How to derive equilibrium occupancies

This is an undergraduate level talk about how to derive the occupancies of each state in a system at equilibrium. It's an appendix to the first talk in this playlist. Click MORE
This is the second video of the playlist on Pharmacological Principles. It explains how to derive the results in the first video, Affinity and Efficacy Explained: • Affinity and efficacy ...
You can download the powerpoint used in this talk from figshare.com/a...
The problem is explained briefly in the first 5 minutes of this video: • Introduction to the pr...
UCL course on Matrix methods for single channel analysis. A playlist of 11 talks: • UCL summer school: An...
Lecture 2 of the UCL course: Matrix algebra in 45 minutes: • Basic matrix algebra i...
The derivation of the general expression for equilibrium occupancies is at 32:50 in lecture 3 of the UCL course: • Macroscopic currents w...
The first separate estimates of affinity and efficacy, (C & Sakmann, 1985): www.onemol.org....
Lape et al, (2008) Current best estimates of affinity and efficacy: www.onemol.org....
A review of the principles of affinity and efficacy (1998): onemol.org.uk/C...
Why the black box (usually) works for antagonists (but not for agonists): www.onemol.org....
A short introduction to the rate at which equilibrium is approached, i.e. kinetics (not dealt with here, but important): How fast do drugs work? (1981): www.onemol.org....
Burzomato, et al, (2004). Journal of Neuroscience 24,10924-10940: www.onemol.org....

[@NickGhale]

Hello Professor, off-topic here, but I learned a lot from your explanations regarding the false positive risk and the misunderstanding of P(D|H) and P(H|D). It was one of the few extremely intuitive descriptions of the problems I’ve heard.
Can I ask you about your take on Magnitude Based Inference? It’s an inference technique that grew out of sports science. Superficially I don’t see problems with it but it has been criticised as being statistically unsound. Could you give your input, if you’re aware of it?