Dr Tom Phillips, Microglia a double edged sword: Neuroinflammation and new routes for drug discovery

In this webinar Dr Tom Phillips, Research Associate for the UK Dementia Research Institute at Cardiff University, talks about microglia's role in dementia (mostly Alzheimer's Disease but also Parkinson's Disease), how that role moves between protective (clearance) and damaging (neuroinflammation) and how new genetic findings point to new therapies. The fill title for this talk is "Microglia a double edged sword: Neuroinflammation and new routes for drug discovery".
Microglia are increasingly recognised as key component in a variety of neurodegenerative conditions including Alzheimer’s and Parkinson’s disease. While microglia have a protective role in these conditions the dysfunction of these cells can lead to neuroinflammation and is believed to be linked to disease progression. Recently risk genes found in microglia have opened a new therapeutic pathway.
This Midday Lecture Webinar was recorded on the 20th May 2020 and is brought to you by the NIHR Dementia Researcher Website, and hosted by Adam Smith, Programme Director at the Office of the NIHR National Director for Dementia Research, University College London - www.dementiaresearcher.nihr.a...
The NIHR Dementia Researcher website is a one-stop-shop to support Early Career Dementia Researchers from across the world. With daily posts and blogs discussing research and careers, and with listings of of upcoming events, jobs and funding opportunities. To find out more, get details on how to deliver your own webinar please visit www.dementiaresearcher.nihr.ac.uk/webinars - here you will also find details on up coming webinars.
NIHR Dementia Researcher also publishes a fortnightly podcast, find this on your favourite podcast app, just search for 'Dementia Researcher'.
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Learn more about the new drugs coming to treat Alzheimer's Disea with this video podcast - "A Closer Look at Lecanemab, Donanemab and Amyloid"
• A Closer Look at Lecan...
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[@mahuubao]

Excellent ... well done ... does silent inflammation in the Gut via Microglia influence Apoplexie ?

[@DementiaResearcher]

There is evidence to suggest that chronic inflammation in the gut can contribute to the development of various health problems, including stroke, which is a type of apoplexy. However, the relationship between silent inflammation in the gut and microglia, which are immune cells found in the brain, is not yet well understood.
Microglia are the resident immune cells in the brain and play a crucial role in brain development, homeostasis, and immune defense. Recent research has suggested that microglia can be activated by gut-derived signals, including bacterial endotoxins, and that this activation may contribute to the development of neurological disorders, including stroke.
Moreover, studies have shown that gut microbiota dysbiosis, which is a condition characterized by an imbalance in the gut microbial community, can lead to inflammation and immune activation that can contribute to the development of stroke. This chronic inflammation, known as silent inflammation, can also cause damage to blood vessels, increasing the risk of stroke.
While there is evidence to suggest that silent inflammation in the gut via microglia can influence the development of apoplexy, further research is needed to fully understand the complex interplay between the gut, brain, and immune system in the development of this condition.

[@MishMacky]

Really great info, but the lecturer is a bit hard to understand... He speaks too fast and mumbles a bit.