Adipose tissue as endocrine organ

White adipose tissue in a normal state generates signals to multiple types of body tissue and the immune system. The resulting physiologic and cellular changes ultimately confer protection from lipotoxicity and metabolic dysfunction. Obesity expert Caroline Apovian, MD, explains.

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Damaged fat and muscle cells, is there a mechanical process the autonomic system to replace the Damaged cells

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What exactly causes fat cells to became inflamed? Fat cell explosion, hypoxia, trans-fats, or refined oils?

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Unhealthy diet and lifestyle

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Adipocytes secrete pro inflammatory factors on their own IIRC; excess amounts of adipocytes lead to excess secretion of these factors