Your treatment is very systematic...a pleasure to follow. At 14:20 you show the two g-V curves and discuss the significance as related to an action potential (i.e. the Na current inward becomes regenerative as reflected in the steep slope of Na g-V curve). To a beginner this allusion to an action potential while looking at these two g-V curves ( remember these g-V curves have no time component) could be (and probably should be) confusing. A beginner would correctly observe that the K and Na g-V curves if overlaid are practically superimposable. One would conclude that currents through these two conductances would cancel out at any Vm. I would recommend that after pointing out that the two g-V curves are "practically superimposable" you segue back to the g-time graphs (which you actually do when you move to the next slide). At this point discuss how the slower gating of the K channels compared to the Na channels explains how the two conductances do NOT in fact cancel out. Then it would be good timing to relate these differential conductance events to the regenerative nature of the AP.
Thanks a lot. The movie was very helpful - it would be good if there is an advanced discussion on the work presented by Hodgkin and Huxley in their 1952 J. Physiol. paper
How do these results distinguish between sequential operation of two separate gates (activation & inactivation), as opposed to only a single gate which opens then closes?
Great explanations! Thank you! Is it possible to obtain the info about potassium channels? I was wondering how they determined when the K-channels closed? Do they even close in the voltage-clamp technique when you maintain the -10 mV (the commander). The K-channels open a bit slower than the Na channels but they also close very slow. I didn't get that, because the K conductance risese and then experienced a plateau. Kind regards!
Very well explained.stay blessed 🙌
Your treatment is very systematic...a pleasure to follow. At 14:20 you show the two g-V curves and discuss the significance as related to an action potential (i.e. the Na current inward becomes regenerative as reflected in the steep slope of Na g-V curve). To a beginner this allusion to an action potential while looking at these two g-V curves ( remember these g-V curves have no time component) could be (and probably should be) confusing. A beginner would correctly observe that the K and Na g-V curves if overlaid are practically superimposable. One would conclude that currents through these two conductances would cancel out at any Vm. I would recommend that after pointing out that the two g-V curves are "practically superimposable" you segue back to the g-time graphs (which you actually do when you move to the next slide). At this point discuss how the slower gating of the K channels compared to the Na channels explains how the two conductances do NOT in fact cancel out. Then it would be good timing to relate these differential conductance events to the regenerative nature of the AP.
Absolutely wonderful videos!
Can’t thank u more:)
Amazing explanation! Thank you!
Such well made videos! Thank you so much for your effort :)
Thank you so much, this is amazing!
Thanks a lot.. very useful
Thanks a lot. The movie was very helpful - it would be good if there is an advanced discussion on the work presented by Hodgkin and Huxley in their 1952 J. Physiol. paper
this is great thank you
How do these results distinguish between sequential operation of two separate gates (activation & inactivation), as opposed to only a single gate which opens then closes?
Great explanations! Thank you! Is it possible to obtain the info about
potassium channels? I was wondering how they determined when the
K-channels closed? Do they even close in the voltage-clamp technique
when you maintain the -10 mV (the commander). The K-channels open a bit
slower than the Na channels but they also close very slow. I didn't get
that, because the K conductance risese and then experienced a plateau.
Kind regards!