The DNA Damage Response | Repair the DNA or Commit Apoptosis?
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- Опубликовано: 13 апр 2019
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Correction to your video:
Succintly, phosphorylated retina blastoma renders dissociation from E2F. Subsequently, E2F can translocate to the nucleus to confer increased expression of E2F target genes, including E2F (positive feedback loop) and cyclin E to propogate entry into S-phase.
CDK = Cyclin-Dependent-Kinase. Per definition, kinases phosphorylate (add phosphor groups to) targets. Thus, CDK will phosphorylate retina blastoma to confer its dissociation from E2F.
Yes the CDK2/Cyclin E phosphorylates PrB, which can release the factors that allow G1 to S.
doesn't the retinoblastic protein release E2F after phosphorylation?
I thought so too. From ‘Signal Transduction, Principles, Pathways, and Processes’, page 141: “Phosphorylation of the pRB family proteins by CDKs during G1 phase causes pRB to dissociate from E2Fs, allowing transcription of target genes that stimulate progression into S phase.”
@@jonathanlehmann2059 Yeah. That is what it says in my textbook as well
milk is cheap protein Good to know, thanks. Mine is a 2013 book, so it’s possible that the field has changed since then, maybe.
Thanks for the information.
Very nice explanation 😺
nicely explained.
in my opinion it should be more like high degredation of p53 in the case of low stress and low degredation of p53 in the case of high stress
Isn't the cdk4/6-cyclinD complex which phosphorylates Rb to release E2F ?
Just double checking but is P21 negative my regulated by MDM2
it is p53 that is degraded by the action of MDM2
Fayaz Feroz Thanks couldn’t quite remember, when revising this I looked up all the gene loci, thanks to the wink wink to revise p53 and non of it came up on the exam
pRb is inactivated when phosphorylated and then it releases E2F which enters the nucleus and acts as a transcription factor for proteins that help in G1 to S phase transition.
king