Parkinson's Disease Drugs
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- Опубликовано: 9 июл 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/par...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Parkinson's Disease Medications. During this lecture we will start by reviewing the Basal Ganglia Anatomy and Physiology. We will also be reviewing the direct and indirect pathway that is affected with Parkinson's disease. We will then transition into the various drug categories used to treat Parkinson's which includes Levodopa or L-Dopa, Dopamine Agonists, COMT inhibitors, MAO-B inhibitors, Amantadine, and Anticholinergics. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Parkinson’s Disease Medications Introduction
1:20 Basal Ganglia Anatomy
4:23 Direct vs. Indirect Pathway
18:23 Pathophysiology of Parkinson’s Disease
21:26 Drug Classes for Parkinson’s Disease
24:36 Mechanism of Action
38:51 L-Dopa + Carbidopa
1:00:22 Dopamine Agonists
1:06:08 COMT-Inhibitors
1:11:39 MAO-B-Inhibitors
1:20:12 Amantadine
1:27:10 Anticholinergics
1:31:18 PD Medications - Practice Problems
1:36:13 Comment, Like, SUBSCRIBE!
Supplemental Lectures:
Basal Ganglia - • Neurology | Basal Gang...
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
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#ninjanerd #parkinsonsdisease #pharmacology
You are remarkable, I have never met a teacher like you.
I am speechless at how gifted you are in teaching. We must protect this man.
From whom? no one hates him😭
Italian medical student here! I'm glad I found you on YT, you're such a life-saver. Thank you for sharing your passion for these subjects, you're amazing man! (and your staff too, of course)
Starting an assignment on PD meds for my pharmacology class today! SO perfect!😍
So helpful. Thank you! ❤
Actually I've been struggling with Parkinson's drugs and mechanisms as I used to hate pharmacology the first medical year in college but this video definitely make it way too easier , I am really feeling grateful, thank you a lot ❤❤❤❤ you are the greatest 💪🏻
Amazing this video save me, I spend many days to read textbooks and watching my lectures and I feel so dumb but now this video is totally make sense to me and put everything I’ve read together, thank you so much 🎉
Your videos are amazing! Clears up so much information left out by professors! Thank you for everything you do.
I never bothered learning WHY we used COMT and MAO B inhibitors before this video, damn thank you!!
You are Excellent. Great teacher. Thanks from retired RNBSN with Parkin sons. Still with thrist for knowledge to understand. Thanks.
didnt watch this yet but without doubtes i know it will be a BANGER
Thank you Dr
You truly are the best teacher ever! Thank you for this video.
I love your passion and teaching, always amazed. Thank you very much.
please please continue making pharmacology videos ,as pharmacy student i find these so helpful
thank you for your effort
You have a gift and I am so grateful for your existence on this earth and time.
Extraordinarily well made video.
Thank you, Zach
Love your passion for teaching! Thank you!
I love your memory and your passion! ROCK STAR!
You are a saviour .Thank you zach🔥
Be healthy sir 🙏 we really need you
i love u man, u made it easy on me to understand the topics
I’m grateful for your existence, you do matter & we appreciate u
I really like these videos, hope you get more recognition
Love this❤❤❤❤Need more! Excellent Teacher.
You are awesome teacher, Man... Thanks for everything
I love the way you you teach I think your are the bestest teacher in this whole world 🌍
Omg thank you!! I take my PANCE in a few weeks and your videos are so good
Thank you so much ninja nerd❤ you're a life saver
the best teacher ever🌹
You are my saver for any exam preparation
As always another great video.
Wife recently diagnosed with Parkinson’s. Been doin a deep dive into high does of B1 (thiamine) for treatment. After adding it to the treatment made a huge improvement over the meds (Rytary $$$$$). Would love to see a deep dive into why/how this mechanism might work. Most doctors don’t know or haven’t heard of this treatment. Obviously no money to be made on a vitamin.
Thanks again for you dedication.
That would be a great topic to cover!
Thanks a lot for the perfect lecture!
Thank you for this video!
Kindly make videos on antidepressents and anxiolytics ...plz
you are a great human being
Thank uuuuu best teacher ever
I used to follow You when the channel has some 70k so soproud that you ve reached the M
You deserve mooooore
I love your videos. Definitely one of the best out there. Also, nice glasses 🤓
thank you for your help! I am grateful! 😇
Sir I appreciate your work
Thank you so much
A love from TANZANIA.......!
Thank you so much!!
Thank you so much for everything❤
I can't thank you enough for this video 🙏
You're just awesome ❤
Thank you so much💕
Love love your videos. Thank you
You are one of a kind 👏👍
God bless you in the ways you do not even imagine!
thank u so much for this video zach 🥰
You are the best of all the time in saving med students life we are craving for more pharmacology
thank you so much sir, may god bless u
Thank you so much.
Very informative. Learnt a lot even as a geriatrics doctor. Perhaps include apomorphine in the drugs? Confess I love your explanation so much I don't want to go back to the books for that!
Really amazing ❤❤!!
The best Ph of medicine
Finally All concept clear 😌Salute to your Passion and Strength. Love from Odisha.
Nice video. Helpful and informative
A great scientist ever❤
great job!! Thank YOu!!
you are great God bless you the best teacher ever am medical student in east Africa Ethiopia
Let this man open his university ❤
Thank you so much❤
Thank you!❤
you are the best! god bless you
Great quality
Great teaching process👍🏻👍🏻👍🏻👍🏻
Gotta love this dude
Excellent video.
Thank you!
Thanks
Thank you ❤
we need more pharmacology videos
Thank you so much
keep doing this thank youu helps a looot
Hello, I admire your job well done, it is very helpful for all of us! I watch you regularly and learn new things! Thanks!
I'm doing a doctorate! I am looking for a connection between impaired understanding of human language, more precisely decoding, in patients with Parkinson's syndrome! What can it be, and where does it come from?
Help!!!
Be healthy and happy 🙂
Great Work!
Amazing 👏
cutest tutor out there xx
Thank you sir
outstanding all the time best teacher❤
thank you so much
Antiparkinson's drugs and hypnotics vids are on time, if only the antipsychotic drugs are on the list it would have been just geeat
You know Zach that your vids are kind of entertainment!
You are intelligent you go deep into it
Great video! It answered almost all of my questions. The only question remaining is, why is it so important for Parkinson’s disease drugs to be giving at specific times with little to no goodwill time? Does it have to do with the effective time?
Thanks doc
Thank you guys!!!
I comment for you before I watch the lesson because I’m sure you are great
You are a hero
Thank you so much ❤❤❤❤
just superb
amazing video
A quick question...does ADR's in brain happens due to excess dopamine? as dopamine cannot cross BBB and if yes, then how does ADR's happens in mesolimbic pathway
Great question. Any drug that increases synthesis of dopamine, prevents breakdown of dopamine can be utilized in dopaminergic pathways in the brain i.e mesocortical or Mesolimbic pathway etc
I remember voting for pharmacology videos many months ago. I don't want to complain but I relied heavily on you to passing anatomy and now that I'm in pharmacology I'm gonna need you to hurry up 😜 . We did Parkinson medications last week 😞
You are amazing ❤
The reason i will be a Pharmacist will be bc you exist! You are much loved in England
Nice vid! Now one about Huntington’s 😊
Hey guys,i have a question and i would appreciate any help.
The cholinergic neurons ultimately have an inhibitory effect on the motor activity of both the direct and indirect pathways. In the video, Ninja Nerd mentions that a tremor arises from overlapping activity of the direct and indirect pathways. However, if both pathways reduce motor activity, it doesn't seem like there would be a contraction of the agonistic and antagonistic muscle, which is what would lead to a tremor. Do you understand what I mean?
So do you know if I may have misunderstood something, or how else does tremor occur? Also, Rigor would be illogical if motor activity were reduced, but we do have Rigor, just like Tremor, in Parkinson's disease.
Thank you! Best wishes from Germany
You are amazing and vibrating
Very useful
Guru of med
love you zachy