What Is a Partial Agonist (Partial Agonist Pharmacology Made Easy, Full Agonist vs Partial Agonist)
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- Опубликовано: 5 янв 2025
- What is a partial agonist? Dive into partial agonist pharmacology to understand the differences between full agonist vs partial agonist medications.
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The video explains the concepts of agonists, partial agonists, antagonists, and inverse agonists, which are important in understanding pharmacodynamics and receptor activity. It uses the analogy of a light bulb to visualize the magnitude of the effect produced by a receptor upon binding with a ligand.
Full agonists produce the maximum response that a system is capable of, represented by the light bulb emitting maximum light. Partial agonists can never achieve the maximum response, as their efficacy is lower than full agonists, leading to a dimmer light output. Constitutive activity refers to the baseline activity of a receptor even when no ligand is bound, represented by a faint glow.
Antagonists have affinity for the receptor but no efficacy, meaning they don't produce any effect on their own. However, they can block the binding of agonists or partial agonists, returning the receptor to its constitutive activity state. Inverse agonists, on the other hand, bind to the receptor and remove even the constitutive activity, resulting in less light output than the baseline.
The video emphasizes that efficacy is distinct from potency (the dose required to produce an effect) and affinity (how tightly a drug binds to the receptor). It also clarifies that efficacy in this context refers to the ability of the receptor to produce a functional response, not the clinical effectiveness of the drug itself.
Overall, the video provides a visual and intuitive explanation of the concepts of "efficacy" and the different types of ligands (agonists, partial agonists, antagonists, and inverse agonists) that interact with receptors, which is crucial for understanding pharmacodynamics and drug action.
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#pharmacology #psychopharmacology #pharmacy
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you deeply understand what you are saying so you made us understand it too
A lot of people have tried to explain this to me before, but this is the first time it made sense.
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Another great video! Easy to understand and follow. Keep them coming! Sincerely, a Psychofarm fan
What about superagonists? Also, Asher Brandt, who is another pharmacology youtuber said this "By the way the term 'full agonist' is a misleading term in pharmacology. The term full agonist refers to the strongest activity we have observed for a drug. If we find a drug that has stronger activity we call the new drug a full agonist."
"Sometimes the endogenous ligand is used as a reference, but not always. In the case of CB1 this is not the case."
Great video, thanks for doing these, it's really educational. I think at 3:16 you meant to say 'decrease the overall light of the system', iiuyc
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Awesome video! You did a great job of explaining the concept clearly.
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Too fast