Hellow Some time dephosphorylation meaning activation and another time dephosphorylation meaning inhibition , so question : what determine this state and how ??
Depends on the enzyme, but typically enzymes in the same family are regulated in a similar fashion. The long answer is the presence or absence of a phosphoryl group changes the structure of the enzyme. The nature of the change dictates whether (de)phosphorylation activates or represses enzyme activity.
Hellow
Some time dephosphorylation meaning activation and another time dephosphorylation meaning inhibition , so question : what determine this state and how ??
Depends on the enzyme, but typically enzymes in the same family are regulated in a similar fashion. The long answer is the presence or absence of a phosphoryl group changes the structure of the enzyme. The nature of the change dictates whether (de)phosphorylation activates or represses enzyme activity.