- Видео 198
- Просмотров 778 308
Joe DeMasi
США
Добавлен 28 авг 2011
Biology professor posting science videos explaining topics in immunology, biochemistry, molecular/cellular biology and cancer biology.
Complement introduction and activation of alternative pathway
Complement introduction and activation of alternative pathway
Просмотров: 889
Видео
Result of complement activation - opsonization
Просмотров 78010 месяцев назад
Result of complement activation - opsonization
Protein-protein interactions
Просмотров 4862 года назад
This video screencast was created with Doceri on an iPad. Doceri is free in the iTunes app store. Learn more at www.doceri.com
Cell cycle analysis
Просмотров 3,6 тыс.2 года назад
A common question asked in many research papers - after treating cells with some drug or other treatment, what happens to their cell cycle progression? If you take any population of cells (let's say you have 10,000 cells in a experiment), some percentage of them are in G1 phase, some percentage of them are in S phase, some percentage of them are in G2 phase, some percentage of them are in M pha...
RNAi knockdown technique
Просмотров 9653 года назад
This video screencast was created with Doceri on an iPad. Doceri is free in the iTunes app store. Learn more at www.doceri.com
Types of vaccines, part 3: DNA vaccines, RNA vaccines, viral vectors
Просмотров 20 тыс.3 года назад
This videos covers how DNA and RNA vaccines work, including mRNA vaccines that are designed to target the SARS-CoV-2 virus (COVID19). It also covers how viral vaccines work.
Types of vaccines, part 1: live vaccines
Просмотров 21 тыс.3 года назад
This video covers how live attenuated vaccines are generated. Examples include the measles vaccine, mumps vaccine, rubella vaccine, rotavirus vaccine, chickenpox vaccine, and the Sabin polio vaccine (also known as the oral polio vaccine).
Types of vaccines, part 2: killed vaccines, subunit vaccines
Просмотров 12 тыс.3 года назад
This video covers killed vaccines as well as subunit vaccines, including how they are made, and examples.
Cell cycle regulation, part 6: Cdki regulation
Просмотров 1,5 тыс.3 года назад
This video provides examples of how cdki proteins (cdk inhibitors) such as p21 and p27 are regulated in normal cells and disregulated in human cancer cells.
Cell cycle regulation, part 5: Cdk Inhibitors
Просмотров 3,9 тыс.3 года назад
This video introduced the function of cdki proteins (cdk inhibitors) such as p21 and p27, as well as ways they are commonly regulated in cells.
Cell cycle regulation, part 3: cyclin D, cyclin E, and Rb
Просмотров 2,9 тыс.3 года назад
This video details the role of cyclin D/cdk4/6 in regulating the Rb tumor suppressor protein, which regulates cyclin E and S-phase genes. Also covered are mutations in these genes and how they would contribute to abnormal cell cycle progression in human cancers.
Cell cycle regulation, part 2: the Cyclin D gene
Просмотров 2,2 тыс.3 года назад
This video covers how the cyclin D gene (CCND1) is regulated by transcription factors, which are in turn regulated by kinases. This video also presents how cyclin D is over expressed in human cancers due to mutations within or upstream of the CCND1 gene.
Cell cycle regulation, part 1: Introduction
Просмотров 2,6 тыс.3 года назад
This video introduces proteins involved in cell cycle regulation: cyclins (such as cyclin D, cyclin E), cdks (cyclin-dependent kinases, such as cdk4, cdk6, cdk2), and Rb, and how these proteins are disregulated in human cancers.
PI3K Akt pathway - part 8: Akt substrates (II of II)
Просмотров 1,3 тыс.3 года назад
This video covers Akt substrates that regulate protein synthesis and the cell cycle. These include the kinases GSK3b and mTOR (part of mTORC1).
PI3K Akt pathway - part 7: Akt substrates (I of II)
Просмотров 1,5 тыс.3 года назад
This video covers Akt substrates that regulate apoptosis and the cell cycle. This includes the pro-apoptotic proteins Bad, Bad, Bim and Caspase 9, the transcription factor FOXO/FKHR, and the p53 regulator mdm2.
PI3K Akt pathway - part 6: Akt regulation
Просмотров 2,4 тыс.3 года назад
PI3K Akt pathway - part 6: Akt regulation
PI3K/Akt pathway - part 4: PI3K in cancer
Просмотров 2,7 тыс.3 года назад
PI3K/Akt pathway - part 4: PI3K in cancer
PI3K/Akt pathway - part 3: PI3K regulation
Просмотров 3 тыс.3 года назад
PI3K/Akt pathway - part 3: PI3K regulation
PI3K/Akt pathway - part 2: PIP2, PIP3, IP3, DAG
Просмотров 6 тыс.3 года назад
PI3K/Akt pathway - part 2: PIP2, PIP3, IP3, DAG
Ras Raf Mek Erk Pathway - Introduction
Просмотров 1,3 тыс.3 года назад
Ras Raf Mek Erk Pathway - Introduction
Very clear explanation.
Very helpful, thank you!
Excellent!!! Superb explanation.
Sir but cip family inhibit E CDK n A CDK not D CDK
Wow, thanks. Your videos are excellent!!!
Thanks .Consice and useful
Thanks you
It’s really good
Joe you are the best, often I come back here to review it and understand it better. What became more clear this time is that once the Rb is off the transcription factor, two things can happen with a certain chance: 1.The transcription factor will encounter a new active non phosphorylated Rb. 2.The transcription factor will encounter rna polymerase and start transcription. Step 1 will become less likely once the concentration of active Rb goes down. Also what is funny is that rna polymerase itself is restricted by active Rb, so once we get a less active Rb there will come more rna polymerase available and step 2 will become more likely.
Great video! What’s the mechanism that the RNA polymerase can ignore the stop codon in the Cu to also transcribe the Cdelta segment?
I think there might be a little mistake in the somatic recombination of light chains: I think there is no deletion or inversion of DNA between the J and C segment(s), the J-C intron is transcribed and then spliced out of the mRNA transcript
Really helpful thank you !
Thanks
wow amazing explanation just subscribed! thank you for making learning free and accessible to all
Your explanations are great! You have no idea how useful these videos are, seriously thank you!!!
Thanks for the feedback! Glad to hear that it was helpful!
Sweet! This is exactly what I was looking for! Well done. Thank you!
Happy I could help!
Amazing
Great explanation. Thanks a lot for such an amazing video.😄
😊😊😊😊😊
very easy to understand, thank you!
Thank you so much. My wife has breast cancer and I am learning a lot from watching your videos. We are in the 21st century and there is science behind something other than chop and burn. Please keep making more.
Am happy
Thank you!
And are all D-type cyclin genes upregulated in cancer.
Could signalpathways PI3K/AKT/PTEN, Ras/Raf and Wnt make CCND2 upregulation ?
Thanks so much for the video! so helpful what textbook should we read to fully understand these topics?
thanks so much
thanks so much You are awesome man
9:55 What are the other signals that could make cell divide other than growth factors?
thanks so much
so if we put one single cell in a culture media without any growth factors, it won't do mitosis?
Great explanation and effective use of sketch models, you definitely know what you’re doing. Thanks for sharing! Just a question: if a mutation on a single allele were to damage the tetramerization domain, what would happen? I’d say that you’d have a reduction in overall production of p53 but the wild type tetramer would still be able to form (and it’d the only homo tetramer to actually assemble) and so in this case we would not be calling about negative dominance effect - the cell would still retain a functional p53 (at least until heterozygosis is kept). Is this correct?
Do you know some article that you can suggest me? Sir!My thesis subject is about Macropinocytosis of regulation system on cancer and the protein we will work about is SHIP2, EPS8, and DYNAMIN2 , So I need the articles and have to understand that. Sorry for my bad english
Thnks alot, Sorry, Whats the name av previous video?
What should you take to eat if you have one good pten gene and one mutated pten gene ?
Thank you so much !!! this makes so much more sense
thank youuu
amazing
Glad you liked it! Please subscribe and share!
thank youu
your videos are great and your voice is so calming. i'm cramming for a stressful exam retake and it finally seems to make sense.
Thanks! All hail hypnotoad! Another futurama fan!
Thanks a lot , This one helped me a lot
You are welcome!
Totally agree- you made this so easy to understand!
Super clear explanation! Thank you!
I can't understand how can antibody of abo attacks hla of donner
Thank you a lot,this really helped me☺️
J
Thanks, profesor🎉🎉
i cannot believe that you explained such a tough concept in 12 minutes, it took me one hour in my lecture and I still didn't get it, your explanation helped me ALOT thank you so much!!!!
Wonderful! You are welcome!
omg, one rare, informative video, that I'm lucky to have found. Thank you sir
Thanks!
What about malaria?