Why does she sound like AI? GREAT INFORMATION but I just feel like she's going to tell me to "download Top War to my mobile phone" when she's done

  • @daryldixon5587
    @daryldixon5587 2 месяца назад

    So when you consume a like species spinalcord/brain can the body not break down the prions within and they have a higher chanc eof misfolding in the digetsive system? I'm not understanding how that leads to more. Doesn't someone have to already be effected by a misfolded prion in order for them to transfer the disease through cannibalism? Or does it have a higher chance of misfolding after death??

  • @我爱猪肉
    @我爱猪肉 2 месяца назад

    You should try using DaVinci Resolve as your editing software.

  • @danielpfaff1802
    @danielpfaff1802 2 месяца назад

    So I could be a zombie but I'm alive with the prions made me alive because prions? I literally should be dead from the life I lived but I just keep going....

  • @AdityaRaj-zk9eh
    @AdityaRaj-zk9eh 2 месяца назад

    thanks alot

  • @renewalguys1852
    @renewalguys1852 2 месяца назад

    Great video! I am a 3/4. I am 53 year old and had a heart attach at the age of 47. are you able to keep your cholesterol low? If so what diet?

  • @rkmugen
    @rkmugen 2 месяца назад

    I'm not a scientist, but I know after doing some very, very light reading that prions are resistant to conventional autoclaving, and even ionizing and UV radiation -- that's absolutely crazy to me. One Google search later, and i see that the Virginia Department of Wildlife Resources stated that temperatures of 900 degrees (C) and up can reliably destroy those little buggers. Now, how that can be applied to treating a prion disease in a living being... I've no idea. Maybe a direct strike from a bolt of lightning (5 times hotter than the surface of the Sun...)? No. *NO.*

  • @kotosqoposrly
    @kotosqoposrly 2 месяца назад

    Thanks so so much for this!!

  • @icarephysio
    @icarephysio 2 месяца назад

    Thank you for this. how did the microclots develop due to covid and the vaccine?

  • @fabianwahle5119
    @fabianwahle5119 2 месяца назад

    still here waiting :-)

  • @johnx9318
    @johnx9318 2 месяца назад

    Stop eating carbs and seed oils.

  • @Risingphoenixx66
    @Risingphoenixx66 2 месяца назад

    Hello,greetings from Europe. Started today with 2000 iu D3. I have Myasthenia Gravis ( since1984) had a Thymectomie. I,ve read some studies where patients reduced their symptoms with D3. I,m scared to take more to be honest. This is an older video so i don,t know if you will read it. Could you please be so kind to give your opinion? Thank you in advance

  • @geethasingh8584
    @geethasingh8584 2 месяца назад

    THANKS FOR SHARING ❤ I HAVE BEEN HAVING BRUISING AND BLEEDING GUMS FOR SOME IVE BEEN TO DR BUT NOT MUCH WAS DONE OR SAID ❤GOD BLESS YOU ❤

  • @Mr.G626
    @Mr.G626 2 месяца назад

    Hard pass

  • @Tinyteacher1111
    @Tinyteacher1111 2 месяца назад

    It’s not always from a tick. It can be from any biting insect. My worst Lyme infection is a LIVE the Babesia Mycroti (like malaria) you mentioned. I also have several others. I’ve been sick for 2 years on treatment. I hurt all over! I also had mold toxicity and breast implants, which I’m finding is a common trail of infections.

  • @lindaHalt1916
    @lindaHalt1916 2 месяца назад

    Thank you so much for this valuable info.

  • @carlosromancastaneda1138
    @carlosromancastaneda1138 2 месяца назад

    Be very careful and evaluate people well before starting Allergen Specific Immunotherapy. I developed Relapsing Polychondritis with renal involvement in the form of mesangial nephropathy, which has evolved into fibrosis and glomerulosclerosis leading to renal failure, during the course of applying SIT with a member of CONICA, COMPEDIA in Guadalajara. There are certainly several reports in the medical literature about the induction of autoimmune diseases during SIT. SIT aims to reduce allergic symptoms by providing tolerance to peripheral T cells through the induction of regulatory T cells. By stimulating Treg cells, the Th1-Th2 balance shifts towards Th1, leading to substantial changes in the T cell cytokine profile, increasing the synthesis of IL-2, IL-12, IL-18, IFN-γ and tumor necrosis factor-β by Th1 (Those are the cells involved in the pathogenesis of Relapsing Polychondritis and Mesangial Nephropathy). My health was destroyed by SIT, just as it has been destroyed for other people. They should be held accountable for the side effects, I am now a lifelong diseased person like many others because of that damned allergen-specific immunotherapy. Be very careful.

  • @RileyAnne26
    @RileyAnne26 3 месяца назад

    I am an AE warrior, a strep infection was left untreated and my parents told the naval hospital to do a throat culture and they said I did not need it.

    • @Tinyteacher1111
      @Tinyteacher1111 2 месяца назад

      I had strep from Scarlet Fever at 6 weeks of age, for 20 years, at least 3 or 4 times a week until my 20’s. Now I have chronic illnesses and horrible pain. Much more went into my horrific condition, but it started with this, I believe.

  • @marynlyn
    @marynlyn 3 месяца назад

    Yes to using a vaccine of a type that has a long history of comparatively safe and effective use. My question here is . . . what "Covid-19" is actually being vaccinated against? The circulating strains now have little to do with the original one. This vaccine was developed against the original strain, correct? So it is not useful to know how effective it is against that; we need to know how effective it is against current strains. What is the answer to that question?

  • @altruismeltayeb7671
    @altruismeltayeb7671 3 месяца назад

    You are an amazing doctor teacher ❤️

  • @OneAnotherGuy
    @OneAnotherGuy 3 месяца назад

    Amazing! Nicely explained. 😊 You are a great teacher. I am also a PhD in Microbiology.

  • @michellecrofts644
    @michellecrofts644 3 месяца назад

    So if I went on a low cholesterol diet, ie whole plant food diet, would that help as Im pretty sure i have APOE 4 like my mum, and ihave high triglyceride level.

  • @stevenalcorn3460
    @stevenalcorn3460 3 месяца назад

    Thank you for the information. There are so many cytokines and defensins to keep straight. I have been taking vitamin D3 for 13 years and my psoriasis and asthma has been nonexistent. I have been keeping my D3 blood level above 50 ng/ml.