Jack Szostak: The Origin of Life: Not as Hard as it Looks?
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- Опубликовано: 11 сен 2024
- Lecture by Dr Jack Szostak, 2009 Nobel laureate in Physiology or Medicine and member of the Molecular Frontiers Scientific Advisory Board, at the Molecular Frontiers Symposium "On Human Origins and the Future of Humanity", at Lund University April 18-19, 2024. The symposium was co-organized with Lund University and the Royal Physiographic Society of Lund.
ABSTRACT:
The combined efforts of laboratories around the world have begun to converge on a reasonable pathway going all the way from planet formation to the beginnings of life itself. Many deeply embedded preconceptions have had to be overcome and discarded in order to enable progress. I will explain how overcoming these conceptual barriers has enabled fresh thinking into how the molecules of life were synthesized on the early Earth and then assembled into the first living cells. Once the ability of life to evolve in a Darwinian sense had become firmly established, life was free to adapt, diversify, and flourish, eventually giving rise to all the varieties of life we see around us today.
Life just requires a system for molecular assembly guided by precise instructions. Easy.
Who provided the instructions prior to there being life?
You’ve not thought this through
@@mcmanustonyInteresting, I had read Juan’s comment as sarcastic (the word easy specifically, I thought Juan meant it was not so much, which interestingly enough is pretty much what Jack says in the video, despite the title).
*Easy?!?!?!?!? Hahahahahahahaha!!!!!!!!!!!!!!!!!!!!!!!*
@@williamwhitten7820 Are you okay?
@@derekbredensteiner3957 *Yes of course.* *I was just responding to Juan Pineda's comment at the head of this thread.*
The most amazing thing about life is that all life uses the same basic biochemistries with the same amino acids!
Only those with left handed chirality. If amino acids spontaneous assemble, they assemble both left and right handed. They don’t self assemble into complex proteins: they break down over time.
Dr JS said hydrothermal vents supplied hot water to the murky ponds filled with protocells and nucleotides, etc.
Actually hydrothermal vents are the source of those ponds. the hot water and everything needed to make life
The work of coscientious scientists like Szostak and Deamer comprise just a few lines in a thorough narrative of life's origin and evolution due to the enormity of the events and chemistry. A new book published by Austin Macauley Publishers titled From Chemistry to Life on Earth outlines abiogenesis in great detail with a solution to the evolution of the genetic code and the ribosome as well as the cell in general using 290 references, 50 illustrations and several information tables with a proposed molecular natural selection formula with a worked example for ATP. Available cheap on kindle and other ebooks.
Yes, let's check James Tour's critique of OoL claims.
ruclips.net/video/xIHMnD2FDeY/видео.html
Richard Dawkins sits mute/deaf/sub-moronic as actual Nobel laureates in biology &
Craig Venter ALL say "It is impossible that humans will EVER know life's origin''
TALK'S CHEAP MFR...UNLESS YOU'RE PAYING DAWKINS' SPEAKING FEES
Tour is a disgraced lying fanatic. He doesn’t work in OoL.
@@WayneLynch69why do you post such pathetic lies? Dawkins IS NOT MUTE.
Why do you people lie so much?
@@mcmanustony
You IMAGINE Dawkins confutes those
three stating that it's "impossible humans will EVER know life's origin"? You're more ignorant than I thought...and that doesn't seem possible.
@@WayneLynch69 what the fuck are you talking about?
Lost credibility when he said he could make a simple cell in the laboratory. Prove that claim. Nobody has created a cell in the lab in a prebiotic way.
When did he make that claim?
@@ActedUponNoMore ….and??
@@mcmanustony J Craig Venter allegedly created bacterium synthetically, he simply replaced the nucleus of a bacterium with recombinant DNA with allegedly minimum genes for reproduction &
Life. I guess his 'synthetic' bacterium degraded in the wild as purposeless and useless in the grand design of life ! That is the legacy of mickey mouse theories-forgotten at best ! That is what happens when DNA is tweaked - ORGANISM STERILITY. JCVenter is prime example of human greed and egocentrism, but the guy made a fortune. That is where his mind and heart dwells .
The Creative Source & Center is well beyond our current science and theology. A closed mind is the enemy.
A simple cell can be easily made in the laboratory, it's called a chemical garden. This is a chemical phenomenon involving a inorganic metal salt and a solution of silica, the reaction between the two precipitates a flexible semi-permiable membrane that mimics properties of simple cells. It has a redox gradient, it also produces a osmotic pressure that causes growth. Several researchers propose the first cells were inorganic, either made of iron sulfide or lipids (soap like polar molecules). Also, it's important to remember that before life emerged, there wasn't anything to eat organic molecules, so a soup of organic molecules could have formed, that would be not have accumulated if there was, life around to eat it.
I don't see how different kinds of nucleotides can just "accumulate" (24:00) in some warm little pond on the primordial earth. Could we make that happen now, even if we tried? No! And if that can't happen, then the whole thing is just wishful thinking, and almost certainly completely impossible.
They belive organic molecules accumulated on sticky mineral surfaces or within proto-cells, which were either inorganic (iron sulfide) or organic (lipid bubbles) semi-permiable cell like compartments (tiny bubbles). It's important to understand, these proto-cellular compartments formed inorganically, without the need for life, and they concentrated biomolecules inside. Inorganic proto-cells form today e.g. Moss Agate. Another good example of a proto-cell is the chemical garden, which mimics some rudimentary properties of living cells.
Wait a minute. No one has even come close to making a proto-cell in any lab! No one has even come close to making the four essential classes of chemicals that are necessary - amino acids, nucleic acids, carbs and lipids - under prebiotic conditions. Have you seen the structure of a simple cell? The membrane alone is exceedingly complex!
As James Tour points out, in chemistry time is the enemy!!
Why doesn't Jack Sosznac respond to Jim Tour?
You'd have a bit more credibility if you could get the name right. SZOSTAK.
"No one has even come close to making the four essential classes of chemicals that are necessary - amino acids, nucleic acids, carbs and lipids - under prebiotic conditions"- really?
Miller Urey was SEVENTY YEARS AGO.
Maybe OoL researchers are too busy working to pay much attention to a screaming, lying zealot such as Tour. He doesn't work in this field, never has, never will and only peddles abuse for religious reasons.
@@mcmanustony kV electric shock delivery created aminoacids ? And then second electric shock destroyed the self-assembly ?
@@danchokonstantinov6735 Wrong. The Miller- Urey apparatus was found later to have synthesized over a dozen amino acids.
@@mcmanustony tens of years later = fraud .
@@danchokonstantinov6735they found amino acids at the time. The found several more later. Fraud? You are lying smear monger. What the fuck is wrong with you people?
Why is life elsewhere consigned to zero probability or "we don't know?" Why doesn't one example, and an example tied to physical processes which exist elsewhere, count for something even if we can't properly apply statistics.
Where is zero probability stated?
“My view is we don’t know” seems like a sensible thing to say when there is low probability, to me, which is what Jack said. Jack did not say zero probability. Are “don’t know” and “zero probability” equivalent to you? If so, why?
*Dr Jack Szostak should admit that science hasn't a clue of how life began.*
That would be dishonest. Science seeks and knocks. Get on board.
pretty sure he said that. he's discussing experiments based on a hypothesis. wwjd
@@michaelcollins8527 *Yea...The "primordial soup" theory was proposed by Alexander Oparin and John Scott Haldane who independently developed the idea around the 1920s, with Oparin first publishing his concept in 1924 and Haldane in 1929.* *It is 2024 and it is still a hypothesis.* *A hundred years and still no go.*
@@williamwhitten7820 Religion still makes claims of magic. They only use the Bible to justify hatred. Isn’t that right?
@@williamwhitten7820 life took 700,000,000 years to emerge on earth. 100 years and it’s not completely understood……therefore Jesus!
Good grief…
My my, Jack - you certainly have not been keeping up! Since Miller-Urey, at least...
I think he understands Miller Urey better than you.
Life is present everywhere but not in form as we expect 😊
Not as hard as it looks then create it bro
@@aunch3 the task is to understand not mimic
What? Bro just be humble and accept that you don’t have all the answers. Just take the L, learn from it, and move on
@@aunch3 what the fuck is wrong with you? No one Szostak included claims the question is settled.
There is a difference between not having all the answers and having none of the answers.
Spare me the sermon…
@@aunch3 what the hell is wrong with you? NO ONE claims to have all the answers. Not Jack Szostak, not Nick Lane, not Addy Pross....not any of the researchers in OoL. It's an open problem in empirical science.
Spare me the sermon...you are utterly clueless.
@@aunch3 Spare me the pompous sermons. Since you like to dish out “advice” try this.
Shut up and learn some science
Alternative theory: In the Beginng God Created the Heavens and the Earth.
Not even close.
That’s a religious fantasy, not a theory. It explains nothing, is not testable…..
Try again.
@@mcmanustony It explains everything.
@@deepcosmiclove wrong.
Nope
bunch of guessing garbage
You should see The Bible if you want some fantasy.
science is the throwing away of garbage guesses
@@danielpaulson8838 keep reading your copy of the "little red book"
@@peter-b7s I’d rather read the Bible. That’s how I know it’s full of really poor values.
@@peter-b7s you seem to have lost your mind. Where were you when you last had it
The problem with our search for knowledge per se, not just the origin of life, is the inbuilt lack of purpose in the IDEAL of science, viz. KNOWLEDGE FOR ITS OWN SAKE OUT OF CURIOSITY, along with its even more misguided criterion of proof: PREDICTIONS tallying with results of experiments and/or observations, as both these lack any direct relevance to the sustenance of life (as commonly understood) on this earth.
On the contrary, the sole purpose cum criterion of proof of all knowledge SHOULD be set as:
PRACTICAL PREVENTION OF ALL EVIL (defined exhaustively as DISASTERS, PREDATION, DISEASES ~ which include all birth defects, all weapons manufacture, all violence ~ and DEATH).
That way, the traditional basing of mathematics and physics on describing PREDICTABLY the celestial motions, without any relevance to life function, can be discarded to set deriving, instead, "the mathematical model of the mechanism how particle interactions inside the earth develop PLANTS on its own surface, to then deliver and sustain living beings here through them" as the sole purpose cum criterion of all knowledge.
Thus integrating arithmetic, geometry and particle physics by interpreting DIGITS, with which we perform calculations in our minds (NOT the electrons in the chips we manufacture ourselves), as unique type of particles with the 4 basic arithmetic operations as the only LAWS OF MOTION for all interactions among them, in our minds AND INSIDE THE CORE OF THE EARTH.
This correspondence of the LAWS OF MOTION of DIGIT interactions in our minds and inside the Core of The Earth substitutes the necessity for Bohr's anthropocentric correspondence requirement as well as the necessity for the application of the two types of mutually incompatible LAWS OF MOTION in physics (Newtonian ones for particles in classical physics and Schrödingers wave function in QM) for calculations of interactions inside the earth that develop PLANTS on its own surface.
As the accuracy of The Model so derived, and all related assumptions as to existence of particle types in formulating it, must be verifiable by any lay person by their applicability for practical influencing of the development of, and growth on, PLANTS neither special experiments nor any special observations would be necessary to prove the accuracy of The Model.
Remember, this earth is the only vessel in the entire known universe, that manufactures bodies of living beings in its bowels to then deliver and sustain them on its own surface through the PLANTS it develops here for that purpose.
Hence it MUST be seen and analyzed as such. And NOT as a mediocre ball of nonliving matter stupidly revolving around an insignificant star for no purpose whatsoever as suggested by Copernicus and accepted as absolute truth, practically by ALL (minus one) ON THIS EARTH, at present.
@@mykrahmaan3408 put the pipe down. Step away from the pipe …
@@mcmanustony
Clever people learn from other people's mistakes.
Ordinary people learn from own mistakes.
FOOLS NEVER LEARN!
@@mykrahmaan3408 did that sound good in your head?
Yawn