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Friendly Neighborhood Immunologist
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Добавлен 14 янв 2021
Hi it's your friendly neighborhood Immunologist! I've had my PhD in Microbiology and Immunology for about 10 years, and I'm here to empower you with knowledge of how the immune system works. Are you concerned about the new COVID vaccine and want to know how mRNA vaccines work? Do you want to know how allergies start and why allergy shots help? Would you like to know how the immune system fights cancer? Well I'm here to break it down for you in great detail one colored pencil drawing and bad joke at a time.
Guillain barre | Molecular mimicry
Guillain barre is the main cause of short-term muscle weakness or the short-term inability to move your muscles. It is primarily caused by the bacteria Campylobacter jenjuni which is found in undercooked, infected chicken. One to three weeks after your immune system fights off the infection, the immune cells begin to target the nerves. This is due to molecular mimicry. The bacteria has a protein that looks almost exactly like the coating of your nerves. Therefore, the B cells, T cells, and macrophages begin to destroy the myelin coating around nerves and even destroy nerves themselves. Nerve destruction leads to the inability to move. Removing the antibodies that the B cells make seem to ...
Просмотров: 2 160
Видео
How does Lyme Disease Happen?
Просмотров 800Год назад
Lyme disease is caused by black legged ticks also known as deer ticks. Lyme disease happens because ticks drink bacteria-infected blood from deer and mice in the wild. The deer and mice have Borrelia bacteria in their system which transfers to the ticks. Then when the ticks bite humans, the ticks transfer the bacteria to people. If caught quickly and treated with antibiotics, Lyme Disease can b...
T cells | Immunology Lecture | MHC-I versus MHC-II
Просмотров 3,4 тыс.Год назад
This lecture is about T cells and major-histocompatibility complex I and II (MHC-I and MHC-II). The video will go over how T cells and antigen presenting cells fit together and activate. We will discuss where proteins come from to load into MHC-I (the cytosol) and MHC-II (vesicles). Furthermore, I will discuss the differences between CD4 and CD8 T cells. We will also cover positive and negative...
Immunology Lecture 5 | Pathogens and the immune response
Просмотров 2,5 тыс.Год назад
Immunology lecture 5 is about pathogens and the immune response. Specifically the life cycles of bacteria, the Gram-stain, life cycles of RNA and DNA viruses. Then we will talk about which parts of the viruses and bacteria bind to toll-like receptors. Lastly we will cover other innate immune mechanisms of killing pathogens including reactive oxygen species such as superoxide and hydrogen peroxi...
Immunology Lecture 4 | Cytokines and Chemokines | Toll like receptor signaling NFkB
Просмотров 9 тыс.Год назад
This lecture is about cytokines and chemokines as well as the toll-like receptor pathway. We will focus on Myd88 and NFkB and how toll-like receptor engagement causes most innate immune cell inflammation. The second half of the lecture will be about individual cytokines such as IL-1, IL-6 and TNF-a.
Immunology Lecture 3 | Innate immune cells | Leukocyte rolling adhesion
Просмотров 3,4 тыс.Год назад
This is immunology lecture 3. We will cover innate immune cells including macrophages, neutrophils, basophils, and natural killer cells. Importantly, we will also cover how immune cells leave the blood stream and enter tissue, a process called leukocyte rolling adhesion. Here's a link to my favorite video about real immune cells during leukocyte rolling adhesion. ruclips.net/video/Ys6RlglMTMg/в...
Immunology Lecture 2 | Primary and Secondary Lymphoid Organs and Blood (Hematopoiesis)
Просмотров 6 тыс.Год назад
Immunology lecture 2 will cover both the primary and secondary lymphoid organs and the components of blood. We will briefly cover innate and adaptive immune cells, as well as granular versus agranular cells. Additionally, you will find information about hematopoiesis.
Immunology Lecture 1 | Brief History of Immunology
Просмотров 14 тыс.Год назад
Welcome to my immunology lecture series! There will be 10 lectures about immunology. The first lecture will be a brief history of Immunology, including the discovery of the microscope, the smallpox vaccine, the cholera vaccine, and the polio vaccine. Additionally, we will talk about the discovery of antibodies and passive versus active immunity. The remaining lectures will be about Neuroimmunol...
Prion Disease | How does Prion Disease Happen
Просмотров 107 тыс.2 года назад
Prion Disease is caused by a single protein that makes a mistake and misfolds. If you want to know how Prion Disease happens then this video is for you. I will go over the top 3 most likely ways a person can get Prion Disease, what Prion proteins do in the body, and the role of the immune system in Prion Disease. Here are my sources: www.hopkinsmedicine.org/health/conditions-and-diseases/prion-...
Vitamin D and the Immune system
Просмотров 28 тыс.2 года назад
Vitamin D and the immune system work together. You might be surprised that vitamin D can boost and suppress the immune system. Vitamin D can boost primitive defenses of macrophages (Cathlecidin, LL-37, and Beta Defensins. However it reduces classic inflammatory cytokines like IL-1beta, Il-6, and TNF-a. Vitamin D also suppresses the adaptive immune system, B and T cells. This means that high lev...
ADE | What is Antibody Dependent Enhancement
Просмотров 17 тыс.2 года назад
Many people are wondering what is Antibody Dependent Enhancement or ADE. Antibody Dependent Enhancement (ADE) is a second key for a virus to enter your immune cells. Viruses have spike proteins that allow it to enter one or two types of cells like lung cells or neurons. That is the first key. If antibodies bind to a virus in a non-neutralizing way, the virus can enter immune cells called macrop...
How scientific papers are published
Просмотров 1,7 тыс.2 года назад
You might be wondering how scientific papers are published. I have published 12 scientific papers, and I can tell you the 7 steps need to publish a scientific paper. I have been accepted and rejected from scientific journals, and I will even show you my reviewer comments from two of my accepted papers. The review of research by other researchers is called peer-review. One peer reviewer is kind ...
A little bit about me
Просмотров 4 тыс.3 года назад
Hi! This is a video about my background, education, a few personal things. Hope it's interesting and helpful. B.S. Microbiology 2006 Ph.D Microbiology 2007-2012 - Studying T cells, microglia and bacteria Post-doctoral research 2012-2016 - Studying Alzheimer's disease and microglia Visiting Assistant Professor 2016-2021
APOE2 | APOE2 Longevity and Alzheimer's Disease
Просмотров 6 тыс.3 года назад
APOE2 is an important protein in the brain. APOE2 has been found to increase longevity in people as well as animals. APOE2 has been found to reduce the risk of Alzheimer's disease. The video is a requested video about doing a deep dive into APOE2. Overall, APOE2 reduces total cholesterol and increases activity which could be why people with APOE2 live longer on average. Review Paper APOE2: mole...
Natural Killer cells | Top 5 ways Natural Killer cells work
Просмотров 36 тыс.3 года назад
Natural killer cells are unique immune cells that kill virus infected and cancer cells. In this video, I will draw the top 5 ways Natural Killer cells work for you. Natural Killer cells are related to B cells and T cells, and interact with your "name tag," the MHC-I receptor that is on all of your cells except your red blood cells. The Natural Killer cell will spare any cell with your name tag,...
Autoimmune Encephalitis | What is Autoimmune Encephalitis
Просмотров 27 тыс.3 года назад
Autoimmune Encephalitis | What is Autoimmune Encephalitis
T cell memory | CD4 and CD8 T cell memory
Просмотров 40 тыс.3 года назад
T cell memory | CD4 and CD8 T cell memory
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
Просмотров 6 тыс.3 года назад
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
Просмотров 22 тыс.3 года назад
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
How do allergy shots work? | Th2 cells and IgE
Просмотров 19 тыс.3 года назад
How do allergy shots work? | Th2 cells and IgE
Why do allergies happen? | Immune cells and allergy
Просмотров 6 тыс.3 года назад
Why do allergies happen? | Immune cells and allergy
How does the immune system fight Cancer
Просмотров 19 тыс.3 года назад
How does the immune system fight Cancer
How does thrombocytopenia happen | Low platelets and the COVID vaccine
Просмотров 27 тыс.3 года назад
How does thrombocytopenia happen | Low platelets and the COVID vaccine
COVID Vaccine side effects are Good! *Mostly
Просмотров 2 тыс.3 года назад
COVID Vaccine side effects are Good! *Mostly
Don't take Tylenol before COVID mRNA vaccine
Просмотров 3,6 тыс.3 года назад
Don't take Tylenol before COVID mRNA vaccine
How does the COVID mRNA Vaccine work?
Просмотров 19 тыс.3 года назад
How does the COVID mRNA Vaccine work?
So when you consume a like species spinalcord/brain can the body not break down the prions within and they have a higher chanc eof misfolding in the digetsive system? I'm not understanding how that leads to more. Doesn't someone have to already be effected by a misfolded prion in order for them to transfer the disease through cannibalism? Or does it have a higher chance of misfolding after death??
You should try using DaVinci Resolve as your editing software.
So I could be a zombie but I'm alive with the prions made me alive because prions? I literally should be dead from the life I lived but I just keep going....
thanks alot
Great video! I am a 3/4. I am 53 year old and had a heart attach at the age of 47. are you able to keep your cholesterol low? If so what diet?
I'm not a scientist, but I know after doing some very, very light reading that prions are resistant to conventional autoclaving, and even ionizing and UV radiation -- that's absolutely crazy to me. One Google search later, and i see that the Virginia Department of Wildlife Resources stated that temperatures of 900 degrees (C) and up can reliably destroy those little buggers. Now, how that can be applied to treating a prion disease in a living being... I've no idea. Maybe a direct strike from a bolt of lightning (5 times hotter than the surface of the Sun...)? No. *NO.*
Thanks so so much for this!!
Thank you for this. how did the microclots develop due to covid and the vaccine?
still here waiting :-)
Stop eating carbs and seed oils.
Hello,greetings from Europe. Started today with 2000 iu D3. I have Myasthenia Gravis ( since1984) had a Thymectomie. I,ve read some studies where patients reduced their symptoms with D3. I,m scared to take more to be honest. This is an older video so i don,t know if you will read it. Could you please be so kind to give your opinion? Thank you in advance
THANKS FOR SHARING ❤ I HAVE BEEN HAVING BRUISING AND BLEEDING GUMS FOR SOME IVE BEEN TO DR BUT NOT MUCH WAS DONE OR SAID ❤GOD BLESS YOU ❤
Hard pass
It’s not always from a tick. It can be from any biting insect. My worst Lyme infection is a LIVE the Babesia Mycroti (like malaria) you mentioned. I also have several others. I’ve been sick for 2 years on treatment. I hurt all over! I also had mold toxicity and breast implants, which I’m finding is a common trail of infections.
Thank you so much for this valuable info.
Be very careful and evaluate people well before starting Allergen Specific Immunotherapy. I developed Relapsing Polychondritis with renal involvement in the form of mesangial nephropathy, which has evolved into fibrosis and glomerulosclerosis leading to renal failure, during the course of applying SIT with a member of CONICA, COMPEDIA in Guadalajara. There are certainly several reports in the medical literature about the induction of autoimmune diseases during SIT. SIT aims to reduce allergic symptoms by providing tolerance to peripheral T cells through the induction of regulatory T cells. By stimulating Treg cells, the Th1-Th2 balance shifts towards Th1, leading to substantial changes in the T cell cytokine profile, increasing the synthesis of IL-2, IL-12, IL-18, IFN-γ and tumor necrosis factor-β by Th1 (Those are the cells involved in the pathogenesis of Relapsing Polychondritis and Mesangial Nephropathy). My health was destroyed by SIT, just as it has been destroyed for other people. They should be held accountable for the side effects, I am now a lifelong diseased person like many others because of that damned allergen-specific immunotherapy. Be very careful.
I am an AE warrior, a strep infection was left untreated and my parents told the naval hospital to do a throat culture and they said I did not need it.
I had strep from Scarlet Fever at 6 weeks of age, for 20 years, at least 3 or 4 times a week until my 20’s. Now I have chronic illnesses and horrible pain. Much more went into my horrific condition, but it started with this, I believe.
Yes to using a vaccine of a type that has a long history of comparatively safe and effective use. My question here is . . . what "Covid-19" is actually being vaccinated against? The circulating strains now have little to do with the original one. This vaccine was developed against the original strain, correct? So it is not useful to know how effective it is against that; we need to know how effective it is against current strains. What is the answer to that question?
You are an amazing doctor teacher ❤️
Amazing! Nicely explained. 😊 You are a great teacher. I am also a PhD in Microbiology.
So if I went on a low cholesterol diet, ie whole plant food diet, would that help as Im pretty sure i have APOE 4 like my mum, and ihave high triglyceride level.
Thank you for the information. There are so many cytokines and defensins to keep straight. I have been taking vitamin D3 for 13 years and my psoriasis and asthma has been nonexistent. I have been keeping my D3 blood level above 50 ng/ml.
Thank you, for your education on Azhimer disease. 😢 I just found out I have it! I started on my medication! I feel the difference. How long can I stay on this medication?😢
The spike protein in the c19 v x ine is prion amyloid
Hell I got it from when I was working at HomeDepot and I fell the bar that holds in the lumber went from the bottom of my back to the middle. I was in a coma for 2months and almost died twice. I had to learn how to read write walk and talk all over again.
wow. extremely complicated.
Very good explanation… crazy to understand why the cascade goes so fast. Don’t be a cannibal!
Plz reply as soon u can
How to cure
Hi, I work for a company that conducts market research and studies related to caregivers and people with Alzheimer’s. If you would like to collaborate with scientific research and earn some money for your time, please let me know
How can we support our CD8-T cells and NK cells so that they last for decades? What is harmful to them?
You can do nothing, it depends on the person but they replicate themselves so it's fine
Is there a natural way to increase our CD8 Tcells?
Thank you so much for this video. You're an amazing teacher. What can we do/eat to support our NK cells? What should we be doing, besides Nyquil, when we get sick?
Here because my wife’s colleague has just put his wife in hospice for this disease. She was fine a few days ago, now she doesn’t know who she is. Terribly sad. I will say I am amazed that humans were at least able to determine how this disease operates. Thanks for the explanation. I am still lost on how a protein can encourage another protein to “mis-fold” if it’s not alive, nor does it carry any type of genetic code.
Go look up a lecture by> Dr Michael Greger-Mad Cow. Read a book titled the Pathological Protein by Philip Yam.
So if prions can’t be eliminated how is infected waste treated to prevent a chain reaction of folded prions by contamination.
Would love to know more about how to counteract APOE 4?
Thank you ❤
So how do we cure it? My sister is currently in a critical state and doctors here don’t know why…recently being treated for TTP but the plasma exchange is not working! Please help!!!
amyloid beta is extracellular and tao protein is intracellular!!!
What specific gene in the human genome in those persons susceptible is responsible?
Excellent explanation.
In the mRNA molecule, the nucleotide Thymine is replaced with Uracil which is unstable and breaks down quickly as you pointed out. So if the cell needs to produce more of a particular protein it sends out more mRNA to the Ribosome to make more of the protein. That was not good for the mRNA vaccine, so Uracil is replaced with pseudouracil in the vaccine which does not break down, and nobody knows how long it lasts. That is the problem I have with the mRNA vaccines. Could you please address that.
A former colleague of mine just passed away about a week ago from prion disease.
🥂!
I am 30YO, female, positive APOE 3 and 4, amazing cholestrol levels, already doing a lot of the recommended but wanting to do even more. curious if theres any supplements to preven to amyloid plaques? what about low dose aspirin for heart health? what about AD as a type 3 diabetes? what type of exercise (HIIT v weight training), and could you talk about the potential to get these genes corrected (on/off), how long that would take (generations), or if that's even possible? Would love to not give my descendants this lol
Thank you
How do I find a doctor that can treat this??? My 17 year old daughter has had this for over 3 years now, and has just been placed in the Austin State Mental Hospital. Who can help her? We don't have good insurance - she's on medicare.
❤
I always thought prion diseases were caused by cannibalism. Is that the case?
In very rare cases it could be transmitted via cannibalism. But that is not common.
They can start randomly in anyone. We all have proteins in our brain. But its rare and it's usually hereditary. It's unknown why it happens though randomly. Still lot of research. Things like Dementia and Alzheimers are cause by proteins not working they way they should be working. I once read there are bio-warfare researchers doing Prion Weapons. It's scary.