Imetelstat: Understanding how this drug fights Myelodysplastic Syndrome (MDS) │ Pharmacology

Myelodysplastic syndrome (MDS) can be a challenging and complex blood disorder. But there's new hope on the horizon with the drug imetelstat. In June 2024, the US FDA approved Geron’s Imetelstat for adults with low to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anaemia. In this video, we break down the science behind this innovative treatment. Learn how imetelstat works at a cellular level to target and fight MDS. We'll also delve into the groundbreaking IMerge Phase III results that led to its approval.
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References:
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2. Bazinet A, Bravo GM. New Approaches to Myelodysplastic Syndrome Treatment. Curr Treat Options Oncol. 2022;23(5):668-687. doi:10.1007/s11864-022-00965-1
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5. Platzbecker U, Santini V, Fenaux P, et al. Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial [published correction appears in Lancet. 2024 Jan 20;403(10423):248. doi: 10.1016/S0140-6736(24)00057-6]. Lancet. 2024;403(10423):249-260. doi:10.1016/S0140-6736(23)01724-5
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