HER2 Amplification and Breast Cancer Part 2

In this video we look at how an amplification of the Her2 gene can constitute a gain of function mutation in the Her2 gene and how this can lead to breast cancer. We also look at the drug Trastuzumab/Herceptin.

[@farazsaifmarwat]

Brilliant just brilliant...

[@marwambarik553]

HER2 is an orphan receptor so the EGF can't bind to HER2. It binds to anothor erbB receptor leading to its dimerisation with HER2.