Iron Overload and the Liver: Part 1
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- Опубликовано: 3 мар 2013
- This Masters in Medicine webcast is one in a three-part series by Dr. Anthony Tavill. This webcast reviews hereditary hemochromatosis and the most current data on the regulation of iron metabolism. Take the opportunity to also learn from Dr. Tavill in Iron Overload and the Liver: Part 2 and Iron Overload and the Liver: Part 3.
To learn more about the Masters in Medicine series or to claim CME credit, visit www.ccfcme.org/Masters
The video was produced by the Cleveland Clinic Foundation Center for Continuing Education.
I studied iron since med school early 90s when I found the research did not support the 'more iron is better' medical and community understanding. HC or iron overload is actually way more common than what he said, maybe at least 1/8 white people. Many people with only heterozygous genetics (or even none) are getting it these days, thanks to iron fortification of the food supply since ww2 (which is insane), and copper deficient soils, thanks to glyphosate which chelates copper (copper regulates iron). Iron is now being linked to dementia, MS, parkinson's, diabetes etc, and Bigpharma are currently rapidly trying to develop non toxic iron chelators to get all this iron OUT. Iron feeds most infections (inc covid), so iron chelation is also being used to help treat infections. There is a big question mark whether anemia is an iron problem, or always? There are natural ways also to chelate iron (I used them), but I would donate blood also if I could have (a combo is probably good). These inc IP6, turmeric, Bragg ACV, lactoferrin, green tea, quercetin, cabbage. I have had bad experiences in Australia with doctors knowing anything about HC, even in emergency departments I tell them and no one takes notice. Many doctors are still pumping people full of iron, and rarely diagnose HC.
Thank u so much for your words! I have a family member loosing her memory and she was exposed to mold and also has genetic high ferritin. Doctors has not said anything.
I will balance the iron as part of the treatment. Thank you!
Agree. Also they took copper out of of diet. Seems like a conspiracy to me. Keep us all overloaded in iron and no real bioaavailable copper to regulate the iron. Making us sick. We used to get up to 4 grams of copper a day. People are lucky if they get 1 now.
Are you a student of Morley's?
Thankyou for your insights 👍👍👍
@@haseebtubing Morley is not med school !!!
After years of Zinc supplements I developed Iron Overload due to Copper deficiency and i was seriously unwell with multiple symptoms and i thankfully recovered with the stopping of Zinc and supplementing with 2 mg Copper Gluconate daily for several months. I can report i am now recovered and in good health.
I’ve been in treatment for HH for 15 years and this is the first lecture (over 3 parts) that explained everything I need to know. An excellent synopsis.
I could listen to this gentleman lecture about anything... wow.
Proper british
11:08 he simply supposes there is such a mechanism that controls iron intake, with the circular logic that there must be because we are not iron overloaded. Which all is based on insufficient blood iron level tests, which don't say anything (the weak correlation to tissue iron and the temporary nature of blood iron status is well known, but we all pretend that problem doesn't exist).
It's not hard to see why iron might be hard to control, since it is a heavy metal, and for some reason we can't prevent uptake of mercury, cadmium etc either.
15:14 the hepcidin theory is flawed. Hepcidin degrades the only protein that shuffles iron out of a cell. That doesn't make it the 'master regulator' unless hepcidin is somehow locally controlled. But it isn't, the liver dumps it. So all this does is temporarily bind the iron tighter to all cells within the body. Also why would exercise, which secretes hepcidin, control the iron intake? Again makes no sense, rather it might make more sense for homeostasis to keep holding iron in place during strenuous movement than have muscles leak iron all over the place.
When he says 15:30 the hepcidin is what keeps the 18mg excessive iron out of the body, that's pure speculation, I have looked for this and not found it in any paper.
Juvenile hemochromatosis might be caused if hepcidin is not working at all, but that only shows that without hepcidin, too much iron winds up in the blood stream, not that it is preventing absorbtion of iron to a significant degree.
It's been only about 10 years since hepcidin was even shown to have a function in iron metabolism, and since, there has not been any new data on how exactly the hepcidin iron exiting function is supposed to control absorbtion. The iron first gets absorbed into the gut cells with the DMT1 transporter. So unless hepcidin is so high that 90% of the iron stays in these cells until 5 days later, the cell is turned over sheds out the GI (average half life), then the supposed control doesn't happen. This would mean hepcidin would have to bind iron tightly for 5 days just so the gut doesn't absorb the iron, all the while completely disregarding iron homeostasis elsewhere in the body where the hepcidin does the same.
19:04 hepcidin cellular targets are not confined to macrophages and GI cells. Ferroportin is responsible for transporting iron out of EVERY cell in the body. Hepcidin is spread indiscriminately by the liver, so it affects the whole body, while we are supposed to believe the point of it is to control iron absorption locally. No, hepcidin is obviously for iron homeostasis within the body.
Excuse my skepticism, but if the community didn't understand iron metabolism until 2012, there is a chance it still doesn't.
Studies of normal rats that are being fed a slightly higher iron diet vs control all accumulate the iron and develop iron overload. The problem is clearly one of intake. Genetic hemochromatosis as a function of hepcidin seems to be more related to indiscriminate flow of iron out of cells into the blood, and therefore causing measurably high blood ferritin levels.
No mention of Cp and how it redoxes the subject molecule? The protagonist is missing!
I just saw both my husband I have one of the herero mutations: DH=H63D; me=C282Y. DH's younger brother died from liver complications due to hemochromatosis. :(
Even after donating blood August and October, 2016, Dec labs show high serum Iron, Saturation 71%, ferritin 112. Grrrr. Donated 12/28/16 & 2/24/17. Noticed 3/2014 Saturation 51%. Whaaat? Dr never said anything and now it's 71%.
I used to donate blood regularly--just because--2-3X/yr from 2009; 2011-2013. Then I mistakenly thought my ferritin too low at 32 and stopped blood donations. More details, but just venting... and exploring. We'll see about April 2017 labs.
I think even blood doctors dont understand hemochromatosis.
Someone from Japan said 10 is his goal.
I've had blood in stool due to hemorrhoids for years, at least twice per week, with normal blood test results.
After getting anemia, I've started supplementing with iron two months ago, and blood leakage stopped.
That's totally inconclusive at best . Iron doesn't clot blood , nor heal hemorrhoids.
@@MrKrueger88 Blood leakages stopped within ten days of starting supplementation.
@@salexbe How did you get diagnosed with anemia? What specific blood test?
my doctor (new) diagnosed me, if it is one in 150 people , why aren't they testing people?
it's way higher than 1 in 150. 1 in 5 is more accurate
Got it. It is not easy.
Because no one makes any money until a person is seriously sick from it----ie: no drug for it!
If a newborn were tested for it, it could be monitored, doing phlebotomies if needed, and Never become a problem .It is all about $$$.
In 2004, the drug used to treat it was 6000 dollars a vial. I worked at a cancer clinic and had to make sure the patient would show up before purchasing. And then it would take a few hours to reconstitute it for IV administration because it was like tar in the vial.
Will blood transfused from a person who has hemachromatosis to an anemic , makes his anemic cured? I think its make sense, as they get iron directly in their blood. What you think?
Great question! With iron overload can I donate blood.
@@kristannchigro2074 unfortunately not all labs will take the donated blood as it is considered toxic for some with the high iron levels.
excellent ±±±
Look up Grant Genereux.
He has written three free e-books talking about vitamin A and how it will cause liver problems since most of vitamin A is normally accumulated in the liver, causing liver problems and then iron problems.
Iron overload is also caused by copper deficiency. Histamine intollerance is caused by iron overload.
Vitamin A is not our problem normally.
But vitamin A in supplements, that are not natural vitamin A aka Retinyl Palmitate.
Real Vitamin A is called Retinol not Retinyl.
Liver damage in this video is caused by iron overload, not vitamin A overload.
It is so complicated.
Hemochromatosis is caused by overload to overload of iron. Because they add iron in everything in processed foods for decades!
@@heide-raquelfuss5580 well said. Can't believe people think real vitamin A not synthetic is the cause of liver issues. Yes vitam A needs copper to regulate it in the body. They both work together. So someone taking a vitamin A synthetic supplement with low copper in the body can get sick. But beef liver has vitamin a and copper In balance.
@@nancygatto4963
Thank you for adding the advice to take in copper too. I did not know that. Another reason to get sick.
In my country you can not buy Retinol aka vit A ( real A ). Only Retynil palmitate ( synthetic ). I have to order Retinol in Germany.
So i eat egg yolks every day to cure some things. I will add more liver! 😉 But copper i did not take. I know copper must be taken in low quantities.
So again thank you.
🌿
High vitamin A aka Retinol, not Retynil palmitate is indeed toxic. But no one eats so much vitamin A anyway.
I read the story of a man in the artic who was starving and consumed a liver of an polarbear. He died from the liver diet a painful death, but when you look at the size of the liver of a polarbear, i can imagine he ate indeed to much at once and poisoned himself.
@@heide-raquelfuss5580 yes people are only supposed to have 4 to 6 oz a week is all.
What do I eat?
Cabbages & TUMERIC.
Dirt...Some good Mud if you can find it..
i have more iron in my body then needed, should i be concerned ??
Yeah Bring it down, talk to ur doctor now
Hypervitaminosis A will make your liver work less good and cause all kinds of problems, just like iron overload. Avoiding toxins will help your liver to function better.
Turmeric can help with iron overload.
mint extract can help with certain cancers, but generally in the form of a super concentrated extract that you can't purchase over the counter and usually has other stabaliser drugs with it.
you shouldn't take these things thinking they're actually helping without first investigating the actual drug, generally it's not the plan it's a compound in the plant at very large doses of which you wouldn't be humanly possible to eat.
waste of time really.
Look up Grant Genereux.
He has written three free e-books talking about vitamin A and how it will cause liver problems since most of vitamin A is normally accumulated in the liver, causing liver problems and then iron problems.
I believe you, a few nights ago before my new diagnosis, I was in much pain and remembered that TUMERIC was a pain killer so I boiled some water and added 1/2t of TUMERIC.
The pain was instantly gone until it wore off in about 5-6hrs then I’d have to drink more.
Or, blood donation
@@kathleenking47 Yes, if someone is able to donate blood that can aid in ridding the body of iron.
How bout acv, tumeric, berberine, and milk thistle
iam 65 just found out today i have HEMO....HOPEFULLY I CAN BE HELPED MAYBE NOT????
try raw cabbage
Change Diet. No red Meat, no Alcohol, reduce Carbohydrates, sugar, bread etc and eat extra Vegetables.
Get regular blood letting.... I did and felt better in 3 months
@@TropicalGardenGuy what was your ferritin (iron levels)??
Before and after 3 months giving blood? How much ml once month blood donation?
@SMD 014 vegetable like that will cleanse the detox the iron
But it’s weird I just turned 46 I’m not white I’m Puerto Rican.. how does diabetics is link to this disease?
slows blood flood and spikes insulin
Mom
What tests need to be takes to find out if liver is loaded in iron
Goto your general doctor and ask for ferritin tests if it is high he will refer you to a hepatologist.
@@irmahamja7467 check memo
The cotton mouth is killing me
I wasn’t so sad before and thought that diet & exercise will be okay, but then realized I have HCT & stage 1 cirrhosis just like the video.
I need to pray & fast, my son is almost legal but still needs his mom & dad. 😢
The govt knows and they are doing this on purpose. 😢
Please drink some water 😭