This is a bit misleading, Pyruvate dehydrogenase is 1 enzyme in the pyruvate dehydrogenase complex, which is a 3-enzyme complex, using 5 co-factors not the 2 mentioned in the video.
I think most would say that saying pyruvate dehydrogenase assumes you’re talking about the complex unless you specify that it’s the E1 pyruvate dehydrogenase. NAD+ and CoA are two of the five cofactors you are talking about and are the important ones in the general overview of the process.
Well explained. 2 enzymes other than pyruvate dehydrogenase are required for the reaction .. dihydrolipoyl transacetylase and D. Dehydrogenase. deficiency or missing those enzymes, it causes metabolism disease
I have observed a tendency for ppl to copy & write the same idea someone else has commented on..for example about her voice which seems to be a very clear/understandable one in contrary to what all these negative comments r saying. I wonder how limited your own individual opinion spectrum has to be for that to happen...
Correction fatty acids can contribute to glucose. The glycerol from triaglycerol can be used to synthesize glucose via gluconeogenesis. Glycerol --> Glycerol phosphate --> DHAP----> glyceraldehyde 3 Phosphate.
marcus cooley Your first statement is incorrect. Fatty acids do not contain the glycerol molecule. It's the backbone of the triacylglycerol. As such, the glycerol molecule of the triacylglycerol is indeed gluconeogenic, not the fatty acid.
Why the hell did you take all this time explaining minor useless details while you can just say the answer in 6:32 This is really a bad explanation and a waste of time
OMG! this is soooooo helpful for understanding the allosteric regulation of the PDH, thanks a lot =)
This is a bit misleading, Pyruvate dehydrogenase is 1 enzyme in the pyruvate dehydrogenase complex, which is a 3-enzyme complex, using 5 co-factors not the 2 mentioned in the video.
nerd
I think most would say that saying pyruvate dehydrogenase assumes you’re talking about the complex unless you specify that it’s the E1 pyruvate dehydrogenase. NAD+ and CoA are two of the five cofactors you are talking about and are the important ones in the general overview of the process.
Rina Colon yeah get it!
Leticia R. Colon b
This makes a lot of sense, thank you!
Great video with excellent clarity.
Amazing Explanation ⭐⭐⭐
Well explained. 2 enzymes other than pyruvate dehydrogenase are required for the reaction .. dihydrolipoyl transacetylase and D. Dehydrogenase. deficiency or missing those enzymes, it causes metabolism disease
Pyruvate dehydrogenase is a complex made up of those three enzymes.
ooh my good , such a great explaination
wooooooow just amaizng vedio but i have a question it does insulin inhibe or stimilut PHD activity
I have observed a tendency for ppl to copy & write the same idea someone else has commented on..for example about her voice which seems to be a very clear/understandable one in contrary to what all these negative comments r saying. I wonder how limited your own individual opinion spectrum has to be for that to happen...
super helpful review! thanks!
Love her 🥺
Thank you so much!!
super clear!
it's just about Allosteric Regulation. there are other important types concerning phos and dephos
very very helpfull thanks
Thanks
I was wondering, does anybody know why Protein Kinase A is an alosteric inhibitor of PDH?
Thanks 😄
Where is go the Co2 that was remove of pyruvate?
it's a waste product and it will be removed into the blood stream and out through our lungs
khan academy is the best!
ayo khan where did u go
I love those cute voices :3 jk jk.. good explanation! I might succeed in just 3 days of studying xD
Correction fatty acids can contribute to glucose. The glycerol from triaglycerol can be used to synthesize glucose via gluconeogenesis. Glycerol --> Glycerol phosphate --> DHAP----> glyceraldehyde 3 Phosphate.
marcus cooley Your first statement is incorrect. Fatty acids do not contain the glycerol molecule. It's the backbone of the triacylglycerol. As such, the glycerol molecule of the triacylglycerol is indeed gluconeogenic, not the fatty acid.
Ville Skåtar you are right...
Fattty acid is not glycerol Marcus, glycerol can, but not fatty acid. Thanx
you are also not describing allosteric regulation
My chemistry teacher aint got nothing on this
Who let Bernadette talk on KhanAcademy?
Bruh this voice is driving me crazy
Misleading video
Why the hell did you take all this time explaining minor useless details while you can just say the answer in 6:32
This is really a bad explanation and a waste of time
this girl talks so fast its fustrating
Work on the the voice
I hate this girl's voice. Bring back the man.