Virology 2025 #2: The Infectious Cycle

Everything that happens when a virus enters a cell is called the infectious cycle. In this lecture we discuss the different parts of the infectious cycle and how they can be studied. These include assay of infectious virus particles by plaque assay, multiplicity of infection, and the particle to pfu ratio. Physical methods for detecting viruses include hemagglutination, serological techniques, polymerase chain reaction, and high-throughput sequencing. We show how these methods were used to identify in early 2020 the new pandemic coronavirus SARS-CoV-2.
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- Who Am I? -
I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.
I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this RUclips channel I share videos of my lectures, podcasts, and more.
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