Excellent lecture! I had learned a bit about this pathway from Dr Richard Johnson and appreciate this level of detail along with the diagrams. The Randle Cycle activation (learned from Prof Bart Kay) and the polyol pathway are two powerful reasons to limit or avoid carbs entirely. Thank You!
As someone who already limits carbs, but still has elevated uric acid and fasted bllood sugar, I'm now looking into increase glycine and reduce branched chain amino acids to further reduce polyol activation.
I ran across this before I was aware of Richard Johnson. A few people notes it sounded like his work, and I had no idea... But looked into it. Saved me a ton of extra work and studying research, as he and a few others had done much of the legwork already. Their data for right into where I left off. Carrying their data further I'm changing my amino acids, incorporating more glycine to reduce my blood sugar thus reduce polyol pathway activation.
I have been following a dietary paradigm for the last 20 years where I consume the meat of ruminant animals, eggs, seafood, organ meats, plenty of fresh fruit, fruit juices and honey. My Fasting Insulin, HA1C and triglycerides are all low and all my other lab results are perfect. I am 63 years old and not that it matters but I have a six pack and feel great. I think that I am going to keep doing what works for me.
He has a channel called Dr Pete’s Keto Klub. Does a more in depth explanation. As a regular LCHF weightlifter I’m stumped why my fasting BG runs so hot at 120mg/dl. But I feel great. Low BP 110/65. BMI of 25. Muscular. He may have an explanation with the switch to the polyol pathway at a BG
I dont know but the key takeaway is not blood glucose but fructose and if you are staying away from fructose (sugar) your glucose levels might not matter as much. You did not say what YOUR HBa1c was. Glucose does not cause high uric acid which is what does the damage, not lactic acid.
@@reivanen If you go to his channel, he goes into a lot more detail. Dave probably limited him to 15 min. Look at the video called … “Polyol|Fructose-Uric Acid: A Unified Theory of Metabolic Disease” at 8:50 into video he shows a slide of all the enzymes necessary to activate the switch. It’s likely my body never sees the first enzyme because it’s ONLY activated with BG < 90. I only see that when I do a 3 day fast. So then… if you have a meal AND it takes you over BG 90 you’re on your way to storage mode. Why? Because as Dr Johnson says….”Nature wants you to be Fat”. I’m not a scientist, just a 64 yo guy who lifts , walks 10k steps/ day and tries to stay healthy. I do LCHF, saw 550 LDL on carnivore, added back none starchy carbs. LDL 300. Feel great. Gonna stay at this level. I recover from most ailments super fast. My HbA1c was about 5.8-6.0 It obviously implied I was pre-diabetic. I’m not. I’m the opposite of that with a fasting insulin
I think the speaker would agree that the important content is what's on the slides. Why are you giving the speaker 90% of the screen? Trying to read the minutia of the slide on a laptop here, and you're not helping.
My feel from the presentation is that sugar is not good for you. If so, my mental reduction from the plethora of signaling molecules with yes/no outcomes is about right.
BTW, the polyol-pathway may be an issue for someone with primary aldosteronism even if he is on a ketogenic diet. That is because the aldosterone increases serum osmolarity which then activates aldose-reductase.
If you have too high blood sugar (which is glucose), a switch is turned around, ALL glucose (good sugar) is turned into fructose (bad sugar), and your liver is made sick by the fructose. Also, all the fructose (which previously was glucose) is turned into fat. Glucose normally is burned in the cells to ATP/ADP/AMP, which is the energy currency of the cells, which is used to power movement, the brain, and all the maintenance stuff that the body does, e.g. build new protein and clear out garbage protein.
Excellent lecture! I had learned a bit about this pathway from Dr Richard Johnson and appreciate this level of detail along with the diagrams. The Randle Cycle activation (learned from Prof Bart Kay) and the polyol pathway are two powerful reasons to limit or avoid carbs entirely. Thank You!
As someone who already limits carbs, but still has elevated uric acid and fasted bllood sugar, I'm now looking into increase glycine and reduce branched chain amino acids to further reduce polyol activation.
Hello from Canary islands...Great conversation. Dr. Robert Lustig talks also about this pathways...in the same way...
This is Richard Johnson's theory, and it makes evolutionary sense...we love Dr. Pete!
I ran across this before I was aware of Richard Johnson.
A few people notes it sounded like his work, and I had no idea... But looked into it.
Saved me a ton of extra work and studying research, as he and a few others had done much of the legwork already.
Their data for right into where I left off.
Carrying their data further I'm changing my amino acids, incorporating more glycine to reduce my blood sugar thus reduce polyol pathway activation.
Great to see Dr Pete out there.
I have been following a dietary paradigm for the last 20 years where I consume the meat of ruminant animals, eggs, seafood, organ meats, plenty of fresh fruit, fruit juices and honey. My Fasting Insulin, HA1C and triglycerides are all low and all my other lab results are perfect. I am 63 years old and not that it matters but I have a six pack and feel great. I think that I am going to keep doing what works for me.
Thank you dr Pete ❤
Very informative video, but i would make the slideshow 50% of the screen. Would be easier to read that way. Thank you for putting this up.
Need to see the screen mostly please
He has a channel called Dr Pete’s Keto Klub. Does a more in depth explanation.
As a regular LCHF weightlifter I’m stumped why my fasting BG runs so hot at 120mg/dl. But I feel great. Low BP 110/65. BMI of 25. Muscular.
He may have an explanation with the switch to the polyol pathway at a BG
I dont know but the key takeaway is not blood glucose but fructose and if you are staying away from fructose (sugar) your glucose levels might not matter as much. You did not say what YOUR HBa1c was. Glucose does not cause high uric acid which is what does the damage, not lactic acid.
he says the switch happens above 90mg/dl ...
@@reivanen
If you go to his channel, he goes into a lot more detail. Dave probably limited him to 15 min.
Look at the video called … “Polyol|Fructose-Uric Acid: A Unified Theory of Metabolic Disease” at 8:50 into video he shows a slide of all the enzymes necessary to activate the switch.
It’s likely my body never sees the first enzyme because it’s ONLY activated with BG < 90. I only see that when I do a 3 day fast.
So then… if you have a meal AND it takes you over BG 90 you’re on your way to storage mode. Why? Because as Dr Johnson says….”Nature wants you to be Fat”.
I’m not a scientist, just a 64 yo guy who lifts , walks 10k steps/ day and tries to stay healthy. I do LCHF, saw 550 LDL on carnivore, added back none starchy carbs. LDL 300. Feel great. Gonna stay at this level. I recover from most ailments super fast.
My HbA1c was about 5.8-6.0
It obviously implied I was pre-diabetic. I’m not. I’m the opposite of that with a fasting insulin
awesome - thanks for sharing ❤
Assess your baseline vagal tone (how much fight or flight physiology is chronically “on”).
Fantastic
Does this mean that I should stop chewing gum every day?😅 How does xylitol and stevia glucosides affect the pathway?
I think the speaker would agree that the important content is what's on the slides. Why are you giving the speaker 90% of the screen? Trying to read the minutia of the slide on a laptop here, and you're not helping.
Agreed
Me too
My feel from the presentation is that sugar is not good for you. If so, my mental reduction from the plethora of signaling molecules with yes/no outcomes is about right.
Once they figure out how to block this pathway human health will be transformed, in the meantime do a keto diet :P
Aldose-reductase-inhibitors are already there...
BTW, the polyol-pathway may be an issue for someone with primary aldosteronism even if he is on a ketogenic diet.
That is because the aldosterone increases serum osmolarity which then activates aldose-reductase.
why can't you switch the layout - slides full person small - takes away from the message
I am not a proponent of the Bible, but...
"Sorry, Eve, leave that apple alone."
Can someone translate this into plain English? 😂
If you have too high blood sugar (which is glucose), a switch is turned around, ALL glucose (good sugar) is turned into fructose (bad sugar), and your liver is made sick by the fructose. Also, all the fructose (which previously was glucose) is turned into fat.
Glucose normally is burned in the cells to ATP/ADP/AMP, which is the energy currency of the cells, which is used to power movement, the brain, and all the maintenance stuff that the body does, e.g. build new protein and clear out garbage protein.