NAC & Glutathione for Aging, Longevity
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- Опубликовано: 8 июн 2024
- Let's discuss more about NAC, Glycine and biologic aging. Several new studies offer incredible insights.
Support your body's Glutathione Synthesis* with the new NAC + Glycine Supreme: bit.ly/NAC-Glycine-Aging
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Links to NAC research: bit.ly/41YvaMv
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----------------------------------------Show Notes-------------------------------------
0:00 Intro
0:13 NAC + Glycine
0:49 Pairing these 2 amino acids
0:59 Studies on NAC + Glycine
2:12 Improvements in aging biomarkers
2:45 Glutathione VS amino acids
3:35 GlyNAC Combo
![RAISE NAD+ WITH APIGENIN & QUERCETIN: Reduce CD38 To Boost NAD+ Levels [2021]](http://i.ytimg.com/vi/iS1Ejg7nsOg/mqdefault.jpg)
I’ve found NAC and Magnesium Glycinate together at bedtime unraveled my sore muscles and gives me great sleep.
Same here.
May i know how do you combine and consume them? Capsule or powder form?
@@yds1133I buy the capsules from my local Vitamin Shoppe
I buy from bulk supplements. They have great deals
I've been taking l-glycine and it is amazing for my energy and mental clarity. I also take golden milk and ACV. Works for me.
I cycle on and off with these. I’ve had no issues either way
I hope you are taking care of your mental health along with your physical health sir. I appreciate your service to the world and want to see you happy and healthy
Excellent content as always! 👍
Kumar's study is probably the most cited regarding Gly-NAC supplementation (for reference). Supplementing with Gly-NAC is recommended for older adults (those in the study were, as I recall, around 61-85 yrs old). This supplement does not appear to have an effect on younger people.
All roads lead to the reality that we are carnivores who also benefit from periodic cellulose consumption to feed the microbiota and to facilitate bowel emptying. If you eat a ton of meat, you'll get plenty of glycine and cysteine. If you inhabit the bottom of their pyramid and subsist mainly on grain, you'll live and die like all the pyramid-building slaves that came before. As we continue down this road, you'll see that spirituality and science merge. We're approaching that point. Gaining momentum. Keep preaching. Truths spread like viruses, only they do good instead of harm.
How often do you mean by "periodic cellulose consumption?
Thanks Mike.
Oh great, I was hoping you would do a dive into GlyNAC. I started on it a month ago.
Excellent presentation on an oftem argued essential need❤, tu
Bone Broth: high natural source for Collagen and has Amino Acid Glycine. A Cheap drink. Just shake we’ll.
Just took NAC with Milk Thistle from Dr. Mercola and Berberine from Vitamin Shoppe
None of them is as effective as the cystine being deposited into the cell.
Love Mercola. I take mine with NR
1) Milk Thistle is recommended to take w Berberine, for better Berberine effectiveness. Likewise, 2) Magnesium Glycinate & NAC enhance ea other to promote Glutathione.
NAC messed my brain up fr. No emotions for a week or so when taking it. No ups. No downs. Cyborg. Almost afraid to ever try it again.
Never had that with NAC , a little bit with Ashwaganda
At what dosage? Remember, there are already a couple of thousand milligrams of cysteine in a day of real food.
Initially, I had bought a capsule form of NAC from the health food store, it didn’t give me a headache per se, but it was not pleasant. I gave his product NAC Glycine Supreme a try, and I am glad I did. It is very good.
NAC destroyed my tendons
@@petejitsuman9025 Me as well.
I've been taking NAC and glycine for years - haven't noticed much. It wasn't until I added 400 to 600mg a day of s-acetyl glutathione that I started feeling better.
You need to do more research into the negative effects of NAC. There was a trial which showed it significantly reduces muscle regrowth and repair after exercise in you athletic males. I took it and it shut down my DOMS imflammatory pathway which means I could no longer get "the burn" and my body no longer healed itself. It was a downward spiral where i did major damage to my tendons. Thankfully I figured it out and stopped taking it. Within a week I had DOMS back, and I began the long road to recovery. Interestingly, the same thing happened last year when i started eating macadamia nuts.
I've heard some negatives of NAC before as well. I've been slowly looking into many supplements being promoted more to see what the adverse effects can be compared to the benefits.
Just as a side note, DOMS are NOT mandatory for muscle growth. Some people get those and some don't. Reason for that is unknown.
Don’t take it right after workouts, take it at bedtime for repair taking right after workouts will move that good inflammation in the muscle out too quickly
@franbelta1533 The inflammatory pathways which NAC shut down took a week to reestablish when i stopped taking it.
@@mark2073 is that what you were told or did you google or webMD that?
I promise to listen to this one. I’m in a position where I need to use everything I can to live longer
54 and take NAC daily. Among other supplements, clean diet, and exercise of course. Very happy where I am at this age, and get lots of compliments.
@@GenXRanter … Nice. I’ll see what it can do for me
@@GenXRanter
How many milligrams are you taking daily, if you don’t mind me asking?
@@Corrupted-file I take 1,200 mg daily.
@@GenXRanter
Thank you, much appreciated.
Its magic, especially when combined with collagen
IMO, Bone Broth, it has natural Collagen. It’s much cheaper than other Collagen products. And also has amino acid Glycine !
Bone Broth- high in Collagen and contains Amino Acid Glycines.
Cheers. Just shake and drink.
Why collagen if you already take glycine? Added benefit must be tiny.
Overall what supplements are the best... I take vit D with vit k mk7, zinc, magnesium multivitamin and NAC almost every other day. I have been thinking of taking Berberine and tumeric soon . Any others you would recommend? Love the videos and info thanks
👍 give 👍 a 👍 like 👍 for 👍 Mike! 👍
I used to spend 1300/mo on my mortgage. Now I spend 2000/mo on supplements I didn't know I needed til I started watching RUclips.
For real though I do buy Myoscience electrolyte powder.
what do you think of milk thistle, which is a natural NAC source?
I drink a small
glass of your NAC mixed with Relax Max after dinner, then take your Vit D, Magnesium and Ashwanghanda before bed and sleep a solid 8-9 hours.
My Cats & Dogs get Bone Broth w ea meal.
Very easy, cheap and they never get picky about their food, too! *No Salt Added varieties.
Ty dosage pls.
Mike, Is TMG also good in place of glycine? It’ll just be one less vitamin to buy.
Depends how much glyvine you want to get out of it. If you want to get 10g of glycine out of it, you would need to take massive doses.
Based Longevity video
How can we naturally get more of these amino acids?
I find it really interesting that providing the precursors (such as glynac and l-citrulline) help increase production of stuff (scientific name, don'tcha know :) ) in the body. It means we aren't getting the basic 'stuff' - is it because of diet, is it because of a lack in the food ingested, is it a breakdown of the mechanisms used to get convert base materials to the precursors?
It's both. Diet for everyone, breakdown for older and sick people.
What about Immunocal?
Can you make a video on hydrogen water?
I take NAC with Collagen overnight before bed.
Dosage?
I started taking nac during rona because it was supposed to be good for lung health. It also seemed to curb my appetite.
In the past few months it gives me severe heartburn. I had to stop and no way i could take it at night. Not sure what's going on with this
Taken for too long a time can disrupt your microbiome.
@susanhaymon8840 thanks. I did not know that. Now not sure what to think...
@@susanhaymon8840at what dose? Cysteine is already in real food, like 1-2 grams per day.
Does anyone know if you can take GlyNac with creatine in the same drink? Adverse Reactions?
Yes, you can. They do different things, used differently by cells. But importantly, NAC helps kidneys process and remove toxins and metabolic by-products
I take ~15 gr glycine daily at night + 2 gr nac. Perfect combo.
I’ve heard that NAC uses up copper stores (slightly below the average marker for copper here). Would supplemental glutathione do the same?
You have to decide. If you supply just the precursors to something, the body can decide how much it needs to make. If you supply the real thing, you don't need to worry about the body not doing the conversion, but you may overdose which might cause other problems. True for basically everything in the body.
Maybe just take some copper or eat more foods with copper
I feel weird when i take NAC. Would the glycine offset that?
NAC gives me severe insomnia. Adding glycine didn't help
It's a vasodilator as well, so could lowered it too much?
I still don't get it why NAC is needed of Cystein alone would do it? Is it just because NAC might be a bit easier on digestion?
I also wonder that. Maybe because cysteine is too inexpensive to make a study worth doing
Hi have glycine in powder form, they look like sugar. How would you recommend consuming it with, other than milk or plain water?
If you can get glycine in an isotonic capable formula, it will be better. Most nutraceutical companies would typically add another type of magnesium, too. The best bet for you would be find a precursor that has a carrier that allows for cystine to enter the cell. They are safer options than NAC that succeeds stomach acids that then therefore allow for cysteine/cystine to get to the cells.
I use glycine powder in my hot teas, it has a sweet taste and mellows out the harshness of green tea. If you add glycine to chamomile tea right before bedtime, you will sleep very deep and restful and have vivid dreams too.
thank you @nsudatta-roy8154 and @delta0921, greatly appreciate the tips
Hi Mike, on doing some quick googling, the first few hits that came up were related to how NAC can affect hormone levels, changing the conversion of testosterone to estrogen. Does this only happen if you are deficient in glycine ?
What foods can induce the effects of NAC, cuz I can’t take supplements since I’m hypersensitive to such?
High protein foods
@@amberwest9478
Oh ok. My diet consists of high amounts of quality animal protein, so I should be ok then. Thanks!
Who takes these here?
NAC causes me massive intestinal inflammation, any known Reasons for that? I’ve tried it several times
Maybe you are sensitive to Sulphur & have a Molybdenum deficciency
Why always NAC. Could we just take Cystine, which is way cheaper.
Plenty of Cystine in animal foods.
@@sebk174 true. My question is why NAC over Cystine?
No real reason. It is just more money is all.
Yes you can! I recommend Pottengers Human YT channel. He has a few videos on this.
@@mj625
Yes I saw pottingers human. Subscribed. He’s just the only one who I’ve ever heard recommend cystine and everyone says NAC
Been doin this for the past year and half daily
Why take NAC when you can take immunocal?
Or take just L-cysteine? Provably depends on how much money you want to spent.
@@wocket42 nothing has the clinical studies or method of use patents proving it raises GSH like Immunocal
NAC gave me hyperpigmentation
How much did you take?
I heard that it only helps in elderly people, over 60. And does not help in younger people. I guess that narrative does not see product.
I took NAC for a year and did not see any changes
So you stopped the general age related decline. Congrats.
If you abused NAC you will get arterial disease. Be forwarned i took it everyday and large doeses sometimes. It has been shown to inhibit angiogenesis. Which can induce atherosclerosis. I have hair loss on both my legs and arterial disease on the right one. When i stop taking nac slowly but surely they grew back. The best time to take NAC is on a recovery day and should not be taken daily.
Any studies that support that?
Never heard of this.
Cysteine is in real food. A couple of grams per day. How high was your supplement dose?
NAC destroyed my tendons. Took months to recover
@@mark2073How does an amino acid destroy your tendons?
Im sorry, but none of these methods work well: NAC has a short half-life. While NAC can raise extra cellular glutathione, investigatory studies dont support this for some people. Getting cysteine/cystine directly into the cell is the most effective and clinically established way to raise intracellular glutathione and raise those lymphocytes (CD4/Cd8) necessary to really make meaningful change.
There are at least 26 placebo controlled studies supporting this.
And how do we get Cystine directly into the cells?
Would having an MTHFR gene variant (homozygous C677T) variation be one of the things you mentioned that prevents cysteine from entering a cell?
HOw do you get it into the cells??
@@d_e_a_n It is a patented process that the scientists aren't sharing. They paired a couple of cysteines and wrapped it in a disulfide protein to withstand tripsin and pepsin. Cysteine in this case is the transporter, and cystine is what enters the cell. This was discovered 40+ yrs ago and has 80 global method-of-use patents to "treat" a number of diseases. Btw, this is natural and is the only natural protocol I know of that has been allowed as a "treatment" and not solely adjunctive. Incidentally, I use this therapy in my practice.
@@kerrigreig5459 As you know, cysteine is the tail-end of methylation. The cystine working with the other two requisite aminos essentially "biohacks" the process to allow for intracellular glutathione and therefore raises immune response sufficient to "clone" cd4 and cd8 cells, whilst creating negative feedback inhibition in offending cells. Incidentally, Dr. Wulf Droge was instrumental in bringing this therapy to market, which incorporates cytokine modulating, and redox tech. In fact, you will learn that he is the pioneer of redox tech.