BiOptimizers Stress Guardian 10% with code Modern10 stressguardian.com/modern. This video brought to you by BiOptimizers. ProHealth 15% discount Code MODERN : prohealth.pxf.io/zNOPoW NMN prohealth.pxf.io/DKeEmd Renue By Science 10% : Code MHS tinyurl.com/35jyuk33 NMN tinyurl.com/ys4hxwyf DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 Pure NMN tinyurl.com/wyzj2f3d Momentous Supplements 15% discount Code MHS momentous.go2cloud.org/SH2s Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
Hi Abdelilah, thanks for comment. Dr Sorrentino spoke at ARDD about trigonelline and also has a paper based on the research currently in the review process. I will talk about the paper when it comes out.
Hi Sparkling, thanks for your comment. Yes, Singapore certainly seems to be thinking about aging in a much more progressive way than many other countries.
Another great reason to consume Coffee. Trigonelline should be even contained in decaffeinated coffee. (As a zwitterion it should be barely soluble in organic solvents)
Liquid CO2 behaves as a solvent much like Aceton. As a chemist I would guess that it should leave the Trigonellin untouched while the much less polar Caffeine dissolves.
One more way to keep NAD+ up and skip all the NMN and NR hype and expense. I recently learned that coffee ( I drink 3 cups of decaf/d) was high in trigonelline (prior presentation by Vincenzo). Also eat other plant foods high in trig. Turns out in testing my blood my trigonelline level (fasting) my level is about 3 times normal (1.5 micromolar per two tests vs about 0.5 micromolar normal plasma level). Haven't correlated to NAD+ level yet however I exercise and do TRE daily which also helps keep NAD+ up among other benefits. Diet and exercise.
Unfortunately many people think truth can only be accessed through prestige, when in reality prestige will more often than not increase the chances that the claims were made with more rigour, because the prestige usually means the person has more knowledge and insight on said topic, meaning the claims have met a higher standard of rigour, than a claim made by someone without that prestige. But what elitists overlook is sometimes prestige can reinforce biases that make truth harder to access. So in short prestige is a very important & vital marker - but only if you understand that it can simultaneously be problematic too.
@@Vgallo I could not agree more. I am a research scientist/mathematician at a prestigious university. My most important works arose when I questioned the status quo and quietly developed my ideas until I knew I had something. However, most research papers in math and science are incremental. Peer reviewing does not catch all mistakes. It is only when others want to cite us that they will go through every detail because their reputations will be at stake. We have a lot to lose if we claim or cite something controversial and it turns out to be wrong. FQXi funds maverick ideas in physics because it can be hard to get funding off the beaten track.
Hi Tim, thanks for your comment and for the people who have replied. I would add that the key topic Dr Sorrentino talked about and the direction of his study, the translation of aging therapies to the clinic, is one of the major obstacles in longevity at the moment. There are also chapters so you can skip to the section you want to listen to.
BiOptimizers Stress Guardian 10% with code Modern10 stressguardian.com/modern. This video brought to you by BiOptimizers.
ProHealth 15% discount Code MODERN : prohealth.pxf.io/zNOPoW NMN prohealth.pxf.io/DKeEmd
Renue By Science 10% : Code MHS tinyurl.com/35jyuk33 NMN tinyurl.com/ys4hxwyf
DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 Pure NMN tinyurl.com/wyzj2f3d
Momentous Supplements 15% discount Code MHS momentous.go2cloud.org/SH2s
Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr
Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN
NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link
☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
in my country Trigonella foenum was used by old grampa's so we can say old ppl know or they were thinking that this is a good think hehehe
Thx Richard for these valuable infos.Would be intresting to have more on this topic.
Hi Abdelilah, thanks for comment. Dr Sorrentino spoke at ARDD about trigonelline and also has a paper based on the research currently in the review process. I will talk about the paper when it comes out.
Great interview, I became a fans of Dr Sorrentino! will follow his works from now on, thank you Richard!
Hey, thanks for you comment. We will be posting more from Dr Sorrentino soon.
Great information!
Hi Thank you!
Richard, another great guest. Singapore now seems another blue zone and maybe why so many brilliant scientists related to aging are moving there.
Hi Sparkling, thanks for your comment. Yes, Singapore certainly seems to be thinking about aging in a much more progressive way than many other countries.
Another great reason to consume Coffee. Trigonelline should be even contained in decaffeinated coffee. (As a zwitterion it should be barely soluble in organic solvents)
Would it also be retained in the CO2 (solvent free) way of decaffeinating coffee?
Hi Rainer, thanks for sharing. Not that I need another reason to drink coffee!
Liquid CO2 behaves as a solvent much like Aceton. As a chemist I would guess that it should leave the Trigonellin untouched while the much less polar Caffeine dissolves.
Great interview and it’s great to hear he is working with Brian Kennedy
One more way to keep NAD+ up and skip all the NMN and NR hype and expense. I recently learned that coffee ( I drink 3 cups of decaf/d) was high in trigonelline (prior presentation by Vincenzo). Also eat other plant foods high in trig. Turns out in testing my blood my trigonelline level (fasting) my level is about 3 times normal (1.5 micromolar per two tests vs about 0.5 micromolar normal plasma level). Haven't correlated to NAD+ level yet however I exercise and do TRE daily which also helps keep NAD+ up among other benefits. Diet and exercise.
In the IKON TRIAL COPD is targeted with NR (Nicotinamide Riboside).
Is there a good chance that Trigonelline can be used for COPD patients?
Thanks Richard.
Take TMG with Niacin
More reasons to drink more lighter roasted coffee?
I'd much rather just here the science, rather than a large explanation of the scientists background
It is important to establish credentials. There are many without them and making false statements.
I found interesting to know more about the scientist though...
Unfortunately many people think truth can only be accessed through prestige, when in reality prestige will more often than not increase the chances that the claims were made with more rigour, because the prestige usually means the person has more knowledge and insight on said topic, meaning the claims have met a higher standard of rigour, than a claim made by someone without that prestige.
But what elitists overlook is sometimes prestige can reinforce biases that make truth harder to access.
So in short prestige is a very important & vital marker - but only if you understand that it can simultaneously be problematic too.
@@Vgallo I could not agree more. I am a research scientist/mathematician at a prestigious university. My most important works arose when I questioned the status quo and quietly developed my ideas until I knew I had something. However, most research papers in math and science are incremental. Peer reviewing does not catch all mistakes. It is only when others want to cite us that they will go through every detail because their reputations will be at stake. We have a lot to lose if we claim or cite something controversial and it turns out to be wrong. FQXi funds maverick ideas in physics because it can be hard to get funding off the beaten track.
Hi Tim, thanks for your comment and for the people who have replied. I would add that the key topic Dr Sorrentino talked about and the direction of his study, the translation of aging therapies to the clinic, is one of the major obstacles in longevity at the moment. There are also chapters so you can skip to the section you want to listen to.
25% Vulcan 75% Italian.......