Thankyou for the most compelling youtube video for a omad ketogenic/coconut oil lifestyle.. Sending to my doubting 48 year old (myasthenia gravis) daughter, her genetically superior mother, and my genuinely inquisitive gp, who is following this 68 year old guinea pig's 6 month transformation.. One (am) meal a day (23hrs).. Skip tuesdays (47hrs).. Skip first wednesday of every month (71hrs).. Works for me.
I did buy your book and noticed the page explaining ordering overseas. I just received my order today, and took 1 mg about six hours ago. I am enthusiastic about taking Rapamycin. Thank you for your great book
Renue By Science* 10% Discount Lipo CoQ10: tinyurl.com/2c2pae4w, Glutathione : tinyurl.com/5n7pym2n Use SUBMHS when buying subscriptions for a continued discount of renewal orders Renue By Science* 10% : tinyurl.com/4yrf4tv3 DoNotAge* 10% discount code MODERNHEALTHSPAN tinyurl.com/ycyn9vhn NOVOS* Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957 ProHealth* 10% discount Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 Bulletproof* 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
I ordered some Rapamycin after hearing this speaker tell us how to do it. However, I am not going to try it yet. This is a very powerful drug and I prefer to wait for proper tests to determine dosages, timings, side effects and effectiveness. There is too much guess work right now. Also, the website is for a company based in China. How can we be certain they are producing pure products? Are their products independently tested? I wrote them to find out, but have not had a response. Other companies make certificates available to the public. I was burnt before with a fake NMN supplement sold by a Chinese company and have learned to enquire.
It's amazing that explanation. My Great-grandmother lived to be 103 and according to my Dad never went to a doctor, and she didn't have any old AGE disease that this generation is suffering.❤❤❤❤
neither did my great-grandma. At some point, she decided it was a good time to depart the Earth. Cause of death: "old age", there was absolutely nothing wrong with her.
I assume you're from the United States as most of the rest of the developed world gives it's citzens coverage. Anyone in the United States can get affordable health insurance by going to the Health Insurance Marketplace as long as your yearly income is over aooriximately $12,800. When you make your application they will give you a quote that is in the $600 to $800 per month range depending on which policy you choose. After that look around at the bottom of the page there'll be a place to apply for a subsidy. I know people who are paying less than $10 a month for their insurance. The subsidy is a sliding scale and if you're making more than $60,000 a year for a single person than the subsidies slowly goes away the higher your income is. Beware and do not buy these junk insurance policies but ones that are rated like platinum or Sapphire or silver. You can always call the health insurance Marketplace number and talk to a licensed health insurance person and they can help you pick out one that may be good for you. For example some policies have better coverage for drug abuse issues than others. At the very least you ought to get a high-deductible policy that would kick in after $10,000 or $20,000 in case you became seriously ill or injured in an accident.
Magnesium Breakthrough 10% Discount bit.ly/3O5tPfu with code Modern10 Renue By Science NMN, 10% discount: tinyurl.com/5n8z97vz Use SUBMHS when buying subscriptions for a continued discount of renewal orders Renue By Science 10% : tinyurl.com/4yrf4tv3 DoNotAge 10% discount code MODERNHEALTHSPAN donotage.org/products/ NOVOS Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957 ProHealth 10% discount Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 Dr Ross Pelton Playlist : ruclips.net/p/PLkfzM7KJv6vbe7sYwXdSuILCX2-lFRV6m
Any thoughts on The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor? Do you think EGCG can be an alternative to Rapamycin in suppressing Mammalian Target of Rapamycin (mTOR)?
Biological aging is not about how many years you have lived. It's about how many poisons you have stuffed into your body: fructose, seed oils, rapamycin...
Thank you Richard, very interesting and informative interview 👍 I personnaly thought it was a drug to take once in your life at high dosage, not something to take weekly and from what I understand for the rest of your life ? Have you already tried this drug for yourself ?
Hi Pierre, thanks for your comment. I have not tried it yet, but am seriously thinking about it now. I will certainly talk about it on the channel when I start.
Rapamycin is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, which acts as a central integrator of nutrient signaling pathways. mTor is a key regulator in maintaining skeletal muscle mass. Rapamycin is an inhibitor of mTOR and mTOR is critical to signaling muscle protein synthesis. Why would rapamycin be used as an anti-aging agent that inhibits muscle protein synthesis? Would resistance muscle training to maintain muscle mass be impaired and cause sarcopenis muscle atrophy?
I am trying very hard to find an answer to this same question. Plz let me know if u have any update on this. What I gathered so far is that although it doesnt improve muscle gain, it helps with muscle “quality” through mediating more efficient mitochondria and ATP production.
No one can answer that yet but in general reducing chronic inflammation is good for most auto immune conditions. Pulsed weekly dosing is important, not daily. There has been some limited studies on rapa being helpful for RA, if you google it.
Been taking it for years to address autoimmune dysfunction that caused joint pain. I’m am free from almost all pain. I also do OMAD and a lot of aerobic exercise. Have never felt better other than I am getting older. Can rarely get my heart rate to 180 on a strenuous cycling event any longer. Not going to live forever- yet….
For blood testing Dr. Ross mentions on checking for levels - one hour, two hours, 8 hrs after taking 5/6 gram dose? What is best timing for blood draw?
Hi Michael, thanks for your question and that is a good point and I did not ask specifically. The numbers he was talking about were in the nanograms per ml which would be the residual levels and since he did not say directly after taking rapamycin then I think it looks like residual levels. It depends if you are checking, am I taking enough to be effective (I would think you need the test shortly after taking rapamycin to see what the peak is) or am I taking too much (where I think you would want to look at the residual levels as you don't want it interfering with mTOR all the time.)
I am a 53 year old cancer survivor. I started a 3 month trial of Rapamycin at 5mg 1x a week. I am in week 10 and have only noticed a side effect of feeling a coating in my mouth. I am losing weight and very happy so far. My local compounding pharmacy charges me $120 for 90 day supply. What's your opinion of doing this intermittently vs life long? I haven't decided what I should do? I have been in remission for 7 years but still get a SAM shot every 2 months. Sequenced amino acid modulation. I also take 4.5 mg of low dose naltrexone each night before bed. I am in good health and on no other medications except for occasional Ivermectin which is a whole other discussion. Thanks
This is very interesting. You mentioned that intermittent fasting works as well and I am wondering whether intermittent fasting is just as good as using Rapamycin to slow aging?
I have read about this. I don't think it's exactly the same, but fasting is definitely very good for longevity and health. My understanding is it would be best to use both intermittent fasting and Rapamycin.
@@HeleneLouise Thanks! Good to know. I wonder why some have mentioned that Rapamycin may also raise lipids and cause insulin issues. I don't want to fix one problem only to create another and wonder whether or not this is accurate.
@@melanie.3837 I actually haven't heard about Rapamycin raising lipid or causing insulin issues. I don't dispute that, I just don't know. As far as lipids, I've never worried at all about cholesterol because I think the science on it being harmful is flawed research. I would be concerned about high triglycerides. I would not like to cause insulin issues. But I had an odd experience with fasting a couple of years ago too. I decided to fast four days a week for twenty six weeks. Well, I was too fasted out to go more than 12 weeks, not surprisingly. I was trying to copy a mouse study where they had ruined the pancreases of these poor little mice, and then put them on the 4 day a week, 26 week fast, and they all regrew normal pancreases. It was as if they had pancreas transplants. But the weird part for me was that my fasting glucose when I did this went up to near diabetic levels. So the bottom line is, that either method could have side effects. My glucose went back to normal after a while. I personally think the Rapamycin is worth trying. Still, there is a whole lot of benefit in fasting.
@@melanie.3837 Hi Melanie. I wanted to add a couple of thoughts to my response to you from yesterday after giving it more thought. There is a well known Rapamycin researcher, Mikhail Blagosklonny, that has written about side effect of using Rapamycin for anti-aging. He pointed out that the side effects that are reported such as raising lipids and insulin issues are taken from patients using larger daily doses for prevention of organ transplant rejection. The once a week smaller doses taken for anti-aging did not show these side effects. In fact, his feeling is that NOT taking Rapamycin is "more dangerous than smoking." I thought I might also mention my own experience with diet and fasting. Fasting has been used for centuries in the treatment of epilepsy. In the 1920s the ketogenic diet was formulated to mimic fasting so that the fasting effect could be longer duration. Having been developed for the treatment of epilepsy by fasting mimicking, the keto diet was and is extremely successful in controlling epilepsy. Being akin to fasting, it also has many of the health benefits of fasting. So, point being, it might be of interest to you. And also, I think both Rapamycin and fasting and keto diets are great ways of improving health and longevity. As far as studies, people are so long lived that most of the evidence for longevity is anecdotal. I am just starting on Sirolimus, which is generic Rapamycin, and I'm surprised to notice immediate benefits. And I have fasted and keto dieted in addition. But, most of the people I've heard talk about Rapamycin do recommend medical oversight, like lab testing.
At one time, dogs did not develop the same diseases and humans. That only began when pet food companies began adding grain, fruit and vegetables to dog food.
Hi Michael, thanks for your question. He said a "low dose" but I did not ask exactly how much. We did speak with Dr Guttuso on lithium and he talks in quite detail about the various doses. Supplemental (as opposed to clinical) seems to normally be in the 1 to 5mg range.
Why not test yourself after 3 days to see the peaked plasma level of the drug? Why wait till day 6 are 7 when the drug is cleared. The Half life of the drug is 62 hours. So on day 7 it should have gone through 3 half-life
@ModernHealthspan Hi Richard, I have read about Rapamycin many times, but was blocked by the need for a prescription. I have finally found a source. Pelton’s book is a paperback and sells for $125, so I will opt out. I note that he has a PhD, not an MD. His consultation fees of $200/hour are more inline with those of an MD. I know the world of celebrated PhDs in academia and $200/hr is unheard of. -Jenny
@@msplateaugalUnderstand. The concept of the company is interesting. A typical medical visit would be $200 or more if you paid for it without insurance. If someone has an HSA that would be a way to pay for this as an example.
My wife and I took a chance on a supplier from India. 500 x 1 mg tabs for $300 delivered. At 6 mg a week, I definitely feel it. It does mess with my blood sugar and being type 1 diabetic, I have been able to figure out a management protocol. Going in Monday to draw blood for a level check. Anecdotally, I do attest to these pills from India are the real deal. I would be happy to share details of you PM me. YT blocks that stuff here. Cheers!
@@dcjohnson2208easier said than done. I think if there is no justification for prescribing the medication most ethical providers would not do it. Too many risks to rapamycin.
Supposedly the stuff from India market is real (unlike the Chinese stuff) but you need to get it imported . I have no experience with importing as I just write my own prescription
Here's the side effects: Accumulation of pus anxiousness, unexplained backache black or red, tarry stools bleeding from the gums or nose blurred vision body aches or pain bone pain bruising burning or stinging of the skin burning while urinating burning, dry, or itching eyes burning, tingling, numbness, or pain in the hands, arms, feet, or legs change in mental status changes in skin color chest pain chills confusion cough dark or bloody urine deafness decreased urine output decreased vision difficulty with breathing or swallowing dilated neck veins discharge from the eyes dizziness drowsiness dry mouth earache excessive tearing eye pain facial hair growth in females faintness or lightheadedness when getting up from lying or sitting position fast, slow, or irregular heartbeat fever flushing or redness of the skin, especially on the face and neck general feeling of discomfort or illness increased hunger increased menstrual flow or vaginal bleeding itching, pain, redness, swelling, tenderness, or warmth on the skin lack or loss of appetite large, flat, blue, or purplish patches in the skin loss of sexual ability, desire, drive, or performance loss of voice muscle pain nasal congestion nausea or vomiting numbness or tingling around the lips, hands, or feet pain in the chest, groin, or legs, especially the calves painful cold sores or blisters on the lips, nose, eyes, or genitals pale skin prolonged bleeding from cuts rapid heartbeat rash red or dark brown urine redness or swelling in the ear redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid ringing in the ears runny nose seizures sensation of pins and needles severe constipation severe vomiting severe, sudden headache slurred speech sore throat sores or white spots on the lips or in the mouth stomach cramps, pain, or upset sudden decrease in the amount of urine sudden loss of coordination sudden, severe weakness or numbness in the arm or leg sweating swollen, painful, or tender lymph glands in the neck, armpit, or groin tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area tremor ulcers on the lips or in the mouth unusual tiredness or weakness vision changes weakness or heaviness of the legs white patches in the mouth or on the tongue yellow skin and eyes Less common Bloating change in size, shape, or color of existing mole hoarseness mole that leaks fluid or bleeds new mole pains in the stomach, side or abdomen, possibly radiating to the back skin ulcer or sores Incidence not known Abnormal wound healing headache hives or itching large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs nails loose or detached puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue swelling of the arms or legs yellow nails lacking a cuticle Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abnormal vision acne belching blistering, crusting, irritation, itching, or reddening of the skin burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling constipation continuing ringing or buzzing or other unexplained noise in the ears cracked, dry, or scaly skin crying decrease in frequency of urination degenerative disease of the joint depersonalization diarrhea difficulty with moving difficulty with passing urine (dribbling) dysphoria ear pain enlarged abdomen or stomach euphoria excess air or gas in the stomach or intestines excessive muscle tone, muscle tension or tightness fear feeling sad or empty hearing loss heartburn inability to have or keep an erection increase in heart rate increased hair growth, especially on the face increased urge to urinate during the night indigestion irritation in the mouth joint pain or swelling leg cramps loss of bladder control loss of energy or weakness loss of interest or pleasure loss of strength lower abdominal or stomach pain muscle aches, pain, stiffness, or weakness nervousness pain in the back, ribs, arms, or legs pain or burning in the throat pain or tenderness around the eyes and cheekbones paranoia pelvic pain quick to react or overreact emotionally rapid breathing rapidly changing moods inflammation, redness, or swelling of the gums or mouth shaking or trembling shivering sleepiness sunken eyes swelling swelling of the scrotum tender or enlarged gums tenderness in the stomach area thickening of the skin trouble concentrating trouble sleeping waking to urinate at night
![Chlöe - Shake (Feat. Jeremih) [Official Visualizer]](http://i.ytimg.com/vi/aDs_1ufpfv8/mqdefault.jpg)
He nailed it. If only more people understood how important not eating all the time is.
Matt Kauberlin, the lead scientist of the dog aging project, has a human protocol for rapamycin too.
Hi Thanks for sharing.
Thankyou for the most compelling youtube video for a omad ketogenic/coconut oil lifestyle..
Sending to my doubting 48 year old (myasthenia gravis) daughter, her genetically superior mother, and my genuinely inquisitive gp, who is following this 68 year old guinea pig's 6 month transformation..
One (am) meal a day (23hrs)..
Skip tuesdays (47hrs)..
Skip first wednesday of every month (71hrs)..
Works for me.
I did buy your book and noticed the page explaining ordering overseas. I just received my order today, and took 1 mg about six hours ago. I am enthusiastic about taking Rapamycin. Thank you for your great book
Renue By Science* 10% Discount Lipo CoQ10: tinyurl.com/2c2pae4w, Glutathione : tinyurl.com/5n7pym2n
Use SUBMHS when buying subscriptions for a continued discount of renewal orders
Renue By Science* 10% : tinyurl.com/4yrf4tv3
DoNotAge* 10% discount code MODERNHEALTHSPAN tinyurl.com/ycyn9vhn
NOVOS* Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957
ProHealth* 10% discount Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976
Bulletproof* 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp
☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
I ordered some Rapamycin after hearing this speaker tell us how to do it. However, I am not going to try it yet. This is a very powerful drug and I prefer to wait for proper tests to determine dosages, timings, side effects and effectiveness. There is too much guess work right now. Also, the website is for a company based in China. How can we be certain they are producing pure products? Are their products independently tested? I wrote them to find out, but have not had a response. Other companies make certificates available to the public. I was burnt before with a fake NMN supplement sold by a Chinese company and have learned to enquire.
It's amazing that explanation. My Great-grandmother lived to be 103 and according to my Dad never went to a doctor, and she didn't have any old AGE disease that this generation is suffering.❤❤❤❤
My grandmother lived to be 103, too. She was never sick. Her children always remarked on this.
neither did my great-grandma. At some point, she decided it was a good time to depart the Earth. Cause of death: "old age", there was absolutely nothing wrong with her.
I assume you're from the United States as most of the rest of the developed world gives it's citzens coverage. Anyone in the United States can get affordable health insurance by going to the Health Insurance Marketplace as long as your yearly income is over aooriximately $12,800. When you make your application they will give you a quote that is in the $600 to $800 per month range depending on which policy you choose. After that look around at the bottom of the page there'll be a place to apply for a subsidy. I know people who are paying less than $10 a month for their insurance. The subsidy is a sliding scale and if you're making more than $60,000 a year for a single person than the subsidies slowly goes away the higher your income is. Beware and do not buy these junk insurance policies but ones that are rated like platinum or Sapphire or silver. You can always call the health insurance Marketplace number and talk to a licensed health insurance person and they can help you pick out one that may be good for you. For example some policies have better coverage for drug abuse issues than others. At the very least you ought to get a high-deductible policy that would kick in after $10,000 or $20,000 in case you became seriously ill or injured in an accident.
Some on the forums recommend grape fruit juice 1-4 hours prior to dosing to increase absorption by 30%
Can someone define natural pharmacist, and the qualifications for one to call themselves such?
Magnesium Breakthrough 10% Discount bit.ly/3O5tPfu with code Modern10
Renue By Science NMN, 10% discount: tinyurl.com/5n8z97vz
Use SUBMHS when buying subscriptions for a continued discount of renewal orders
Renue By Science 10% : tinyurl.com/4yrf4tv3
DoNotAge 10% discount code MODERNHEALTHSPAN donotage.org/products/
NOVOS Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957
ProHealth 10% discount Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976
Dr Ross Pelton Playlist : ruclips.net/p/PLkfzM7KJv6vbe7sYwXdSuILCX2-lFRV6m
Any thoughts on The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor? Do you think EGCG can be an alternative to Rapamycin in suppressing Mammalian Target of Rapamycin (mTOR)?
Hi Richard. Thanks for sharing this.
Great interview. Thanks!
Hi Olya, thanks! Great to see you.
Great info, especially the source option.
Hi Monty, thanks for your comment.
It's been VERY hard for me to pay for the outside purchases. No crypto, zelle didn't seem to work. The FDA runs a tight ship!
I was just commenting on this topic today elsewhere on RUclips. You read my mind 😂 Thanks!
Hi thank you. I hope that you found the video helpful.
Biological aging is not about how many years you have lived. It's about how many poisons you have stuffed into your body: fructose, seed oils, rapamycin...
Thank you Richard, very interesting and informative interview 👍 I personnaly thought it was a drug to take once in your life at high dosage, not something to take weekly and from what I understand for the rest of your life ? Have you already tried this drug for yourself ?
Hi Pierre, thanks for your comment. I have not tried it yet, but am seriously thinking about it now. I will certainly talk about it on the channel when I start.
Anyone have any problems with ordering from the anti-aging store in Hong Kong? Thank you
Great episode, curious question, do you have any plans on starting taking Rapamycin also?
Rapamycin is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, which acts as a central integrator of nutrient signaling pathways.
mTor is a key regulator in maintaining skeletal muscle mass.
Rapamycin is an inhibitor of mTOR and mTOR is critical to signaling muscle protein synthesis.
Why would rapamycin be used as an anti-aging agent that inhibits muscle protein synthesis?
Would resistance muscle training to maintain muscle mass be impaired and cause sarcopenis muscle atrophy?
I am trying very hard to find an answer to this same question. Plz let me know if u have any update on this. What I gathered so far is that although it doesnt improve muscle gain, it helps with muscle “quality” through mediating more efficient mitochondria and ATP production.
He encourages people to take this medication, and I would love to, but what doctor is going to give me A prescription for this?
I have 3 autoimmune diseases which I am trying to deal with. Would rapamycin be appropriate for me?
No one can answer that yet but in general reducing chronic inflammation is good for most auto immune conditions. Pulsed weekly dosing is important, not daily.
There has been some limited studies on rapa being helpful for RA, if you google it.
Been taking it for years to address autoimmune dysfunction that caused joint pain. I’m am free from almost all pain. I also do OMAD and a lot of aerobic exercise. Have never felt better other than I am getting older. Can rarely get my heart rate to 180 on a strenuous cycling event any longer. Not going to live forever- yet….
Thumbs up 👍
For blood testing Dr. Ross mentions on checking for levels - one hour, two hours, 8 hrs after taking 5/6 gram dose? What is best timing for blood draw?
Not gram but milligram.
Yes, what is the right timing and the corresponding target levels in blood?
Hi Michael, thanks for your question and that is a good point and I did not ask specifically. The numbers he was talking about were in the nanograms per ml which would be the residual levels and since he did not say directly after taking rapamycin then I think it looks like residual levels. It depends if you are checking, am I taking enough to be effective (I would think you need the test shortly after taking rapamycin to see what the peak is) or am I taking too much (where I think you would want to look at the residual levels as you don't want it interfering with mTOR all the time.)
@@ModernHealthspan Great points you make! Try to catch the peak to tweak dosage and to catch the residual to tweak the frequency.
I am a 53 year old cancer survivor. I started a 3 month trial of Rapamycin at 5mg 1x a week. I am in week 10 and have only noticed a side effect of feeling a coating in my mouth. I am losing weight and very happy so far. My local compounding pharmacy charges me $120 for 90 day supply. What's your opinion of doing this intermittently vs life long? I haven't decided what I should do? I have been in remission for 7 years but still get a SAM shot every 2 months. Sequenced amino acid modulation. I also take 4.5 mg of low dose naltrexone each night before bed. I am in good health and on no other medications except for occasional Ivermectin which is a whole other discussion. Thanks
I'd like to know of people who ordered with International Anti Aging Systems and what their experience was.
Hi Monte, thanks for your question. I am thinking of ordering from them and will update if and when I do.
@@ModernHealthspan When you get them, can you take them to a lab of some sort and see if they can tell you if the product is the real deal?
This is very interesting. You mentioned that intermittent fasting works as well and I am wondering whether intermittent fasting is just as good as using Rapamycin to slow aging?
I have read about this. I don't think it's exactly the same, but fasting is definitely very good for longevity and health. My understanding is it would be best to use both intermittent fasting and Rapamycin.
@@HeleneLouise Thanks! Good to know. I wonder why some have mentioned that Rapamycin may also raise lipids and cause insulin issues. I don't want to fix one problem only to create another and wonder whether or not this is accurate.
@@melanie.3837 I actually haven't heard about Rapamycin raising lipid or causing insulin issues. I don't dispute that, I just don't know. As far as lipids, I've never worried at all about cholesterol because I think the science on it being harmful is flawed research. I would be concerned about high triglycerides. I would not like to cause insulin issues. But I had an odd experience with fasting a couple of years ago too. I decided to fast four days a week for twenty six weeks. Well, I was too fasted out to go more than 12 weeks, not surprisingly. I was trying to copy a mouse study where they had ruined the pancreases of these poor little mice, and then put them on the 4 day a week, 26 week fast, and they all regrew normal pancreases. It was as if they had pancreas transplants. But the weird part for me was that my fasting glucose when I did this went up to near diabetic levels. So the bottom line is, that either method could have side effects. My glucose went back to normal after a while. I personally think the Rapamycin is worth trying. Still, there is a whole lot of benefit in fasting.
@@melanie.3837 Hi Melanie. I wanted to add a couple of thoughts to my response to you from yesterday after giving it more thought. There is a well known Rapamycin researcher, Mikhail Blagosklonny, that has written about side effect of using Rapamycin for anti-aging. He pointed out that the side effects that are reported such as raising lipids and insulin issues are taken from patients using larger daily doses for prevention of organ transplant rejection. The once a week smaller doses taken for anti-aging did not show these side effects. In fact, his feeling is that NOT taking Rapamycin is "more dangerous than smoking." I thought I might also mention my own experience with diet and fasting. Fasting has been used for centuries in the treatment of epilepsy. In the 1920s the ketogenic diet was formulated to mimic fasting so that the fasting effect could be longer duration. Having been developed for the treatment of epilepsy by fasting mimicking, the keto diet was and is extremely successful in controlling epilepsy. Being akin to fasting, it also has many of the health benefits of fasting. So, point being, it might be of interest to you. And also, I think both Rapamycin and fasting and keto diets are great ways of improving health and longevity. As far as studies, people are so long lived that most of the evidence for longevity is anecdotal. I am just starting on Sirolimus, which is generic Rapamycin, and I'm surprised to notice immediate benefits. And I have fasted and keto dieted in addition. But, most of the people I've heard talk about Rapamycin do recommend medical oversight, like lab testing.
Where I can find doctor in US give me Rapamycine ? Please help
At one time, dogs did not develop the same diseases and humans. That only began when pet food companies began adding grain, fruit and vegetables to dog food.
What amount does Dr Ross supplement with lithium? Also read other doctors take lithium orathate version. More side effects with aspartate version.
Hi Michael, thanks for your question. He said a "low dose" but I did not ask exactly how much. We did speak with Dr Guttuso on lithium and he talks in quite detail about the various doses. Supplemental (as opposed to clinical) seems to normally be in the 1 to 5mg range.
Take 1 gm a day. Do not take high dose amounts as this can cause Lithium toxicity.
I TELL that to my OIANO STUDENTS.
Piano
I've been taking Magnesium BREAKTHROUGH FOR MONTHS . MY wife takes MAGTECH a magnesium COMPLEX.❤
Hi Manuel , thanks for sharing. I hope that it is working for you and your students.
Why not test yourself after 3 days to see the peaked plasma level of the drug? Why wait till day 6 are 7 when the drug is cleared. The Half life of the drug is 62 hours. So on day 7 it should have gone through 3 half-life
@ModernHealthspan Hi Richard, I have read about Rapamycin many times, but was blocked by the need for a prescription. I have finally found a source. Pelton’s book is a paperback and sells for $125, so I will opt out. I note that he has a PhD, not an MD. His consultation fees of $200/hour are more inline with those of an MD. I know the world of celebrated PhDs in academia and $200/hr is unheard of. -Jenny
His book is a paperback and sells for $125!
@@javadivawithdog He also charges $200/hour for consultations. He has a PhD, not an MD. I am walking away. There are others.
@@msplateaugalI think that is PharmD?
@@msplateaugalUnderstand. The concept of the company is interesting. A typical medical visit would be $200 or more if you paid for it without insurance. If someone has an HSA that would be a way to pay for this as an example.
Also one's age is a factor to consider in starting. Don't start under age 40. Probably no need.
With several generics - which found to be best for consistent quality and best for consistent absorption - any information on this?
My wife and I took a chance on a supplier from India. 500 x 1 mg tabs for $300 delivered. At 6 mg a week, I definitely feel it. It does mess with my blood sugar and being type 1 diabetic, I have been able to figure out a management protocol. Going in Monday to draw blood for a level check. Anecdotally, I do attest to these pills from India are the real deal. I would be happy to share details of you PM me. YT blocks that stuff here. Cheers!
Hi Michael, thanks for your question and please if anyone has experience jump in! I am thinking of trying the one, rapapro, suggested by Dr Pelton.
does any one know where to get this drug ..
By the sounds of things you need a prescription from your doc as it is used to treat certain conditions so it's a recognised drug.
@@bluecurlygirl i know but my doctor refues to give one ..
@@tedschwartz2142change doctors
@@dcjohnson2208easier said than done. I think if there is no justification for prescribing the medication most ethical providers would not do it. Too many risks to rapamycin.
@@dcjohnson2208how did you get it?
Where is safe to obtain rapamycin?
Hi Nerin, thanks for your question. Dr Pelton talks about this from 29:15 onwards. I have also added a link to the website that he mentions.
Supposedly the stuff from India market is real (unlike the Chinese stuff) but you need to get it imported .
I have no experience with importing as I just write my own prescription
Well ancestors had shorter life span right? Maybe you should not refere to the ancestors with much shorter life span and this mtor.
Pelton makes a lot of unsubstantiated claims and recommendations.
Here's the side effects:
Accumulation of pus
anxiousness, unexplained
backache
black or red, tarry stools
bleeding from the gums or nose
blurred vision
body aches or pain
bone pain
bruising
burning or stinging of the skin
burning while urinating
burning, dry, or itching eyes
burning, tingling, numbness, or pain in the hands, arms, feet, or legs
change in mental status
changes in skin color
chest pain
chills
confusion
cough
dark or bloody urine
deafness
decreased urine output
decreased vision
difficulty with breathing or swallowing
dilated neck veins
discharge from the eyes
dizziness
drowsiness
dry mouth
earache
excessive tearing
eye pain
facial hair growth in females
faintness or lightheadedness when getting up from lying or sitting position
fast, slow, or irregular heartbeat
fever
flushing or redness of the skin, especially on the face and neck
general feeling of discomfort or illness
increased hunger
increased menstrual flow or vaginal bleeding
itching, pain, redness, swelling, tenderness, or warmth on the skin
lack or loss of appetite
large, flat, blue, or purplish patches in the skin
loss of sexual ability, desire, drive, or performance
loss of voice
muscle pain
nasal congestion
nausea or vomiting
numbness or tingling around the lips, hands, or feet
pain in the chest, groin, or legs, especially the calves
painful cold sores or blisters on the lips, nose, eyes, or genitals
pale skin
prolonged bleeding from cuts
rapid heartbeat
rash
red or dark brown urine
redness or swelling in the ear
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
ringing in the ears
runny nose
seizures
sensation of pins and needles
severe constipation
severe vomiting
severe, sudden headache
slurred speech
sore throat
sores or white spots on the lips or in the mouth
stomach cramps, pain, or upset
sudden decrease in the amount of urine
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
sweating
swollen, painful, or tender lymph glands in the neck, armpit, or groin
tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
tremor
ulcers on the lips or in the mouth
unusual tiredness or weakness
vision changes
weakness or heaviness of the legs
white patches in the mouth or on the tongue
yellow skin and eyes
Less common
Bloating
change in size, shape, or color of existing mole
hoarseness
mole that leaks fluid or bleeds
new mole
pains in the stomach, side or abdomen, possibly radiating to the back
skin ulcer or sores
Incidence not known
Abnormal wound healing
headache
hives or itching
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
nails loose or detached
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
swelling of the arms or legs
yellow nails lacking a cuticle
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Abnormal vision
acne
belching
blistering, crusting, irritation, itching, or reddening of the skin
burning feeling in the chest or stomach
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling
constipation
continuing ringing or buzzing or other unexplained noise in the ears
cracked, dry, or scaly skin
crying
decrease in frequency of urination
degenerative disease of the joint
depersonalization
diarrhea
difficulty with moving
difficulty with passing urine (dribbling)
dysphoria
ear pain
enlarged abdomen or stomach
euphoria
excess air or gas in the stomach or intestines
excessive muscle tone, muscle tension or tightness
fear
feeling sad or empty
hearing loss
heartburn
inability to have or keep an erection
increase in heart rate
increased hair growth, especially on the face
increased urge to urinate during the night
indigestion
irritation in the mouth
joint pain or swelling
leg cramps
loss of bladder control
loss of energy or weakness
loss of interest or pleasure
loss of strength
lower abdominal or stomach pain
muscle aches, pain, stiffness, or weakness
nervousness
pain in the back, ribs, arms, or legs
pain or burning in the throat
pain or tenderness around the eyes and cheekbones
paranoia
pelvic pain
quick to react or overreact emotionally
rapid breathing
rapidly changing moods
inflammation, redness, or swelling of the gums or mouth
shaking or trembling
shivering
sleepiness
sunken eyes
swelling
swelling of the scrotum
tender or enlarged gums
tenderness in the stomach area
thickening of the skin
trouble concentrating
trouble sleeping
waking to urinate at night
😂 are you serious dude