Thank you so much for another terrific presentation on dry eye treatment Dr. Tran! I too suffer from dry eyes and remember the sting when first used prescription dry eye treatment drops. Tyrvaya definitely appear to be great alternative to avoid that discomfort. I look forward to bringing up Tyrvaya with my Eye Doctor!
Good video….EXCEPT … YOU DONT SPRAY IT UP YOUR NOSE LIKE A NASAL SPRAY … YOU SPRAY AGAINST INSIDE WALL LOWER WIDER AREA OF NOSE DIRECTING TOWARD YOUR EAR. NOT UP INTO NOSE. After spraying you hold nose shut a minute. Yes, I sneeze about 3 times and that’s it.
None of these videos seem to disclose the Psychiactric side effects of the medication which is very disturbing. Psychiatric Very common (10% or more): Insomnia (up to 19%), abnormal dreams (up to 13%), depressed mood disorders and disturbances (up to 11%), irritability (up to 11%) Common (1% to 10%): Agitation, anxiety, depressed mood, depression, hostility, middle insomnia, nervousness, nightmare, restlessness, sleep disorder, tension I'm not saying don't try the medication, but I feel people should be informed before deciding to.
Interesting point. Which study are you pulling your data from? This is pulled from the efficacy study. "SIDE EFFECTS Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In three clinical studies of dry eye disease conducted with varenicline solution nasal spray, 349 patients received at least 1 dose of TYRVAYA. The majority of patients had 31 days of treatment exposure, with a maximum exposure of 105 days. The most common adverse reactions reported in 82% of TYRVAYA treated patients was sneezing. Other common adverse reactions that were reported in >5% of patients include cough (16%), throat irritation (13%), and instillation-site (nose) irritation (8%)." And this "6 ADVERSE REACTIONS 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In three clinical studies of dry eye disease conducted with varenicline solution nasal spray, 349 patients received at least 1 dose of TYRVAYA. The majority of patients had 31 days of treatment exposure, with a maximum exposure of 105 days. The most common adverse reactions reported in 82% of TYRVAYA treated patients was sneezing. Other common adverse reactions that were reported in >5% of patients include cough (16%), throat irritation (13%), and instillation-site (nose) irritation (8%)."
@@AmericanPatriots87 Thanks for sharing. I think that has to do with oral delivery of varenicline. I would have to look at that actual study itself. Where the medications are delivered is important. A medication that may be safe orally may not be save as an IV medication. Similarly, a medication that is sprayed in the nose may have little to none of the psychiatric side effects as oral medication. The ORAL form of this medication is Chantix which is used to stop smoking, so it makes sense that their are side effects with oral delivery. I think its fabulous that you have read up on the medication. I will also inquire and see if I can find more information about any association with intranasal delivery and those side effects listed.
@@DrJeffreyTran I've been on Tyrvaya for over a year. I've experienced no negative psychiatric side effects. Tyrvaya was a game changer for my dry eye disease (that I've dealt with for over 30 years). I'm much less irritable, my eyes don't hurt and I can breathe/sleep better with tyrvaya.
Definitely does have all of those side effects, used it for a few days and didn’t have one good nights sleep I was so scared I had to stop. I’d say stay away if you can. Thanks for finally pointing this out seems like none of the doctors have mentioned this, which like you said is scary. Makes me wonder if all these positive reviews are fake 🤔
@@swingevnts Unfortunately it's always been an issue with the medical industry that they do this. Look up itear it's a physical device that stimulates tear production without drugs. I've been doing blueberry and pineapple smoothies and take krill oil supplements and they seem to have helped me.
I recommend asking your eye doctor to try using a specialty pharmacy. Sometimes there are coupons that can be applied to make it affordable. Everyone has different pharmacy benefits, but regardless I do think it works well for my patients. Best of luck!
Thank you so much for another terrific presentation on dry eye treatment Dr. Tran! I too suffer from dry eyes and remember the sting when first used prescription dry eye treatment drops. Tyrvaya definitely appear to be great alternative to avoid that discomfort. I look forward to bringing up Tyrvaya with my Eye Doctor!
We can definitely talk about it!
I live in Brazil and we don´t have Tyrvaya... do you think Chantix works too?
I would love to try this for my dry eyes 😩🙏🏾
We can definitely talk about it! It’s a good option for many!
You should call your local eye doctor!
Good video….EXCEPT … YOU DONT SPRAY IT UP YOUR NOSE LIKE A NASAL SPRAY … YOU SPRAY AGAINST INSIDE WALL LOWER WIDER AREA OF NOSE DIRECTING TOWARD YOUR EAR. NOT UP INTO NOSE. After spraying you hold nose shut a minute. Yes, I sneeze about 3 times and that’s it.
None of these videos seem to disclose the Psychiactric side effects of the medication which is very disturbing.
Psychiatric
Very common (10% or more): Insomnia (up to 19%), abnormal dreams (up to 13%), depressed mood disorders and disturbances (up to 11%), irritability (up to 11%)
Common (1% to 10%): Agitation, anxiety, depressed mood, depression, hostility, middle insomnia, nervousness, nightmare, restlessness, sleep disorder, tension
I'm not saying don't try the medication, but I feel people should be informed before deciding to.
Interesting point. Which study are you pulling your data from? This is pulled from the efficacy study.
"SIDE EFFECTS
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In three clinical studies of dry eye disease conducted with varenicline solution nasal spray, 349 patients received at least 1 dose of TYRVAYA. The majority of patients had 31 days of treatment exposure, with a maximum exposure of 105 days.
The most common adverse reactions reported in 82% of TYRVAYA treated patients was sneezing. Other common adverse reactions that were reported in >5% of patients include cough (16%), throat irritation (13%), and instillation-site (nose) irritation (8%)."
And this
"6 ADVERSE REACTIONS
6.1 Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In three clinical studies of dry eye disease conducted with varenicline solution nasal spray, 349 patients received at least 1 dose of TYRVAYA. The majority of patients had 31 days of treatment exposure, with a maximum exposure of 105 days.
The most common adverse reactions reported in 82% of TYRVAYA treated patients was sneezing. Other common adverse reactions that were reported in >5% of patients include cough (16%), throat irritation (13%), and instillation-site (nose) irritation (8%)."
@@AmericanPatriots87 Thanks for sharing. I think that has to do with oral delivery of varenicline. I would have to look at that actual study itself. Where the medications are delivered is important. A medication that may be safe orally may not be save as an IV medication. Similarly, a medication that is sprayed in the nose may have little to none of the psychiatric side effects as oral medication. The ORAL form of this medication is Chantix which is used to stop smoking, so it makes sense that their are side effects with oral delivery. I think its fabulous that you have read up on the medication. I will also inquire and see if I can find more information about any association with intranasal delivery and those side effects listed.
@@DrJeffreyTran I've been on Tyrvaya for over a year. I've experienced no negative psychiatric side effects. Tyrvaya was a game changer for my dry eye disease (that I've dealt with for over 30 years). I'm much less irritable, my eyes don't hurt and I can breathe/sleep better with tyrvaya.
Definitely does have all of those side effects, used it for a few days and didn’t have one good nights sleep I was so scared I had to stop. I’d say stay away if you can. Thanks for finally pointing this out seems like none of the doctors have mentioned this, which like you said is scary. Makes me wonder if all these positive reviews are fake 🤔
@@swingevnts Unfortunately it's always been an issue with the medical industry that they do this. Look up itear it's a physical device that stimulates tear production without drugs. I've been doing blueberry and pineapple smoothies and take krill oil supplements and they seem to have helped me.
How can I purchase in pakistan?
This is a prescription
This nasal spray is very expensive in the United States
I recommend asking your eye doctor to try using a specialty pharmacy. Sometimes there are coupons that can be applied to make it affordable. Everyone has different pharmacy benefits, but regardless I do think it works well for my patients. Best of luck!
@@DrJeffreyTranyes phil rx