Prions have been a concern to me for years now. A year ago the state of Arkansas set up check stations for deer hunters to bring in their meat to get tested. At that time it was stated that there was a 40% increase in the number of deer tested being infected. That's scary to me. I have been telling people I know to get their meat tested but they all laugh at me and eat it anyway. I fear that 15 to 20 years from now, we will see a huge number of people with prion disease. I hope I'm wrong
Yes I used to hunt big game, but in the late 90s I quit because I learned about the upcoming problem. I hear CWD is very low in areas with wolves. Wolves will target animals in the early sick stage, killing them before the animal becomes extremely contagious. And wolves are resistant to Prion disease, so the disease is stopped in its tracks.
@@friendlyneighborhoodimmuno7192 It's hard to believe that you're an immunologist who doesn't know 1 single thing about CWD being transmitted from deer to deer by simple contact. Studies prove it can transmit to humans. If it does and remains as virulent as CWD is in deer, the human race is screwed. Prion seeding is found in saliva, tears, urine, feces, scent glands on the legs and in muscle tissue itself, and skin cells. Very similar to SCJD patients. Well, whattya know. If CWD transmitted to a human it would cause an SCJD subtype in humans. Now kick back and fear the iatrogenic implications of what I just told you.
Here because my wife’s colleague has just put his wife in hospice for this disease. She was fine a few days ago, now she doesn’t know who she is. Terribly sad. I will say I am amazed that humans were at least able to determine how this disease operates. Thanks for the explanation. I am still lost on how a protein can encourage another protein to “mis-fold” if it’s not alive, nor does it carry any type of genetic code.
Here in Chile, the ratio of people is very high (3,5 cases in 1 million) compared to other countries, and it has almost nothing to do with animals. According to the neurologist that diagnosed my dad, in Chile is just sporadic or genetic. In this case it might be sporadic, and I could carry it too. My dad is on his 3rd month and is 57 years old. As far as I know, Chile has the highest rate of incidents and even a whole family was affected by this. There is a small group in Facebook that has also shared their experiences and a lot of them had lost at least 3 relatives just because it could be hereditary. I’m truly scared of this, but now, I have to take care of my dad and be the main support for my mom. I hope that more research could be done so future people can have some kind of medicine. This is so quick that seems unreal :/
Most diseases that are said to be genetic are actually metabolic. This is one of the biggest lies in the medical industry. You can’t just trust everything a doctor tells you 100% it’s called Medical PRACTICE for a reason. Please don’t discard the point that this is most likely a metabolic disease and can be prevented with diet since diet is what triggers it to begin with.
chile is among the top 10 countries in average elevation from sea level. for people that don't know, our atmosphere protects us from harmful cosmic radiation (typically cancer, but likely also mutated prion proteins). the higher elevation and lower atmospheric protection might explain the higher incidence.
I'm really sorry about your dad and I wish this wouldn't happen to you But I would like to ask you if there is any tracking of the ancestry of the patients being done?
I was looking for a simple yet informative description of CJD for my surgical nurse interns and your explanation and teaching visuals are perfection! I also developed a better understanding of Prion disease, CJD and vCJD because you presented this material so well. I've never completely grasped how prion disease happens but you made it so much clearer! Thank you very much!
As a 16 years old student doing a research.. that is terrifying to know that the immune system cant do much about it. But it’s interesting to know a lot about the topic prion disease.
Excellent explanation! I can finally understand why prion dieases are so damaging to the brain and can cause so many neurodegenerative diseases. 1) It seemed to me that the 'mad cow disease' developed pretty fast in the victims. Is that because of the amount of infected prions consumed? Does the amount of infected prions accelerate the process? 2) Just to make it clear, no amount of cooking can prevent someone from "catching infected prions" if the meat is contaminated?
Thanks! 1) Yes the amount of prions ingested does affect how long it takes a person to develop CJD. The more infected/misfolded prions the worse disease progression will be. 2) No amount of regular stove top cooking can kill prions, but you can kill them in lab with an autoclave. It's a machine that is very hot and super high pressure.
I would really like to know if novavax contains pirons , I watched it in a video and some are saying it’s false but would love to know if it does ? As they say the novavax could cause mad cow disease
I have a great interest and appreciation for science. I just fell on your videos and love your explanation and drawings. You're a great teacher! I look forward to more of your videos
Excellent video. I just watched the Australian documentary about the Kuru tribe in Papua New Guinea. The disease can lay dormant for so long!! It’s horrifying. 🥺
I van tell you exactly how this is happening now. "No creature should ever eat it's own kind." Well... we've been feeding cows, cows! We're putting Tallow on Corn at Feedlots and feeding it to cattle. The cycle continues and continues. The cows are not alive long enough to show signs of the damage. But, as it continues, I suspect we will see more and more of this with people. Eat only grass-fed cows. Best way to avoid this issue. Remember, Tallow is made in the same plant that the cows are slaughtered in. Tallow may contain brain matter from the cows considering the brain contains a lot of fat and would be useful in the production of Tallow for use at Feedlots. This is a disgusting practice that was never meant to happen. The feedlots will defend this practice until the end of time saying it is useful for making the cows bigger for more meat production to feed more people. It's disgusting and is probably killing people. It's very sad.
@americanviking i couldnt agree MORE my friend. I think its a disgusting & unethical practice. I'm betting that they use the entire brain in the making of tallow because it's a cost cutter. We all know how cheap these vomosnies want theur bottom line to be so they can make the MOST $$ per customer, sickening.. These same companies will use N.D.A.'s on their employees& staff to keep them from blowing the whistle. I HOPE & PRAY better days are coming. I will keep my faith in GOD & know that HE sees all& will act accordingly. God bless you& yours✌🏻🙏🏻🤜🏻🤛🏻
Although I too think it's disgusting, unnatural and probably harmful in some way, I think your theory falls apart when you consider that chronic wasting disease in deer is also a prion disease...
@mclagett1043 Cows contracted BSE (a Prion disease) through being fed contaminated feed that contains parts of other cows and sheep. This isn't a theory, but a fact.
@@Moco_Cork1 I don't know enough about the situation you speak of to make a judgement.... All I'm saying is most prion disease doesn't spread this way...
It is possible that rare types of dementia are due to prions. Typically the type of dementia a person has cannot be diagnosed 100% until after they pass away. There are some researchers who hypothesize that amyloid beta in people with Alzheimer's is a prion protein, but I don't think there's enough evidence to prove that right now.
I have to do a project presentation and I was given PrP as my topic. I have been reading article on top of article and none have explained it remotely near as good as you have. Thanks
I wish you could explain ALS in your excellent way. My father had ALS for >20 years and one of my aging cousins also have had ALS for that length of time. I had a former co-worker who died of CJD, sad!
Thank you! This has been the best explanation ive seen! Im studying medical laboratory technology and heard about CWD from family members, so naturally, I went down the google/youtube rabbit hole about prions haha. Keep it up, I like the drawings. I thought the BBB would prevent proteins from entering so this was very informative.
@@TANSZ548 I am so sorry. That must have been tough. It was hard enough to see cognitive function deteriorate quickly, but your dad’s path sound so much more difficult. May he rest in peace.
@@mpoharper Sorry to hear about your loss. May I ask, did he have the covid vaccines? I ask because they apparently somehow affect prior coding, for the purpose of preventing CJD and so on.
What are the plans for a possible treatment ? Maybe we should experiment on dendritic cells and make them effective against misfolded prions, then update our dendritic cells or production with CRiSPR. Is it possible? Or is there a better plan already ?
Hie, amazing video! Just a doubt : how do these proteins actually escape being digested by the enzymes of GI tract incase one has eaten infected meat? Thanks in advance.
They’re really hard to destroy. Without like 400°f heat over a long, sustained period of time they’ll usually make it out of whatever it is just fine, because they don’t have any genetic material they’re even resistant to radiation.
How was it that 3 European science researchers were studying misfolded proteins under a microscope and somehow became contaminated and died shortly after ?
I guess one of them you're referring to is the French lab tech who died in 2019. She apparently stabbed herself with forceps while cleaning a container that contained mouse brains that simulated infectious human prions. This happened in 2010.
Can prion diseases pass through dairy or colostrum? I have read theoretically they can. I have been interested in colostrum supplements and their health benefits and even ordered some, but then read that prions could pass through colostrum and so I haven't taken it yet.
Hi, I loved your video! Everything is clear and well-explained. Thank you so much! I have a question. Is it possible for different proteins to get unfolded by the contact with defective prions? I read something about amyloid beta, but I'm sure I didn't get it. 😢
Thank you…you made this topic very easily understandable. I had been curious because of the wild deer that have been coming down with a Chronic Wasting disease 🦠 (zombie deer disease) that they say is a type of prion disease and how people can potentially catch it from eating this meat
It is a type of prion disease. There is a risk for humans. Research has not been conclusive but has not ruled out the risk either. I would not take any chances.
My question is, how could we even know that a person has the disease before they start to show symptoms from neuron loss? I mean if removing the lymph nodes is an option, that would mean that we need to do so BEFORE the misfolded proteins cross the brain-blood barrier and thus start causing the damage which would in turn develop the symptoms. I understand this could still help people with the genetic variant since you can test for that but as stated that is just 10-15% of the cases. My question refers to the acquired type. Could anyone please clarify?
Theres cases where transplant patients have contracted prion disease. Also patients being infected from contaminated surgical and dental tools. Thats why a lot of sugical and dental tools are disposable.
There are 7 prion-like domains in the S1 part of the spike protein in the vaccines. The abstract from the paper "A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review" goes into detail.
The S1 part of the spike protein found in vaccines, particularly those targeting the SARS-CoV-2 virus, contains seven prion-like domains. These domains are regions within the protein that share structural similarities with prions, which are misfolded proteins associated with neurodegenerative diseases. In the case of the spike protein, these prion-like domains have been identified due to their propensity to adopt alternative, self-propagating conformations. However, it's important to note that the presence of these domains does not imply that the spike protein itself can cause prion diseases. Instead, they play a role in the protein's function, helping it bind to host cells and facilitate viral entry, which is a crucial step in the development of an immune response against the virus. Extensive safety testing is conducted during vaccine development to ensure that any potential risks associated with these domains are carefully assessed and mitigated, and vaccines have proven to be safe and effective tools in combating the spread of COVID-19.
@@amelliamendel2227 There are cases of CJD caused by the vaccine, so I don't buy your explanation. I take it you didn't read the abstract. Also, that's a lie that extensive testing was done. We all know that zero safety testing was done: EMERGENCY USE DECLARATION, remember? We are the safety testing. ...and it ain't working out.
@@amelliamendel2227 On Christmas Day, my GF and I spent 7 hours visiting, eating, and chatting with about 17 people who are all fully vaccinated. At least 8 of them are either currently sick with covid or just getting over it. One guy who is also fully vaccinated and recently boosted tested positive for covid on the 23rd, so chose to stay home/missed the party. Neither of us have had any vaccines at all, and are doing just fine today w zero symptoms. Have since heard from countless others non-jabbers that report experiencing the exact same thing.
So when you consume a like species spinalcord/brain can the body not break down the prions within and they have a higher chanc eof misfolding in the digetsive system? I'm not understanding how that leads to more. Doesn't someone have to already be effected by a misfolded prion in order for them to transfer the disease through cannibalism? Or does it have a higher chance of misfolding after death??
In Saskatchewan we have a growing problem with Chronic Waisting Disease in whitetail and mule deer as well as in elk (and maybe other animals like moose and antelope). As a result, we can turn in the heads (or some brain matter) to have it tested. But by then our butchering equipment would be contaminated. Can it be decontaminated? We are also told that young animals (of that year) will not be tested; the claim is that they cannot carry and / or cannot infect the person consuming their muscle tissue. What is your opinion on these concerns?
Hi. Your video is Great. It's easy understanding and very useful for me to better know how people would be affected by this. But one thing I want to know more is how do you find only 500 hundred case during the past years. I'm in China and my father has been diagnosed as CJD last month and he is now dying. Then I talk with the people around me and I found 3 people get this desease and died in recent years. Then I explore in China forums I found a lot of families have same situation. Seems it's not that rare. I really hope I was wrong but if it's true then it would be horrible. My family is in pain and i really don't want to see more families would encounter this.
I'm not a scientist, but I know after doing some very, very light reading that prions are resistant to conventional autoclaving, and even ionizing and UV radiation -- that's absolutely crazy to me. One Google search later, and i see that the Virginia Department of Wildlife Resources stated that temperatures of 900 degrees (C) and up can reliably destroy those little buggers. Now, how that can be applied to treating a prion disease in a living being... I've no idea. Maybe a direct strike from a bolt of lightning (5 times hotter than the surface of the Sun...)? No. *NO.*
Thank you. There has never been any evidence that vaccines including Novavax have caused even one case of Prion Disease. There are no prion proteins in vaccines. However, years ago some vaccines used gelatin made from cow hooves in small amounts. They were checked for prions and there were none, but now cow gelatin has been removed from most US vaccine processing.
@@friendlyneighborhoodimmuno7192 thank you - even though the presentation was very scientifically presented and explained, I didn't think that they would be able to keep something like that hidden!!
I remember reading about how some MD went to a small secluded native society that was particularly riddled with prion disease to do research. He discovered that they essentially had a lot of cannibalistic practices and, in particular, a very prevalent practice was to eat the brains of their dead relatives (due to some religious belief of some sort). So... is this disease something that might be considered living....?
If you mean to ask if prions are alive or not then the answer is no. They’re proteins, basically just string of amino acid. They’re don’t contain any genetic material.
I have booked in for No v a vac and have complex health issues and am concerned still about the spike after a suspected case in early 2020 and a year of hell thst i feel was related from lingering spikes or damage. I hsce read NV may cause prion disease. Can you please help me understand if that is something that can happen from the protein V NV?
I wonder if some lab is playing with prion. Trying to make an anti ubiquiton Prions. Is it possible we will have a hyper prion attack one day? I pray not.
As an immunologist, you should know prions are only more prevalent today because the population is increasing exponentially, and of course the numbers will reflect this.
اهلا .لقد تلقيت لقاحات عضة الكلب وبعدها بعشرون وم فقدت النوم نهائيا تحولت حياتي الى جحيم مرعب .هل اللقاحات فيها بريونات ؟ من فضلك اجبني بصفة عالم مناعة
So basically, the point of origination for prions in general is unknown right now. Are there any research articles published that discuss theories about how a healthy protein might become a prion without coming into contact with other misfolded proteins?
No discussion here of scrapie disease in sheep, the earliest known prionic disease which passes as an infection. Sheep are not meat eaters so cannabilism is out. So how does the infaction spread?
Fun fact Tyson foods sells livestock feed with pork brain and spinal tissue that's fed to hogs to this day. It would cost Tyson 17 cents per hog to prevent spinal tissue and brain from entering the inedible feed. But because there's no evidence... It's not a matter of IF but when. The USDA will make no regulation without evidence. I've been concerned about this for over 8 years. Tyson foods - kill floor supervisor, logansport Indiana
PrPC is located on cell surface tethered to plasma membrane. If this PrPC is located here and was originally meant as means to withstand temporary low oxygen environments......If you look at these maps where the disease is discovered and you see high altitude environments as a point of origin where cases where found in the 60's...Is hijacking happening through the GPI anchor? Is their also a mechanical explanation for this problem? Are their changes related to chirality, gravitational changes, magnetic spin states, alterations in the plants the deer are consuming in certain areas? Does this disease go past the brain? I am seeing a video of a deer walking around with what appears to be a section of its body missing and the deer seems oblivious to this. Seems strange someone would post automatically saying its CWD as an assumption. Seems like the CWD in deer is concerning. A Tic as a vector of transmission has been brought up. What is causing the Lysosome to not destroy it ? Is it pH alone or is it the type of Hydrogen needed to destroy it, or is it the chirality or spin of the Hydrogen that needs to be adjusted? 3 isotopes of hydrogen exist? What type exists in the Lysosome? Something is very unusual about these prions. Have any sources of Water changed near areas where this disease is occurring? By changes I mean changes related to properties of hydrogen? www.usgs.gov/media/images/distribution-chronic-wasting-disease-north-america-0 There is a very mechanical reason for this disease and the mechanics may more than likely be outside the origin of the host. Something may be mechanically altering the chiral preference of a life form and it may be somehow magnetically or some unusual radiation and the entry point may be the GPI. I believe Buck Institute is researching Mechanoimmunology ...might want to pass this over to them. I am not an immunologist so will not be taken seriously.
I’m certain I’ve got vcjd in Early September 2020 I was woken up from my sleep with a lethal feeling that I’d been punched in the gut then two weeks later muscle twitches started along with sleep disturbances visual disturbances and a year later I started feeling weakness in my right leg and a blind patch in my left eye, and just to clarify vcjd spreads from the gut to the brain.
Do you think I haven’t had long enough to know this disease is fatal, cause I have I just went a year not bothering cus I thought it was ms, now I know different
@blockerhall4532 You very obviously have health anxiety. Diagnosing yourself with CJD because you had stomach pains is pretty obvious. You'd be hospitalised by now if you actually had CJD.
Prions have been a concern to me for years now. A year ago the state of Arkansas set up check stations for deer hunters to bring in their meat to get tested. At that time it was stated that there was a 40% increase in the number of deer tested being infected. That's scary to me. I have been telling people I know to get their meat tested but they all laugh at me and eat it anyway. I fear that 15 to 20 years from now, we will see a huge number of people with prion disease. I hope I'm wrong
Whoa. I wasn’t aware of the prion problem in deer. Definitely going to keep an eye on that.
May i have sources?
Yes I used to hunt big game, but in the late 90s I quit because I learned about the upcoming problem. I hear CWD is very low in areas with wolves. Wolves will target animals in the early sick stage, killing them before the animal becomes extremely contagious. And wolves are resistant to Prion disease, so the disease is stopped in its tracks.
@@friendlyneighborhoodimmuno7192 It's hard to believe that you're an immunologist who doesn't know 1 single thing about CWD being transmitted from deer to deer by simple contact. Studies prove it can transmit to humans. If it does and remains as virulent as CWD is in deer, the human race is screwed. Prion seeding is found in saliva, tears, urine, feces, scent glands on the legs and in muscle tissue itself, and skin cells. Very similar to SCJD patients. Well, whattya know. If CWD transmitted to a human it would cause an SCJD subtype in humans. Now kick back and fear the iatrogenic implications of what I just told you.
@@iQmliAwyrMRyPWfVOverview. www.usgs.gov/centers/nwhc/science/chronic-wasting-disease#overview
Here because my wife’s colleague has just put his wife in hospice for this disease. She was fine a few days ago, now she doesn’t know who she is. Terribly sad. I will say I am amazed that humans were at least able to determine how this disease operates. Thanks for the explanation. I am still lost on how a protein can encourage another protein to “mis-fold” if it’s not alive, nor does it carry any type of genetic code.
Go look up a lecture by> Dr Michael Greger-Mad Cow. Read a book titled the Pathological Protein by Philip Yam.
Here in Chile, the ratio of people is very high (3,5 cases in 1 million) compared to other countries, and it has almost nothing to do with animals. According to the neurologist that diagnosed my dad, in Chile is just sporadic or genetic. In this case it might be sporadic, and I could carry it too. My dad is on his 3rd month and is 57 years old. As far as I know, Chile has the highest rate of incidents and even a whole family was affected by this. There is a small group in Facebook that has also shared their experiences and a lot of them had lost at least 3 relatives just because it could be hereditary. I’m truly scared of this, but now, I have to take care of my dad and be the main support for my mom.
I hope that more research could be done so future people can have some kind of medicine. This is so quick that seems unreal :/
Sorry to hear about your dad. I wish your family the best
Most diseases that are said to be genetic are actually metabolic. This is one of the biggest lies in the medical industry. You can’t just trust everything a doctor tells you 100% it’s called Medical PRACTICE for a reason. Please don’t discard the point that this is most likely a metabolic disease and can be prevented with diet since diet is what triggers it to begin with.
chile is among the top 10 countries in average elevation from sea level. for people that don't know, our atmosphere protects us from harmful cosmic radiation (typically cancer, but likely also mutated prion proteins).
the higher elevation and lower atmospheric protection might explain the higher incidence.
I'm really sorry about your dad and I wish this wouldn't happen to you
But I would like to ask you if there is any tracking of the ancestry of the patients being done?
Per Bruce Lipton, genes are not the problem. The environment is responsible for turning those genes on.
Look him up!!!
May God bless you!
I was looking for a simple yet informative description of CJD for my surgical nurse interns and your explanation and teaching visuals are perfection! I also developed a better understanding of Prion disease, CJD and vCJD because you presented this material so well. I've never completely grasped how prion disease happens but you made it so much clearer! Thank you very much!
As a 16 years old student doing a research.. that is terrifying to know that the immune system cant do much about it. But it’s interesting to know a lot about the topic prion disease.
I love your drawings and cutouts. So much faster (?) and more artistic than computer-generated animations :). Really adds a human touch.
Excellent explanation! I can finally understand why prion dieases are so damaging to the brain and can cause so many neurodegenerative diseases.
1) It seemed to me that the 'mad cow disease' developed pretty fast in the victims. Is that because of the amount of infected prions consumed? Does the amount of infected prions accelerate the process?
2) Just to make it clear, no amount of cooking can prevent someone from "catching infected prions" if the meat is contaminated?
Thanks! 1) Yes the amount of prions ingested does affect how long it takes a person to develop CJD. The more infected/misfolded prions the worse disease progression will be.
2) No amount of regular stove top cooking can kill prions, but you can kill them in lab with an autoclave. It's a machine that is very hot and super high pressure.
I would really like to know if novavax contains pirons , I watched it in a video and some are saying it’s false but would love to know if it does ? As they say the novavax could cause mad cow disease
@@lauradigney8232 same. I want to know before have mine this week
@Laura Digney
Sounds like typical vaccine misinformation to me
Uh… u mean vaccine..?
Great information. You explained really well in a very simple yet detailed way. Thanks
I have a great interest and appreciation for science. I just fell on your videos and love your explanation and drawings. You're a great teacher! I look forward to more of your videos
Excellent video. I just watched the Australian documentary about the Kuru tribe in Papua New Guinea. The disease can lay dormant for so long!! It’s horrifying. 🥺
I van tell you exactly how this is happening now. "No creature should ever eat it's own kind." Well... we've been feeding cows, cows! We're putting Tallow on Corn at Feedlots and feeding it to cattle. The cycle continues and continues. The cows are not alive long enough to show signs of the damage. But, as it continues, I suspect we will see more and more of this with people. Eat only grass-fed cows. Best way to avoid this issue. Remember, Tallow is made in the same plant that the cows are slaughtered in. Tallow may contain brain matter from the cows considering the brain contains a lot of fat and would be useful in the production of Tallow for use at Feedlots. This is a disgusting practice that was never meant to happen. The feedlots will defend this practice until the end of time saying it is useful for making the cows bigger for more meat production to feed more people. It's disgusting and is probably killing people. It's very sad.
Stop. Eating. Meat. See also:. HEK 293 cells
@americanviking i couldnt agree MORE my friend. I think its a disgusting & unethical practice. I'm betting that they use the entire brain in the making of tallow because it's a cost cutter. We all know how cheap these vomosnies want theur bottom line to be so they can make the MOST $$ per customer, sickening.. These same companies will use N.D.A.'s on their employees& staff to keep them from blowing the whistle. I HOPE & PRAY better days are coming. I will keep my faith in GOD & know that HE sees all& will act accordingly. God bless you& yours✌🏻🙏🏻🤜🏻🤛🏻
Although I too think it's disgusting, unnatural and probably harmful in some way, I think your theory falls apart when you consider that chronic wasting disease in deer is also a prion disease...
@mclagett1043 Cows contracted BSE (a Prion disease) through being fed contaminated feed that contains parts of other cows and sheep. This isn't a theory, but a fact.
@@Moco_Cork1 I don't know enough about the situation you speak of to make a judgement.... All I'm saying is most prion disease doesn't spread this way...
Interesting and wonderful to have you back. I wonder if certain types of dementia (non alzheimer's) could be attributable to prion infections?
It is possible that rare types of dementia are due to prions. Typically the type of dementia a person has cannot be diagnosed 100% until after they pass away. There are some researchers who hypothesize that amyloid beta in people with Alzheimer's is a prion protein, but I don't think there's enough evidence to prove that right now.
@@friendlyneighborhoodimmuno7192any treatment could please suggest atleast tablet names we need emergency
I have to do a project presentation and I was given PrP as my topic. I have been reading article on top of article and none have explained it remotely near as good as you have. Thanks
I wish you could explain ALS in your excellent way. My father had ALS for >20 years and one of my aging cousins also have had ALS for that length of time.
I had a former co-worker who died of CJD, sad!
She's back! 🥳 Happy New Year!💪🧠
Happy New Year to you too!
I'm really glad I stopped eating beef due to a sensitivity. Prion diseases are terrifying and often kick start my health anxiety.
They are super scary, but thankfully very uncommon.
Haven’t eaten beef in over 3 years
Knowing about prions make me paranoid asf
Thank you. Please continue teaching us!!! You are a great educator.
love her drawings, shes put so much effort into making this
Thank you! This has been the best explanation ive seen! Im studying medical laboratory technology and heard about CWD from family members, so naturally, I went down the google/youtube rabbit hole about prions haha. Keep it up, I like the drawings. I thought the BBB would prevent proteins from entering so this was very informative.
My brother just passed from CJD. It's the most horrific way for a person to die.
My daughter’s father in law died of CJD.
@@mpoharper i lost my dad to this but he had fatal sporadic insomnia where the prion attack the thalamus
@@TANSZ548 I am so sorry. That must have been tough. It was hard enough to see cognitive function deteriorate quickly, but your dad’s path sound so much more difficult. May he rest in peace.
@@mpoharper Sorry to hear about your loss.
May I ask, did he have the covid vaccines?
I ask because they apparently somehow affect prior coding, for the purpose of preventing CJD and so on.
@@safeeffective385 no it was years ago. He did eat a lot of game though.
What are the plans for a possible treatment ? Maybe we should experiment on dendritic cells and make them effective against misfolded prions, then update our dendritic cells or production with CRiSPR. Is it possible? Or is there a better plan already ?
You sound smart lol
None of that has been proven successful. Science just published an article of a possible treatment using viral vector gene silencing.
I researched it for years, but the central nervous system doesn't heal itself unlike the peripheral nervous system.
Loved your explanation
Even without technology you made it clear and interesting
Hie, amazing video!
Just a doubt : how do these proteins actually escape being digested by the enzymes of GI tract incase one has eaten infected meat?
Thanks in advance.
They are very stable and therefore immune to destruction,nor by cooking or denaturation
They’re really hard to destroy. Without like 400°f heat over a long, sustained period of time they’ll usually make it out of whatever it is just fine, because they don’t have any genetic material they’re even resistant to radiation.
How was it that 3 European science researchers were studying misfolded proteins under a microscope and somehow became contaminated and died shortly after ?
source?
Mind sending the source?
Punchline?
I guess one of them you're referring to is the French lab tech who died in 2019. She apparently stabbed herself with forceps while cleaning a container that contained mouse brains that simulated infectious human prions. This happened in 2010.
@Boris Cuduco
Every article says that happened to her in late 2010
Thanks for the explanation of prion disease. My gf died from this horrible disease.
@@THEDSTRTNPipe down, you degenerate.
I'm very genetically likely to be a rare one. I've known this a long time and I'm struggling with memory and sleep now. So, here I am.
fatal sporadic insomnia is a prion disease they attack the thalamus
Thank you for a very clear description of prion disease.
Quality info. Thanks for the presentation
Thanks for this fantastic explanation!
Can prion diseases pass through dairy or colostrum? I have read theoretically they can. I have been interested in colostrum supplements and their health benefits and even ordered some, but then read that prions could pass through colostrum and so I haven't taken it yet.
Excellent, short simple and effective.
Hi, I loved your video! Everything is clear and well-explained. Thank you so much!
I have a question. Is it possible for different proteins to get unfolded by the contact with defective prions? I read something about amyloid beta, but I'm sure I didn't get it. 😢
Only prion proteins get misfolded by misfolded prion, just like amyloid beta.
Excellent explanation.
If prions use the immune system to enter nueral tissue, could immunosuppressant therapy be used soon after infection to prevent progression?
No because the prions also travel up the spinal cord via axons.
Thank you for sharing your knowledge....well done...may you stay safe
Thank you…you made this topic very easily understandable. I had been curious because of the wild deer that have been coming down with a Chronic Wasting disease 🦠 (zombie deer disease) that they say is a type of prion disease and how people can potentially catch it from eating this meat
It is a type of prion disease. There is a risk for humans. Research has not been conclusive but has not ruled out the risk either. I would not take any chances.
This video was well done. Great job!
Ive learned that there are other illnesses that are caused by malfunctioning proteins that attack other parts of the body. For example Amyloidosis.
Once more Thank You !! And wishing you a Happy and safe New Year…
Thanks! Same to you too.
My question is, how could we even know that a person has the disease before they start to show symptoms from neuron loss? I mean if removing the lymph nodes is an option, that would mean that we need to do so BEFORE the misfolded proteins cross the brain-blood barrier and thus start causing the damage which would in turn develop the symptoms. I understand this could still help people with the genetic variant since you can test for that but as stated that is just 10-15% of the cases. My question refers to the acquired type. Could anyone please clarify?
Is there any chance you could do a video on T-cell exhaustion as it seems to be in the news lately?
Theres cases where transplant patients have contracted prion disease. Also patients being infected from contaminated surgical and dental tools. Thats why a lot of sugical and dental tools are disposable.
This is wonderfully explained; thank you☺
There are 7 prion-like domains in the S1 part of the spike protein in the vaccines.
The abstract from the paper "A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review" goes into detail.
The S1 part of the spike protein found in vaccines, particularly those targeting the SARS-CoV-2 virus, contains seven prion-like domains. These domains are regions within the protein that share structural similarities with prions, which are misfolded proteins associated with neurodegenerative diseases. In the case of the spike protein, these prion-like domains have been identified due to their propensity to adopt alternative, self-propagating conformations. However, it's important to note that the presence of these domains does not imply that the spike protein itself can cause prion diseases. Instead, they play a role in the protein's function, helping it bind to host cells and facilitate viral entry, which is a crucial step in the development of an immune response against the virus. Extensive safety testing is conducted during vaccine development to ensure that any potential risks associated with these domains are carefully assessed and mitigated, and vaccines have proven to be safe and effective tools in combating the spread of COVID-19.
@@amelliamendel2227
There are cases of CJD caused by the vaccine, so I don't buy your explanation.
I take it you didn't read the abstract.
Also, that's a lie that extensive testing was done.
We all know that zero safety testing was done:
EMERGENCY USE DECLARATION, remember?
We are the safety testing.
...and it ain't working out.
🎯
انا فقدت النوم منذ ان تلقبت لقاحات جراؤ عضة كلب لذا انا متاكدة بان اللقاح فيه البريون
@@amelliamendel2227 On Christmas Day, my GF and I spent 7 hours visiting, eating, and chatting with about 17 people who are all fully vaccinated. At least 8 of them are either currently sick with covid or just getting over it.
One guy who is also fully vaccinated and recently boosted tested positive for covid on the 23rd, so chose to stay home/missed the party.
Neither of us have had any vaccines at all, and are doing just fine today w zero symptoms.
Have since heard from countless others non-jabbers that report experiencing the exact same thing.
Fascinating,educational and Terror inducing. Thank you.
So when you consume a like species spinalcord/brain can the body not break down the prions within and they have a higher chanc eof misfolding in the digetsive system? I'm not understanding how that leads to more. Doesn't someone have to already be effected by a misfolded prion in order for them to transfer the disease through cannibalism? Or does it have a higher chance of misfolding after death??
In Saskatchewan we have a growing problem with Chronic Waisting Disease in whitetail and mule deer as well as in elk (and maybe other animals like moose and antelope). As a result, we can turn in the heads (or some brain matter) to have it tested. But by then our butchering equipment would be contaminated. Can it be decontaminated?
We are also told that young animals (of that year) will not be tested; the claim is that they cannot carry and / or cannot infect the person consuming their muscle tissue.
What is your opinion on these concerns?
You are correct my advice is don't eat it is way unreported in the us
thanks I have a microbio exam tomorrow!
Hi. Your video is Great. It's easy understanding and very useful for me to better know how people would be affected by this. But one thing I want to know more is how do you find only 500 hundred case during the past years. I'm in China and my father has been diagnosed as CJD last month and he is now dying. Then I talk with the people around me and I found 3 people get this desease and died in recent years. Then I explore in China forums I found a lot of families have same situation. Seems it's not that rare. I really hope I was wrong but if it's true then it would be horrible. My family is in pain and i really don't want to see more families would encounter this.
Sorry I watched again and found it's 500 people died per year. But still I think the actual number is bigger .
Sorry to hear about your dad. Unfortunately governments aren’t known for being honest
@@AndersenTrades Agreed and thanks. my father died one month ago, I really hope someday human are able to cure this.
"One in a million," THEY say...yeah, RIGHT! I am so sorry about your dad, how is he doing?
@@jennifergreen6109 He died 3 months ago. Like 3 weeks after I left the previous message.
Now where has my favorite youtuber went :((
So if prions can’t be eliminated how is infected waste treated to prevent a chain reaction of folded prions by contamination.
Are the lysosome and ubiquitin-proteasome processes examples of proteolysis? Wrapping my head around some basic terms 😅
CJD is the basis for the story in "Knox Goes Away" with Michael Keaton.
Beautifully explained
Very good explanation… crazy to understand why the cascade goes so fast. Don’t be a cannibal!
I'm not a scientist, but I know after doing some very, very light reading that prions are resistant to conventional autoclaving, and even ionizing and UV radiation -- that's absolutely crazy to me. One Google search later, and i see that the Virginia Department of Wildlife Resources stated that temperatures of 900 degrees (C) and up can reliably destroy those little buggers. Now, how that can be applied to treating a prion disease in a living being... I've no idea. Maybe a direct strike from a bolt of lightning (5 times hotter than the surface of the Sun...)? No. *NO.*
I love your easy to understand presentations and many thanks for those :) Is it true that the Novavax vaccine can cause Prion disease?
Thank you. There has never been any evidence that vaccines including Novavax have caused even one case of Prion Disease. There are no prion proteins in vaccines. However, years ago some vaccines used gelatin made from cow hooves in small amounts. They were checked for prions and there were none, but now cow gelatin has been removed from most US vaccine processing.
@@friendlyneighborhoodimmuno7192 thank you - even though the presentation was very scientifically presented and explained, I didn't think that they would be able to keep something like that hidden!!
Shit, I have this after Novavax
@@janclifford1 🙄
@@stoms8238اجبني اخي حتى مرضت جراء اخذ اللقاحات
Similar to the risk of being struck by lightning, so nothing to be concerned about. Worrying will increase your chances of getting cancer.
i like this lecture. i’m getting ASMR tingles from it
You a freak.
I remember reading about how some MD went to a small secluded native society that was particularly riddled with prion disease to do research. He discovered that they essentially had a lot of cannibalistic practices and, in particular, a very prevalent practice was to eat the brains of their dead relatives (due to some religious belief of some sort).
So... is this disease something that might be considered living....?
If you mean to ask if prions are alive or not then the answer is no. They’re proteins, basically just string of amino acid. They’re don’t contain any genetic material.
A former colleague of mine just passed away about a week ago from prion disease.
Luc montagnier said the covid vaccines could make prions if u have a long exposure in ur system Tru ?
No vaccines contain prions
I've heard the same thing. Just another thing to worry about the unproven clot shot.
🎯
This is false.
I have booked in for No v a vac and have complex health issues and am concerned still about the spike after a suspected case in early 2020 and a year of hell thst i feel was related from lingering spikes or damage. I hsce read NV may cause prion disease. Can you please help me understand if that is something that can happen from the protein V NV?
I wonder if some lab is playing with prion. Trying to make an anti ubiquiton Prions.
Is it possible we will have a hyper prion attack one day?
I pray not.
Thanks so so much for this!!
As an immunologist, you should know prions are only more prevalent today because the population is increasing exponentially, and of course the numbers will reflect this.
اهلا .لقد تلقيت لقاحات عضة الكلب وبعدها بعشرون وم فقدت النوم نهائيا تحولت حياتي الى جحيم مرعب .هل اللقاحات فيها بريونات ؟ من فضلك اجبني بصفة عالم مناعة
What specific gene in the human genome in those persons susceptible is responsible?
Excellent presentation 👍
thank you for this. great video
Herbivores are short lived animals and don't seem to have ways of transmission between themselves
Would they be more vulnerable?
Such great explanation 💯💯 thanks
So basically, the point of origination for prions in general is unknown right now. Are there any research articles published that discuss theories about how a healthy protein might become a prion without coming into contact with other misfolded proteins?
Many. They are heavy biophysics topics.
No discussion here of scrapie disease in sheep, the earliest known prionic disease which passes as an infection. Sheep are not meat eaters so cannabilism is out. So how does the infaction spread?
Prions can live in soil and be taken up by grasses that sheep etc eat
thank you so much I needed this 💕
Is this disease contagious from person to person?
Not if you don't feast on their neural tissue
I would use the same precautions you would use with strangers as far as bodily fluids and so on.
Very interesting thank you.
Does the medication bupropion have any side effects similar to prion disease ???
Not at all. The names simply have coincidental similarities.
Can prions be transmitted from working with cadavers. If your handling a cadaver brain and dont perform proper hand washing or precautions?
You should always wear gloves.
Yes
اصلا جسم الانسان يفرز هرمونات الموت تكون جزيئاتها غير قابلة للهضم وتعتبر بريونات لذا تستعمل في السحر لجعل الضخية غير مبال وكىيب وكانه مدفون
The spike protein in the c19 v x ine is prion amyloid
As a Greek individual, I regularly indulge in deep-fried lamb brains. Is there a risk of danger due to prions?
yes
By carnism and/or canniblism and/or with cross-contamination of human hands and/or DNA?
IF you hunt & eat what you kill, esp deer, PLEASE HAVE YOUR MEAT TESTED FOR PRIONS!
Can any protein anywhere in the world (ex. shake) become Prion?
This was so good.
Great video. Thank you.
"Medicago", the first 'plant based' vaccine is about to gain approval in Canada. Would be interested in your thoughts 🙂
Do you have any more information on this?
Thanks for this video!
Fun fact Tyson foods sells livestock feed with pork brain and spinal tissue that's fed to hogs to this day. It would cost Tyson 17 cents per hog to prevent spinal tissue and brain from entering the inedible feed. But because there's no evidence... It's not a matter of IF but when. The USDA will make no regulation without evidence. I've been concerned about this for over 8 years. Tyson foods - kill floor supervisor, logansport Indiana
🎯🎯🎯 zombie apocalypse, anyone ? Game on!
Do prions not aggregate and form these huge fiber-like strands?
Later in disease prions do form long aggregates that can kill neurons
I've had consistent bad and vivid dreams every night for over a year now, waking me up each night at least once. Could this be a symptom?
Nope you should still go see a doctor though
are dendritic cells the only way that prions are able to cross the blood-brain barrier?
No, there's other ways too
Thanks for the explanation?
I’m just beginning to learn about biological topics and this is a great concise but easy to understand video- thanks!
PrPC is located on cell surface tethered to plasma membrane. If this PrPC is located here and was originally meant as means to withstand temporary low oxygen environments......If you look at these maps where the disease is discovered and you see high altitude environments as a point of origin where cases where found in the 60's...Is hijacking happening through the GPI anchor? Is their also a mechanical explanation for this problem? Are their changes related to chirality, gravitational changes, magnetic spin states, alterations in the plants the deer are consuming in certain areas? Does this disease go past the brain? I am seeing a video of a deer walking around with what appears to be a section of its body missing and the deer seems oblivious to this. Seems strange someone would post automatically saying its CWD as an assumption. Seems like the CWD in deer is concerning. A Tic as a vector of transmission has been brought up. What is causing the Lysosome to not destroy it ? Is it pH alone or is it the type of Hydrogen needed to destroy it, or is it the chirality or spin of the Hydrogen that needs to be adjusted? 3 isotopes of hydrogen exist? What type exists in the Lysosome? Something is very unusual about these prions. Have any sources of Water changed near areas where this disease is occurring? By changes I mean changes related to properties of hydrogen? www.usgs.gov/media/images/distribution-chronic-wasting-disease-north-america-0 There is a very mechanical reason for this disease and the mechanics may more than likely be outside the origin of the host. Something may be mechanically altering the chiral preference of a life form and it may be somehow magnetically or some unusual radiation and the entry point may be the GPI. I believe Buck Institute is researching Mechanoimmunology ...might want to pass this over to them. I am not an immunologist so will not be taken seriously.
That sounds like a SEVIRE design flaw in the human body
Like " death by normal chain reaction "
I thought a prion was by definition a misfolded protein. I knew someone who died of MSA, which is a prion disease caused by alpha synuclein.
Prion protein is a normal protein but their misfolded form is called a prion.
I’m certain I’ve got vcjd in Early September 2020 I was woken up from my sleep with a lethal feeling that I’d been punched in the gut then two weeks later muscle twitches started along with sleep disturbances visual disturbances and a year later I started feeling weakness in my right leg and a blind patch in my left eye, and just to clarify vcjd spreads from the gut to the brain.
You do know that thing is fatal, right? And really quickly so. Like half a year prognosis of certain unavoidable death fast
Do you think I haven’t had long enough to know this disease is fatal, cause I have I just went a year not bothering cus I thought it was ms, now I know different
Sounds like Parkinson’s or Lewy body dementia from your description. Just my opinion.
@@blockerhall4532 it usually kills within4-5 months. 2.5 yrs top. Some neurological disease take 2-4 5-8 and some 10-20 yrs
@blockerhall4532 You very obviously have health anxiety. Diagnosing yourself with CJD because you had stomach pains is pretty obvious. You'd be hospitalised by now if you actually had CJD.
Thank you ❤
Can you ingest misfolded prions from just tasting brain/spinal cord and spitting it out? Just curious lol
Human one’s yes, unless the animal you tried where exposed to its own species brain or cord