3. Urea cycle- site, steps, regulation, energetics and disorders

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  • Опубликовано: 29 дек 2024

Комментарии • 283

  • @tg_wrld
    @tg_wrld 4 года назад +192

    You are the hero of biochemistry.. Thank you to explain better than once

    • @Biology20
      @Biology20 2 года назад

      Urea cycle trick/mnemonic 👇 [Short Video]
      ruclips.net/user/shorts3-EgPGu61dk?feature=share

    • @Devil-ji5fe
      @Devil-ji5fe 2 года назад +6

      Really very nice explanation

    • @sumaiyaafrida9664
      @sumaiyaafrida9664 10 месяцев назад +1

      😅 0:02

  • @muqaddasasghar9125
    @muqaddasasghar9125 Год назад +28

    This man convert boring subject into interesting...mind blowing teaching skills ❤️❤️ MashAllah

  • @rajipoakshardham1146
    @rajipoakshardham1146 Год назад +15

    You are the lord of biochemistry
    MBBS is incomplete without you∞🙇🏿‍♀️🙇🏿‍♀️🙇🏿‍♀️🧑‍⚕️👨‍⚕️👩‍⚕️👩‍⚕️

  • @kishorekumarbanerjee6372
    @kishorekumarbanerjee6372 Год назад +17

    Wonderful lecture sir ..... Thank you for making such lovely videos
    11:21 - Argininosuccinate synthetase ( synthetase is different from synthease because synthetase uses ATP for conversion but synthease is no such of a compunction)
    Thank you sir 😊❤

  • @Spiritlife178
    @Spiritlife178 2 года назад +10

    you are best biochemistry lecturer on youtube. thank you Dr Rajesh.

  • @gururaghavendrarajusarikon586
    @gururaghavendrarajusarikon586 9 месяцев назад +6

    With your classes i get pass in bio chemistry ntr University

  • @ayeshafarooq6975
    @ayeshafarooq6975 3 года назад +14

    very comprehensive and complete explanation. Thank you so much.

  • @PoojaChavan-gl4wx
    @PoojaChavan-gl4wx 2 года назад +20

    You have made my life 10x easier. Thankyou for posting such valuable content.

  • @ankitakumawat8372
    @ankitakumawat8372 4 года назад +22

    Ur video is of great importance!.. nicely and easily explained.it means a lot to me...keep it up 🤗

  • @panimalars9017
    @panimalars9017 3 года назад +5

    I was searching clear explanation for this topic and u was clearly explained and it is very easy to study thanks for releveing my burdern sir...

  • @GauravDash007
    @GauravDash007 2 месяца назад +1

    From Watching sirs videos for 1st proff exams to watching sir's videos for neet pg, we've come a long way. Sir has been there throughout ❤

  • @ramyagubba6779
    @ramyagubba6779 4 года назад +17

    Sir ,please prepare viedo on imp questions in bio chemistry for 1st year final exam
    Iam not getting how to prepare these many questions sir...
    Sir, please say the important questions.this year pattern also changed sir .

    • @kapildevthalor4295
      @kapildevthalor4295 4 года назад +3

      See the all video of rajesh sir ji .. u will definitely get good marks in biochemistry ❤️

    • @pneumaticsky843
      @pneumaticsky843 3 года назад +1

      I think you are talking about CBME pattern, for knowing possible ways of questions refer CBME Questions of each chapter given either after index or in between topics as in BDC.

  • @Dinky-zv4hc
    @Dinky-zv4hc 5 лет назад +31

    You are an amazing teacher. Thankyou sir.

    • @Biology20
      @Biology20 2 года назад

      Urea cycle trick/mnemonic 👇
      ruclips.net/user/shorts3-EgPGu61dk?feature=share

  • @vivekpaidakula1442
    @vivekpaidakula1442 3 года назад +4

    Sir.really helpful thank u sir..takea bow for ur patience🙏

  • @doctorwhiteangel2108
    @doctorwhiteangel2108 3 года назад +5

    Your lectures gives subjects in finger tips. Thank you sir:)

  • @sapnamisal1999
    @sapnamisal1999 Год назад +2

    Sir I am student of PG-DMLT. Your lecture helping me lot...thank U Sir..🙏

  • @01.bhetariyadivya4
    @01.bhetariyadivya4 2 года назад +2

    You are the hero of biochemistry sir ...jakasss😀😀

  • @mihirpatel5632
    @mihirpatel5632 3 года назад +4

    Superb Explanation Sir!! 😇 Thanks you Very Very Much Sir🙏🙂

  • @nileshpawar4351
    @nileshpawar4351 3 года назад +2

    Ur genius of biochemistry 🙏🙏👍👍👍

  • @reshmasenthil2463
    @reshmasenthil2463 3 года назад +4

    Very clear explanation sir thank you so much. Such a life saver

  • @thefoodieeemedico8402
    @thefoodieeemedico8402 3 года назад +8

    Best explanation, Thank you sir , Love from Pakistan 🇵🇰♥️

  • @saranyasaa8046
    @saranyasaa8046 2 года назад +3

    Amazing class.... Beyond words... thank you so much sir 🥺💯💯

  • @kapildevthalor4295
    @kapildevthalor4295 4 года назад +6

    U are god of biochemistry sir ji❤️👍🙏 without your video i will never thinking to complete biochemistry in just 5 days

  • @nidhikamat5269
    @nidhikamat5269 4 года назад +4

    Thank you so much, khup clarity milali, thank you tumhala 🙏

  • @anuchowhan200
    @anuchowhan200 3 месяца назад

    Sir i am thankingyou becoz i studied whole biochemistry from your notes and your video lecturers ...finally i got Distinction in biochemistry ...❤❤❤❤thankyou soooooooooooooo much for your efforts....🙏

    • @mirarshid9951
      @mirarshid9951 2 месяца назад

      Where from class notes

    • @anuchowhan200
      @anuchowhan200 2 месяца назад

      @@mirarshid9951 sir has written a book in which all video lectures QR code is pt and class related topics are written ......

  • @kritisinha6908
    @kritisinha6908 3 года назад +4

    Thankyou so much sir. You made it so easy to understand 👍

  • @rajibul987
    @rajibul987 3 года назад +1

    Very helpful ♥️♥️
    Thanku sir more vdos plz

  • @bishnughorasaine5544
    @bishnughorasaine5544 4 года назад +2

    Just here to tell you that you are awesome teacher👌👌

  • @doctor_sarvam
    @doctor_sarvam 4 года назад +4

    Sir have EPIC teaching skills but should explain briefly about clinicals like given in the text books.

  • @kalyan2104GRMC
    @kalyan2104GRMC Год назад +2

    Sir the enzymes catalysing the step 1 and step 3 are synthetases....... please make a note of it sir......and the classes are really good and it's saviour for students at any time.....Thank you sir.... ❤️

  • @muhammadtalal2290
    @muhammadtalal2290 5 лет назад +6

    When aspartate is condensed with cirtulline the enzyme is arginnosuccinate synthetase not synthase cuz it uses ATP.
    The first cytosolic rxn im talkin about.

  • @cheenumdubey4521
    @cheenumdubey4521 3 года назад +2

    Thank you sir ....your videos help me a lot 👍

  • @072harleenkaur7
    @072harleenkaur7 3 года назад +3

    Very helpful video sir .keep it up sir🥰

  • @goodgirl-j7x
    @goodgirl-j7x 5 месяцев назад

    Teaching style is so amazing 👏

  • @manjiniarul7192
    @manjiniarul7192 5 лет назад +8

    Nice explanation thank you sir

  • @sonamhariyana9047
    @sonamhariyana9047 Год назад

    You are
    Best teacher of Biochemistry

  • @udumulakavya5232
    @udumulakavya5232 2 года назад +3

    Thank you.. sir u explained very clearly......

  • @alirahman5672
    @alirahman5672 Год назад

    I was hesitate from biochemistry but after watching your vedios nothing in bio chame thank you sir

  • @beautyofnature.7258
    @beautyofnature.7258 4 года назад

    Your teaching methods is very brilliant 😘😘😘😘😘😘

  • @hassnainhijab2533
    @hassnainhijab2533 4 года назад +4

    Thankew so much sir u r the best one teacher and teaching in a well way manner.
    Plzz sir after writing the lecture, take a side from the board , ta k hum screen shots le saky ok sir.
    Thanks ❤️❤️

  • @pippallahemasree4129
    @pippallahemasree4129 3 года назад +1

    Great explanation sir😊thank uu soo much

  • @shruticharokar4016
    @shruticharokar4016 4 года назад +5

    wonderful explanation sir......ur student from pcms and i was ur student in icmr project also i hope u remember me

  • @harikrishnan9852
    @harikrishnan9852 5 лет назад +4

    Thank u so much sir..
    Your lectures are great

  • @fancyworld2077
    @fancyworld2077 4 года назад +10

    sir one correction NADH+H+ is formed during the conversion of Malate to Oxaloacetate.. not Fumarate to MAlate!

  • @learnerart3922
    @learnerart3922 Год назад +1

    Bravo you teach soo amazing sir👍🏻

  • @sohandas1802
    @sohandas1802 5 лет назад +10

    Sir at 6:02 the enzyme is ARGINOSUCCINATE SYNTHETASE ... by mistake u said it synthase ... ATP is used so it should be synthetase

    • @sohandas1802
      @sohandas1802 5 лет назад

      Thank you for your videos they are really helpful sir thank u so much

    • @urbanproductions5584
      @urbanproductions5584 4 года назад

      Waah bhaiya full observation baazi✌

  • @farhanadar4116
    @farhanadar4116 3 месяца назад

    Loved learning this topic thoroughly

  • @soumyaranjanswain2263
    @soumyaranjanswain2263 5 лет назад +4

    Sir please make a video on 'Carbon skeleton of Glucogenic and Ketogenic amino acids'

  • @vidhyaloginirajavel3722
    @vidhyaloginirajavel3722 3 года назад +3

    I listen most of your class sir...clear explanation.. thank you

  • @meerwasil842
    @meerwasil842 2 года назад +1

    Thanku sir u made my exam very easy 😮

  • @uniquegirl7344
    @uniquegirl7344 4 года назад +1

    Well explained sir.. Hats off to you.. 🌸..

  • @drnamsoon
    @drnamsoon Год назад

    Thank you sir ❤
    Love from Pakistan 🇵🇰

  • @i_mermaid
    @i_mermaid 5 лет назад +3

    Very nicely explained Sir. ..

  • @deepikasingla1099
    @deepikasingla1099 4 года назад +2

    Thank u very much sir, nice explanation! 🙂

  • @dipalisharma8593
    @dipalisharma8593 Год назад +3

    Thank you sir 🙏🙏❣️❣️❣️

  • @sakinashakir7814
    @sakinashakir7814 4 года назад +1

    2:56 it is carbamoyl phosphate 'Synthetase' Although you said ATP utilized in it but still that makes difference

    • @Rajesh_Jambhulkar
      @Rajesh_Jambhulkar  4 года назад +5

      Only some authors differentiate between synthase and synthetase. According to standard books there is no such difference and they used these terms synonymously.

  • @ayushigurjar6134
    @ayushigurjar6134 5 лет назад +4

    Sir plzz app Biophyscs k bhi topic k liye vedio bnaye kyuki biophysics subject ki koi bhi vedio nhi bnata app bht accha padhate ho plzz sir

  • @rushikeshpatil1736
    @rushikeshpatil1736 4 года назад +1

    Very useful video 👌 sir
    Thank you so much!!

  • @ghanshyamchaudhary9741
    @ghanshyamchaudhary9741 11 месяцев назад

    Yaar sir aap kitna achha padhate ho ❤

  • @hafizmuhammadalihassan579
    @hafizmuhammadalihassan579 3 года назад +11

    Hey ! Sir first of all I'm grateful to you 💖
    Secondly I wanna ask how does it inhibits GABA and increase serotonin production ? Please explain🥺

    • @muskankhan648
      @muskankhan648 3 года назад

      Same question

    • @mrparacetamol2190
      @mrparacetamol2190 3 года назад +2

      @@muskankhan648 Alpha keto glutarate used for conversion to glutamate and GABA …if there will be deficiency in alpha kato glutarate …then it will leads to deficiency of gaba

    • @Biology20
      @Biology20 2 года назад

      Urea cycle trick/mnemonic 👇
      (Short video)
      ruclips.net/user/shorts3-EgPGu61dk?feature=share

  • @priyankaapriyankaa3194
    @priyankaapriyankaa3194 Год назад +2

    U are our savior🥺

  • @oyangtayor61
    @oyangtayor61 2 года назад +1

    Thank u so much... Sir... Now i got what is BIOCHEMISTRY...?

  • @sanjibpal3332
    @sanjibpal3332 3 года назад +1

    Sir which are the important topics of carbohydrate metabolism
    Sir thank you so much for clear explanation of urea cycle

  • @swalihakhan4248
    @swalihakhan4248 4 года назад +2

    Sir your videos are good for revision😊thnku🙏, sir this year pattern has changed plz upload some new videos on imp topics🙏

  • @doctorsahab7578
    @doctorsahab7578 4 года назад +2

    Best explained 😍😍

  • @sakshisingh-rv9fs
    @sakshisingh-rv9fs 3 года назад +1

    Thank you sir for clearing my concept.

  • @cateyessoumili8989
    @cateyessoumili8989 3 года назад +1

    Sir can I add H2O with CO2 and NH3...pls reply sir

  • @ramyagubba6779
    @ramyagubba6779 4 года назад +2

    Incredible sir 👏👌

  • @muhammadsabirhussain6190
    @muhammadsabirhussain6190 4 года назад +1

    Sir you are superb teacher😍❤😘

  • @sofiyasultana0612
    @sofiyasultana0612 2 года назад +1

    I wish , you would be our biochemistry sir.... Anyways thank you sir 💫

  • @athirav.r4158
    @athirav.r4158 4 года назад

    Tq so much sir.......🙂🙂🙂🙂🙂🙂🙂 explanation very nicely ☺

  • @fatimaghazal2398
    @fatimaghazal2398 3 года назад

    Sir,Brilliant classes.As a good student it is my duty to point out any mistake
    ,the enzymes are synthetases and not synthase

  • @mahimameshram3101
    @mahimameshram3101 2 года назад +2

    Thank you So much Sir ❤

  • @rutujasartape6827
    @rutujasartape6827 Год назад

    Thank You sir for good explanation 😊

  • @monikumari5303
    @monikumari5303 5 лет назад +2

    Sir Please make video on Amino acid synthesis

  • @mahekarora779
    @mahekarora779 3 года назад +2

    Superb explanation

  • @sumitbajaj5740
    @sumitbajaj5740 4 года назад +1

    excellent sir as always,thanks a ton

  • @seemamande9635
    @seemamande9635 3 года назад +1

    Sir pls make video for whole solution of university question paper

  • @coronaavidbiologyamankhan2177
    @coronaavidbiologyamankhan2177 4 года назад +1

    love you sir g .love and respect from lahore,pakistan 😍😍😍

  • @aishwaryawadkar2240
    @aishwaryawadkar2240 Год назад

    Sir .. I'm big big fan of urs videos thanks alot.. Sir this deamination reaction occurs in liver peroxisome ?

  • @manidhaliwal8493
    @manidhaliwal8493 3 года назад

    The most beautiful thing is that sir you don't teach from book ...

  • @ArchanaSingh-zi7kf
    @ArchanaSingh-zi7kf 3 года назад +1

    Ache se smjhi aa gyi urea cycle

  • @yeswinmeena847
    @yeswinmeena847 Год назад

    Sir i was terrified od bcem in college, thx for helping 😄

  • @akhilam626
    @akhilam626 4 года назад +1

    Pls upload more vedio in biochemistry

  • @swetahomekitchen2504
    @swetahomekitchen2504 3 года назад

    Sir one NADH-H gives 3 molecule of ATP
    Not 2.5

  • @VasundharaSanaboina
    @VasundharaSanaboina Год назад

    Sir but that cps is synthetase ,as it was utilising Atp

  • @rituparnakar4483
    @rituparnakar4483 4 года назад +1

    Thank u for explaining so nicely sir

  • @kashifmehmood5375
    @kashifmehmood5375 3 года назад +2

    Thanks alot sir ❤️❤️ very helpful

  • @dharakodiyatar9770
    @dharakodiyatar9770 4 года назад +2

    Superb sir 👌

  • @namshinaz7697
    @namshinaz7697 3 года назад +1

    Very helpful ❤️

  • @user-rp8hv1sw4y
    @user-rp8hv1sw4y 5 лет назад +1

    Thanks sir for summary in last

  • @medicaleducation8978
    @medicaleducation8978 4 года назад +1

    Sir this topic will be enough for my ist year mbbs exam

  • @candy13x
    @candy13x 2 года назад +2

    Thankyou sir for your amazing support 🤍

  • @karthikeyan.02
    @karthikeyan.02 4 года назад +1

    Sir metabolism of protein or amino acid? Please explain

    • @MedBees
      @MedBees 4 года назад +1

      Do check out
      ruclips.net/p/PLOliwi7X0rSspmj8Hj-YrxU50-w452YB1

  • @animalloveshuman7229
    @animalloveshuman7229 5 лет назад +1

    Fumarate converts to malate in tca cycle. But in that step no nadh is released. Can you explain how?

    • @animalloveshuman7229
      @animalloveshuman7229 5 лет назад

      You explained in vedio that in that step there is production of nadh. What is the net gain of Atp in that case?

    • @just_ayahuasca
      @just_ayahuasca 4 года назад

      Yes i m having the same doubt.....sir plz clear the doubt

    • @RamanDeep-ig6nb
      @RamanDeep-ig6nb 4 года назад

      Same here . Im confuses

    • @RamanDeep-ig6nb
      @RamanDeep-ig6nb 4 года назад

      Confused*

  • @nishthabhalla172
    @nishthabhalla172 4 года назад +1

    Sir too good explanation
    sir kindly suggest good book for biochemistry

    • @Rajesh_Jambhulkar
      @Rajesh_Jambhulkar  4 года назад +1

      DM Vasudevan

    • @nishthabhalla172
      @nishthabhalla172 4 года назад

      Ok sir thank you so much

    • @nishthabhalla172
      @nishthabhalla172 4 года назад +1

      Sir please do make more videos related to biochemistry topics and separate video for all important mcqs related to the chapter 👍

  • @sivashankar2636
    @sivashankar2636 3 года назад +3

    Jambhulkar sir - THE XAVIOUR

  • @harshvardhan5622
    @harshvardhan5622 4 года назад +1

    Sir, How does elevated NH3 decrease GABA and increase serotonin secrection?

    • @___s___8071
      @___s___8071 3 года назад +2

      Increased NH3 causes increased conversion of Alpha ketoglutarate to glutamate and glutamate to glutamine. Thus glutamate levels decrease.
      GABA is synthesized from glutamate by the action of glutamate carboxylase enzyme. So decrease in glutamate => decrease GABA synthesis.
      NH3 also interferes with Tryptophan metabolism and decreases serotonin synthesis as serotonin is formed by hydrozylation followed by decarboxylation of tryptophan.

  • @sk81224
    @sk81224 Год назад

    Sir one doubt.. synthase and synthetase both are same...??

    • @Rajesh_Jambhulkar
      @Rajesh_Jambhulkar  Год назад +1

      Many authors use these synonymously. Synthetase required ATP

  • @ayishakhalid1588
    @ayishakhalid1588 4 года назад

    Sir, in some text the ATP utilized is.3....how it comes?