Miss Sheekey, I like your show. I think you deserve many more followers. However, may I ask an off topic a question? What app do you use for highlightting text in papers (pdfs?) I realy like the light pastel colours of your highlights. They are nice to read. I use MS Edge for making highlights in pdfs, but the highlights are in strong sharp colours. Thanks.
Challenging and enlightening topic presented with skillful clarity! I’ll have to watch it again and that’s a testament to it’s value. Content that stretches the understanding of lay people like me is a real contribution.
So the best of both worlds would be to have faster translation during development and then slow it down as we mature and stop the accumulation of errors - and weed them out with autophagy and apoptosis (right?)
Wonderful summary! One thing you only hinted at in your video is the possibility of a positive feedback loop that leads to an error cascade: initial mistakes make further mistakes more probable due to disruptions of the machinery for translation itself, which leads to more faulty proteins, etc. (not necessarily indefinitely, there could be an upper limit, which Dr. Leslie Orgel pointed out ages ago). Analogous to the way a DNA mutation in a DNA repair gene can eventually lead to the loss of genome integrity. cool factoid: naked mole rats -> higher protein fidelity and better UPR.
Really cool Sheekey! Have you come across any literature on: - Translation accuracy in animals that tend to live longer than humans? - Translation speed effect on wound healing? It seems reasonable to assume that slower translation might also slow down wound healing.
Why Lysine rather than Arginine. Speed may very well be the answer. However, if Lysine is more plentiful in the food available it would make sense that that Lysine would be preferred by the cells over arginine for a basic life sustaining process occurring in every cell in the body. Not sure if that hypothesis has been looked at.
Fascinating! Does this suggest that inhibiting mTORC1 provides all the benefit to health and longevity? That is, if a drug or supplement inhibited only mTORC1, would it provide all the benefit of rapamycin?
Objective is to increase accuracy by slowing down synthesis then equally conserve these quality proteins. mTOR is not the best point because it is either/or, meaning decreasing the rate of synthesis through mTOR inversely increases non-selective autophagy of the quality proteins which need conserved. Instead, first consider the nuclear factors which particularly govern the rate of synthesis, while mTOR is simply the intercellular integrator.
You may find an article in Chemical and Engineering News entitled “Lost in Translation” Sept. 20, 2021 by Ryan Cross of interest. It describes the potential use of suppressor tRNAs to suppress premature stop codons in mRNA.
Hi Sheekey! I watch all your videos, many thanks! When you said “This is a Theory”, maybe you meant “this is a hypothesis”? Aren’t Theories things that we believe to be proved, like Darwin’s or Einstein’s?
@@PinataOblongata the thing is science constantly changes what is precise one week, isn't the same the next. Obviously precision is a massive factor in everything. Things always change so just take what you can from the information and come to your own conclusions.
@@Chris-kr7gg Whoosh. I meant that using precise language and terminology is important in science, it's not pedantry, so your accusation of pedantry is unfounded and it's correct to say that either you're using a "theoretical" model or your idea for a mechanism is still hypothetical, not that your idea is "a theory". As to whether precision changes, nope wrong again. New results are always adding to our understanding, but the concept of precision does not change. I was referring to precise language, but precision in terms of measurements and results refers to repeatability and error size.
Great show, love the content. As an English teacher I should say though, although it's spelt al-be-it, it's pronounced all-be-it. Keep up the great work!
@@KenOtwell How do you do that? I try and watch her but usually give up after about one minute because she speaks too fast and it jumbles her words together.
@@user-qt6mm9gg5w lower right on your screen there's a "gear" icon for settings. One of them is the speed setting - set it to a slower speed and try that.
My mistake was not adding a picture of a mammoth at 03:45 !! :D
Especially since we are going to see live ones in a few years.... ;)
Evolution!? 🧬 study, smoking gun of humanity” 4500 years ago back to Noah’s children. Inbreeding errors
Ahhh... the elephant in the room!?
Is there any natural ways or foods or supplements to have better protein or to do this so to acheive longevity ?
Thank You yah
Thank You
Thank You
Miss Sheekey, I like your show. I think you deserve many more followers. However, may I ask an off topic a question? What app do you use for highlightting text in papers (pdfs?) I realy like the light pastel colours of your highlights. They are nice to read. I use MS Edge for making highlights in pdfs, but the highlights are in strong sharp colours. Thanks.
Challenging and enlightening topic presented with skillful clarity! I’ll have to watch it again and that’s a testament to it’s value. Content that stretches the understanding of lay people like me is a real contribution.
Ja takođe ,ali i zbog njenog dijakekta ,užasan je kao i moje znanje engleskog !
So the best of both worlds would be to have faster translation during development and then slow it down as we mature and stop the accumulation of errors - and weed them out with autophagy and apoptosis (right?)
Wonderful summary!
One thing you only hinted at in your video is the possibility of a positive feedback loop that leads to an error cascade: initial mistakes make further mistakes more probable due to disruptions of the machinery for translation itself, which leads to more faulty proteins, etc. (not necessarily indefinitely, there could be an upper limit, which Dr. Leslie Orgel pointed out ages ago). Analogous to the way a DNA mutation in a DNA repair gene can eventually lead to the loss of genome integrity.
cool factoid: naked mole rats -> higher protein fidelity and better UPR.
Thank you for sharing your references. I will link to this video on my linked in page.
You're on the right track. The integrated stress response is how you restore normal protein production in aging.
Could heat and cold shock reset this ?
Like that both study has common ground, reducing speed of protein synthesis increases accuracy.
Really cool Sheekey! Have you come across any literature on:
- Translation accuracy in animals that tend to live longer than humans?
- Translation speed effect on wound healing? It seems reasonable to assume that slower translation might also slow down wound healing.
Very nice. What's that drawing app with the infinite canvas?
I’m curious what’s the endpoint for the PEARL trial?
Why Lysine rather than Arginine. Speed may very well be the answer.
However, if Lysine is more plentiful in the food available it would make sense that that Lysine would be preferred by the cells over arginine for a basic life sustaining process occurring in every cell in the body.
Not sure if that hypothesis has been looked at.
Fascinating! Does this suggest that inhibiting mTORC1 provides all the benefit to health and longevity? That is, if a drug or supplement inhibited only mTORC1, would it provide all the benefit of rapamycin?
Objective is to increase accuracy by slowing down synthesis then equally conserve these quality proteins. mTOR is not the best point because it is either/or, meaning decreasing the rate of synthesis through mTOR inversely increases non-selective autophagy of the quality proteins which need conserved. Instead, first consider the nuclear factors which particularly govern the rate of synthesis, while mTOR is simply the intercellular integrator.
You may find an article in Chemical and Engineering News entitled “Lost in Translation” Sept. 20, 2021 by Ryan Cross of interest. It describes the potential use of suppressor tRNAs to suppress premature stop codons in mRNA.
On days that I eat totally plant based I still get more than enough protein
With minimum BCAAs
dont forget to supplement creatine, b12s and omega6s if you go plant devourin
What a great video, thanks a lot !
Good info
Hi Sheekey! I watch all your videos, many thanks! When you said “This is a Theory”, maybe you meant “this is a hypothesis”? Aren’t Theories things that we believe to be proved, like Darwin’s or Einstein’s?
Pedantic to an extreme.
@@Chris-kr7gg he is right. a theory is not a hypothesis. theories have some amount of proof to back up the claim.
@@Chris-kr7gg If you think being precise is a bad thing, science is not for you.
@@PinataOblongata the thing is science constantly changes what
is precise one week, isn't the same the next. Obviously precision is a massive factor in everything. Things always change so just take what you can from the information and come to your own conclusions.
@@Chris-kr7gg Whoosh. I meant that using precise language and terminology is important in science, it's not pedantry, so your accusation of pedantry is unfounded and it's correct to say that either you're using a "theoretical" model or your idea for a mechanism is still hypothetical, not that your idea is "a theory".
As to whether precision changes, nope wrong again. New results are always adding to our understanding, but the concept of precision does not change. I was referring to precise language, but precision in terms of measurements and results refers to repeatability and error size.
Great show, love the content. As an English teacher I should say though, although it's spelt al-be-it, it's pronounced all-be-it. Keep up the great work!
Spelt? I'm not an English teacher, but shouldn't that be 'spelled'?
@@jaydickey1049 Not if you're British, as I am.
@@houndofzoltan Ah yes, us Septics have tinkered a bit with the Kings English. Cheerio!
Good job smarty pants.
Yeah she thinks she's soooo clever, don't she?
much too difficult to understand speech
Use your yourube settings to slow it down a bit.
@@KenOtwell How do you do that? I try and watch her but usually give up after about one minute because she speaks too fast and it jumbles her words together.
@@user-qt6mm9gg5w lower right on your screen there's a "gear" icon for settings. One of them is the speed setting - set it to a slower speed and try that.
Where’s the RUclips setting to slow down protein synthesis, LOL
@@KenOtwell Thanks. Sounds a little weird now but it does help.
uff, I could‘t follow.