Anti-HER2 Mechanisms of Approved HER2 Inhibitors

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Patients whose disease progresses or relapses on trastuzumab now have 3 new
therapeutic options: lapatinib, pertuzumab, and T-DM1. Each of these agents has a unique
mechanism of targeting HER-2 signaling and cross-talk among HER family members. When
considering treatment for patients past the first-line setting, the goals of therapy should be
to improve survival and minimize treatment-related toxicity. Only T-DM1 has demonstrated
survival benefits over other traditional choices, such as lapatinib and capecitabine, and
should therefore represent a standard of care for second-line patients. Dual HER2 blockade
with lapatinib and trastuzumab also led to a survival advantage over lapatinib alone in
more heavily pretreated patients than those enrolled in EMILIA. This combination of HER2-
targeting agents also offers a low toxicity profile. Finally, once T-DM1 and lapatinib strategies
have been exhausted, continuation of trastuzumab in combination with chemotherapy has
proven activity. The increasing number of options in the second-line setting and beyond is
good news for patients faced with trastuzumab-refractory metastatic breast cancer

[@avantikadogra850]

Thank you.

[@user-mm5py7wz4l]

ميت من الطفش، متشكرين

[@lakshmideepthi3266]

Very useful..

[@ishapandey28]

Nice explaination 👍

[@simonleitner7292]

what an interesting video! thanks :)

[@yummyfuzz1]

This demonstrates the mechanism and effect Her2 anti-cancer drugs have on the diseased cells.

[@mabelnnah2713]

Disorders of blood pressure regulation

[@md.riponhossen6178]

How to give anti her -2 therapy?

[@tamrinimelda]

ManTEpnyeE obat mahal 👍 (kanker payudara) #salamtamrinGANTENK