18: How Stem Cells Work, Use in Brain Injury and the CCR5 Receptor l Stanley Carmichael MD, PhD
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- Опубликовано: 28 май 2024
- In this episode of the UCLA BrainSPORT Podcast, Adel discusses Stem Cells with the chair of the UCLA Department of Neurology and accomplished stem cell and brain injury research scientist, Dr. Stanley Carmichael. The two discuss what stem cells actually are, how they work and the evidence for their use in brain and spinal cord injury. They further discuss what utilizing stem cells to treat these injuries might look like in the future and current research directions. The pair then shift to discuss Dr. Carmichael's latest work, researching the blockade of the brain's CCR5 receptor. This has demonstrated great potential to enhance brain injury recovery, reverse the effects of dementia and even enhance healthy brain function.
For more information on the UCLA Steve Tisch BrainSPORT Program: ucla.in/3t6Q77b
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*This video is for informational purposes only and is not intended as a substitute or supplement for professional medical advice, consultation, or expertise. Please see a medical professional if you have any questions or concerns regarding any symptoms or injuries you have had.
#BrainSPORT #UCLA #UCLAHealth #UCLACommunity #StemCell #Neurology #BrainInjury #SpinalCordInjury #Dementia #BrainInjuryRecovery
00:00 - Intro
5:12 - What are Stem Cells?
13:52 - Exosomes
17:53 - Evidence for Stem Cell Use in Brain Injury
25:24 - How do Stem Cells Work?
30:53 - Enhancing Stem Cell Survivability after Implantation
32:42 - Stem Cells for Spinal Cord Injury
34:29 - Tracking Stem Cell function with Optogenetics
37:08 - Longest Survival Time of a Stem Cell in the Brain
37:54 - fMRI to track Stem Cell Integration
39:15 - Stem Cell Migration to Injury
42:12 - Stem Cells and Neuroplasticity
43:54 - What would Stem Cell Implantation look like in practice?
46:15 - Stem Cells with Mutations?
47:19 - Best Timing for Stem Cell Implantation
49:40 - Potential Adverse Effects of Stem Cell Implantation
53:12 - Challenges to Stem Cell Therapy
58:25 - Future Direction of Research in Stem Cell Therapy
1:01:16 - The CCR5 Brain Receptor
1:03:34 - Evolutionary Function of the CCR5 Receptor
1:05:31 - CCR5 blockade enhances brain injury recovery
1:13:50 - The current drug that already blocks CCR5
1:15:12 - Can CCR5 blockade reverse effects of dementia?
1:16:36 - Enhancing learning and memory by blocking CCR5
1:19:08 - Potential adverse effects of CCR5 blockade
1:22:02 - Final words on Regenerative Medicine 
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I'm planning on going to Mexico for intrathecal administration of mesenchymal stem cells to treat an acquired brain injury (abscess, not stroke) and would love to know if it's truly a viable option to help heal faster.
WE NEED TO DEMAND MORE OF OUR TAX DOLLARSA GO TO THIS.
Grow up
@@dmd7472 i am 55 years old running a plumbing heating company 38 years. i know more about life than anyone you will ever know. so, WISE UP.
are you still looking trial partizipans
How can I get in contact with Dr, Carmichael?
Please, what is the name of the drug at 1.14 minute?
l love Dr Pius Ozigbe! My daughter and I loved watching him and his sister in operation Ouch and his "Dr who gave up drugs" He seems like such a genuine, empathetic, no bullshit guy who genuinely cares and makes complex issues easy to understand for the lay person.
Sadly we are so far away from any effective and reliable therapies. The hype and promises made a decade ago didn’t pan out and most of the funding and research dried up because our knowledge was so comically superficial and lacking. This is a much more complicated process than we ever imagined. We missed the creation of mutations and tumors because we do not understand the stem cells signaling. Not in our lifetimes will we understand this well enough to bring a ground breaking discovery to market.
Yyyy
What?!? Leronlimab is the gem of the CCR5 antagonist. It’s the FDA that’s slow walking this molecule!
@westfield90, i agree on the complexities and frustrations many feel about the progress-or perceived lack thereof-in stem cell research and therapies. However, I'd like to share a different perspective. While it's true that the field has its challenges, effective treatments might be closer than you think. My husband underwent stem cell treatment 10 months ago, (just 1 month after his injury). The improvements have been pretty dramatic, to say the least.
The real issue, as you touched upon, isn't just the technology itself, but rather access to that technology and patients' rights to utilize it. We had to fly a great distance to get the treatment, which shouldn't have to be the case. But the fact that the treatment exists and showed remarkable results speaks to how far the field has actually come. tis a complicated process, but progress is being made, even if it doesn't always seem like it sometimes
Thanks for sharing.
@marydat6578 just because the treatment looks like it worked doesn't mean it actually was causal, the fact you traveled means you went to a place that doesn't actually have any science behind it
Lets discuss the real problem. Why is the funding not there?
In My sons case So called Autism(brain injured) get practicly no funding... Yet we send the Ukrain 65 billion dollarsa????? We asrent that stupd.
Coming from someone with a brain injury it's truly infuriating to watch all our tax dollars get thrown at someone else's war! And the FDA won't approve this type of treatment vecause it would actually cure diseases!
mAKE AMERICA GREAT AGAIN, end lobby money, create term limits, NOW!
1 in 50 children affected....not important enough? C,mon its obviouse.