Does NAD+ Actually boost longevity? | Dr. Matt Kaeberlein

Matt Kaeberlein discusses what the research and data says on sirtuins and NAD+ for boosting longevity. In particular, he discusses SIRT6 and is a skeptic when it comes to NAD+ research (NMN and NR) for longevity.
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Website: kaeberlein.org/
Twitter: / mkaeberlein
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Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
#nad #sirtuins #nmn #longevity #antiaging #aging

[@bob-ss4wx]

Matt is one of the best thing that happened to Rapamycin. Getting the information out there.

[@peterz53]

Thanks for reminder! On SIrt6, Vera Gorbunova's lab has done interestting work relating sirt6 to double strand DNA breaks, which are supposedly a key driver of aging. Her lab investigates mechanisms by which some animals live ling lives (bats, certain rodents, whales, etc.). Seems that one problem with supplements is that they are dumped into the body without regard to what else is going on at the time, and they often have short biological half-lives. Interventions that maintain homeostasis (change many things in synchrony over longer time frames), like exercise and diet, also modulate NAD+, etc. likley with more effect.

[@livelongerworld]

Absolutely! And as Brian Kennedy points out in my podcast, combining different supplements may cancel out the effects too. Agreed with the point exercise and better lifestyle habits for maintaining homeostasis.