I'm Irish-stubborn, keep my own counsel, don't tell me what I can't do...if only doggedness were monetized 😂 "They call you crazy till you prove them wrong, then they just call you lucky."
Nick, all these experiments that you are documenting and putting out to others is extremely beneficial to everyone. Instead of starving obese people for 14 or 30 days and making ridiculous conclusions, the idea of studying people who Don’t gain weight no matter what they do is going to open up the world of knowledge. It is quite amazing all the things you are willing to do and eat. Thank you.
I find it heartbreaking to see people, mostly women, that are overweight, struggle with all the signs of insulin resistance and they are trying desperately to lose weight - and they say "I eat close to nothing. Oatmeal with skim milk, and banana and an apple + a small glas of orange juice" and of course here everybody knows what a desaster of a breakfast that is - but good luck trying to get them to think of two eggs, bacon in butter and a coffee with heavy cream as the weightloss alternative.. They think you are making a bad joke, bc the TikTok Influencer that said "watch out to not pour to much olive oil on your salad as this is a hidden calorie bomb" never mentioned THIS!
thanks for this!!! I love your open mind and your integrity. I also did the Feldman protocol, just to see what would happen- before my LDL was 310, afterwards my LDL jumped to 524! It shocked me. My triglycerides doubled (still under 100- my tris are usually around 43), and my HDL went from 81 to 89. 1 lb weight gain. Also my heart rate jumped from 57 to 73 and my blood pressure went from 90/54 to 116/72. Overfeeding is REALLY not my friend. I started adding in 40 grams of carbs a day, divided between two meals and my LDL dropped to 180, my tri's back down to 45 and my HDL went back to 81. Interesting sh*t.
I love your nuanced approach. Your honest understanding of what missing data means to the health community, and your recommendations as few and far between as those recommendations are.
All this indicates is that variability between people and the fact that these LDL metrics change so quickly depending on what you eat, there is no way this metric can be used to assess anything. It's just a convenient measurement because it can be done so easily, but to base a whole treatment plan on something so variable makes no sense at all. I don't understand how the statin and decreasing cholesterol theory is still pertinent.
I've used this protocol to reduce my LDL to pass a military medical twice now, it works in just two days of 5,000 calories a day of fats, a third and fourth day reduces it a bit more each day but for me, most of the LDL reduction happened in the first 48 hours. I did have a blood test after two days, then the third and forth day to see the change. Warning! Eating that many calories of pure cream and cheese is not pleasant, OMG, stuffed. Try drinking 1000 ml of heavy cream in one shot, not so fun. Again, my LDL went DOWN, not up, but most important for what I needed was the LDL to HDL ratios went back to the normal range which is what I needed to pass the test, otherwise I was going to have to due a nuclear stress test with heart echocardiogram which I wanted to avoid due to my age, fearing I'd fail it due to being too out of shape. What I did was a CHEAT, but most doctors are clueless this can be done.
Shawn baker did something like this as well…cholesterol is a dynamic measurement, putting people on drugs for a dynamic measurement is complete insanity
@@nicknorwitzPhD talking about dynamic measurements so is your fast glucose this is just a waste of time also. I’m currently using a cgm and it changes depending on exercise, time of the day or carb eating which have only eaten to check things out. My glucose doesn’t change when I eat my normal meal of meat. Which means my glucose level is always a fasting reading except when carbs are introduced. Btw without carbs tit varies from 120-60
Hi Nick, this comment is unrelated to the current video but I was wondering if you’d be willing to make a compilation video of sorts on the keto foods/meals you eat in a week. I can’t speak for anyone else but I personally would find that very helpful/interesting. Thank you for taking the time to read this comment.
I love, absolutely love your approach to explain and modify your existing hypothesis to accommodate this last experiment instead of writing it off as an outlier like has been done by controversial figures in nutrition research. It really seems like you, Feldman, and colleagues are developing are great working theory of human metabolism that's been missing
I tried the Feldman protocol and my LDL went up and my TG went down. I am not lean mass, I am obese. The Feldman protocol obviously does not work for everybody. I could not speculate as to the reasons why. I did not want to tell my GP what I had done and had to argue about refusing statins.
Like you, I'm obese, so I'm saying this as someone with similar experience, not in a negative way. We are obese because we are metabolically unhealthy with chronically high insulin and damaged mitochondria. It's impossible to lose weight until our insulin is low. Our fat cells are already jam packed full. The Feldman protocol is clearly for someone who is metabolically healthy.
Oh, and just wanted to give a tool for talking to your doctor about what is more important, statins or something else (like diet). Here's a link to a video by Dr Ken Berry, "How to NOT DIE from a Heart Attack" ruclips.net/video/BIg8A_i4hhI/видео.html
I have no idea what to think or believe anymore. I’ve eaten meat my entire life and avoided vegetables because they taste like shit. Last few years I’ve been avoiding carbs. I fast a lot because I’m never hungry and not by a conscious decision to starve myself. I seem healthy enough but I really have no idea!
@@Ge1Ri4, Except that the scan for CAC only shows hard (calcified) plaques. Soft plaques not detected by it are less stable and more prone to break loose and cause a clot/blockage. See Dr. Ford Brewer's videos comparing different methods (CIMT, stress test, NIVL Duplex Scan, CAC score) of assessing risks for cardiovascular disease.
Thanks for the video! My personal experiment didn’t go so well: it appeared that carnivore plus TRT gives you a heart attack. I’ve been preaching low-carb diets for about 18 years. Last five years I’m on carnivore. And also was abusing PED’s for about 10 years. Now I have my coronary arteries plaqued. I am about to do a surgery. Unfortunately we do not have much data on that the price is too high guys
I'm already lost the plot but here are some possibly related ideas: - Eating that much fat might not get absorbed (bile secretion works as a safety valve), and the increased protein would lead to effectively higher protein ratio which might turn into glucose. - I heard someone mention that cholesterols and plant sterols would affect LDL differently so if you changed your fat sources, things could change. Also, in case of unabsorbed fat, some types of fat could absorb with different priority.
so much passion I love your vids helps me stay keto, while almost everybody around me says Im crazy and have dead wish, and one more beautiful thing about keto after a heavy workout next day my muscles are not sore as they used to be when I was thinking that carb are the MAIN fuel for energy, I said sore, what I meant was actually next day I feel stronger and it lasts longer
Hi Nick. I just watched a few of your videos and subscribed. I have a question. Do you think the size of your lipid cells could be a factor in your experiment? The reason I ask is because I was told that I have large “fluffy”lipid cells in my blood and not the smaller “sticky “ lipid cells that can clump together……causing plaque formation in the arteries. ( my cholesterol is very high but I have a low blood pressure)
That is so cool. At 59 I’m not going to try this one, but I did realize my own variability in adding carbohydrates to lower LDL. I needed 200 grams of sourdough bread to achieve your Oreo rate of decrease. 😃 I added about 50 grams a day for two months and barely changed my labs from strict keto LDL 344, HDL 111 and triglycerides 71. Interestingly, my insulin rose in that time from 3.5 to 7.2. I’m slowing down my bio hacking to every 90 days to save money 😃 thanks for a great video Nick
Hey Nick. Interesting results! I recently got my labs done and my LDL continues to climb up to 20.51 (canadian measurement) which translates to 793.12 American measurements. My doctor is freaking out understandably. I'm 65 and 109 lbs and I am very active athletically. I have a zero cac score. Any thoughts? Oh and pretty much Carnivore.
CAC isn't a reliable score, not matter what the Carnivore charlatans tell you. Once you have calcified plaque, you are very, very atherogenic. But, likely you won't listen to science. But, $30 or so, get an APOB test and see where you stand.
You are missing the effect of the FADH2:NADH ratio - you might want to read up on the proton series at hyperlipid. Fat is not one thing - but a family of things - each with different effects. We did not evolve to eat high dosages of plant oils. Anyway - the LDL theory of CVD is pretty much dis proven - a better way to look at CVD is as a thrombotic disease - A good place to start is with Kendricks' books. Insulin levels are way more predictive - chronically high insulin as is found in people suffering from T2D. Insulin is not just about blood glucose levels - it shuts down autophagy - reducing the ability to re-absorb blood clots that lead to narrowed arteries.
You share the facts/results of your experiment with everybody, and then start with your thoughts and explanation 👍. A lot of people don’t do it like that…
I am like you nick, same frame and build. Always ate close to keto for the last 10 years unintentionally. Now about to move to full keto... Cheers for the breakdown. Your a very clever boy.
@@nicknorwitzPhD have you posted anywhere the breakdown of what you eat daily? Not trying to copy. Have my own stuff l will always eat. Specially makeral and sardines. Always looking for ideas
Hi Nick. Always interesting videos. I have been following you and the posse (Feldman, Baker Cywes, Chaffee, Berry etc) for quit sometime. I am perplexed that after seemingly debunking LDL as bad cholesterol (quite awhile ago) everyone continues to try to find ways to lower it, or determine what makes it go up (or down) or why LMHR respond the way we do. I have learned from all of you that there is not a single clinical trial that shows a "causative" role for LDL in heart disease. I love Dr. Ali's comment, "is LDL the firefighter or the arsonist in heart disease"? I have a stake in this discussion as I have atherosclerosis and 2 stents. I have been carnivore for about a year now and feeling great. Thanks
@@snyderflyer7365 I have noticed that many of the content creators that disclose their lipid panels, have high ldl and 0 calcium scores. I've wondered if ldl helps to keep arteries clear. If pharmaceutical companies wanted to keep the statin train going, what better way than hinder ldl cholesterol from doing its job. I wear my tin foil had often. By the way, I have 1 stent, so this discussion is also important to me.
I will see your 2 stents and raise you a recent triple bypass. I am a thin 66 year old and I too am trying to figure out what I think about LDL-C as a risk factor. After surgery I took an intense course of statins but I never intended to use them long term. If nothing else I find the high LDL theory too simplistic. I think Malcolm Kendrick’s book cites several other proven factors that correlate to CAD (even if one is not convinced about his thrombotic hypothesis.)
At 67, my health and longevity *IS* a crap shoot. They lied to us about the 'dangers' of saturated fat; The disregard for carbohydrates' effect on insulin levels affected my ability to lose weight; The poisoning of my metabolism with industrially processed seed oils which have no place in the human diet; And the messaging by the federal government nutritional guidelines to avoid meat (in itself a religious belief, which makes it un-constitutional IMHO); means that I had to get guidance from RUclips. I believe that this community saved my life. where would you put your money?
Some variables that might not be accounted for in this experiment. Eating a certain number of calories assumes those calories are all going into the body, there are variables that can change this even in the same person. Going to guess that your GI wasn't too happy and let you know. Also, that change in fiber would impact the microbiome in your gut which would be another variable that would make a difference, guessing trying to get the calories but limiting that fiber increase would change things, especially considering your GI history. You could also have a microbiome vastly different from your "average" person given past history, I think you mentioned having Inflammatory Bowel Disease, CD I think, damage to the gut from that would change how or what gets absorbed along with the potential of having gut bacteria that interacts with food much differently from others. I don't know the types of fats that you ate, but different types of fat absorb more or less depending on their type, the fiber can also change how much gets absorbed. Without being used to eat that many calories or those type of calories I'm not sure what impact that would have, the microbiome and the cells of the gut can change depending on what you eat and likely would take longer to absorb more of what you eat. Finally, there does seem to be impact of what food goes in based upon gut/brain interactions, as you likely have pointed out, we are not a test tube and the biology of our body is much more complex than most realize. Also recommend listening to the recent Huberman podcast where he talks with someone about the Gut/Brain interactions, that added some context to gut things that I hadn't thought about and would likely help you with future experiments involving food.
This is a great response to consider. We are learning more and more about the micro biome and how much it really affects how we respond to food. So it really isn’t so much the calories. It’s what type of food, the makeup of the food, nutrient density and how gut bacteria interact with it. We all know someone who can eat anything and not gain a single lb. Yet some people swear they gain a pound just walking past the bakery.
Answering virtually every comment, I have to admire the commitment. And having the capacity to do this in the context of keeping research and med school responsibilities on track. When I was in med school after prepping and eating some real food, keeping myself washed, dressed and fit, the only time left in each day was for about 4 hrs of sleep. I reassured myself at the time it would only be for a short while. It turned out that was the baseline for the next 40 years.
@@nicknorwitzPhD Perhaps I was whining. Rather, I would see it as a near optimal path for me. Some more sleep would give me a few less grey hairs and slightly better metabolic health. But the memories are irreplaceable. I was never able to attend a game or graduation but despite that my 4 children are all in the health care space. Like me they thought I was doing important work and having fun. Don't slow down, I'm just impressed. In 40 years I won't be around to compare notes to see who saved more lives or had more fun.
I’m a LMHR, went carnivore/low carb 2 years ago. Before that for 3 years my RHR averaged 55 BPM, since starting low carb it’s been averaging 61. I used to struggle with POTS type symptoms but I haven’t since eating 90% meat diet with zero to a few low carb days a week. I feel better and lost weight but wonder why low carb made my RHR go up. Just staying curious!
Your passion for science and learning is inspiring! I am hoping that I can participate in similar academic discourse and discovery when I start medical school!
@@nicknorwitzPhD Not confirmed acceptance yet. Taking my MCAT in a few weeks 🤞 . Hoping to attend University of MN. This would be a second career for me!
Love the structure of this video. It was very well explained and easy to follow! A quick question - I am aware that our levels of bile set some hard limit on our ability to metabolize fat. Given you were eating so much fat, do you think it's possible that the actual calories you metabolized is somewhat lower than the 26,000 consumed due to the inability of the body to process so much fat in a short amount of time?
If he was short of bile to absorb the fat, he would get steatorrhea. Greasy floating stools. This is a basic medical phenomenon that every 1st year student knows about, ie. he would have seen it and known it was the issue.
Your intelligent, self experimenting fascinates me. I appreciate your willingness to share your personal medical information. Please be careful that you don’t permanently damage your health.
Hey, this may sound strange but, have you noticed any changes in your stool consistency, smell, etc, during the 6000kcal diet? Also what is your normal energy intake (before/after the experiment)?
Yes, we are all similar but not exact. Yes differences in fat cell hyperplasia vs hypertrophy. Be interesting to see the starting triglycerides and ending triglycerides. Fun experience. An open mind is great. Too many find something they feel that works and then stop.
I am glad you added the disclaimer section, I think with the tendency toward polarization that we are living in, it is important to state and restate precisely where you stand and sometimes more importantly, where do you NOT stand. I unfortunately have seen your name used to defend people advising those with actual FH to let their LDL rip as high as possible, stating that they were of the belief that you have FH yourself and are not concerned about it since LDL is good.
Thank you for doing your amazing work and being so public and entertaining about it. Great term this LMHR! That used to be called YSSJEM (You So Skinny, Just Eat More) - Im fascinated by all this and for once this community is about skinny people :)
I'm a lay person so forgive my ignorance. Am I correct in understanding that thr reason the Feldman protocol did not work for Nick was because he raised his energy expenditure ie he was doing more exercise while he was on it than he normally does?
How much extra water did you drink? Fat is a water storage too so if you ate all that without drinking more water I am curious as to what your body is doing with all of it.
If you ever decide to repeat this experiment, it would be very interesting to know how your insulin levels were affected by the additional food. I’m not sure if someone can significantly expand fat cells without an insulin signal to do so? I’ve had the same suspicions about my response to overeating. I used to eat tons of cheese (and I ignored my mom’s pleas to “at least have some crackers with it”). Sometimes cheese would be my entire dinner. It didn’t result in any fat gain-just things like nervous energy, inability to wind down at night, increased thermogenesis, desire to go for very long walks, etc.
Great point. I guess his weight gain was linked to the protein overeating and thus the extra insulin secretion. Actually, it seems like Nicholas performed the kind of study Dr Benjamin Bikman is calling for to dismantle the calorie hypothesis.
Highly interesting video as usual. Question: You mentioned that your insulin levels went up due to the high calorie intake in this experiment, and that's an explanation for the increased LDL levels. But in your OREO-test, your insulin levels would most likely have increasedeven more, but with a drop of LDL. Isn't that contradicting?
"You mentioned that your insulin levels went up due to the high calorie intake in this experiment, and that's an explanation for the increased LDL levels." -- where did I say this was causal? As mentioned, there are "push-pull" factors and fat cell growth/insulin appeared to "lose" the day.
When I removed added saturated fat and cut back on red meat. I used olive oil only after that on whatever I ate and ate mostly seafood, my LDL-C dropped from 360 to 145. On Keto/carnivore diet.
This is similar to the Hadza experiment. Feeding them with SAD. No effect in energy metabolism short term. Nick nows almost nothing about POMC but some about Leptin. That is the key to this.
Did you monitor your salt/sodium intake? I read that increased salt can elevate osmolality, which can induce indigenous fructose production. This process helps achieve the transient insulin resistance required to store fat, right? I hope to see an experiment on the effects of excessive salt during a keto diet.
I understand we are all different, but would love to get more details into your diet and what you think is the best bang for buck calories. What I mean by bang for buck is not the energy calories in the food alone, but the total energy all things considered (i.e. thermic effect of food, etc.) and with all things considered can the difference be significant or negligible. Thank you.
My question is: did the size of your waste dumps dramatically increase? Is it possible that the bulk of what you were eating was simply expelled because the natural function of your body couldn’t fully process it?
I find these n=1 experiments really interesting. Keep going! I switched from Plant based high carb diet to omnivore low carb recently, and have started seeing LMHR signs in blood tests (I've been lean all my life, and last 3 years at at my 15 year lowest weight).
@@nicknorwitzPhD My fiber intake is >20g a day (20-30 I'd say). Fat around 65-70% of calories. BMI = 18,4. It used to be 20,5 before my 3y plant based period 😅 Trying to do more strength exercise and eat what my body asks for without forcing (I'm tired of forcing to gain weight). My plan is to stay low carb, although I do exceptions, and to alternate with some keto periods. I just targeted being in ketosis once and I entered ketosis (I measured), without big effort (staying below 50g carbs). My evolution in 9 months since I changed from Plant based (high carbs low-medium fat) to omnivore (decreasing carbs and increasing fat intake over this period, but still moderate-low carbs when I did my test 3m ago): LDL from 79 to 210; Trigl from 124 to 76; HDL from 36 to 65. I'll get a blood test done soon, will see how it goes now that I've been low carb (with exceptions). Thank you!!
@@nicknorwitzPhD Thanks for your answer. I'd say my fiber intake is >20g (20-30), and 65-70% fat. Why you ask especially for this ratio? My BMI is 18,4 😅. It used to be 20,4 before WFPB diet with normal activity. Now I eat: Vegetables or salad with every meal (2 or 3) (prioritizing low glycemic index), some nuts/seeds. Meat, fish, eggs, some goat/sheep cheese/yogurt. Raw Coconut & Olive Extra virgin oils, avocados. I don't eat (only occasionally): sugars, flours, starches (only resistant ones), refined oils. Evolution in 9 months since I progressivly changed from Whole Foods Plant Based (high carbs, low fat) to 3 months ago (omnivore low/mid carb) (when I got lab test). During that time I : LDL from 79 to 211 HDL from 36 to 65 Trigl from 124 to 76 My plan is to continue low carb with Keto phases, to reassess shortly as I'll get some blood tests done soon. Thank you! Best regards.
Spitballing here. Could the type of fat matter? In one success example you mentioned, a woman's fat source was predominantly cream. I've run across a few things lately about C15 being high in dairy products. Could that have anything to do with the results?
@@nicknorwitzPhD That particular saturated fatty acid, yes. I don't know enough about the science, but I do work with data and I watch too much RUclips. 😊 So take my "I wonder if" with that in mind. I noticed that that was a difference (other than sex) between you and your example success case. The particular saturated fatty acid that's been coming up in my feed about metabolic syndrome is C15. From Wikipedia: "Pentadecylic acid, also known as pentadecanoic acid or C15:0, is an odd-chain saturated fatty acid. Its molecular formula is CH₃(CH₂)₁₃CO₂H. It is a colorless solid. A laboratory preparation involves permanganate oxidation of 1-hexadecene." It's in dairy, but I do not believe it's in macadamia nut butter. It's also available in a pricy over the counter pill form and some of the hype could be coming from that manufacturer.
I've been eating an excess of 900 calories fat per day for the last year, my weight remains stubbornly at 65KG, I may be eating less other stuff but I'm not consciously restricting what I eat.
There are no actual calorie receptors. There are pathways that are responsive to general energy status, like AMPK. But I wouldn’t consider this any form of receptor. I’d recommend checking out my video on trapped fat and the fuel partitioning model of obesity. I think that’s a more intellectually rigorous and functional way to think about energy in your diet.
Disclaimer, my not fully understanding the physiology, but I have 2 questions. First one is simple. Was the increase in NEAT due to the thermogenic effect of food? And second, could it be that you appear to be so very lean, that there wasn't enough fat mass to expand? Perhaps comparing to others who have done this (Sioban), Calories per body weight or per kg of fat mass. Might there be an inflection point of overfeeding beyond which LDL would increase rather than decrease? Again, indexed to, say, total body weight or fat mass? Rather than just an increase in energy expenditure.
When eating a healthy diet, you are doing little to no damage, requiring you to use cholesterol. Thereby using the cholesterol eaten in the food, was added in to your serum cholesterol. This fits with my theory. When you eat a species specific diet, for humans that would be zero carb, high fat, moderate protein. The number of calories are irrelevant. When I started carnivore, to cure my type 2 diabetes, was eating a diet of 0% carbs, 70% fat, 30% protein. Equaling on average, every day for a month, 5,000 calories. With zero exercise. I lost 60 pounds. Going from 250 to 190 in 30 days.
@@user-jl2ec2ko4v I have. Glad I did too. Cured my diabetes. Reversed my cancer. The answer to great health, pure health, is simply this. Do not eat plants.
A lot of food for thought here, great vid. As someone who's also chronically lean and doing similar experiments, let me add some: I guess your diet wasn't ketogenic anymore due to the insane amount of protein and total calories. When I go overboard like that, sometimes it knocks me out of ketosis for more than 24 hours. Also my morning glucose is way higher than I'd like and it's difficult to get to comfortable levels during the day. The level of protein is specially important here. It seems your diet was very Omega 6 heavy (relatively speaking), I would definitely ditch nut butters next time (a teaspoon per meal max). Macadamia is not the worst offender but it adds up. Coconut milk is a great source of calories for this kind of thing. Thanks for sharing this experiment 👍
Did do you know food is suns barcode and deuterium storage? I am a LMHR ten years down a keto carnivore n=1 rabbit hole gone bioquantum thus shifting from biochemistry forward on.
Hi Nick You are one of the very few people trying to push the conversation of diet and health forward and you do a great service to all of us. On a different note then this video, max heart rates and training zones are measured from some arbitrary numbers (like 220-age) Like yourself I have a low resting heart rate (66 years and 46 RHR) I’ve wondered why resting heart rate wouldn’t be used as a base because you are actually raising it from that rested number instead of an arbitrary number which doesn’t take into account someone age 66 who would be supposed to have the same max rate as me may have a resting heart rate of 65 instead of like my 46. That’s almost a 20 beat difference yet we would have the same max and zones. Thanks hope you find this thought interesting.
"You are one of the very few people trying to push the conversation of diet and health forward and you do a great service to all of us." - Thanks v trials. Re RHR... my age didn't really change during this week... I'd consider high 40s my baseline and it increases to 60s, as shown in graph
Thanks for the reply but i was more interested in your thoughts on RHR and zones (in general) in relation to some people having lower or higher RHR but the standard max heart rate numbers don’t seem to take that into account If you do the standard 220-age First person E.g age. 65 RHR 45 Max HR 155 Other person: E.g age 65 RHR 65 Max HR 155 You see first person has 15 more heart beats per minute before reaching 155from his resting number. That seems to me like that would be an important piece of information to put in a formula or factor for their Max HR I was interested in your thoughts or if it would provoke you to look further as I’ve not seen any one else consider this. Thanks
I'm curious, if you monitored sleep scores during this experiment; and if you did, did the calorie increase and increased RHR negatively affect your sleep. I find that high calorie days increase my RHR at the end of the day. That increase seems to crash my sleep scores.
Don't actually own a sleep tracker... feel like it would screw with my sleep. I'm the type to get in my own head about it. That said, my sleep hours did decrease... just felt "buzzed"
Interesting. Thanks for sharing. It would have been interesting to see subcutaneous vs visceral fat ratio diff before and after . To do justice to that, you would have had to get a DEXXA scan. Personally, my priority is on keeping my visceral fat at optimal levels. Subcutaneous fat may look ugly as you prolly already know, it is not as cardiometabolically lethal. Anecdotally speaking only with all other things being equal , I know that when I dramatically overconsume calories even for a week with all other things be equal(no sleep deprivation, no change in cardio or resistance training, etc.,) or more, the first place any minimal bf% goes is viscreally as per pre and post Dexxa scan. In the interests of fairness and respectfully, I have not had any pre and post bloodwork done doing that to see how it messes with my LDL. That would be interesting to do in the future to directly track how any visceral bf% increase no matter how minimal effects that I presume there would likely be a significant jump in LDL and if nothing else Triglycerides. Interestingly and on a somewhat related issue, I found absolutely no increase or decrease in my RHR Thanks again, I love that you think outside the box,,and are not afraid of backlash. Keep up the great work. I love all your content
Have you ever tested postprandial triglycerides (4hr after a meal)? It’s supposed to be less than 220mg/dL and a better risk predictor than fasting triglycerides.
I've done this as well before prior to certain labs just to test it out. Definitely worked for my cholesterol lowering. Doctor didn't care much, though. I will say whenever I ate so much my temperature will _always_ go up by A LOT. Like I'll be waking up at night in a pool of sweat and so on. My heart rate can as well go from 45-50 resting to a whopping 100 resting heart rate depending on just how much I've eaten the previous day. I don't gain much weight either as my weight will usually drop to below previously measured within a week or two tops, no matter how much I tried to overfeed myself. It's quite interesting. I've done a 10MCal a day for a week experiment before as well, though with processed foods. It didn't end well as I literally couldn't walk by the end, it was wild, but it taught me what ultra porcessed foods do to your body really well. Meanwhile overeating (though less kcal) on a keto-diet had none of thse bad symptoms.
Doesn't heavy cream have carbs? Consuming a full carton a day could have enough to lower ldl due to carbs alone? Also why do you consume macadamia butter instead of regular butter?
I would be interested to know what your apoB was before and after. I am a LMHR who has given up trying to gain weight. I can eat a million calories a day and I never gain weight. This explains a lot about individual results.My CAC is scheduled soon I am curious about the results of this test also. Thanks for your great work.
Hey Nick, with most of the calories in the form of fat and only 40 grams of carbs. Would most of the fat go through the GI track into the toilet. If this happens, we can assume that the stool will be loose and float. With a low carb intake, your insulin level would also be low, therefore inhibiting fat storage. Great content as always, just wanted to add some input.
Do you mean an up titration or elevated dose before "steady state" dosing... either way, I'm not aware of data on such protocols... from what I've been 3g daily would be routine... there aren't human long-term data on bone response to mechanical loading w/ cit. So, IDK
I had 6 eggs, 2 oz of cheddar cheese and 1 pound of pork for breakfast. I had 2 pounds of beef for lunch and I am going to have 3 pounds of Heart attack chicken and 1 pound of Heart Attack shrimp for dinner. I eat like this almost ever day. How many 'calories" is that? I am 6'6" tall 190 pounds and my weight never increases.
Thanks Nick, always something new to challenge our thinking! I have a question. Another person says, 'they lied to us about the 'dangers' of saturated fat'. I'm aware there was a study in 2018 (Mozaffarian) stating Sat fats have health benefits - which was contrary his 2011 study; - saturated fats are harmful. The NZ Heart Foundation advice is based on the 2011 study! Are there other studies by M or others, that confirm saturated fats are not harmful? Thanks for all you do.
Cashew? You mean macadamia? Probably very little. Sat vs Unsat doesn't appear to impact my LDL-C much w/ my highest LDL-C of all time being when intake was 1:5.67 sat:unsat ratio
I tried this also before a blood test and disappointed, my Gp having heart attack with my ldl and trigs going up, total 14.5. only adding carbs drops mine to 8 with trigs still,
Yes, LDL rises with fat & protein intake & reduces as you have proved on a carbs- sugar diet. High LDLs should be the norm, but the average Joe or Jill with their largely carb diet ( sugar diet) reduces LDL to what many think is a normal range.
Thanks, my main take away from this is the power of individual variability when making any comparisons even when the population cohort share many attributes such as LMHR. Every individual strives to achieve an optimal homeostasis based on his/her very individual circumstances at any particular time. I would go as far as to say that your individual measurements of bio-markers yield PERFECT RESULTS FOR YOU as an individual regardless of expectations based on averages taken from other population cohorts and especially from general population averages.
Was there any change in your triglycerides and HDL ? Would be interesting to know, what the trend is (according to your n=1) of the expected response......As per lipid energy model, assuming your LDL went up because of your increased energy expenditure, and as you have been a lean mass hyperresponder, for enough time to reach homeostasis, a mild increase in HDL and mild decrease in triglycerides as well
Crazy with a purpose. You should put that on you Dr lab coat
HA! Giving me thoughts...
@@nicknorwitzPhD
Make it merch! 🧬
Agreed!! 👌🏼
not too different from Marie Currie or any other scientist
I'm Irish-stubborn, keep my own counsel, don't tell me what I can't do...if only doggedness were monetized 😂 "They call you crazy till you prove them wrong, then they just call you lucky."
Nick, all these experiments that you are documenting and putting out to others is extremely beneficial to everyone. Instead of starving obese people for 14 or 30 days and making ridiculous conclusions, the idea of studying people who Don’t gain weight no matter what they do is going to open up the world of knowledge. It is quite amazing all the things you are willing to do and eat. Thank you.
You’re not the first to say that… but thank you 🙏🏻
So what drives NEAT in “hard gainers “ like yourself? Are there other factors involved with hard gainers?
I find it heartbreaking to see people, mostly women, that are overweight, struggle with all the signs of insulin resistance and they are trying desperately to lose weight - and they say "I eat close to nothing. Oatmeal with skim milk, and banana and an apple + a small glas of orange juice" and of course here everybody knows what a desaster of a breakfast that is - but good luck trying to get them to think of two eggs, bacon in butter and a coffee with heavy cream as the weightloss alternative.. They think you are making a bad joke, bc the TikTok Influencer that said "watch out to not pour to much olive oil on your salad as this is a hidden calorie bomb" never mentioned THIS!
thanks for this!!! I love your open mind and your integrity. I also did the Feldman protocol, just to see what would happen- before my LDL was 310, afterwards my LDL jumped to 524! It shocked me. My triglycerides doubled (still under 100- my tris are usually around 43), and my HDL went from 81 to 89. 1 lb weight gain. Also my heart rate jumped from 57 to 73 and my blood pressure went from 90/54 to 116/72. Overfeeding is REALLY not my friend. I started adding in 40 grams of carbs a day, divided between two meals and my LDL dropped to 180, my tri's back down to 45 and my HDL went back to 81. Interesting sh*t.
Interesting. Are you "chronically lean" too?
What's interesting the more veganism is forced upon us the more they move these markers to suit themselves.
I m about to add carbs to my diet to "normalize" my lipids numbers. Question: did u bring the fat down o did u maintain it at the same level? thx
I love your nuanced approach. Your honest understanding of what missing data means to the health community, and your recommendations as few and far between as those recommendations are.
Lovely comment. Very much appreciated!
All this indicates is that variability between people and the fact that these LDL metrics change so quickly depending on what you eat, there is no way this metric can be used to assess anything. It's just a convenient measurement because it can be done so easily, but to base a whole treatment plan on something so variable makes no sense at all. I don't understand how the statin and decreasing cholesterol theory is still pertinent.
"LDL metrics change so quickly depending on what you eat" -- this is revolutionary to some... DYNAMIC
I've used this protocol to reduce my LDL to pass a military medical twice now, it works in just two days of 5,000 calories a day of fats, a third and fourth day reduces it a bit more each day but for me, most of the LDL reduction happened in the first 48 hours. I did have a blood test after two days, then the third and forth day to see the change.
Warning! Eating that many calories of pure cream and cheese is not pleasant, OMG, stuffed. Try drinking 1000 ml of heavy cream in one shot, not so fun. Again, my LDL went DOWN, not up, but most important for what I needed was the LDL to HDL ratios went back to the normal range which is what I needed to pass the test, otherwise I was going to have to due a nuclear stress test with heart echocardiogram which I wanted to avoid due to my age, fearing I'd fail it due to being too out of shape. What I did was a CHEAT, but most doctors are clueless this can be done.
Shawn baker did something like this as well…cholesterol is a dynamic measurement, putting people on drugs for a dynamic measurement is complete insanity
@@nicknorwitzPhD talking about dynamic measurements so is your fast glucose this is just a waste of time also.
I’m currently using a cgm and it changes depending on exercise, time of the day or carb eating which have only eaten to check things out. My glucose doesn’t change when I eat my normal meal of meat. Which means my glucose level is always a fasting reading except when carbs are introduced. Btw without carbs tit varies from 120-60
It's pertinent because it's profitable that's it.
This right here is epic!! I’m still new to keto/ketovore community. Great work!
Glad you enjoyed. Hopefully made you think... I do enjoy n = 1 and this, interpreted appropriately, they can be immensely valuable.
@@nicknorwitzPhD Interpreted as N:1, so basically irrelevant. You are young, so you have time to fix your mistakes.
@@tresero2862 13:28
Hi Nick, this comment is unrelated to the current video but I was wondering if you’d be willing to make a compilation video of sorts on the keto foods/meals you eat in a week. I can’t speak for anyone else but I personally would find that very helpful/interesting. Thank you for taking the time to read this comment.
See my recent Newsletter, section on Transparency, and you'll gather why I tend not to do "what I eat" videos...
I love, absolutely love your approach to explain and modify your existing hypothesis to accommodate this last experiment instead of writing it off as an outlier like has been done by controversial figures in nutrition research.
It really seems like you, Feldman, and colleagues are developing are great working theory of human metabolism that's been missing
I tried the Feldman protocol and my LDL went up and my TG went down. I am not lean mass, I am obese. The Feldman protocol obviously does not work for everybody. I could not speculate as to the reasons why. I did not want to tell my GP what I had done and had to argue about refusing statins.
Like you, I'm obese, so I'm saying this as someone with similar experience, not in a negative way. We are obese because we are metabolically unhealthy with chronically high insulin and damaged mitochondria. It's impossible to lose weight until our insulin is low. Our fat cells are already jam packed full. The Feldman protocol is clearly for someone who is metabolically healthy.
Oh, and just wanted to give a tool for talking to your doctor about what is more important, statins or something else (like diet). Here's a link to a video by Dr Ken Berry, "How to NOT DIE from a Heart Attack"
ruclips.net/video/BIg8A_i4hhI/видео.html
It's not about LDL cholesterol lowers statins hit the market in 1984 and Heart Disease continues to rise ,, ask for Lipid Partical testing
You shouldn’t be worrying about cholesterol, you should be worrying about obesity. Maybe try Ozempic?
@@Starfish2145 Ozempic?? Uh, no! It will paralyze your stomach and cause long term problems. Just go ultra low carb or carnivore.
😮 Fascinating!
😊Love your integrity!
Keep up the great work.
Thanks... WILL DO!
I have no idea what to think or believe anymore. I’ve eaten meat my entire life and avoided vegetables because they taste like shit. Last few years I’ve been avoiding carbs. I fast a lot because I’m never hungry and not by a conscious decision to starve myself. I seem healthy enough but I really have no idea!
Get a calcium scoring scan from your doctor. If you get a zero score, you're golden, and carry on what you're doing.
@@Ge1Ri4 And if it’s not? Eat a bunch of toxic veggies and become mental again? No thanks.
@@Ge1Ri4,
Except that the scan for CAC only shows hard (calcified) plaques. Soft plaques not detected by it are less stable and more prone to break loose and cause a clot/blockage. See Dr. Ford Brewer's videos comparing different methods (CIMT, stress test, NIVL Duplex Scan, CAC score) of assessing risks for cardiovascular disease.
Stop eating omega 6
That is crazy. You are probably nutritionally deficient. Why do you hate vegetables? Were your parents terrible cooks?
Don’t always agree with you but admire your willingness to test theories on yourself and you really present things well.
Thanks for the video! My personal experiment didn’t go so well: it appeared that carnivore plus TRT gives you a heart attack. I’ve been preaching low-carb diets for about 18 years. Last five years I’m on carnivore. And also was abusing PED’s for about 10 years. Now I have my coronary arteries plaqued. I am about to do a surgery. Unfortunately we do not have much data on that the price is too high guys
Another excellent discussion. And the reminder at the end continues to add value.
" continues to add value" -- that's the goal! Then I'll die.
I'd love to see data comparing outcomes between people who've gone hypercaloric using only animal fats vs using plant fats or mixed sources.
I am on a fat fast as we speak.
I'm already lost the plot but here are some possibly related ideas:
- Eating that much fat might not get absorbed (bile secretion works as a safety valve), and the increased protein would lead to effectively higher protein ratio which might turn into glucose.
- I heard someone mention that cholesterols and plant sterols would affect LDL differently so if you changed your fat sources, things could change. Also, in case of unabsorbed fat, some types of fat could absorb with different priority.
so much passion I love your vids helps me stay keto, while almost everybody around me says Im crazy and have dead wish, and one more beautiful thing about keto after a heavy workout next day my muscles are not sore as they used to be when I was thinking that carb are the MAIN fuel for energy, I said sore, what I meant was actually next day I feel stronger and it lasts longer
I went from 80 gm carbs daily to 20. My LDL went from 55 to 110 to 182.
I’ve seen you. You’re pretty lean. Not surprised.
Superb, interesting science combined with an excellent presentation. Good on Sir!
Glad you liked it!
Bro, a rebranding and top pay video editor and it's 10/10 content with the deserved following and according pay that comes with it
Hi Nick. I just watched a few of your videos and subscribed. I have a question. Do you think the size of your lipid cells could be a factor in your experiment? The reason I ask is because I was told that I have large “fluffy”lipid cells in my blood and not the smaller “sticky “ lipid cells that can clump together……causing plaque formation in the arteries. ( my cholesterol is very high but I have a low blood pressure)
That is so cool. At 59 I’m not going to try this one, but I did realize my own variability in adding carbohydrates to lower LDL. I needed 200 grams of sourdough bread to achieve your Oreo rate of decrease. 😃 I added about 50 grams a day for two months and barely changed my labs from strict keto LDL 344, HDL 111 and triglycerides 71. Interestingly, my insulin rose in that time from 3.5 to 7.2. I’m slowing down my bio hacking to every 90 days to save money 😃 thanks for a great video Nick
Dr Ford Brewer is using CIMT to detect soft plaque which is cheaper
Great video. One question. One person, one month?
Hey Nick. Interesting results! I recently got my labs done and my LDL continues to climb up to 20.51 (canadian measurement) which translates to 793.12 American measurements. My doctor is freaking out understandably. I'm 65 and 109 lbs and I am very active athletically. I have a zero cac score. Any thoughts? Oh and pretty much Carnivore.
What's your HDL and triglycerides?
My triglycerides are 118 and HDL is 81. I would like the triglycerides to be lower but not sure how to do that.
CAC isn't a reliable score, not matter what the Carnivore charlatans tell you. Once you have calcified plaque, you are very, very atherogenic. But, likely you won't listen to science. But, $30 or so, get an APOB test and see where you stand.
You are missing the effect of the FADH2:NADH ratio - you might want to read up on the proton series at hyperlipid. Fat is not one thing - but a family of things - each with different effects. We did not evolve to eat high dosages of plant oils. Anyway - the LDL theory of CVD is pretty much dis proven - a better way to look at CVD is as a thrombotic disease - A good place to start is with Kendricks' books. Insulin levels are way more predictive - chronically high insulin as is found in people suffering from T2D. Insulin is not just about blood glucose levels - it shuts down autophagy - reducing the ability to re-absorb blood clots that lead to narrowed arteries.
You share the facts/results of your experiment with everybody, and then start with your thoughts and explanation 👍. A lot of people don’t do it like that…
Thanks!
I am like you nick, same frame and build. Always ate close to keto for the last 10 years unintentionally. Now about to move to full keto... Cheers for the breakdown. Your a very clever boy.
You’re very welcome ☺️
@@nicknorwitzPhD have you posted anywhere the breakdown of what you eat daily? Not trying to copy. Have my own stuff l will always eat. Specially makeral and sardines. Always looking for ideas
Hi Nick. Always interesting videos. I have been following you and the posse (Feldman, Baker Cywes, Chaffee, Berry etc) for quit sometime. I am perplexed that after seemingly debunking LDL as bad cholesterol (quite awhile ago) everyone continues to try to find ways to lower it, or determine what makes it go up (or down) or why LMHR respond the way we do. I have learned from all of you that there is not a single clinical trial that shows a "causative" role for LDL in heart disease. I love Dr. Ali's comment, "is LDL the firefighter or the arsonist in heart disease"? I have a stake in this discussion as I have atherosclerosis and 2 stents. I have been carnivore for about a year now and feeling great. Thanks
Thank you! Excellent question!
@@PardieDiem I just found your comment lower in the comment "feed". We're on the same page! I am curious if we will get an answer.
@@snyderflyer7365 I have noticed that many of the content creators that disclose their lipid panels, have high ldl and 0 calcium scores. I've wondered if ldl helps to keep arteries clear. If pharmaceutical companies wanted to keep the statin train going, what better way than hinder ldl cholesterol from doing its job. I wear my tin foil had often. By the way, I have 1 stent, so this discussion is also important to me.
I will see your 2 stents and raise you a recent triple bypass. I am a thin 66 year old and I too am trying to figure out what I think about LDL-C as a risk factor. After surgery I took an intense course of statins but I never intended to use them long term. If nothing else I find the high LDL theory too simplistic. I think Malcolm Kendrick’s book cites several other proven factors that correlate to CAD (even if one is not convinced about his thrombotic hypothesis.)
@@agfairfield8575 How is your insulin and blood glucose? Triglycerides?
At 67, my health and longevity *IS* a crap shoot.
They lied to us about the 'dangers' of saturated fat;
The disregard for carbohydrates' effect on insulin levels affected my ability to lose weight;
The poisoning of my metabolism with industrially processed seed oils which have no place in the human diet;
And the messaging by the federal government nutritional guidelines to avoid meat (in itself a religious belief, which makes it un-constitutional IMHO);
means that I had to get guidance from RUclips.
I believe that this community saved my life.
where would you put your money?
I'm 69, and I would say ditto, ditto ditto!
Well said encapsulation of the shared frustrating experience of all of humanity over the last 100 yeez.
Well... I put my money into medical school atm... $$$!
@@nicknorwitzPhD You have good role models to follow, and You'll do good for all of us! Thanks for the effort.
I'm 76 and I wholeheartedly agree!
Some variables that might not be accounted for in this experiment. Eating a certain number of calories assumes those calories are all going into the body, there are variables that can change this even in the same person. Going to guess that your GI wasn't too happy and let you know. Also, that change in fiber would impact the microbiome in your gut which would be another variable that would make a difference, guessing trying to get the calories but limiting that fiber increase would change things, especially considering your GI history. You could also have a microbiome vastly different from your "average" person given past history, I think you mentioned having Inflammatory Bowel Disease, CD I think, damage to the gut from that would change how or what gets absorbed along with the potential of having gut bacteria that interacts with food much differently from others. I don't know the types of fats that you ate, but different types of fat absorb more or less depending on their type, the fiber can also change how much gets absorbed. Without being used to eat that many calories or those type of calories I'm not sure what impact that would have, the microbiome and the cells of the gut can change depending on what you eat and likely would take longer to absorb more of what you eat. Finally, there does seem to be impact of what food goes in based upon gut/brain interactions, as you likely have pointed out, we are not a test tube and the biology of our body is much more complex than most realize. Also recommend listening to the recent Huberman podcast where he talks with someone about the Gut/Brain interactions, that added some context to gut things that I hadn't thought about and would likely help you with future experiments involving food.
You could summarize your wall of text with:
Calories are a horrible way of measuring someones food intake.
@@snaxximan5737 Uh, no, it's not just calories, helps to read before you comment. LOL
This is a great response to consider. We are learning more and more about the micro biome and how much it really affects how we respond to food. So it really isn’t so much the calories. It’s what type of food, the makeup of the food, nutrient density and how gut bacteria interact with it.
We all know someone who can eat anything and not gain a single lb. Yet some people swear they gain a pound just walking past the bakery.
Lordy Nick, I would puke eating that. 🤣😂 you crazy!
Definitely a "don't do this at home kids"
Got slightly nauseated listening to what he ate.
@@Deanriley steak and eggs makes you nauseated?
Thank you,Nick! I stand with you in your declaration statement! So interesting, why some people don’t gain weight!
Glad you enjoyed this one :)
Answering virtually every comment, I have to admire the commitment. And having the capacity to do this in the context of keeping research and med school responsibilities on track. When I was in med school after prepping and eating some real food, keeping myself washed, dressed and fit, the only time left in each day was for about 4 hrs of sleep. I reassured myself at the time it would only be for a short while. It turned out that was the baseline for the next 40 years.
Ya… I’m trying to avoid that possibility… I’ve seen what toll it takes 😳
@@nicknorwitzPhD Perhaps I was whining. Rather, I would see it as a near optimal path for me. Some more sleep would give me a few less grey hairs and slightly better metabolic health. But the memories are irreplaceable. I was never able to attend a game or graduation but despite that my 4 children are all in the health care space. Like me they thought I was doing important work and having fun.
Don't slow down, I'm just impressed. In 40 years I won't be around to compare notes to see who saved more lives or had more fun.
I’m a LMHR, went carnivore/low carb 2 years ago. Before that for 3 years my RHR averaged 55 BPM, since starting low carb it’s been averaging 61. I used to struggle with POTS type symptoms but I haven’t since eating 90% meat diet with zero to a few low carb days a week. I feel better and lost weight but wonder why low carb made my RHR go up. Just staying curious!
Your passion for science and learning is inspiring! I am hoping that I can participate in similar academic discourse and discovery when I start medical school!
Love it Jared! When do you start? Where?
@@nicknorwitzPhD Not confirmed acceptance yet. Taking my MCAT in a few weeks 🤞 . Hoping to attend University of MN. This would be a second career for me!
@@jarednordstrom6041 Lovely! Best of luck Jared!
He doesn't have a passion for science. He has a passion for data that fits his narrative. There is a difference.
Love the structure of this video. It was very well explained and easy to follow! A quick question - I am aware that our levels of bile set some hard limit on our ability to metabolize fat. Given you were eating so much fat, do you think it's possible that the actual calories you metabolized is somewhat lower than the 26,000 consumed due to the inability of the body to process so much fat in a short amount of time?
If he was short of bile to absorb the fat, he would get steatorrhea. Greasy floating stools. This is a basic medical phenomenon that every 1st year student knows about, ie. he would have seen it and known it was the issue.
Your intelligent, self experimenting fascinates me. I appreciate your willingness to share your personal medical information. Please be careful that you don’t permanently damage your health.
Great channel…thanks for your time☺️
Thanks for your time! You’re the one who just spent 19 min on me 😅
Hey, this may sound strange but, have you noticed any changes in your stool consistency, smell, etc, during the 6000kcal diet? Also what is your normal energy intake (before/after the experiment)?
Yes, we are all similar but not exact. Yes differences in fat cell hyperplasia vs hypertrophy. Be interesting to see the starting triglycerides and ending triglycerides. Fun experience. An open mind is great. Too many find something they feel that works and then stop.
TG remain low... 40-60.
I am glad you added the disclaimer section, I think with the tendency toward polarization that we are living in, it is important to state and restate precisely where you stand and sometimes more importantly, where do you NOT stand.
I unfortunately have seen your name used to defend people advising those with actual FH to let their LDL rip as high as possible, stating that they were of the belief that you have FH yourself and are not concerned about it since LDL is good.
Thank you for doing your amazing work and being so public and entertaining about it. Great term this LMHR! That used to be called YSSJEM (You So Skinny, Just Eat More) - Im fascinated by all this and for once this community is about skinny people :)
Thank you for sharing your experiment. How you did you feel, in terms of sleep, alertness, energy levels and digestion?
Jittery. Less sleep. Very alert. High energy. Digestion "so-so" but certainly not as bad as the Oreo experiment
@nicknorwitzPhD That is exactly how one feels when eating a big meal too close to bedtime. Makes sense.
I'm a lay person so forgive my ignorance. Am I correct in understanding that thr reason the Feldman protocol did not work for Nick was because he raised his energy expenditure ie he was doing more exercise while he was on it than he normally does?
My body “auto-compensated” by increasing my involuntary energy expenditure through increased body temperature, heart rate, and NEAT
How much extra water did you drink? Fat is a water storage too so if you ate all that without drinking more water I am curious as to what your body is doing with all of it.
I am not a camel 🐫
I am fascinated by your experiments and your results!
Let's go!
I am in the same condition as you, Nicholas. I have a skinny body and high LDL cholesterol. What is the ideal solution for something like this?!
If you ever decide to repeat this experiment, it would be very interesting to know how your insulin levels were affected by the additional food. I’m not sure if someone can significantly expand fat cells without an insulin signal to do so?
I’ve had the same suspicions about my response to overeating. I used to eat tons of cheese (and I ignored my mom’s pleas to “at least have some crackers with it”). Sometimes cheese would be my entire dinner. It didn’t result in any fat gain-just things like nervous energy, inability to wind down at night, increased thermogenesis, desire to go for very long walks, etc.
Great point. I guess his weight gain was linked to the protein overeating and thus the extra insulin secretion. Actually, it seems like Nicholas performed the kind of study Dr Benjamin Bikman is calling for to dismantle the calorie hypothesis.
Hormones are a factor regarding lipid energy processing, especially estrogen level that fluctuates in women and also declines significantly with age.
Highly interesting video as usual.
Question:
You mentioned that your insulin levels went up due to the high calorie intake in this experiment, and that's an explanation for the increased LDL levels.
But in your OREO-test, your insulin levels would most likely have increasedeven more, but with a drop of LDL.
Isn't that contradicting?
"You mentioned that your insulin levels went up due to the high calorie intake in this experiment, and that's an explanation for the increased LDL levels." -- where did I say this was causal? As mentioned, there are "push-pull" factors and fat cell growth/insulin appeared to "lose" the day.
Do you think the increased metabolic rate would be visible in the thyroid hormones?
Love this. How many days did it take to see an increase in body temperature & resting heart rate?
You can see in the graph... effect was basically overnight... metabolism pretty dynamic
When I removed added saturated fat and cut back on red meat. I used olive oil only after that on whatever I ate and ate mostly seafood, my LDL-C dropped from 360 to 145. On Keto/carnivore diet.
Hey, this question may sound strange but, did you notice any changes in stool consistency, smell, etc. during this experiment?
Nice! How long have you been eating Keto Bricks? I'm considering trying some!
They’re new to me. Very yummy!!!
This is similar to the Hadza experiment. Feeding them with SAD. No effect in energy metabolism short term. Nick nows almost nothing about POMC but some about Leptin. That is the key to this.
Did you monitor your salt/sodium intake? I read that increased salt can elevate osmolality, which can induce indigenous fructose production. This process helps achieve the transient insulin resistance required to store fat, right?
I hope to see an experiment on the effects of excessive salt during a keto diet.
I understand we are all different, but would love to get more details into your diet and what you think is the best bang for buck calories. What I mean by bang for buck is not the energy calories in the food alone, but the total energy all things considered (i.e. thermic effect of food, etc.) and with all things considered can the difference be significant or negligible. Thank you.
10:30... how did I miss this cool explanation of where HDL fits into the energy model before?
Sounds like you're learning... and loving it?
My question is: did the size of your waste dumps dramatically increase? Is it possible that the bulk of what you were eating was simply expelled because the natural function of your body couldn’t fully process it?
is macademia low in LA? How much deuterium in non animal sources. We know deuterium is fat promoting. Did you consider this? Ghee is low in D2
I find these n=1 experiments really interesting. Keep going!
I switched from Plant based high carb diet to omnivore low carb recently, and have started seeing LMHR signs in blood tests (I've been lean all my life, and last 3 years at at my 15 year lowest weight).
What does your diet look like specifically in terms of fiber and fatty acid ratio. What is your BMI?
@@nicknorwitzPhD My fiber intake is >20g a day (20-30 I'd say). Fat around 65-70% of calories. BMI = 18,4. It used to be 20,5 before my 3y plant based period 😅 Trying to do more strength exercise and eat what my body asks for without forcing (I'm tired of forcing to gain weight).
My plan is to stay low carb, although I do exceptions, and to alternate with some keto periods. I just targeted being in ketosis once and I entered ketosis (I measured), without big effort (staying below 50g carbs).
My evolution in 9 months since I changed from Plant based (high carbs low-medium fat) to omnivore (decreasing carbs and increasing fat intake over this period, but still moderate-low carbs when I did my test 3m ago): LDL from 79 to 210; Trigl from 124 to 76; HDL from 36 to 65. I'll get a blood test done soon, will see how it goes now that I've been low carb (with exceptions). Thank you!!
@@nicknorwitzPhD Thanks for your answer.
I'd say my fiber intake is >20g (20-30), and 65-70% fat. Why you ask especially for this ratio?
My BMI is 18,4 😅. It used to be 20,4 before WFPB diet with normal activity.
Now I eat: Vegetables or salad with every meal (2 or 3) (prioritizing low glycemic index), some nuts/seeds. Meat, fish, eggs, some goat/sheep cheese/yogurt. Raw Coconut & Olive Extra virgin oils, avocados.
I don't eat (only occasionally): sugars, flours, starches (only resistant ones), refined oils.
Evolution in 9 months since I progressivly changed from Whole Foods Plant Based (high carbs, low fat) to 3 months ago (omnivore low/mid carb) (when I got lab test). During that time I :
LDL from 79 to 211
HDL from 36 to 65
Trigl from 124 to 76
My plan is to continue low carb with Keto phases, to reassess shortly as I'll get some blood tests done soon.
Thank you! Best regards.
@@JssRider Interesting. Consistent w/ present data for sure.
Spitballing here. Could the type of fat matter? In one success example you mentioned, a woman's fat source was predominantly cream. I've run across a few things lately about C15 being high in dairy products. Could that have anything to do with the results?
So you’re suggesting that swapping unsaturated for saturated fats would lower LDL?
@@nicknorwitzPhD That particular saturated fatty acid, yes. I don't know enough about the science, but I do work with data and I watch too much RUclips. 😊 So take my "I wonder if" with that in mind.
I noticed that that was a difference (other than sex) between you and your example success case. The particular saturated fatty acid that's been coming up in my feed about metabolic syndrome is C15. From Wikipedia: "Pentadecylic acid, also known as pentadecanoic acid or C15:0, is an odd-chain saturated fatty acid. Its molecular formula is CH₃(CH₂)₁₃CO₂H. It is a colorless solid. A laboratory preparation involves permanganate oxidation of 1-hexadecene."
It's in dairy, but I do not believe it's in macadamia nut butter. It's also available in a pricy over the counter pill form and some of the hype could be coming from that manufacturer.
I've been eating an excess of 900 calories fat per day for the last year, my weight remains stubbornly at 65KG, I may be eating less other stuff but I'm not consciously restricting what I eat.
Hey don't feel bad about getting it wrong. I myself was wrong once back in 1970. It happens to the best of us.
I don't feel bad! I feel enthused! Being wrong is where learning starts!
😂😂😂
A great video. I gained insight into our interior workings.
Glad you found it interesting and valuable
Non scientist here, where are calorie receptors and how does the body keep track of calorie count in and calories burned
There are no actual calorie receptors. There are pathways that are responsive to general energy status, like AMPK. But I wouldn’t consider this any form of receptor. I’d recommend checking out my video on trapped fat and the fuel partitioning model of obesity. I think that’s a more intellectually rigorous and functional way to think about energy in your diet.
So in a normal person this has the opposite effect? Does it effect A1C as well?
Disclaimer, my not fully understanding the physiology, but I have 2 questions. First one is simple. Was the increase in NEAT due to the thermogenic effect of food? And second, could it be that you appear to be so very lean, that there wasn't enough fat mass to expand? Perhaps comparing to others who have done this (Sioban), Calories per body weight or per kg of fat mass. Might there be an inflection point of overfeeding beyond which LDL would increase rather than decrease? Again, indexed to, say, total body weight or fat mass? Rather than just an increase in energy expenditure.
Genious video!!
What would your (hard gainer) approach be to gaining weight?
When eating a healthy diet, you are doing little to no damage, requiring you to use cholesterol. Thereby using the cholesterol eaten in the food, was added in to your serum cholesterol.
This fits with my theory. When you eat a species specific diet, for humans that would be zero carb, high fat, moderate protein. The number of calories are irrelevant. When I started carnivore, to cure my type 2 diabetes, was eating a diet of 0% carbs, 70% fat, 30% protein. Equaling on average, every day for a month, 5,000 calories. With zero exercise. I lost 60 pounds. Going from 250 to 190 in 30 days.
And you got this from? "When you eat a species specific diet, for humans that would be zero carb, high fat, moderate protein. " Yeah, out of your A.
@@tresero2862 Reading. Paying attention. Science.
@@Technichian462 Source: Trust me bro. Do your own research. XD
@@user-jl2ec2ko4v I have. Glad I did too. Cured my diabetes. Reversed my cancer. The answer to great health, pure health, is simply this. Do not eat plants.
@@user-jl2ec2ko4v what are you saying I failed to research? I definitely did the research. And it all panned out.
can you do a video on guidelines and advice for people who want to fix metabolic syndrome and/or diabetes type 2? which is a lot of ppl today
A lot of food for thought here, great vid.
As someone who's also chronically lean and doing similar experiments, let me add some:
I guess your diet wasn't ketogenic anymore due to the insane amount of protein and total calories. When I go overboard like that, sometimes it knocks me out of ketosis for more than 24 hours. Also my morning glucose is way higher than I'd like and it's difficult to get to comfortable levels during the day. The level of protein is specially important here.
It seems your diet was very Omega 6 heavy (relatively speaking), I would definitely ditch nut butters next time (a teaspoon per meal max). Macadamia is not the worst offender but it adds up.
Coconut milk is a great source of calories for this kind of thing.
Thanks for sharing this experiment 👍
Did do you know food is suns barcode and deuterium storage?
I am a LMHR ten years down a keto carnivore n=1 rabbit hole gone bioquantum thus shifting from biochemistry forward on.
Hi Nick
You are one of the very few people trying to push the conversation of diet and health forward and you do a great service to all of us.
On a different note then this video, max heart rates and training zones are measured from some arbitrary numbers (like 220-age)
Like yourself I have a low resting heart rate (66 years and 46 RHR)
I’ve wondered why resting heart rate wouldn’t be used as a base because you are actually raising it from that rested number instead of an arbitrary number which doesn’t take into account someone age 66 who would be supposed to have the same max rate as me may have a resting heart rate of 65 instead of like my 46.
That’s almost a 20 beat difference yet we would have the same max and zones.
Thanks hope you find this thought interesting.
"You are one of the very few people trying to push the conversation of diet and health forward and you do a great service to all of us." - Thanks v trials. Re RHR... my age didn't really change during this week... I'd consider high 40s my baseline and it increases to 60s, as shown in graph
Thanks for the reply but i was more interested in your thoughts on RHR and zones (in general) in relation to some people having lower or higher RHR but the standard max heart rate numbers don’t seem to take that into account
If you do the standard 220-age
First person
E.g age. 65
RHR 45
Max HR 155
Other person:
E.g age 65
RHR 65
Max HR 155
You see first person has 15 more heart beats per minute before reaching 155from his resting number. That seems to me like that would be an important piece of information to put in a formula or factor for their Max HR
I was interested in your thoughts or if it would provoke you to look further as I’ve not seen any one else consider this.
Thanks
I'm curious, if you monitored sleep scores during this experiment; and if you did, did the calorie increase and increased RHR negatively affect your sleep. I find that high calorie days increase my RHR at the end of the day. That increase seems to crash my sleep scores.
Don't actually own a sleep tracker... feel like it would screw with my sleep. I'm the type to get in my own head about it. That said, my sleep hours did decrease... just felt "buzzed"
Interesting. Thanks for sharing. It would have been interesting to see subcutaneous vs visceral fat ratio diff before and after . To do justice to that, you would have had to get a DEXXA scan. Personally, my priority is on keeping my visceral fat at optimal levels. Subcutaneous fat may look ugly as you prolly already know, it is not as cardiometabolically lethal. Anecdotally speaking only with all other things being equal , I know that when I dramatically overconsume calories even for a week with all other things be equal(no sleep deprivation, no change in cardio or resistance training, etc.,) or more, the first place any minimal bf% goes is viscreally as per pre and post Dexxa scan. In the interests of fairness and respectfully, I have not had any pre and post bloodwork done doing that to see how it messes with my LDL. That would be interesting to do in the future to directly track how any visceral bf% increase no matter how minimal effects that I presume there would likely be a significant jump in LDL and if nothing else Triglycerides. Interestingly and on a somewhat related issue, I found absolutely no increase or decrease in my RHR Thanks again, I love that you think outside the box,,and are not afraid of backlash. Keep up the great work. I love all your content
Have you ever tested postprandial triglycerides (4hr after a meal)? It’s supposed to be less than 220mg/dL and a better risk predictor than fasting triglycerides.
Yes.
Are you of the opinion that u need fiber/carbs as u did eat quite some of them a day (especially fiber)?
Try eating over 6000 cal & 0 g of fiber for a week… GL
What is your normal food intake? Or how many calories a day do you regularly eat before this experiment?
Varies. Usually I don't count but when I started the expt it was south of 3000.
I do enjoy your experiments. Its sort of like - going where no man's gone before. :))
Glad you enjoy it!
I've done this as well before prior to certain labs just to test it out. Definitely worked for my cholesterol lowering. Doctor didn't care much, though.
I will say whenever I ate so much my temperature will _always_ go up by A LOT. Like I'll be waking up at night in a pool of sweat and so on. My heart rate can as well go from 45-50 resting to a whopping 100 resting heart rate depending on just how much I've eaten the previous day. I don't gain much weight either as my weight will usually drop to below previously measured within a week or two tops, no matter how much I tried to overfeed myself. It's quite interesting.
I've done a 10MCal a day for a week experiment before as well, though with processed foods. It didn't end well as I literally couldn't walk by the end, it was wild, but it taught me what ultra porcessed foods do to your body really well. Meanwhile overeating (though less kcal) on a keto-diet had none of thse bad symptoms.
Doesn't heavy cream have carbs?
Consuming a full carton a day could have enough to lower ldl due to carbs alone?
Also why do you consume macadamia butter instead of regular butter?
Not much
@@nicknorwitzPhD According to cronometer, 1.6l of heavy cream has 45g of net carbs.
Have you done this experiment with non keto foods? Would that have brought down your LDL levels?
yes... see Oreo vs Statin experiment
I would be interested to know what your apoB was before and after. I am a LMHR who has given up trying to gain weight. I can eat a million calories a day and I never gain weight. This explains a lot about individual results.My CAC is scheduled soon I am curious about the results of this test also. Thanks for your great work.
My ApoB tends to parallel by LDL-C, although my non-HDL/ApoB ratio is very high
You can use ad libidum saturated F by long fasting period. I experienced higher resting heart rate and body temperature with an 11 days water fast...
Is there a protocol to raise ldl? I’d like to spoof my results the other way so I can get insurance to give me pcsk9 inhibitors
Hey Nick, with most of the calories in the form of fat and only 40 grams of carbs. Would most of the fat go through the GI track into the toilet. If this happens, we can assume that the stool will be loose and float. With a low carb intake, your insulin level would also be low, therefore inhibiting fat storage. Great content as always, just wanted to add some input.
We just don't know. We should, of course, keep trying to know, but we need huge levels of humility about what we claim to know presently.
Great content!
Question from last video.... is there a loading phase for L-citrulline?
Do you mean an up titration or elevated dose before "steady state" dosing... either way, I'm not aware of data on such protocols... from what I've been 3g daily would be routine... there aren't human long-term data on bone response to mechanical loading w/ cit. So, IDK
I had 6 eggs, 2 oz of cheddar cheese and 1 pound of pork for breakfast. I had 2 pounds of beef for lunch and I am going to have 3 pounds of Heart attack chicken and 1 pound of Heart Attack shrimp for dinner. I eat like this almost ever day. How many 'calories" is that? I am 6'6" tall 190 pounds and my weight never increases.
Me too Rick ,I'm 6'4 and often eat 6lbs of pork a day sometimes more than that and I'm 180 lbs cant gain a single lb even on carbs
Thanks Nick, always something new to challenge our thinking! I have a question. Another person says, 'they lied to us about the 'dangers' of saturated fat'. I'm aware there was a study in 2018 (Mozaffarian) stating Sat fats have health benefits - which was contrary his 2011 study; - saturated fats are harmful. The NZ Heart Foundation advice is based on the 2011 study! Are there other studies by M or others, that confirm saturated fats are not harmful? Thanks for all you do.
www.jacc.org/doi/abs/10.1016/j.jacc.2020.05.077
@@nicknorwitzPhD Awesome, thanks so much
How much did the unsaturated fat of cashew and olive oil affect the outcome?
Cashew? You mean macadamia? Probably very little. Sat vs Unsat doesn't appear to impact my LDL-C much w/ my highest LDL-C of all time being when intake was 1:5.67 sat:unsat ratio
I tried this also before a blood test and disappointed, my Gp having heart attack with my ldl and trigs going up, total 14.5. only adding carbs drops mine to 8 with trigs still,
Nick Norwitz: I do this crazy with a purpose experiment so you don't have too. lol
Yes, LDL rises with fat & protein intake & reduces as you have proved on a carbs- sugar diet.
High LDLs should be the norm, but the average Joe or Jill with their largely carb diet ( sugar diet) reduces LDL to what many think is a normal range.
Thanks, my main take away from this is the power of individual variability when making any comparisons even when the population cohort share many attributes such as LMHR. Every individual strives to achieve an optimal homeostasis based on his/her very individual circumstances at any particular time. I would go as far as to say that your individual measurements of bio-markers yield PERFECT RESULTS FOR YOU as an individual regardless of expectations based on averages taken from other population cohorts and especially from general population averages.
"power of individual variability" -- YES!
Was there any change in your triglycerides and HDL ?
Would be interesting to know, what the trend is (according to your n=1) of the expected response......As per lipid energy model, assuming your LDL went up because of your increased energy expenditure, and as you have been a lean mass hyperresponder, for enough time to reach homeostasis, a mild increase in HDL and mild decrease in triglycerides as well