Ras, part 2: Sos, GDP, and GTP

This videos introduces the concept of guanine nucleotide exchange, and how the exchange occurs on Ras via the guanine nucleotide exchange factor (GEF) protein called SOS, and how SOS is regulated by RTKs (receptor tyrosine kinases).

[@elliewilson3914]

This video is extremely helpful for my molecular and cellular biology module which I am finding super difficult. So glad I found your channel! Thank you

[@JoeDeMasiScience]

Cool! Please subscribe!

[@lehu8529]

Can't help but smile when I watch your videos! I actually really enjoy studying this way! And what you’re doing so well is that you don't make things overly complicated, but you always give a little hint on how complex things can get without overwhelming the viewer in a way that they lose track of things. Born teacher!

[@sumanbhunia4836]

Radhe Radhe Radhe-Krishna, রাধে রাধে রাধে-শ্যাম॥

[@umulbaneen9861]

Well explained

[@JoeDeMasiScience]

Thanks! Happy to help!

[@hanakhan8302]

thanks this helped me alot for my exam :)

[@Vivekmishra00]

Best video series on immunology and neoplasm,please continue the good work......HIDDEN TREASURE ON RUclips

[@JoeDeMasiScience]

Thank you for the kind words!

[@drnykterstein_]

Hello sir, greetings! I'm just so confused on why EGFR inhibitor cannot be used in activating mutation of KRAS. Can you please help me? Regards.

[@JoeDeMasiScience]

Because EGFR is upstream of KRAS. If you inhibited EGFR, Mutated KRAS would still be boing with GTP and activating downstream pathways.

[@drnykterstein_]

@@JoeDeMasiScience so mutated KRAS wouldnt need EGFR binding on its receptor?