Pregabalin & Gabapentin for Anxiety | Dr. Jeff Knuppel

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  • Опубликовано: 8 сен 2024

Комментарии • 108

  • @JeffreyKnuppelMD
    @JeffreyKnuppelMD  7 месяцев назад +8

    I'd like to hear what's worked best for YOU for anxiety. Please share any experiences you've had with gabapentin or pregabalin as well.

    • @Chrisbybeebee
      @Chrisbybeebee 7 месяцев назад +3

      Intense exercise like biking, swimming & Bikram's Hot Yyoga worked best for me! I sleep like a baby when I get outdoors.

    • @whatsitlikebeingadruid5314
      @whatsitlikebeingadruid5314 7 месяцев назад +2

      I am not going to take it anymore. Researched some other vids too. Halving my dosage on my own and will be talking to my provider about stopping it completely. Would stop all together but I have heard it is dangerous to just outright stop.
      I have felt very tired since on it but thought it was because I was exercising more. I don't even think it is really benefiting me. Pretty certain exercise and diet are way more effective.
      Please keep making your videos.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +1

      Which med are you on - pregabalin or gabapentin? I hope you find a better path forward for your anxiety.

    • @whatsitlikebeingadruid5314
      @whatsitlikebeingadruid5314 7 месяцев назад +1

      @@JeffreyKnuppelMD Gabapentin. It says in smaller print "generic neurotonin". I think it may have made me dizzy too a few times. I thought it was from working out though I was surprised to be dizzy. Now I wonder if it was the gabapentin.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +1

      Yeah, sedation is one of the common reasons some people don’t tolerate it.

  • @SusanDallas-dq8fu
    @SusanDallas-dq8fu Месяц назад +13

    Both Lyrica and Gabapentin are horrible to get off of. Horrid withdrawal. I’ll never touch either again. Even missing one dose would cause huge discomfort.

    • @Guriidhaliwal922
      @Guriidhaliwal922 Месяц назад

      How you get off from it

    • @dellamcconnochie
      @dellamcconnochie 24 дня назад +4

      I had no trouble ran out of pregablin and as I had found they didn't make
      Any difference so didn't take anymore no reaction we are all different

    • @SusanDallas-dq8fu
      @SusanDallas-dq8fu 24 дня назад

      @@Guriidhaliwal922 I opened the gabapentin capsules and removed about 1/4 of the medication every day for 1 wk, then about 1/2 removed for 1 wk, etc. After 1 wk of taking 1/4 of dose every night, I then took i1/4 dose every other night 1 wk. and then was done.
      With Lyrica I think I did it about the same way…

  • @RichardSmith-ot3zk
    @RichardSmith-ot3zk 2 месяца назад +7

    I would not have thought a medicine would have helped my generalized anxiety as much as gabapentin has. SSRIs, SNRIs, etc never did much for me. I was having, for lack of a medical term, a nervous breakdown over a year ago. I had to walk off my job and didn't know if I'd ever be back. I went on gabapentin (300mg twice a day or as needed) along with lamotrigine. Within a matter of days, I was much, much better. The nurse practitioner was very surprised how calm and relaxed I was less than a week later.
    I would almost say I don't have anxiety now (though there's mild bipolar II left). My brain used to be so noisy I couldn't follow a train of thought. The suicidal ideation I had daily for 30+ years is gone. I don't overthink things to the point of choice paralysis anymore. And my nighttime itching is gone.
    Of course my results aren't typical. For me, it's be life changing. I hope more research is done to see who it helps and who it doesn't work for.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  2 месяца назад

      Thanks for sharing your story. I'm glad that gabapentin has helped you and that you were able to figure that out.

    • @michaelfredmon4748
      @michaelfredmon4748 Месяц назад +1

      I’m real pleased to hear of your positive outcomes

    • @kirstenhorte5488
      @kirstenhorte5488 14 дней назад +2

      Lamotrigine was life changing for me too, mood stabilizer wise, as SSRIs etx etc also didn't do anything for me. I'm on pregabalin 400 MG a day for arthritis and 1.5 MG Clonazepam for anxiety as needed. But Lamotrigine works on your GABA receptors so to me it makes sense why it calmed the storm so to speak in my head. Best of luck ❤

  • @danpatrick5015
    @danpatrick5015 5 месяцев назад +8

    Calm, collective info with no panic or over the top statements seen on YT. Thank you

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  5 месяцев назад +1

      You're welcome! Thank you for watching and for your comment.

  • @Dave-if5qj
    @Dave-if5qj 15 дней назад +3

    Ive found it almost effective as
    benzos for anxiety also effective for my neuropathy
    And im only on 100 mg 3 x day

    • @TokeE420
      @TokeE420 22 часа назад

      Does it constipate you? I got fast metabolism but it gives me intense constipation far worse than Opioids.

  • @redleb1871
    @redleb1871 4 месяца назад +6

    Excellent information. Obviously a top rate doctor, with wonderful bedside manner. Thank you.

  • @janeb6098
    @janeb6098 6 месяцев назад +6

    I take Pregabalin 75mg for restless leg syndrome. It also worked to switch off a severe Anxiety attack that lasted weeks. With this attack brought on by a health crisis, my thinking got back to normal after a fortnight but my body was still having severe symptoms of sweating and uncontrolled shaking during the night. Pregabalin was very effective after just 2 or 3 daily doses. It clearly switched off the fight or flight response or whatever was happening in the amygdala. However, possibly due to CKD, i cannot take it more than once in 24hrs. When I did, I had the rare reaction of bradycardia with a pulse of 38 to 41 overnight. So i have to wait at least 30 hrs between doses. I find it to be very effective for anxiety and especially restless legs.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  6 месяцев назад +2

      Thanks for sharing that. It’s such a frustrating situation when you find something that helps but causes side effects. Meds have their place, but your situation is a good example of why they should be prescribed cautiously as they’re not risk-free.

  • @user-mackster40
    @user-mackster40 4 месяца назад +7

    I've started pregablin for anxiety and it's working straight away

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  4 месяца назад

      Great to hear! Thanks for sharing.

    • @stu77t68
      @stu77t68 4 месяца назад +2

      Me too started on 25 mg 2 x day hopefully move me up

  • @mattjones3709
    @mattjones3709 6 месяцев назад +7

    I tried 6 different SSRI’s, all of them gave me terrible reactions and made my anxiety so much worse.
    My psychiatrist prescribed gabapentin. Started at 300 mg a day. I noticed a slight difference within 3 days and I had NO bad reactions. None. I’m currently up to 1200mg a day after 3 months and I’m feeling great so far. It was supposed to help with insomnia but unfortunately it didn’t and I’m still working on that part. I’m very grateful so far.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  6 месяцев назад

      I’m glad to hear you found something that works for you. Thanks for sharing your experience!

  • @joseph8468
    @joseph8468 7 месяцев назад +6

    Thank you, Doctor, for this informative video.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад

      I’m glad it was helpful! Thanks for watching.

  • @hismajestyericcartmanthese5755
    @hismajestyericcartmanthese5755 7 месяцев назад +10

    Since being on Gabapentin I can see goodbye to diazepam. Before Gabapentin I was taking Diazepam every three hours.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +1

      Good for you! That must be a relief.

    • @heatherulm8587
      @heatherulm8587 6 месяцев назад +5

      Benzos scare the hell out of me.

  • @MichaelDerousselle
    @MichaelDerousselle 6 месяцев назад +5

    I have been through the gammut of medications. Then my psych tried Gabapentin. It made a huge difference. I have Generalized Anxiety, depression (which comes with unmanaged anxiety) and Essential Tremor. I have been on 600mg 3x a day, for a few years.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  6 месяцев назад

      Thanks for sharing your experience. I’m glad to hear you found something that works for you!

    • @mitch5222
      @mitch5222 2 месяца назад

      Does it help?

  • @Dave-if5qj
    @Dave-if5qj 15 дней назад +1

    Its supposed to be the
    Most off label prescribed
    Medication in psychiatry

  • @allgunsblazed9106
    @allgunsblazed9106 2 месяца назад +3

    I've been taking a high dose for a while 400mg a day, it's for chronic back pain and occipital neuralgia though. Definitely helps keep my mood stable. I'm 22 😂

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  2 месяца назад

      Thanks for your comment, I’m glad it’s helping you.

  • @Kingboo1081
    @Kingboo1081 7 месяцев назад +9

    I found daily Pregabalin (300mg twice daily) to not be effective what so ever for my anxiety.
    However, when I took it on an as needed basis, it would give me a lot of relief (almost 100%) from anxiety, and even improved mood.
    I wish I understood why? Is it ever used on an as needed basis?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +2

      I can’t explain why pregabalin didn’t help your anxiety when taken regularly but did help on an as-needed basis. The fact that it helped quickly when taken as needed doesn’t really surprise me though since it usually works to some degree within a couple of hours. For anxiety, it’s still usually prescribed on an ongoing basis.

    • @danielk6117
      @danielk6117 7 месяцев назад +2

      Tollerance

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +1

      That’s certainly possible or tachyphylaxis (some drugs suddenly stop working).

    • @xtina4621
      @xtina4621 5 месяцев назад +2

      Because your body built up a tolerance to it taken regular!

    • @corykroeger9358
      @corykroeger9358 4 месяца назад +1

      I've been on it for 2 months and it hasn't helped me. In fact it made me worse as far as anxiety. Now I'm slowly tapering off

  • @sakuragi9607
    @sakuragi9607 7 месяцев назад +8

    Wouldn’t you think a doctor would prescribe Lyrica/pregabalin over Xanax I’ve tried 4+ sssri and 2 SSNRI I don’t want a benzodiazepine I’m only 21 and im afraid doctors will think I wanna abuse drugs even I’m just trying to help my anxiety since my accident

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +5

      I can’t comment about what’s right for you, but generally speaking I would prefer to use pregabalin over Xanax. You might want to check out the video I released yesterday about Benzodiazepines for Anxiety Disorders. I specifically talk about why most prescribers don’t think Xanax is usually a good idea.

    • @heatherulm8587
      @heatherulm8587 6 месяцев назад +2

      I took Xanax for 2 weeks straight and coming off of it was terrifying. I'm an opioid addict too and coming off Xanax was scarier.

    • @markydiamond3439
      @markydiamond3439 2 месяца назад

      ​@heatherulm8587 Get away from that trap, the cycle of prescription abuse is straight treacherous!! God gave us a natural remedy for every problem we have, it's just not publicly acknowledged as it should be

  • @t.fernandez7399
    @t.fernandez7399 6 месяцев назад +2

    Thank you Dr.

  • @volt8684
    @volt8684 4 месяца назад +1

    In India ihave read a research that pregab max is 50 -75 a day. Gabapentin max 300 for nerve pain. Balance of efficacy and side effects

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  4 месяца назад

      Interesting. That’s certainly not how it’s prescribed in the U.S.

  • @donnarowe1890
    @donnarowe1890 6 месяцев назад +3

    Thank you Doctor for this informative video!

  • @brandonm8131
    @brandonm8131 3 месяца назад

    Thanks for the information. Im going to ask my doctor about Pregabalin. I take Gabapentin now but it doesnt help much, and it causes headaches. Hopefully Pregabalin will help with anxiety and sleep as well as restlessness.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  3 месяца назад

      You're welcome! I hope you figure out what works best for you and also agrees with you.

  • @KXFOX
    @KXFOX 5 месяцев назад +2

    Tried ever SSRI under the sun also buspirone. Took Clonazapam for 10 years but Texas is a piece of shit now so they cut me off to have seizures and almost died. Just got on Gabapentin and it seems like it's helping. Hoping it will be enough to help me stop buying Alprazalam and taking .5 mg once a day illegally. Sorry for being so blunt but thanks for the info and video

    • @EdwardBose
      @EdwardBose 3 месяца назад

      I’m in Canada and they made me get off clonazepam too…which basically saved my life

  • @KetoCutie68
    @KetoCutie68 5 месяцев назад +3

    Gabapentin has been a lifesaver for me.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  5 месяцев назад

      That’s great to hear! Thanks for sharing.

  • @rachellemedina8395
    @rachellemedina8395 3 месяца назад +1

    Ive been on dulo 60 + 20
    Gabapentin 300 3x a day
    And on pregab now 150 2x a day
    Im not looking for drugs im looking for pain relief
    It seems that everything I've taken results in not working.
    I do take another wacko meds it starts a V
    But as time goes on it doesn't work anymore
    So tired of this. I'm on the down side of my life and would rather be dead than have to deal with it anymore 😢

    • @horstlauer5368
      @horstlauer5368 3 месяца назад

      I feel sorry for u.I have Phn.10/10 on d painscale.Since i tough pregabalin i can survive.Without i would give d spoon up.

  • @nakedsnake2669
    @nakedsnake2669 2 месяца назад

    Thank you.

  • @nenadcubric2663
    @nenadcubric2663 7 месяцев назад +3

    Could i take Gabapentin or Pregabalin toogether with Trazodone??

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +3

      They are sometimes prescribed together, but the main concern would be possible sedation (not just that sleep might improve but that there could be daytime sedation as well). As far as what's best for you, though, please discuss with your prescriber.

    • @danh2310
      @danh2310 5 месяцев назад

      Yes

    • @matovicmmilan
      @matovicmmilan 2 месяца назад +1

      Тразодон има снажно седативно дејство које траје 24 сата и то није оно пријатно опуштајуће као код бензодијазепина. Да бар има неко антидепресивно дејство па можда неко процени да му ипак помаже али нисам никад чуо.

    • @nenadcubric2663
      @nenadcubric2663 2 месяца назад

      @@matovicmmilan a kažu da antidepresivno djelovanje ima tek iznad doze od 300 mg

    • @matovicmmilan
      @matovicmmilan 2 месяца назад

      @@nenadcubric2663
      Он се даје само као додатни антидепресив али и за то има других опција. Искрено не знам зашто је уопште регистрован и даље, боље да нису искључили тј. да су оставили антидепресиве из групе инхибитори МАО. Они су такође стара генерација лекова и имају мало израженије нуз ефекте али они бар разбијају депресију и анксиозност тако да ако се ССРИ, СНРИ, Велбутрин, Агомелатин, Анафранил итд. покажу неуспешним или недовољним, онда апсолутно има смисла пробати њих.

  • @bayapapaya-
    @bayapapaya- 6 месяцев назад +1

    Just was offered this for anxiety and chronic insomnia. Has anyone had weight gain?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  6 месяцев назад +1

      Gabapentin and pregabalin can both cause weight gain, but it’s a more common side effect of pregabalin. Since different people respond to and tolerate different meds differently though, it’s impossible to predict whether this will happen to a particular person. I’d say that most of the time my patients don’t develop weight gain from either one.

  • @awe_possum
    @awe_possum 4 дня назад

    Pregabalin made me gain 20 kilos in 8 months. I had horrible withdrawal when I went off it. Never touching it again.

  • @mentalhealth-runner-fit-
    @mentalhealth-runner-fit- 2 месяца назад +1

    Pregabalin is amazing for the first few weeks then it stops working and trying to get off it is horrific , suicidal thoughts fill your mind without any let up , my only choice was to go back on the drug

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  2 месяца назад

      Thanks for sharing your experience. That sounds beyond frustrating.

  • @nuttshelleynutt8302
    @nuttshelleynutt8302 6 месяцев назад

    I take both medications for nerve pain. I take in the am and the afternoon. If took both at night would it last all day for the pain? I do get tired during the day. Sounds like taking them at night would best. But want to make sure I don't have any pain in the day time.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  6 месяцев назад +1

      It depends on the person -- I've seen it work both ways. It's something you'd have to discuss with your doctor to see if trying that would make sense for you.

  • @nenadcubric2663
    @nenadcubric2663 7 месяцев назад +2

    Do they work, which 1 Best for Social Anxiety?? And for Fibromialgya

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +3

      I discussed in the video if they work and also that they are often used for fibromyalgia and sometimes for social anxiety. As far as which one is "best," like I said in the video, it depends on the person -- sometimes gabapentin works bettter, sometimes pregabalin works better.

    • @nenadcubric2663
      @nenadcubric2663 7 месяцев назад

      @@JeffreyKnuppelMD Thanks

  • @rastanostra7
    @rastanostra7 7 месяцев назад +2

    Is it addective?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +2

      I discussed that in the video. They can be but probably less so than benzodiazepines.

  • @SilviaGeorgieva-wl4xh
    @SilviaGeorgieva-wl4xh 3 месяца назад

    I’ve been prescribed with Prozac for eating disorder and panic attacks but on the 5th day of intake great anxiety appeared something I never experienced before(I’ve been on Escitalopram before and it didn’t occur), Hydroxizine didn’t cope with the symptoms made me only sleepy but still anxious so a doc prescribed Gabapentin, another one Tofisopam, I tried Gabapentin 400mg twice a day and the anxiety was on and off, do you think I can switch to Pregabalin or try Tofisopam?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  3 месяца назад

      I wouldn’t be able to say as I’d be guessing-I can’t give out medical advice unless I’m actually treating a patient and know their full history. I’d guess the Prozac likely activated you and made your anxiety worse. It does this in some people especially when they’re started on too high of a dose (in people with anxiety it should be started really low). This usually goes away, but it’s understandably a reason some people want to stop it right away. I hope you can work with your doctor and figure out the best path forward for you.

    • @SilviaGeorgieva-wl4xh
      @SilviaGeorgieva-wl4xh 3 месяца назад

      @@JeffreyKnuppelMDyes I understand, unfortunately Prozac is available only in one dosage here, 20mg capsules, so no way of starting lower

    • @SilviaGeorgieva-wl4xh
      @SilviaGeorgieva-wl4xh 3 месяца назад

      @@JeffreyKnuppelMD also I tried an alterative treatment with ibogaine a couple of months ago but didnt quite work, I was wondering if possibly as advertised it renewed some receptors thus this reaction to SSRI but probably it was just the medication itself

  • @afonsob7756
    @afonsob7756 2 месяца назад

    Can you drink while on pregabalin?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  2 месяца назад

      It’s not a good idea as smaller amounts of alcohol may have much greater effects than they normally would.

  • @patricklily9072
    @patricklily9072 2 месяца назад +1

    Do you prefer Pregablin or Gabapentin Doctor?

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  2 месяца назад

      I wouldn’t say that I prefer one over the other. Lots of factors would go into the decision about which one to prescribe, assuming one of the two was appropriate in a particular situation.

    • @twiggyclarklondon
      @twiggyclarklondon 3 дня назад

      I prefer Pregab’s 👍🏻to Gab …for my anxiety/ low moods

  • @JonnyQ408
    @JonnyQ408 7 месяцев назад

    I have really bad panic attack. I’m also afraid of taking medication.

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад

      Panic attacks are terrifying but are usually treatable. It’s a good idea to go see your doctor even if you’re afraid to take or don’t want to take medication. Your doctor can make sure you don’t have a medical problem causing the panic attacks. A mental health therapist can help you manage the panic attacks without medication although sometimes using medication at least short-term helps get things under control more quickly and can make it easier to start working with a therapist. Thanks for your comment. I hope you can find someone to work with to help you with your panic attacks.

    • @deepdive5092
      @deepdive5092 7 месяцев назад +2

      Then GABApentin’s the med for you! Seriously, your fear would be justified if you were receiving a benzodiazepine rx. Step aside from your worry and realize that’s a symptom of the disorder you are intending to treat. Think of it this way, you are becoming independent of your anxiety.

  • @janisjansons5707
    @janisjansons5707 7 месяцев назад +1

    Silexan ????

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад

      I'm sorry, I don't understand your question. The video wasn't about silexan.

    • @janisjansons5707
      @janisjansons5707 7 месяцев назад

      @@JeffreyKnuppelMD Sorry!Can you make video about Silexan ???

    • @JeffreyKnuppelMD
      @JeffreyKnuppelMD  7 месяцев назад +1

      I will consider your suggestion. Thank you.

  • @user-lj9zq4dr5t
    @user-lj9zq4dr5t 3 месяца назад +1

    I'm on 300mg Pregabalin a day for about a month now, I'm looking to ask my doctor to increase it to 400mg.

    • @stmrp8622
      @stmrp8622 2 месяца назад

      Do you suffer from gad or any other condition related to anxiety?

    • @user-lj9zq4dr5t
      @user-lj9zq4dr5t Месяц назад

      @@stmrp8622 Yes I suffer from anxiety I'm on 400mg a day now