Cell cycle regulation, part 3: cyclin D, cyclin E, and Rb

This video details the role of cyclin D/cdk4/6 in regulating the Rb tumor suppressor protein, which regulates cyclin E and S-phase genes. Also covered are mutations in these genes and how they would contribute to abnormal cell cycle progression in human cancers.

[@aj-uo3uh]

Joe you are the best, often I come back here to review it and understand it better. What became more clear this time is that once the Rb is off the transcription factor, two things can happen with a certain chance:
1.The transcription factor will encounter a new active non phosphorylated Rb.
2.The transcription factor will encounter rna polymerase and start transcription.
Step 1 will become less likely once the concentration of active Rb goes down.
Also what is funny is that rna polymerase itself is restricted by active Rb, so once we get a less active Rb there will come more rna polymerase available and step 2 will become more likely.

[@robertserge2431]

Totally agree- you made this so easy to understand!

[@user-oo8fd2ov5m]

thanks so much

[@hypnotoad0435]

your videos are great and your voice is so calming. i'm cramming for a stressful exam retake and it finally seems to make sense.

[@JoeDeMasiScience]

Thanks! All hail hypnotoad! Another futurama fan!

[@phobos_miner4288]

Excellent videos. The best out there if you ask me. Thank you.

[@raniadaher954]

amazing

[@JoeDeMasiScience]

Glad you liked it! Please subscribe and share!

[@cansutacettin3024]

Simply an unbelievable explanation! You're SO good at explaining concepts!! Thank you for making these videos.

[@JoeDeMasiScience]

You are too kind! Thanks!

[@veronicavaldivino2131]

This video is amazing, I was having a hadache trying to understand this, your explanation is really something incredible, I also would like if you could explain the relation of cyclin E cicle and the transcription of cyclin A, thank you very much for your amazing class

[@chx99]

Nice and clear videos. Thank you so much!!! Helped a lot XD